TY - JOUR A1 - Zhubanova, Azhar A. A1 - Aknazarov, S. K. A1 - Mansurov, Zulkhair A1 - Digel, Ilya A1 - Kozhalakova, A. A. A1 - Akimbekov, Nuraly S. A1 - O'Heras, Carlos A1 - Tazhibayeva, S. A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül T1 - Adsorption of bacterial Lipopolysaccharides and blood plasma proteins on modified carbonized materials N2 - Bacterial lipopolysaccharides (endotoxins) show strong biological effects at very low concentrations in human beings and many animals when entering the blood stream. These include affecting structure and function of organs and cells, changing metabolic functions, raising body temperature, triggering the coagulation cascade, modifying hemodynamics and causing septic shock. Because of this toxicity, the removal of even minute amounts is essential for safe parenteral administration of drugs and also for septic shock patients' care. The absence of a general method for endotoxin removal from liquid interfaces urgently requires finding new methods and materials to overcome this gap. Nanostructured carbonized plant parts is a promising material that showed good adsorption properties due to its vast pore network and high surface area. The aim of this study was comparative measurement of endotoxin- and blood proteins-related adsorption rate and adsorption capacity for different carboneous materials produced at different temperatures and under different surface modifications. As a main surface modificator, positively cbarged polymer, polyethileneimine (PEl) was used. Activated carbon materials showed good adsorption properties for LPS and some proteins used in the experiments. During the batch experiments, several techniques (dust removal, autoclaving) were used and optimized for improving the material's adsorption behavior. Also, with the results obtained it was possible to differentiate the materials according to their adsorption capacity and kinetic characteristics. Modification of the surface apparently has not affected hemoglobin binding to the adsorbent's surface. Obtained adsorption isotherms can be used as a powerful tool for designing of future column-based setups for blood purification from LPS, which is especially important for septic shock treatment. KW - Kohlenstofffaser KW - Lipopolysaccharide KW - nanostrukturierte carbonisierte Pflanzenteile KW - lipopolysaccharides KW - nanostructured carbonized plant parts Y1 - 2010 ER - TY - JOUR A1 - Wiescher, A. A1 - Kotliar, Konstantin A1 - Neuhann, T. A1 - Lanzl, Ines M. T1 - Rasch progrediente Visusminderung beider Augen bei einem jungen Patienten JF - Der Ophthalmologe N2 - Ein 34-jähriger männlicher Patient stellte sich zur Abklärung einer seit dem 9. Lebensjahr bestehenden und im letzten Jahr rasch progredienten Visusminderung beider Augen bei uns vor. Er beschrieb eine subjektiv zunehmende, im Spiegel für ihn selbst sichtbare, weißliche Trübung in der Pupille beidseits und eine starke Blendempfindlichkeit. Nebenbefundlich gab er rezidivierende Konjunktivitiden und morgens verklebte Lider an. Eine Allergie auf Gräserpollen und eine Unverträglichkeit auf Alkohol sowie mehrere Lebensmittel seien ebenfalls bekannt. Zusätzlich leidet der Patient an stark ausgeprägtem atopischem Ekzem. Dieses wurde nie systemisch, sondern nur bei Bedarf mit kortisonhaltiger Salbe therapiert. Y1 - 2010 U6 - https://doi.org/10.1007/s00347-007-1586-x SN - 1433-0423 VL - 105 IS - 4 SP - 389 EP - 392 PB - Springer CY - Berlin ER - TY - CHAP A1 - Werner, Frederik A1 - Spelthahn, Heiko A1 - Schöning, Michael Josef A1 - Krumbe, Christoph A1 - Wagner, Torsten A1 - Yoshinobu, Tatsuo A1 - Keusgen, Michael T1 - Neue Ansteuerungselektronik für LAPS-basierte Biosensoren zur gleichzeitig ortsaufgelösten Messung der pH-Konzentration T2 - Tagungsband: Sensoren und Messsysteme 2010 N2 - Ein lichtadressierbarer