TY - JOUR T1 - Dimensionen 1-2018: Magazin der FH Aachen University of Applied Sciences - Grenzgänge N2 - Grenzgänge: Op jöck in Vaals mit Peter Sparla Inhaltsverzeichnis 6 "Mr. Vaals": Ein Spaziergang mit Peter Sparla durch die niederländische Gemeinde 14 Ein Verein hebt ab: Von der Theorie in die Praxis: Die Flugtechnische Arbeitsgemeinschaft will Studierende fürs Fliegen begeistern 18 Vom Flugplatzkind zur Ingenieurin: Sarah Hamacher hat Luft- und Raumfahrt studiert und arbeitet jetzt bei der ADAC-Luftfahrttechnik 20 Mit Sonne im Tank durch das australische Outback: FH-Student Enno Dülberg berichtet von der World Solar Challenge 24 Es steckt mehr dahinter: Eine Eschweiler Firma entwickelt Elektronik-Lösungen für Anhängerkupplungen - mit Unterstützung der FH Aachen 27 Von Meknès nach Jülich: Die Geschichte von Rabab Azizi 28 Das blaue Wunder neu erleben: Aachener Tuchtradition soll wieder in Mode kommen 32 Es werde Licht: Markus van Hauten macht spektakuläre Landschaftsfotos 36 Maschinenbau von morgen: Dr. Julia Kessler forscht zu additiv gefertigten Leichtbaustrukturen 39 Vier Siebenen und eine Eins: Kopfnuss 40 Auf Tuchfühlung mit der Praxis: Das ausbildungsintegrierende Studium ist anspruchsvoll und fordernd. Aber es bietet den Studierenden und Unternehmen auch viel. 44 Eine große Bühne für die Forschung: FH aachen präsentiert das Spektrum ihrer wissenschaftlichen Arbeit 46 Eine Erfolgsstory: Das Institut für Nano- und Biotechnologien feiert sein 10-jähriges Jubiläum 49 Das Ingenieurstudium früher und heute: Der Verein "Ingenieurfreunde der FH Aachen" blickt auf eine ereignisreiche Zeit zurück 50 Ist es ein Flugzeug? Ist es ein Multikopter: Nein es ist PhoenAix! Das Fluggerät soll Vorteile von Flugzeug- und Hubschraubertechnik kombinieren 54 Güterwagen der Zukunft: Im Studiengang Schienfahrzeugtechnik wird an intelligenten und hoch technisierten Güterwaggons gearbeitet 58 Wenn Gedanken Gestalt annehmen: Prof. Thomas Tünnemann zum Projekt Neo Forma 60 Vorhang auf für die Wissenschaft: Future-Lab-Gala im Theater Aachen 62 Impressum T3 - Dimensionen - Magazin der FH Aachen University of Applied Sciences - 2018, 1 Y1 - 2018 ER - TY - JOUR T1 - Dimensionen 2-2018: Magazin der FH Aachen University of Applied Sciences - Virtuelle Realitäten N2 - Virtuelle Realitäten Inhaltsverzeichnis 6 Erweiterte Dimensionen: Special zum Thema Virtual Reality 10 "VR und AR werden unsere Welt durchdringen": Ein Interview zum Potenzial von Virtual und Augmented Reality 14 Lernen aus einem anderen Blickwinkel: VR wird in Studium und Lehre zunehmend angewandt 18 Parallele Realitäten in der Forschung: Virtual und Augmented Reality in Forschungsprojekten 22 Willkommen in der Welt der Möglichkeiten: Wie real ist die Illusion der Realität 24 Eine zündende Idee: Institut für Mikrowellen- und Plasmatechnik (IMP) entwickelt neue Plasmazündkerze für sparsamere Benzinmotoren 28 Der Elefant im Park: "WESTPARK story constructed": Studierende bauen skulpturales Möbel 30 Herr Bernoulli geht auf Reisen: Das "aero | race lab" bringt Experimente zur Luft- und Raumfahrt an die Schulen 32 Eine Auszeit vom Alltag: Martin Stockberg schafft Kunstwerke im Sand 36 Der Einer im urbanen Mobilitätstetris: An der FH Aachen wird urbane Elektromobilität neu gedacht 39 Der Primzahlwürfel: Kopfnuss 40 Schwarz Weiß Bunt: Die politische Kunst des FH-Absolventen Ralf Metzenmacher 44 Die Champions League des Schweißens: LaVa-X will das Laserstrahlschweißen im Vakuum etablieren 46 Auf der Suche nach dem goldenen Schnatz: Stöcke statt Besen. Spielfeld statt Arena. In Jülich spielen Studierende Quidditch. 48 Bei ihm wird Science-Fiction zu Science-Fact: Volker Schmid erzählt von seiner Arbeit beim Deutschen Zentrum für Luft- und Raumfahrt (DLR) 52 Die Ideenschmieden: Junge Menschen aus aller Welt diskutieren bei den Summerschools über Zukunftsthemen 56 Forschung auf höchstem Niveau: Dr. Jan Oberländer und Doktorand Dua Özsoylu stehen für das, was das Institut für Nano- und Biotechnologien auszeichnet 58 Der Dom und ich: Dompublikation und LEGO-Throne zum Jubiläum 40 Jahre UNESCO-Weltkulturerbe 62 Sag "Ja" zum Studium: Der neue kooperative Bachelorstudiengang "Elektrotechnik mit Orientierungssemester" 63 Impressum T3 - Dimensionen - Magazin der FH Aachen University of Applied Sciences - 2018, 2 Y1 - 2018 CY - Aachen ER - TY - JOUR A1 - Aboulnaga, E. A. A1 - Zou, H. A1 - Selmer, Thorsten A1 - Xian, M. T1 - Development of a plasmid-based, tunable, tolC-derived expression system for application in Cupriavidus necator H16 JF - Journal of Biotechnology N2 - Cupriavidus necator H16 gains increasing attention in microbial research and biotechnological application due to its diverse metabolic features. Here we present a tightly controlled gene expression system for C. necator including the pBBR1-vector that contains hybrid promoters originating from C. necator native tolC-promoter in combination with a synthetic tetO-operator. The expression of the reporter gene from these plasmids relies on the addition of the exogenous inducer doxycycline (dc). The novel expression system offers a combination of advantageous features as; (i) high and dose-dependent recombinant protein production, (ii) tight control with a high dynamic range (On/Off ratio), which makes it applicable for harmful pathways or for toxic protein production, (iii) comparable cheap inducer (doxycycline, dc), (iv) effective at low inducer concentration, that makes it useful for large scale application, (v) rapid, diffusion controlled induction, and (vi) the inducer does not interfere within the cell metabolism. As applications of the expression system in C. necator H16, the growth ability on glycerol was enhanced by constitutively expressing the E. coli glpk gene-encoding for glycerol kinase. Likewise, we used the system to overcome the expression toxicity of mevalonate pathway in C. necator H16. With this system, the mevalonate-genes were successfully introduced in the host and the recombinant strains could produce about 200 mg/l mevalonate. Y1 - 2018 U6 - http://dx.doi.org/10.1016/j.jbiotec.2018.03.007 SN - 0168-1656 VL - 274 SP - 15 EP - 27 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Albanna, Walid A1 - Kotliar, Konstantin A1 - Lüke, Jan Niklas A1 - Alpdogan, Serdar A1 - Conzen, Catharina A1 - Lindauer, Ute A1 - Clusmann, Hans A1 - Hescheler, Jürgen A1 - Vilser, Walthard A1 - Schneider, Toni A1 - Schubert, Gerrit Alexander T1 - Non-invasive evaluation of neurovascular coupling in the murine retina by dynamic retinal vessel analysis JF - Plos one N2 - Background Impairment of neurovascular coupling (NVC) was recently reported in the context of subarachnoid hemorrhage and may correlate with disease severity and outcome. However, previous techniques to evaluate NVC required invasive procedures. Retinal vessels may represent an alternative option for non-invasive assessment of NVC. Methods A prototype of an adapted retinal vessel analyzer was used to assess retinal vessel diameter in mice. Dynamic vessel analysis (DVA) included an application of monochromatic flicker light impulses in predefined frequencies for evaluating NVC. All retinae were harvested after DVA and electroretinograms were performed. Results A total of 104 retinal scans were conducted in 21 male mice (90 scans). Quantitative arterial recordings were feasible only in a minority of animals, showing an emphasized reaction to flicker light impulses (8 mice; 14 scans). A characteristic venous