TY  - JOUR
A1  - Kopp, Alexander
A1  - Schmeets, Ralf
A1  - Gosau, Martin
A1  - Friedrich, Reinhard E.
A1  - Fuest, Sandra
A1  - Behbahani, Mehdi
A1  - Barbeck, Mike
A1  - Rutkowski, Rico
A1  - Burg, Simon
A1  - Kluwe, Lan
A1  - Henningsen, Anders
T1  - Production and Characterization of Porous Fibroin Scaffolds for Regenerative Medical Application
JF  - In Vivo
Y1  - 2019
U6  - http://dx.doi.org/10.21873/invivo.11536
SN  - 1791-7549
VL  - 33
IS  - 3
SP  - 757
EP  - 762
ER  - 
TY  - CHAP
A1  - Marinova, V.
A1  - Kerroumi, I.
A1  - Lintermann, A.
A1  - Göbbert, J.H.
A1  - Moulinec, C.
A1  - Rible, S.
A1  - Fournier, Y.
A1  - Behbahani, Mehdi
T1  - Numerical Analysis of the FDA Centrifugal Blood Pump
T2  - NIC Symposium 2016
Y1  - 2016
SN  - 978-3-95806-109-5
SP  - 355
EP  - 364
ER  - 
TY  - CHAP
A1  - Behbahani, Mehdi
A1  - Rible, Sebastian
A1  - Moulinec, Charles
A1  - Fournier, Yvan
A1  - Nicolai, Mike
A1  - Crosetto, Paolo
T1  - Simulation of the FDA Centrifugal Blood Pump Using High Performance Computing
T2  - World Academy of Science, Engineering and Technology International Journal of Mechanical and Mechatronics Engineering
Y1  - 2015
VL  - 9
IS  - 5
ER  - 
TY  - CHAP
A1  - Behbahani, Mehdi
T1  - An Experimental Study of Thrombocyte Reactions in Response to Biomaterial Surfaces and Varying Shear Stress
T2  - Proceedings of the International Conference on Biomedical Engineering and Systems Prague, Czech Republic, August 14-15, 2014
Y1  - 2014
SP  - Paper 125
ER  - 
TY  - JOUR
A1  - Tran, Linda
A1  - Mottaghy, K.
A1  - Arlt-Körfer, Sabine
A1  - Waluga, Christian
A1  - Behbahani, Mehdi
T1  - An experimental study of shear-dependent human platelet adhesion and underlying protein-binding mechanisms in a cylindrical Couette system
JF  - Biomedizinische Technik
Y1  - 2017
U6  - http://dx.doi.org/10.1515/bmt-2015-0034
SN  - 0013-5585
VL  - 62
IS  - 4
SP  - 383
EP  - 392
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Pookhalil, Ali
A1  - Amoabediny, Ghassem
A1  - Tabesh, Hadi
A1  - Behbahani, Mehdi
A1  - Mottaghy, Khosrow
T1  - A new approach for semiempirical modeling of mechanical blood trauma
JF  - The international journal of artificial organs
N2  - Purpose
Two semi-empirical models were recently published, both making use of existing literature data, but each taking into account different physical phenomena that trigger hemolysis. In the first model, hemoglobin (Hb) release is described as a permeation procedure across the membrane, assuming a shear stress-dependent process (sublethal model). The second model only accounts for hemoglobin release that is caused by cell membrane breakdown, which occurs when red blood cells (RBC) undergo mechanically induced shearing for a period longer than the threshold time (nonuniform threshold model). In this paper, we introduce a model that considers the hemolysis generated by both these possible phenomena.
Methods
Since hemolysis can possibly be caused by permeation of hemoglobin through the RBC functional membrane as well as by release of hemoglobin from RBC membrane breakdown, our proposed model combines both these models. An experimental setup consisting of a Couette device was utilized for validation of our proposed model.
Results
A comparison is presented between the damage index (DI) predicted by the proposed model vs. the sublethal model vs. the nonthreshold model and experimental datasets. This comparison covers a wide range of shear stress for both human and porcine blood. An appropriate agreement between the measured DI and the DI predicted by the present model was obtained.
Conclusions
The semiempirical hemolysis model introduced in this paper aims for significantly enhanced conformity with experimental data. Two phenomenological outcomes become possible with the proposed approach: an estimation of the average time after which cell membrane breakdown occurs under the applied conditions, and a prediction of the ratio between the phenomena involved in hemolysis.
Y1  - 2016
U6  - http://dx.doi.org/10.5301/ijao.5000474
SN  - 1724-6040
VL  - 39
IS  - 4
SP  - 171
EP  - 177
PB  - Sage
CY  - London
ER  - 
TY  - JOUR
A1  - Jiminez German, Salvador
A1  - Behbahani, Mehdi
A1  - Miettinen, Susanna
A1  - Grijpma, Dirk W.