potentiometrischer Sensor (LAPS) kann die Konzentration eines oder mehrerer Analyten ortsaufgelöst auf der Sensoroberfläche nachweisen. Dazu wird mit einer modulierten Lichtquelle die Halbleiterstruktur des zu untersuchenden Bereiches angeregt und ein entsprechender Photostrom ausgelesen. Durch gleichzeitige Anregung mehrere Bereiche durch Lichtquellen mit unterschiedlichen Modulationsfrequenzen können diese auch zeitgleich ausgelesen werden. Mit der neuen, hier vorgestellten Ansteuerungselektronik integriert in einem "Field Programmable Gate Array" (FPGA) ist es möglich, mehrere Leuchtquellen gleichzeitig mit unterschiedlichen, während der Laufzeit festlegbaren Frequenzen, Phasen und Lichtintensitäten zu betreiben. Somit kann das Frequenzverhalten des Sensors untersucht und die Konzentration des Analyten über das Oberflächenpotential mit Hilfe von Strom/Spannungs-Kurven und Phase/Spannungs-Kurven bestimmt werden. Y1 - 2010 SN - 978-3-8007-3260-9 N1 - Sensoren und Messsysteme 2010 - 15. ITG/GMA-Fachtagung, 18.05.2010 - 19.05.2010 in Nürnberg SP - 109 EP - 114 PB - VDE Verlag CY - Berlin ER - TY - JOUR A1 - Wagner, Torsten A1 - Werner, Frederik A1 - Miyamoto, Ko-ichiro A1 - Ackermann, Hans-Josef A1 - Yoshinobu, Tatsuo A1 - Schöning, Michael Josef T1 - FPGA-based LAPS device for the flexible design of sensing sites on functional interfaces JF - Physica Status Solidi (A) N2 - The development of new interfaces for (bio-)chemical sensors requires comprehensive analyses and testing. The light-addressable potentiometric sensor (LAPS) can be used as a platform to investigate the sensitivity of a newly developed interface towards (bio-)chemical agents. LAPS measurements are spatially resolved by utilisation of focused light beams to define individual measurement spots. In this work, a new digitally modulated LAPS set-up based on an FPGA design will be introduced to increase the number of measurement spots, to shorten the measurement time and to improve the measurement accuracy. Y1 - 2010 U6 - https://doi.org/10.1002/pssa.200983320 SN - 1862-6300 N1 - Special Issue: Engineering of Functional Interfaces EnFI 2009 VL - 207 IS - 4 SP - 844 EP - 849 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Wagner, Torsten A1 - Miyamoto, Ko-ichiro A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Novel combination of digital light processing (DLP) and light-addressable potentiometric sensors (LAPS) for flexible chemical imaging JF - Procedia Engineering N2 - Chemical imaging systems allow the visualisation of the distribution of chemical species on the sensor surface. This work represents a new flexible approach of read out in a light-addressable potentiometric sensor (LAPS) with the help of a digital light processing (DLP) set-up. The DLP, known well for video projectors, consists of a mirror-array MEMS device which allows fast and flexible generation of light patterns. With the help of these light patterns the sensor surface of the LAPS device can be read out sequentially in a raster like scheme (scanning LAPS). The DLP approach has several advantages compared to conventional scanning LAPS set-ups, e.g., the spot size, the shape and the intensity of the light pointer can be changed easily and no mechanical movement is necessary, which reduces the size of the set-up and increases the stability and speed of measurement. Y1 - 2010 U6 - https://doi.org/10.1016/j.proeng.2010.09.161 SN - 1877-7058 N1 - Eurosensor XXIV Conference, 5-8 September 2010, Linz, Austria VL - 5 SP - 520 EP - 523 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Ullrich, Sebastian A1 - Grottke, Oliver A1 - Rossaint, Rolf A1 - Staat, Manfred A1 - Deserno, Thomas M. A1 - Kuhlen, Torsten T1 - Virtual Needle Simulation with Haptics for Regional Anaesthesia Y1 - 2010 N1 - IEEE Virtual Reality 2010, Workshop