response to flicker light, however, could observed in the majority of animals. Repeated measurements resulted in a significant decrease of baseline venous diameter (7 mice; 7 scans, p < 0.05). Ex-vivo electroretinograms, performed after in-vivo DVA, demonstrated a significant reduction of transretinal signaling in animals with repeated DVA (n = 6, p < 0.001). Conclusions To the best of our knowledge, this is the first non-invasive study assessing murine retinal vessel response to flicker light with characteristic changes in NVC. The imaging system can be used for basic research and enables the investigation of retinal vessel dimension and function in control mice and genetically modified animals. Y1 - 2018 U6 - http://dx.doi.org/10.1371/journal.pone.0204689 VL - 13 IS - 10 PB - PLOS CY - San Francisco ER - TY - CHAP A1 - Alhwarin, Faraj A1 - Ferrein, Alexander A1 - Scholl, Ingrid T1 - CRVM: Circular Random Variable-based Matcher - A Novel Hashing Method for Fast NN Search in High-dimensional Spaces T2 - Proceedings of the 7th International Conference on Pattern Recognition Applications and Methods, ICPRAM 2018 Y1 - 2018 SN - 978-989-758-276-9 U6 - http://dx.doi.org/10.5220/0006692802140221 SP - 214 EP - 221 ER - TY - CHAP A1 - Alhwarin, Faraj A1 - Schiffer, Stefan A1 - Ferrein, Alexander A1 - Scholl, Ingrid T1 - Optimized KinectFusion Algorithm for 3D Scanning Applications T2 - Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 2: BIOIMAGING Y1 - 2018 SN - 978-989-758-278-3 U6 - http://dx.doi.org/10.5220/0006594700500057 SP - 50 EP - 57 ER - TY - JOUR A1 - Altherr, Lena A1 - Brötz, Nicolas A1 - Dietrich, Ingo A1 - Gally, Tristan A1 - Geßner, Felix A1 - Kloberdanz, Hermann A1 - Leise, Philipp A1 - Pelz, Peter Franz A1 - Schlemmer, Pia A1 - Schmitt, Andreas T1 - Resilience in mechanical engineering - a concept for controlling uncertainty during design, production and usage phase of load-carrying structures JF - Applied Mechanics and Materials N2 - Resilience as a concept has found its way into different disciplines to describe the ability of an individual or system to withstand and adapt to changes in its environment. In this paper, we provide an overview of the concept in different communities and extend it to the area of mechanical engineering. Furthermore, we present metrics to measure resilience in technical systems and illustrate them by applying them to load-carrying structures. By giving application examples from the Collaborative Research Centre (CRC) 805, we show how the concept of resilience can be used to control uncertainty during different stages of product life. Y1 - 2018 SN - 1662-7482 U6 - http://dx.doi.org/10.4028/www.scientific.net/AMM.885.187 VL - 885 SP - 187 EP - 198 PB - Trans Tech Publications CY - Bäch ER - TY - JOUR A1 - Altherr, Lena A1 - Ederer, Thorsten A1 - Pfetsch, Marc E. A1 - Pelz, Peter F. T1 - Maschinelles Design eines optimalen Getriebes JF - ATZ - Automobiltechnische Zeitschrift N2 - Nahezu 100.000 denkbare Strukturen kann ein Getriebe bei gleicher Funktion aufweisen - je nach Ganganzahl und gefordertem Freiheitsgrad. Mit dem traditionellen Ansatz bei der Entwicklung, einzelne vielversprechende Systemkonfigurationen manuell zu identifizieren und zu vergleichen, können leicht innovative und vor allem kostenminimale Lösungen übersehen werden. Im Rahmen eines Forschungsprojekts hat die TU Darmstadt spezielle Optimierungsmethoden angewendet, um auch bei großen Lösungsräumen zielsicher ein für die individuellen Zielstellungen optimales Layout zu finden. Y1 - 2018 SN - 2192-8800 U6 - http://dx.doi.org/10.1007/s35148-018-0131-3 VL - 120 IS - 10 SP - 72 EP - 77 PB - Springer Nature CY - Cham ER - TY - JOUR A1 - Altherr, Lena A1 - Joggerst, Laura A1 - Leise, Philipp A1 - Pfetsch, Marc E. A1 - Schmitt, Andreas A1 - Wendt, Janine T1 - On obligations in the development process of resilient systems with algorithmic design methods JF - Applied Mechanics and Materials N2 - Advanced computational methods are needed both for the design of large systems and to compute high accuracy solutions. Such methods are efficient in computation, but the validation of results is very complex, and highly skilled auditors are needed to verify them. We investigate legal questions concerning obligations in the development phase, especially for technical systems developed using advanced methods. In particular, we consider methods of resilient and robust optimization. With these techniques, high performance solutions can be found, despite a high variety of input parameters. However, given the novelty of these methods, it is uncertain whether legal obligations are being met. The aim of this paper is to discuss if and how the choice of a specific computational method affects the developer’s product liability. The review of legal obligations in this paper is based on German law and focuses on the requirements that must be met during the design and development process. KW - legal obligations KW - product liability KW - design of technical systems KW - optimization KW - resilience Y1 - 2018 SN - 1662-7482 U6 - http://dx.doi.org/10.4028/www.scientific.net/AMM.885.240 VL - 885 IS - 885 SP - 240 EP - 252 PB - Trans Tech Publications CY - Bäch ER - TY - JOUR A1 - Altherr, Lena A1 - Leise, Philipp A1 - Pfetsch, Marc E. A1 - Schmitt, Andreas T1 - Algorithmic design and resilience assessment of energy efficient high-rise water supply systems JF - Applied Mechanics and Materials N2 - High-rise water supply systems provide water flow and suitable pressure in all levels of tall buildings. To design such state-of-the-art systems, the consideration of energy efficiency and the anticipation of component failures are mandatory. In this paper, we use Mixed-Integer Nonlinear Programming to compute an optimal placement of pipes and pumps, as well as an optimal control strategy.Moreover, we consider the resilience of the system to pump failures. A resilient system is able to fulfill a predefined minimum functionality even though components fail or are restricted in their normal usage. We present models to measure and optimize the resilience. To demonstrate our approach, we design and analyze an optimal resilient decentralized water supply system inspired by a real-life hotel building. KW - MINLP KW - Buffering Capacity KW - Uncertainty KW - Water Supply Networks KW - Booster Stations Y1 - 2018 U6 - http://dx.doi.org/10.4028/www.scientific.net/AMM.885.211 SN - 1662-7482 VL - 885 SP - 211 EP - 223 PB - Trans Tech Publications CY - Bäch ER - TY - CHAP A1 - Anic, Filip A1 - Penava, Davorin A1 - Guljas, Ivica A1 - Sarhosis, Vasilis A1 - Abrahamczyk, Lars A1 - Butenweg, Christoph T1 - The Effect of Openings on Out-of-Plane Capacity of Masonry Infilled Reinforced Concrete Frames T2 - 16th European Conference on Earthquake Engineering, Thessaloniki, 18-21 June, 2018 Y1 - 2018 N1 - Paper No 10168 SP - 1 EP - 11 ER - TY - CHAP A1 - Artmann, Gerhard A1 - Meruvu, Haritha A1 - Kizildag, Sefa A1 - Temiz Artmann, Aysegül ED - Artmann, Gerhard ED - Temiz Artmann, Aysegül ED - Zhubanova, Azhar A. ED - Digel, Ilya T1 - Functional Toxicology and Pharmacology Test of Cell Induced Mechanical Tensile Stress in 2D and 3D Tissue Cultures T2 - Biological, Physical and Technical Basics of Cell Engineering N2 - Mechanical forces/tensile stresses are critical determinants of cellular growth, differentiation and migration patterns in health and disease. The innovative “CellDrum technology” was designed for measuring