TY  - JOUR
A1  - Honarvarfard, Elham
A1  - Gamella, Maria
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Katz, Evgeny
T1  - An enzyme-based reversible Controlled NOT (CNOT) logic gate operating on a semiconductor transducer
JF  - Applied Materials Today
N2  - An enzyme-based biocatalytic system mimicking operation of a logically reversible Controlled NOT (CNOT) gate has been interfaced with semiconductor electronic transducers. Electrolyte–insulator–semiconductor (EIS) structures have been used to transduce chemical changes produced by the enzyme system to an electronically readable capacitive output signal using field-effect features of the EIS device. Two enzymes, urease and esterase, were immobilized on the insulating interface of EIS structure producing local pH changes performing XOR logic operation controlled by various combinations of the input signals represented by urea and ethyl butyrate. Another EIS transducer was functionalized with esterase only, thus performing Identity (ID) logic operation for the ethyl butyrate input. Both semiconductor devices assembled in parallel operated as a logically reversible CNOT gate. The present system, despite its simplicity, demonstrated for the first time logically reversible function of the enzyme system transduced electronically with the semiconductor devices. The biomolecular realization of a CNOT gate interfaced with semiconductors is promising for integration into complex biomolecular networks and future biosensor/biomedical applications.
KW  - Electrolyte–insulator–semiconductor
KW  - Capacitive field-effect
KW  - CNOT
KW  - XOR
KW  - Enzyme logic gate
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.apmt.2017.08.003
SN  - 2352-9407
VL  - 9
SP  - 266
EP  - 270
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Jablonski, Melanie
A1  - Koch, Claudia
A1  - Bronder, Thomas
A1  - Poghossian, Arshak
A1  - Wege, Christina
A1  - Schöning, Michael Josef
T1  - Field-Effect Biosensors Modified with Tobacco Mosaic Virus Nanotubes as Enzyme Nanocarrier
T2  - MDPI Proceeding
Y1  - 2017
U6  - http://dx.doi.org/10.3390/proceedings1040505
N1  - Eurosensors 2017 Conference, Paris, France, 3–6 September 2017
VL  - 1
IS  - 4
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Bronder, Thomas
A1  - Wu, Chunsheng
A1  - Scheja, Sabrina
A1  - Jessing, Max
A1  - Metzger-Boddien, Christoph
A1  - Keusgen, Michael
A1  - Poghossian, Arshak
T1  - Label-Free DNA Detection with Capacitive Field-Effect Devices—Challenges and Opportunities
JF  - Proceedings
N2  - Field-effect EIS (electrolyte-insulator-semiconductor) sensors modified with a positively charged weak polyelectrolyte layer have been applied for the electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge. The EIS sensors are able to detect the existence of target DNA amplicons in PCR (polymerase chain reaction) samples and thus, can be used as tool for a quick verification of DNA amplification and the successful PCR process. Due to their miniaturized setup, compatibility with advanced micro- and nanotechnologies, and ability to detect biomolecules by their intrinsic molecular charge, those sensors can serve as possible platform for the development of label-free DNA chips. Possible application fields as well as challenges and limitations will be discussed.
Y1  - 2017
U6  - http://dx.doi.org/10.3390/proceedings1080719
SN  - 2504-3900
N1  - This article belongs to the Proceedings of "Proceedings of the 5th International Symposium on Sensor Science (I3S 2017)"
VL  - 1
IS  - 8
SP  - Artikel 719
PB  - MDPI
CY  - Basel
ER  -