on Medical Virtual Environments, Waltham, MA, USA, March 21, 2010 ER - TY - JOUR A1 - Turek, Monik A1 - Heiden, Wolfgang A1 - Guo, Sharon A1 - Riesen, Alfred A1 - Schubert, Jürgen A1 - Zander, Willi A1 - Krüger, Peter A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Simultaneous detection of cyanide and heavy metals for environmental analysis by means of µISEs JF - Physica Status Solidi (A) N2 - In environmental analysis, cyanide and heavy metals play an important role, because these substances are highly toxic for biological systems. They can lead to chronic and acute diseases. Due to the chemical properties of cyanide it is frequently used for industrial processes such as extraction of silver and gold. Heavy metals can be found as trace elements in nature and are often applied in industries e.g., galvanization processes. Up to now, cyanide and heavy metals can be detected by several sensors separately and their detection is often limited to laboratory investigations. In this publication, with regard to an in situ analysis, a new miniaturized silicon-based sensor system for the simultaneous detection of cyanide and heavy metals in aqueous solutions is presented that is based on chalcogenide glass-based micro ion-selective electrodes (µISEs). The µISEs are incorporated into a specially designed measuring system for the simultaneous detection of heavy metals and cyanide in solutions and validated by simultaneous measurements of Cu2+- and CN−-ions, Cd2+- and CN−- ions and Pb2+- and CN−-ions. The particular sensor system has shown good sensor properties in the µ-molar ion-concentration range. For simultaneous measurements in complex heavy metal and cyanide solutions an intelligent software using fuzzy logic is discussed. Y1 - 2010 U6 - https://doi.org/10.1002/pssa.200983303 SN - 1862-6300 N1 - Special Issue: Engineering of Functional Interfaces EnFI 2009 VL - 207 IS - 4 SP - 817 EP - 823 PB - Wiley-VCH CY - Berlin ER - TY - CHAP A1 - Tran, Thanh Ngoc A1 - Staat, Manfred T1 - Shakedown analysis of two dimensional structures by an edge-based smoothed finite element method Y1 - 2010 N1 - 4th European Conference on Computational Mechanics (Solids, Structures and Coupled Problems in Engineering), ECCOMAS ECCM 2010, Paris, France, May 17 – 21, 2010 ER - TY - RPRT A1 - Temiz Artmann, Aysegül T1 - Frühgeburtenrate mindern durch ein Prognoseverfahren für den vorzeitigen Blasensprung - PROMPT (Premature rupture of membranes prediction test) : Abschlussbericht ; Laufzeit des Vorhabens: 01.03.2007 - 31.12.2009 Y1 - 2010 U6 - https://doi.org/10.2314/GBV:644277858 N1 - Förderkennzeichen BMBF 1772X07 PB - Technische Informationsbibliothek u. Universitätsbibliothek CY - Aachen ER - TY - CHAP A1 - Staat, Manfred A1 - Sponagel, Stefan A1 - Nguyen, Nhu Huynh T1 - Experiment and material model for soft tissue materials T2 - Constitutive models for rubber VI N2 - Biomechanics studies biological soft tissue materials (growth, remodeling) in vivo. For this objective, the detailed information of material properties must be well defined to construct reliable constitutive models. In the paper, the bulge test is carried out with elastomers in order to develop a test method. Then, application of the test for soft tissue materials is straightforward due to the similarities between elastomers with soft tissue materials as proved in Holzapfel 2005, Ogden 2009. It means, after the preliminary experiments and parameter identification with rubber materials has been setup, experiments on soft tissue materials can be similarly carried out. Elastomers have a complex behavior which strongly depends on the largest previous load cycle. For simplicity we consider only the first loading. Y1 - 2010 SN - 9780429206597 (eBook) U6 - https://doi.org/10.1201/NOE0415563277-90 PB - Taylor & Francis CY - London ER -