mechanical tensile stress of cultured cell monolayers/thin tissue constructs routinely. These are cultivated on very thin silicone membranes in the so-called CellDrum. The cell layers adhere firmly to the membrane and thus transmit the cell forces generated. A CellDrum consists of a cylinder which is sealed from below with a 4 μm thick, biocompatible, functionalized silicone membrane. The weight of cell culture medium bulbs the membrane out downwards. Membrane indentation is measured. When cells contract due to drug action, membrane, cells and medium are lifted upwards. The induced indentation changes allow for lateral drug induced mechanical tension quantification of the micro-tissues. With hiPS-induced (human) Cardiomyocytes (CM) the CellDrum opens new perspectives of individualized cardiac drug testing. Here, monolayers of self-beating hiPS-CMs were grown in CellDrums. Rhythmic contractions of the hiPS-cells induce membrane up-and-down deflections. The recorded cycles allow for single beat amplitude, single beat duration, integration of the single beat amplitude over the beat time and frequency analysis. Dose effects of agonists and antagonists acting on Ca2+ channels were sensitively and highly reproducibly observed. Data were consistent with published reference data as far as they were available. The combination of the CellDrum technology with hiPS-Cardiomyocytes offers a fast, facile and precise system for pharmacological and toxicological studies. It allows new preclinical basic as well as applied research in pharmacolgy and toxicology. Y1 - 2018 SN - 978-981-10-7904-7 U6 - http://dx.doi.org/10.1007/978-981-10-7904-7_7 SP - 157 EP - 192 PB - Springer CY - Singapore ER - TY - BOOK A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül A1 - Zhubanova, Azhar A. A1 - Digel, Ilya ED - Artmann, Gerhard ED - Temiz Artmann, Aysegül ED - Zhubanova, Azhar A. ED - Digel, Ilya T1 - Biological, physical and technical basics of cell engineering Y1 - 2018 SN - 978-981-10-7903-0 PB - Springer CY - Singapore ER - TY - CHAP A1 - Baader, Fabian A1 - Reiswich, M. A1 - Bartsch, M. A1 - Keller, D. A1 - Tiede, E. A1 - Keck, G. A1 - Demircian, A. A1 - Friedrich, M. A1 - Dachwald, Bernd A1 - Schüller, K. A1 - Lehmann, R. A1 - Chojetzki, R. A1 - Durand, C. A1 - Rapp, L. A1 - Kowalski, Julia A1 - Förstner, R. T1 - VIPER - Student research on extraterrestrical ice penetration technology T2 - Proceedings of the 2nd Symposium on Space Educational Activities N2 - Recent analysis of scientific data from Cassini and earth-based observations gave evidence for a global ocean under a surrounding solid ice shell on Saturn's moon Enceladus. Images of Enceladus' South Pole showed several fissures in the ice shell with plumes constantly exhausting frozen water particles, building up the E-Ring, one of the outer rings of Saturn. In this southern region of Enceladus, the ice shell is considered to be as thin as 2 km, about an order of magnitude thinner than on the rest of the moon. Under the ice shell, there is a global ocean consisting of liquid water. Scientists are discussing different approaches the possibilities of taking samples of water, i.e. by melting through the ice using a melting probe. FH Aachen UAS developed a prototype of maneuverable melting probe which can navigate through the ice that has already been tested successfully in a terrestrial environment. This means no atmosphere and or ambient pressure, low ice temperatures of around 100 to 150K (near the South Pole) and a very low gravity of 0,114 m/s^2 or 1100 μg. Two of these influencing measures are about to be investigated at FH Aachen UAS in 2017, low ice temperature and low ambient pressure below the triple point of water. Low gravity cannot be easily simulated inside a large experiment chamber, though. Numerical simulations of the melting process at RWTH Aachen however are showing a gravity dependence of melting behavior. Considering this aspect, VIPER provides a link between large-scale experimental simulations at FH Aachen UAS and numerical simulations at RWTH Aachen. To analyze the melting process, about 90 seconds of experiment time in reduced gravity and low ambient pressure is provided by the REXUS rocket. In this time frame, the melting speed and contact force between ice and probes are measured, as well as heating power and a two-dimensional array of ice temperatures. Additionally, visual and infrared cameras are used to observe the melting process. Y1 - 2018 SP - 1 EP - 6 ER - TY - JOUR A1 - Babilon, Katharina A1 - Wilbring, Daniela A1 - Tappert, Tim A1 - Pfaff, Raphael A1 - Enning, Manfred T1 - Schienenfahrzeugtechnik hands on – FH Aachen IMechE Railway Challenge JF - Ingenieurspiegel Y1 - 2018 SN - 1868-5919 IS - 2 SP - 20 EP - 22 PB - Public Verlag CY - Bingen ER - TY - JOUR A1 - Balakirski, Galina A1 - Kotliar, Konstantin A1 - Pauly, Karolin J. A1 - Krings, Laura K. A1 - Rübben, Albert A1 - Baron, Jens M. A1 - Schmitt, Laurenz T1 - Surgical Site Infections After Dermatologic Surgery in Immunocompromised Patients: A Single-Center Experience JF - Dermatologic Surgery N2 - BACKGROUND Immunosuppression is often considered as an indication for antibiotic prophylaxis to prevent surgical site infections (SSI) while performing skin surgery. However, the data on the risk of developing SSI after dermatologic surgery in immunosuppressed patients are limited. PATIENTS AND METHODS All patients of the Department of Dermatology and Allergology at the University Hospital of RWTH Aachen in Aachen, Germany, who underwent hospitalization for a dermatologic surgery between June 2016 and January 2017 (6 months), were followed up after surgery until completion of the wound healing process. The follow-up addressed the occurrence of SSI and the need for systemic antibiotics after the operative procedure. Immunocompromised patients were compared with immunocompetent patients. The investigation was conducted as a retrospective analysis of patient records. RESULTS The authors performed 284 dermatologic surgeries in 177 patients. Nineteen percent (54/284) of the skin surgery was performed on immunocompromised patients. The most common indications for surgical treatment were nonmelanoma skin cancer and malignant melanomas. Surgical site infections occurred in 6.7% (19/284) of the cases. In 95% (18/19), systemic antibiotic treatment was needed. Twenty-one percent of all SSI (4/19) were seen in immunosuppressed patients. CONCLUSION According to the authors' data, immunosuppression does not represent a significant risk factor for SSI after dermatologic surgery. However, larger prospective studies are needed to make specific recommendations on the use of antibiotic prophylaxis while performing skin surgery in these patients. The available data on complications after dermatologic surgery have improved over the past years. Particularly, additional risk factors have been identified for surgical site infections (SSI). Purulent surgical sites, older age, involvement of head, neck, and acral regions, and also the involvement of less experienced surgeons have been reported to increase the risk of the SSI after dermatologic surgeries.1 In general, the incidence of SSI after skin surgery is considered to be low.1,2 However, antibiotics in dermatologic surgeries, especially in the perioperative setting, seem to be overused,3,4 particularly regarding developing antibiotic resistances and side effects. Immunosuppression has been recommended to be taken into consideration as an additional indication for antibiotic prophylaxis to prevent SSI after skin surgery in special cases.5,6 However, these recommendations do not specify the exact dermatologic surgeries, and were not specifically developed for dermatologic surgery patients and treatments, but adopted from other surgical fields.6 According to the survey conducted on American College of Mohs Surgery members in 2012, 13% to 29% of the surgeons administered antibiotic prophylaxis to immunocompromised patients to prevent SSI while performing dermatologic surgery on noninfected skin,3 although this was not recommended by Journal of the American Academy of Dermatology Advisory Statement. Indeed, the data on the risk of developing SSI after dermatologic surgery in immunosuppressed patients are limited. However, it is possible that due to the insufficient evidence on the risk of SSI occurrence in this patient group, dermatologic surgeons tend to overuse perioperative antibiotic prophylaxis. To make specific recommendations on the use of antibiotic prophylaxis in immunosuppressed patients in the field of skin surgery, more information about the incidence of SSI after dermatologic surgery in these patients is needed. The aim of this study was to fill this data gap by investigating whether there is an increased risk of SSI after skin surgery in immunocompromised patients compared with immunocompetent patients. Y1 - 2018 U6 - http://dx.doi.org/10.1097/DSS.0000000000001615 IS - 44 (12) SP - 1525 EP - 1536 PB - Wolters Kluwer ER - TY - JOUR A1 - Baringhaus, Ludwig A1 - Gaigall, Daniel T1 - Efficiency comparison of the Wilcoxon tests in paired and independent survey samples JF - Metrika N2 - The efficiency concepts of Bahadur and Pitman are used to compare the Wilcoxon tests in paired and independent survey samples. A comparison through the length of corresponding confidence intervals is also done. Simple conditions characterizing the dominance of a procedure are derived. Statistical tests for checking these conditions are suggested and discussed. KW - Wilcoxon tests KW - Pitman efficiency KW - Bahadur efficiency KW - Length of confidence intervals KW - Kernel density estimator Y1 - 2018 U6 - http://dx.doi.org/10.1007/s00184-018-0661-4 SN - 1435-926X VL - 2018 IS - 81 SP - 891 EP - 930 PB - Springer CY - Berlin ER - TY - JOUR A1 - Baringhaus, Ludwig A1 - Gaigall, Daniel A1 - Thiele, Jan Philipp T1 - Statistical inference for L²-distances to uniformity JF - Computational Statistics N2 - The paper deals with the asymptotic behaviour of estimators, statistical tests and confidence intervals for L²-distances to uniformity based on the empirical distribution function, the integrated empirical distribution function and the integrated empirical survival function. Approximations of power functions, confidence intervals for the L²-distances and statistical neighbourhood-of-uniformity validation tests are obtained as main applications. The finite sample behaviour of the procedures is illustrated by a simulation study. KW - Integrated empirical distribution (survival) function KW - Goodness-of-fit tests for uniformity KW - Numerical inversion of Laplace transforms KW - Coverage probability KW - Equivalence test Y1 - 2018 U6 - http://dx.doi.org/10.1007/s00180-018-0820-0 SN - 1613-9658 VL - 2018 IS - 33 SP - 1863 EP - 1896 PB - Springer CY - Berlin ER - TY - CHAP A1 - Bensberg, Frank A1 - Auth, Gunnar A1 - Czarnecki, Christian ED - Hofmann, Georg Rainer ED - Alm, Wolfgang T1 - Unterstützung von Wissenstransferprozessen durch Erschließung von Literaturdatenbanken - ein gestaltungsorientierter Ansatz auf Basis von Text Analytics T2 - Wissenstransfer in der Wirtschaftsinformatik Fachgespräch im Rahmen der MKWI 2018 N2 - Angesichts des anhaltenden Wachstums wissenschaftlicher Veröffentlichungen werden Instrumente benötigt, um Literaturanalysen durch Digitalisierung produktiver zu gestalten. Dieser Beitrag stellt einen Ansatz vor, der bibliographische Daten aus der Literaturdatenbank EBSCO Discovery Service mithilfe von Text-Analytics-Methoden erschließt. Die Lösung basiert auf dem Textanalysesystem IBM Watson Explorer und eignet sich für explorative Literaturanalysen, um beispielsweise den Status quo emergierender Technologiefelder in der Literatur zu reflektieren. Die generierten Ergebnisse sind in den Kontext der zunehmenden Werkzeugunterstützung des Literaturrechercheprozesses einzuordnen und können für intra- sowie interinstitutionelle Wissenstransferprozesse in Forschungs- und Beratungskontexten genutzt werden. KW - Wissenstransfer KW - Text Analytics KW - Literaturdaten KW - Literaturanalyse KW - Literatur-analyse-prozess Y1 - 2018 SN - 9783981844207 N1 - MKWI 2018: Multikonferenz Wirtschaftsinformatik 2018 in Lüneburg, 06.03.2018-09.03.2018 SP - 6 EP - 15 PB - IMI-Verlag ; Hochschule Aschaffenburg, Information Management Institut CY - Aschaffenburg ER - TY - JOUR A1 - Bensberg, Frank A1 - Auth, Gunnar A1 - Czarnecki, Christian T1 - Einsatz von Text Analytics zur Unterstützung literaturintensiver Forschungsprozesse: Konzeption, Realisierung und Lessons Learned JF - Anwendungen und Konzepte der Wirtschaftsinformatik N2 - Das anhaltende Wachstum wissenschaftlicher Veröffentlichungen wirft die Fragestellung auf, wie Literaturana-lysen im Rahmen von Forschungsprozessen digitalisiert und somit produktiver realisiert werden können. Insbesondere in informationstechnischen Fachgebieten ist die Forschungspraxis durch ein rasant wachsendes Publikationsaufkommen gekennzeichnet. Infolgedessen bietet sich der Einsatz von Methoden der Textanalyse (Text Analytics) an, die Textdaten automatisch vorbereiten und verarbeiten können. Erkenntnisse entstehen dabei aus Analysen von Wortarten und Subgruppen, Korrelations- sowie Zeitreihenanalysen. Dieser Beitrag stellt die Konzeption und Realisierung eines Prototypen vor, mit dem Anwender bibliographische Daten aus der etablierten Literaturdatenbank EBSCO Discovery Service mithilfe textanalytischer Methoden erschließen können. Der Prototyp basiert auf dem Analysesystem IBM Watson Explorer, das Hochschulen lizenzkostenfrei zur Verfügung steht. Potenzielle Adressaten des Prototypen sind Forschungseinrichtungen, Beratungsunternehmen sowie Entscheidungsträger in Politik und Unternehmenspraxis. KW - Text Analytics KW - Literaturanalyse KW - Forschungsprozess KW - EBSCO Discovery Service KW - IBM Watson Explorer Y1 - 2018 U6 - http://dx.doi.org/10.26034/lu.akwi.2018.3221 SN - 2296-4592 VL - 2018 IS - 8 SP - 1 EP - 6 PB - AKWI CY - Luzern ER - TY - CHAP A1 - Bensberg, Frank A1 - Auth, Gunnar A1 - Czarnecki, Christian A1 - Wörndle, Christopher ED - Kemal İlter, H. T1 - Transforming literature-intensive research processes through text analytics – design, implementation and lessons learned N2 - The continuing growth of scientific publications raises the question how research processes can be digitalized and thus realized more productively. Especially in information technology fields, research practice is characterized by a rapidly growing volume of publications. For the search process various information systems exist. However, the analysis of the published content is still a highly manual task. Therefore, we propose a text analytics system that allows a fully digitalized analysis of literature sources. We have realized a prototype by using EBSCO Discovery Service in combination with IBM Watson Explorer and demonstrated the results in real-life research projects. Potential addressees are research institutions, consulting firms, and decision-makers in politics and business practice. KW - Text analytics KW - Text mining KW - Literature review KW - Research process Y1 - 2018 U6 - http://dx.doi.org/10.6084/m9.figshare.7582073.v1 N1 - 5th International Management Information Systems Conference. October 24-26 2018, Ankara ER - TY - JOUR A1 - Berg, Alexander-Karl A1 - Schleser, Markus A1 - Delidovich, Artem A1 - Houben, Alexander T1 - Ultraschallunterstützter Schmelzklebstoffauftrag JF - adhäsion KLEBEN & DICHTEN Y1 - 2018 U6 - http://dx.doi.org/10.1007/s35145-018-0089-z VL - Volume 62 IS - Issue 12 SP - 32 EP - 37 PB - Springer ER - TY - RPRT A1 - Bernecker, Andreas A1 - Boyer, Pierre A1 - Gathmann, Christina T1 - The Role of Electoral Incentives for Policy Innovation: Evidence from the US Welfare Reform T2 - CESifo Working Paper Y1 - 2018 SN - ISSN 2364‐1428 (electronic version) IS - No. 6964 ER - TY - JOUR A1 - Bernecker, Andreas A1 - Klier, Julia A1 - Stern, Sebastian A1 - Thiel, Lea T1 - Sustaining high performance beyond public-sector pilot projects. Y1 - 2018 IS - September 2018 ER - TY - THES A1 - Bhattarai, Aroj T1 - Constitutive modeling of female pelvic floor dysfunctions and reconstructive surgeries using prosthetic mesh implants Y1 - 2018 SN - 978-3-9818074-8-6 U6 - http://dx.doi.org/10.17185/duepublico/70340 N1 - Duisburg-Essen, Univ., Diss., 2018 ER - TY - CHAP A1 - Bhattarai, Aroj A1 - Frotscher, Ralf A1 - Staat, Manfred T1 - Computational Analysis of Pelvic Floor Dysfunction T2 - Women's Health and Biomechanics N2 - Pelvic floor dysfunction (PFD) is characterized by the failure of the levator ani (LA) muscle to maintain the pelvic hiatus, resulting in the descent of the pelvic organs below the pubococcygeal line. This chapter adopts the modified Humphrey material model to consider the effect of the muscle fiber on passive stretching of the LA muscle. The deformation of the LA muscle subjected to intra-abdominal pressure during Valsalva maneuver is compared with the magnetic resonance imaging (MRI) examination of a nulliparous female. Numerical result shows that the fiber-based Humphrey model simulates the muscle behavior better than isotropic constitutive models. Greater posterior movement of the LA muscle widens the levator hiatus due to lack of support from the anococcygeal ligament and the perineal structure as a consequence of birth-related injury and aging. Old and multiparous females with uncontrolled urogenital and rectal hiatus tend to develop PFDs such as prolapse and incontinence. KW - Pelvic muscle KW - Muscle fibers KW - Passive stretching KW - Pelvic floor dysfunction Y1 - 2018 SN - 978-3-319-71574-2 U6 - http://dx.doi.org/10.1007/978-3-319-71574-2_17 N1 - Lecture Notes in Computational Vision and Biomechanics, vol 29 SP - 217 EP - 230 PB - Springer CY - Cham ER - TY - JOUR A1 - Bhattarai, Aroj A1 - Jabbari, Medisa A1 - Anding, Ralf A1 - Staat, Manfred T1 - Surgical treatment of vaginal vault prolapse using different prosthetic mesh implants: a finite element analysis JF - tm - Technisches Messen N2 - Particularly multiparous elderly women may suffer from vaginal vault prolapse after hysterectomy due to weak support from lax apical ligaments. A decreased amount of estrogen and progesterone in older age is assumed to remodel the collagen thereby reducing tissue stiffness. Sacrocolpopexy is either performed as open or laparoscopic surgery using prosthetic mesh implants to substitute lax ligaments. Y-shaped mesh models (DynaMesh, Gynemesh, and Ultrapro) are implanted in a 3D female pelvic floor finite element model in the extraperitoneal space from the vaginal cuff to the first sacral (S1) bone below promontory. Numerical simulations are conducted during Valsalva maneuver with weakened tissues modeled by reduced tissue stiffness. Tissues are modeled as incompressible, isotropic hyperelastic materials whereas the meshes are modeled either as orthotropic linear elastic or as isotropic hyperlastic materials. The positions of the vaginal cuff and the bladder base are calculated from the pubococcygeal line for female pelvic floor at rest, for prolapse and after repair using the three meshes. Due to mesh mechanics and mesh pore deformation along the loaded direction, the DynaMesh with regular rectangular mesh pores is found to provide better mechanical support to the organs than the Gynemesh and the Ultrapro with irregular hexagonal mesh pores. Insbesondere ältere, mehrgebährende Frauen leiden häufiger an einem Scheidenvorfall nach einer Hysterektomie aufgrund der schwachen Unterstützung durch laxe apikale Bänder. Es wird angenommen, dass eine verringerte Menge an Östrogen und Progesteron im höheren Alter das Kollagen umformt, wodurch die Gewebesteifigkeit reduziert wird. Die Sakrokolpopexie ist eine offene oder laparoskopische Operation, die mit prothetischen Netzimplantaten durchgeführt wird, um laxe Bänder zu ersetzen. Y-förmige Netzmodelle (DynaMesh, Gynemesh und Ultrapro) werden in einem 3D-Modell des weiblichen Beckenbodens im extraperitonealen Raum vom Vaginalstumpf bis zum Promontorium implantiert. Numerische Simulationen werden während des Valsalva-Manövers mit geschwächtem Gewebe durchgeführt, das durch eine reduzierte Gewebesteifigkeit modelliert wird. Die Gewebe werden als inkompressible, isotrop hyperelastische Materialien modelliert, während die Netze entweder als orthotrope linear elastische oder als isotrope hyperlastische Materialien modelliert werden. Die Positionen des Vaginalstumpfs, der Blase und der Harnröhrenachse werden anhand der Pubococcygeallinie aus der Ruhelage, für den Prolaps und nach der Reparatur unter Verwendung der drei Netze berechnet. Aufgrund der Netzmechanik und der Netzporenverformung bietet das DynaMesh mit regelmäßigen rechteckigen Netzporen eine bessere mechanische Unterstützung und eine Neupositionierung des Scheidengewölbes, der Blase und der Urethraachse als Gynemesh und Ultrapro mit unregelmäßigen hexagonalen Netzporen. Y1 - 2018 U6 - http://dx.doi.org/10.1515/teme-2017-0115 SN - 2196-7113 VL - 85 IS - 5 SP - 331 EP - 342 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Bhattarai, Aroj A1 - Staat, Manfred T1 - Modelling of Soft Connective Tissues to Investigate Female Pelvic Floor Dysfunctions JF - Computational and Mathematical Methods in Medicine N2 - After menopause, decreased levels of estrogen and progesterone remodel the collagen of the soft tissues thereby reducing their stiffness. Stress urinary incontinence is associated with involuntary urine leakage due to pathological movement of the pelvic organs resulting from lax suspension system, fasciae, and ligaments. This study compares the changes in the orientation and position of the female pelvic organs due to weakened fasciae, ligaments, and their combined laxity. A mixture theory weighted by respective volume fraction of elastin-collagen fibre compound (5%), adipose tissue (85%), and smooth muscle (5%) is adopted to characterize the mechanical behaviour of the fascia. The load carrying response (other than the functional response to the pelvic organs) of each fascia component, pelvic organs, muscles, and ligaments are assumed to be isotropic, hyperelastic, and incompressible. Finite element simulations are conducted during Valsalva manoeuvre with weakened tissues modelled by reduced tissue stiffness. A significant dislocation of the urethrovesical junction is observed due to weakness of the fascia (13.89 mm) compared to the ligaments (5.47 mm). The dynamics of the pelvic floor observed in this study during Valsalva manoeuvre is associated with urethral-bladder hypermobility, greater levator plate angulation, and positive Q-tip test which are observed in incontinent females. Y1 - 2018 U6 - http://dx.doi.org/10.1155/2018/9518076 SN - 1748-6718 VL - 2018 IS - Article ID 9518076 SP - 1 EP - 16 PB - Hindawi CY - New York, NY ER - TY - CHAP A1 - Bhattarai, Aroj A1 - Staat, Manfred ED - Artmann, Gerhard ED - Temiz Artmann, Aysegül ED - Zhubanova, Azhar A. ED - Digel, Ilya T1 - Mechanics of soft tissue reactions to textile mesh implants T2 - Biological, Physical and Technical Basics of Cell Engineering N2 - For pelvic floor disorders that cannot be treated with non-surgical procedures, minimally invasive surgery has become a more frequent and safer repair procedure. More than 20 million prosthetic meshes are implanted each year worldwide. The simple selection of a single synthetic mesh construction for any level and type of pelvic floor dysfunctions without adopting the design to specific requirements increase the risks for mesh related complications. Adverse events are closely related to chronic foreign body reaction, with enhanced formation of scar tissue around the surgical meshes, manifested as pain, mesh erosion in adjacent structures (with organ tissue cut), mesh shrinkage, mesh rejection and eventually recurrence. Such events, especially scar formation depend on effective porosity of the mesh, which decreases discontinuously at a critical stretch when pore areas decrease making the surgical reconstruction ineffective that further augments the re-operation costs. The extent of fibrotic reaction is increased with higher amount of foreign body material, larger surface, small pore size or with inadequate textile elasticity. Standardized studies of different meshes are essential to evaluate influencing factors for the failure and success of the reconstruction. Measurements of elasticity and tensile strength have to consider the mesh anisotropy as result of the textile structure. An appropriate mesh then should show some integration with limited scar reaction and preserved pores that are filled with local fat tissue. This chapter reviews various tissue reactions to different monofilament mesh implants that are used for incontinence and hernia repairs and study their mechanical behavior. This helps to predict the functional and biological outcomes after tissue reinforcement with meshes and permits further optimization of the meshes for the specific indications to improve the success of the surgical treatment. Y1 - 2018 SN - 978-981-10-7904-7 U6 - http://dx.doi.org/10.1007/978-981-10-7904-7_11 SP - 251 EP - 275 PB - Springer CY - Singapore ER - TY - CHAP A1 - Bhattarai, Aroj A1 - Staat, Manfred ED - Fernandes, P.R. ED - Tavares, J. M. T1 - Pectopexy to repair vaginal vault prolapse: a finite element approach T2 - Proceedings CMBBE 2018 N2 - The vaginal prolapse after hysterectomy (removal of the uterus) is often associated with the prolapse of the vaginal vault, rectum, bladder, urethra or small bowel. Minimally invasive surgery such as laparoscopic sacrocolpopexy and pectopexy are widely performed for the treatment of the vaginal prolapse with weakly supported vaginal vault after hysterectomy using prosthetic mesh implants to support (or strengthen) lax apical ligaments. Implants of different shape, size and polymers are selected depending on the patient’s anatomy and the surgeon’s preference. In this computational study on pectopexy, DynaMesh®-PRP soft, GYNECARE GYNEMESH® PS Nonabsorbable PROLENE® soft and Ultrapro® are tested in a 3D finite element model of the female pelvic floor. The mesh model is implanted into the extraperitoneal space and sutured to the vaginal stump with a bilateral fixation to the iliopectineal ligament at both sides. Numerical simulations are conducted at rest, after surgery and during Valsalva maneuver with weakened tissues modeled by reduced tissue stiffness. Tissues and prosthetic meshes are modeled as incompressible, isotropic hyperelastic materials. The positions of the organs are calculated with respect to the pubococcygeal line (PCL) for female pelvic floor at rest, after repair and during Valsalva maneuver using the three meshes. Y1 - 2018 N1 - 15th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering and 3rd Conference on Imaging and Visualization. CMBBE 2018. 26-29 March 2018, Lisbon, Portugal ER - TY - JOUR A1 - Bhattarai, Aroj A1 - Staat, Manfred T1 - Computational comparison of different textile implants to correct apical prolapse in females JF - Current Directions in Biomedical Engineering N2 - Prosthetic textile implants of different shapes, sizes and polymers are used to correct the apical prolapse after hysterectomy (removal of the uterus). The selection of the implant before or during minimally invasive surgery depends on the patient’s anatomical defect, intended function after reconstruction and most importantly the surgeon’s preference. Weakness or damage of the supporting tissues during childbirth, menopause or previous pelvic surgeries may put females in higher risk of prolapse. Numerical simulations of reconstructed pelvic floor with weakened tissues and organ supported by textile product models: DynaMesh®-PRS soft, DynaMesh®-PRP soft and DynaMesh®-CESA from FEG Textiletechnik mbH, Germany are compared. Y1 - 2018 U6 - http://dx.doi.org/10.1515/cdbme-2018-0159 VL - 4 IS - 1 SP - 661 EP - 664 PB - De Gruyter CY - Berlin ER - TY - CHAP A1 - Bindzus, Manuel A1 - Bragard, Michael T1 - Motivating Intuitive Understanding of the Switched Reluctance Machine in the Education of Undergraduate Students T2 - 2018 IEEE 59th International Scientific Conference on Power and Electrical Engineering of Riga Technical University (RTUCON) Y1 - 2018 SN - 978-1-5386-6903-7 U6 - http://dx.doi.org/10.1109/RTUCON.2018.8659870 SP - 1 EP - 6 ER - TY - JOUR A1 - Birgel, Stefan A1 - Leschinger, Tim A1 - Wegmann, Kilian A1 - Staat, Manfred T1 - Calculation of muscle forces and joint reaction loads in the shoulder area via an OpenSim based computer model JF - tm - Technisches Messen N2 - Using the OpenSim software and verified anatomical data, a computer model for the calculation of biomechanical parameters is developed and used to determine the effect of a reattachment of the Supraspinatus muscle with a medial displacement of the muscle attachment point, which may be necessary for a rupture of the supraspinatus tendon. The results include the influence of the operation on basic biomechanical parameters such as the lever arm, as well as the calculated the muscle activations for the supraspinatus and deltoid. In addition, the influence on joint stability is examined by an analysis of the joint reaction force. The study provides a detailed description of the used model, as well as medical findings to a reattachment of the supraspinatus. Mit der Software OpenSim und überprüften anatomischen Daten wird ein Computermodell zur Berechnung von biomechanischen Parametern entwickelt und genutzt, um den Effekt einer Refixierung des Supraspinatusmuskels mit einer medialen Verschiebung des Muskelansatzpunktes zu ermitteln, wie sie unter anderem nach einem Riss der Supraspinatussehne notwendig sein kann. Die Ergebnisse umfassen hierbei den Einfluss der Operation auf grundlegende biomechanische Parameter wie den Hebelarm sowie die berechneten Muskelaktivierungen für den Supraspinatus und Deltoideus. Zusätzlich wird der Einfluss auf die Gelenkstabilität betrachtet und durch eine Analyse der Gelenkreaktionskraft untersucht. Die Studie bietet eine detaillierte Beschreibung des genutzten Modells, sowie medizinische Erkenntnisse zu einer Refixierung des Supraspinatus. Y1 - 2018 U6 - http://dx.doi.org/10.1515/teme-2017-0114 SN - 2196-7113 VL - 85 IS - 5 SP - 321 EP - 330 PB - De Gruyter CY - Berlin ER - TY - CHAP A1 - Birkl, Josef A1 - Diendorfer, Gerhard A1 - Kern, Alexander A1 - Thern, Stephan T1 - Extremely high lightning peak currents T2 - 34th International Conference on Ligntning Protection, 02-07 September 2018 Y1 - 2018 SN - 978-1-5386-6635-7 ER - TY - JOUR A1 - Birkl, Josef A1 - Diendorfer, Gerhard A1 - Kern, Alexander A1 - Thern, Stephan T1 - Extrem hohe Blitzströme JF - Elektropraktiker N2 - Blitze sind nach wie vor eine enorme Schadensquelle für Personenschäden, Brände, mechanische Zerstörungen und insbesondere auch Überspannungen. Das zeigen nicht zuletzt aktuelle Statistiken der Schadensversicherer. Immer wieder gibt es Meldungen über extrem hohe Blitzströme, die natürlich auch zu großen Schäden und Zerstörungen führen können. Dabei werden Scheitelwerte von teilweise deutlich über 300 kA genannt. Dies wirft Fragen auf, da die „klassische“ Blitzstatistik (z. B. nach CIGRE und IEC [8][10]) bisher solche Werte nicht kennt. Diese extremen Blitzströme werden meist aus den Daten von Blitzortungssystemen ermittelt. Y1 - 2018 VL - 72 IS - 3 SP - 217 EP - 225 PB - Huss Medien CY - Berlin ER - TY - CHAP A1 - Blanke, Tobias A1 - Dring, Bernd A1 - Vontein, Marius A1 - Kuhnhenne, Markus T1 - Climate Change Mitigation Potentials of Vertical Building Integrated Photovoltaic T2 - 8th International Workshop on Integration of Solar Power into Power Systems : 16-17 October 2018, Stockholm, Sweden Y1 - 2018 SP - 1 EP - 7 ER - TY - CHAP A1 - Blome, Hans-Joachim T1 - Über die kulturelle Bedeutung der Raumfahrt T2 - Überleben im Weltraum. Auf dem Weg zu neuen Grenzen. 21. Berliner Kolloquium der Daimler und Benz Stiftung 24. Mai 2017 Y1 - 2018 SP - 5 EP - 5 ER - TY - CHAP A1 - Bosse, Elke A1 - De Clercq, Mikael A1 - Barnat, Miriam T1 - The Role of Diversity for the Transition to Higher Education T2 - EARLI SIG 4, Giessen Y1 - 2018 ER - TY - CHAP A1 - Bragard, Michael A1 - Hoek, Hauke van A1 - Hoegen, Anne von A1 - Doncker, Rik W. De T1 - Motivation-based Learning: Teaching Fundamentals of Electrical Engineering with an LED Spinning Top T2 - 2018 IEEE 59th International Scientific Conference on Power and Electrical Engineering of Riga Technical University (RTUCON) Y1 - 2018 SN - 978-1-5386-6903-7 U6 - http://dx.doi.org/10.1109/RTUCON.2018.8659810 SP - 1 EP - 6 ER - TY - CHAP A1 - Brockmann, Carsten A1 - Sultanow, Eldar A1 - Czarnecki, Christian ED - Czarnecki, Christian ED - Brockmann, Carsten ED - Sultanow, Eldar ED - Koschmider, Agnes ED - Selzer, Annika ED - Gesellschaft für Informatik e. V., T1 - Enterprise architectures between agility and traditional methodologies T2 - GI Edition Proceedings Band 285 Workshops der INFORMATIK 2018 N2 - For this year’s workshop on Enterpirse Architecture in Research and Practice we have received eight submissions from which four have passed the rigorous peer-review. The acceptance quote of 50% assures that only advancements in the field are included in our workshop. KW - Agility KW - agile KW - Enterprise Architecture Y1 - 2018 SN - 9783885796794 SN - 1617-5468 N1 - 26.-27. September 2018 Berlin PB - Köllen CY - Bonn ER - TY - JOUR A1 - Bronder, Thomas A1 - Jessing, Max P. A1 - Poghossian, Arshak A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Detection of PCR-Amplified Tuberculosis DNA Fragments with Polyelectrolyte-Modified Field-Effect Sensors JF - Analytical Chemistry N2 - Field-effect-based electrolyte-insulator-semiconductor (EIS) sensors were modified with a bilayer of positively charged weak polyelectrolyte (poly(allylamine hydrochloride) (PAH)) and probe single-stranded DNA (ssDNA) and are used for the detection of complementary single-stranded target DNA (cDNA) in different test solutions. The sensing mechanism is based on the detection of the intrinsic molecular charge of target cDNA molecules after the hybridization event between cDNA and immobilized probe ssDNA. The test solutions contain synthetic cDNA oligonucleotides (with a sequence of tuberculosis mycobacteria genome) or PCR-amplified DNA (which origins from a template DNA strand that has been extracted from Mycobacterium avium paratuberculosis-spiked human sputum samples), respectively. Sensor responses up to 41 mV have been measured for the test solutions with DNA, while only small signals of ∼5 mV were detected for solutions without DNA. The lower detection limit of the EIS sensors was ∼0.3 nM, and the sensitivity was ∼7.2 mV/decade. Fluorescence experiments using SybrGreen I fluorescence dye support the electrochemical results. Y1 - 2018 U6 - http://dx.doi.org/10.1021/acs.analchem.8b01807 SN - 0003-2700 VL - 90 IS - 12 SP - 7747 EP - 7753 PB - ACS Publications CY - Washington, DC ER - TY - CHAP A1 - Bung, Daniel B. A1 - Tullis, Blake T1 - Hydraulic Structures - ISHS2018 in Perspective T2 - 7th IAHR International Symposium on Hydraulic Structures, Aachen, Germany, 15-18 May Y1 - 2018 SN - 978-0-692-13277-7 U6 - http://dx.doi.org/10.15142/T3WH2B ER - TY - JOUR A1 - Bung, Daniel B. A1 - Valero, Daniel T1 - Re-aeration on stepped spillways with special consideration of entrained and entrapped air JF - Geosciences N2 - As with most high-velocity free-surface flows, stepped spillway flows become self-aerated when the drop height exceeds a critical value. Due to the step-induced macro-roughness, the flow field becomes more turbulent than on a similar smooth-invert chute. For this reason, cascades are oftentimes used as re-aeration structures in wastewater treatment. However, for stepped spillways as flood release structures downstream of deoxygenated reservoirs, gas transfer is also of crucial significance to meet ecological requirements. Prediction of mass transfer velocities becomes challenging, as the flow regime differs from typical previously studied flow conditions. In this paper, detailed air-water flow measurements are conducted on stepped spillway models with different geometry, with the aim to estimate the specific air-water interface. Re-aeration performances are determined by applying the absorption method. In contrast to earlier studies, the aerated water body is considered a continuous mixture up to a level where 75% air concentration is reached. Above this level, a homogenous surface wave field is considered, which is found to significantly affect the total air-water interface available for mass transfer. Geometrical characteristics of these surface waves are obtained from high-speed camera investigations. The results show that both the mean air concentration and the mean flow velocity have influence on the mass transfer. Finally, an empirical relationship for the mass transfer on stepped spillway models is proposed. Y1 - 2018 SN - 2076-3263 VL - 8 IS - 9 SP - Article number 333 PB - MDPI CY - Basel ER - TY - CHAP A1 - Bung, Daniel B. A1 - Valero, Daniel A1 - Hermens, G. T1 - Hybrid investigation on the hydraulic performance of a new trapezoidal fishway T2 - 7th IAHR International Symposium on Hydraulic Structures, ISHS 2018 Y1 - 2018 SN - 978-069213277-7 U6 - http://dx.doi.org/10.15142/T3S06R SP - 184 EP - 193 ER - TY - JOUR A1 - Butenweg, Christoph A1 - Marinkovic, Marko T1 - Erdbebensicherer Anschluss von Ausfachungsmauerwerk in Stahlbetonrahmentragwerken mit Entkopplungselementen JF - Bauingenieur N2 - Stahlbetonrahmentragwerke mit Mauerwerksausfachungen weisen nach Erdbebenereignissen häufig schwere Schäden auf, da die Ausfachungen ohne weitere konstruktive Maßnahmen mit vollem Kontakt zum Stahlbetonrahmen eingemauert werden. Durch die unplanmäßige Beteiligung am horizontalen Lastabtrag erfahren die Ausfachungen Belastungen in Wandebene und beeinflussen das globale Schwingungsverhalten der Rahmentragwerke. In Kombination mit den gleichzeitig auftretenden seismischen Trägheitskräften senkrecht zur Wand führt dies in vielen Fällen zu einem Versagen der mit niedrigen Festigkeiten ausgeführten Ausfachungen. Dies war der Anlass in dem europäischen Forschungsprojekt INSYSME ein Entkopplungssystem zu entwickeln, mit dem Rahmen und Ausfachung durch ein spezielles Profil aus Elastomeren entkoppelt werden. Das Profil ermöglicht Relativverschiebungen zwischen Rahmen und Ausfachung und stellt gleichzeitig die Aufnahme von Belastungen senkrecht zur Wand sicher. Der Beitrag erläutert zunächst den Aufbau des Systems und gibt einen Überblick über die in Kleinbauteilversuchen ermittelten Tragfähigkeiten. Zudem werden experimentelle Untersuchungen an mit hochwärmedämmenden Mauerziegeln ausgefachten Stahlbetonrahmen mit und ohne Entkopplungssystem für getrennte und kombinierte Belastungen in und senkrecht zur Wandebene vorgestellt. Auf Grundlage einer Versuchsauswertung und eines Ergebnisvergleichs werden Wirkungsweise und Effektivität des entwickelten Entkopplungssystems demonstriert. Y1 - 2018 SN - 0005-6650 VL - 93 IS - 9 SP - 333 EP - 341 PB - VDI Fachmedien CY - Düsseldorf ER - TY - CHAP A1 - Butenweg, Christoph A1 - Marinkovic, Marko T1 - Damage reduction system for masonry infill walls under seismic loading T2 - ce/papers N2 - Reinforced concrete (RC) frames with masonry infills are frequently used in seismic regions all over the world. Generally masonry infills are considered as nonstructural elements and thus are typically neglected in the design process. However, the observations made after strong earthquakes have shown that masonry infills can modify the dynamic behavior of the structure significantly. The consequences were total collapses of buildings and loss of human lives. This paper presents the new system INODIS (Innovative Decoupled Infill System) developed within the European research project INSYSME (Innovative Systems for Earthquake Resistant Masonry Enclosures in RC Buildings). INODIS decouples the frame and the masonry infill by means of special U-shaped rubbers placed in between frame and infill. The effectiveness of the system was investigated by means of full scale tests on RC frames with masonry infills subjected to in-plane and out-of-plane loading. Furthermore small specimen tests were conducted to determine material characteristics of the components and the resistances of the connections. Finally, a micromodel was developed to simulate the in-plane behavior of RC frames infilled with AAC blocks with and without installation of the INODIS system. KW - earthquakes KW - in-plane and out-of-plane failure KW - INODIS KW - RC frames Y1 - 2018 U6 - http://dx.doi.org/10.1002/cepa.863 N1 - Special Issue: ICAAC ‐ 6th International Conference on Autoclaved Aerated Concrete VL - 2 IS - 4 SP - 267 EP - 273 PB - Ernst & Sohn Verlag CY - Berlin ER - TY - CHAP A1 - Butenweg, Christoph A1 - Marinkovic, Marko A1 - Fehling, Ekkehard A1 - Pfetzing, Thomas A1 - Kubalski, Thomas T1 - Experimental and Numerical Investigations of Reinforced Concrete Frames with Masonry Infills under Combined In- and Out-of-plane Seismic Loading T2 - 16th European Conference on Earthquake Engineering, Thessaloniki, 18-21 June, 2018 Y1 - 2018 N1 - Paper No 11477 SP - 1 EP - 12 ER - TY - JOUR A1 - Butenweg, Christoph A1 - Marinković, Marko A1 - Fehling, Ekkehard A1 - Pfetzing, Thomas T1 - Stahlbetonrahmentragwerke mit Ausfachungen aus Mauerwerk unter kombinierten seismischen Belastungen in und senkrecht zur Wandebene JF - Bauingenieur Y1 - 2018 SN - 0005-6650 N1 - Der Artikel befindet sich in der Beilage "D–A–CH – Mitteilungsblatt – Erdbebeningenieurwesen und Baudynamik" (ISSN 1434–6591) VL - 93 SP - 2 EP - 10 PB - VDI Fachmedien CY - Düsseldorf ER - TY - JOUR A1 - Butenweg, Christoph A1 - Marinković, Marko A1 - Kubalski, Thomas A1 - Fehling, Ekkehard A1 - Pfetzing, Thomas A1 - Meyer, Udo ED - Voss, Michael T1 - Auslegung von Stahlbetonrahmentragwerken mit Ausfachungen aus Ziegelmauerwerk (Teil 1) T1 - Design of reinforced concrete enclosures infilled with clay block masonry (Part 1) JF - Ziegelindustrie international : ZI = Brick and tile industry international N2 - Im Rahmen des europäischen Verbundprojekts INSYSME wurden von den deutschen Partnern die Systeme IMES und INODIS zur Verbesserung des seismischen Verhaltens von ausgefachten Stahlbetonrahmen entwickelt. Ziel beider Systeme ist es, Stahlbetonrahmen und Ausfachung zu entkoppeln, anstatt die Tragfähigkeit durch aufwendige und kostspielige zusätzliche Bewehrungseinlagen zu erhöhen. Erste Ergebnisse des Systems IMES für Belastungen in und senkrecht zu der Wandebene werden vorgestellt. N2 - Within the scope of the joint European project INSYSME, the German partners developed two systems - IMES and INODIS - for improving the seismic behaviour of masonry infilled reinforced concrete frames. The purpose of both systems is to decouple frame and infill instead of working to improve their load-bearing capacity by means of elaborate, expensive, supplementary reinforcing elements. Initial findings for the IMES system with regard to the loads acting in-plane and perpendicular to the wall plane (out-of-plane) are presented. Y1 - 2018 SN - 0341-0552 IS - 4 SP - 30 EP - 39 PB - Bauverlag BV GmbH CY - Gütersloh ER - TY - JOUR A1 - Butenweg, Christoph A1 - Marinković, Marko A1 - Kubalski, Thomas A1 - Fehling, Ekkehard A1 - Pfetzing, Thomas A1 - Meyer, Udo ED - Voss, Michael T1 - Auslegung von Stahlbetonrahmentragwerken mit Ausfachungen aus Ziegelmauerwerk (Teil 2) T1 - Design of reinforced concrete enclosures infilled with clay block masonry (Part 2) JF - Ziegelindustrie international : ZI = Brick and tile industry international N2 - Im Rahmen des europäischen Verbundprojekts INSYSME wurden von den deutschen Partnern die Systeme IMES und INODIS zur Verbesserung des seismischen Verhaltens von ausgefachten Stahlbetonrahmen entwickelt. Ziel beider Systeme ist es, Stahlbetonrahmen und Ausfachung zu entkoppeln, anstatt die Tragfähigkeit durch aufwendige und kostspielige zusätzliche Bewehrungseinlagen zu erhöhen. Erste Ergebnisse des Systems IMES für Belastungen in und senkrecht zu der Wandebene werden vorgestellt. N2 - Within the scope of the joint European project INSYSME, the German partners developed two systems - IMES and INODIS - for improving the seismic behaviour of masonry infilled reinforced concrete frames. The purpose of both systems is to decouple frame and infill instead of working to improve their load-bearing capacity by means of elaborate, expensive, supplementary reinforcing elements. Initial findings for the IMES system with regard to the loads acting in-plane and perpendicular to the wall plane (out-of-plane) are presented. Y1 - 2018 SN - 0341-0552 IS - 6 SP - 24 EP - 43 PB - Bauverlag BV GmbH CY - Gütersloh ER -