A1  - Haimi, Suvi P.
T1  - Proliferation and differentiation of adipose stem cells towards smooth muscle cells on poly(trimethylene carbonate) membranes
JF  - Macromolecular symposia
Y1  - 2013
SN  - 0258-0322
VL  - Vol. 334
IS  - Iss. 1
SP  - 133
EP  - 142
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Mai, A.
A1  - Bergmann, B.
A1  - Waluga, C.
A1  - Behr, M.
A1  - Tran, L.
A1  - Vonderstein, K.
A1  - Mottaghy, K.
T1  - Modeling and Numerical Simulation of Blood Damage
Y1  - 2010
N1  - Posterpresentation ; Umbrella Symposium "Modelling and Simulation in Medicine, Engineering and Sciences", Forschungszentrum Jülich, January 18-20, 2010
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Waluga, C.
A1  - Arlt, S.
A1  - Behr, M.
A1  - Mottaghy, K.
T1  - Computational Analysis of Platelet Aggregation in a Taylor-Couette System
JF  - The International Journal of Artificial Organs. 31 (2008), H. 7
Y1  - 2008
SN  - 0391-3988
N1  - Posterpresentation ; European Society of Artificial Organs (ESAO), Geneva, Switzerland
SP  - 643
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Mai, A.
A1  - Waluga, C.
A1  - Bergmann, B.
A1  - Tran, L.
A1  - Vonderstein, K.
A1  - Behr, M.
A1  - Mottaghy, K.
T1  - Numerical Modeling of Flow-Related Thrombus Formation under Physiological and Non-Physiological Flow Conditions
JF  - Acta Physiologica
Y1  - 2010
SN  - 1748-1716
N1  - Joint Congress of the Scandinavian and German Physiological Societies, Copenhagen, Denmark, March 27-30, 2010
VL  - 198
IS  - Supplement 677
SP  - 185
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Probst, M.
A1  - Mai, A.
A1  - Behr, M.
A1  - Tran, L.
A1  - Vonderstein, K.
A1  - Mottaghy, K.
T1  - Numerical Prediction of Blood Damage in Biomedical Devices
Y1  - 2010
N1  - Posterpresentation ; Biomedica Congress, Aachen, March 17-18, 2010
ER  - 
TY  - JOUR
A1  - Probst, M.
A1  - Behbahani, Mehdi
A1  - Borrmann, E.
A1  - Elgeti, S.
A1  - Nicolai, M.
A1  - Behr, M.
T1  - Hemodynamic Modeling for Numerical Analysis and Design of Medical Devices
Y1  - 2010
N1  - Posterpresentation ; NIC Symposium 2010 ; 24 - 25 February 2010 Jülich, Germany
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Waluga, C.
A1  - Stock, S.
A1  - Mai, A.
A1  - Bergmann, B.
A1  - Behr, M.
A1  - Tran, L.
A1  - Vonderstein, K.
A1  - Scheidt, H.
A1  - Oedekoven, B.
A1  - Mottaghy, K.
T1  - Modelling and Numerical Analysis of Platelet Reactions and Surface Thrombus Growth
Y1  - 2009
N1  - Posterpresentation ; European Society of Biomaterials (ESB), Lausanne, Switzerland, September 7-10, 2009
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Nam, J.
A1  - Waluga, C.
A1  - Behr, M.
A1  - Pasquali, M.
A1  - Mottaghy, K.
T1  - Modeling and Numerical Analysis of Platelet Activation, Adhesion and Aggregation in Artificial Organs
Y1  - 2010
U6  - http://dx.doi.org/10.1097/01.mat.0000369377.65122.a3
N1  - Posterpresentation American Society of Artificial Organs (ASAIO), Baltimore, USA, May 27-29, 2010
ER  - 
TY  - JOUR
A1  - Jansen, S. V.
A1  - Behbahani, Mehdi
A1  - Laumen, M.
A1  - Kaufmann, T.
A1  - Hormes, M.
A1  - Behr, M.
A1  - Schmitz-Rode, T.
A1  - Steinseifer, U.
T1  - Investigation of Steady Flow Through a Realistic Model of the Thoracic Human Aorta Using 3D Stereo PIV and CFD-Simulation
Y1  - 2010
N1  - Posterpresentation ; American Society of Artificial Organs (ASAIO), Baltimore, USA, May 27-29, 2010
ER  - 
TY  - JOUR
A1  - Nam, J.
A1  - Arora, D.
A1  - Behbahani, Mehdi
A1  - Probst, M.
A1  - Benkowski, R.
A1  - Behr, M.
A1  - Pasquali, M.
T1  - New computational method in hemolysis analysis for artificial heart pump
Y1  - 2010
N1  - Posterpresentation ; American Society of Artificial Organs (ASAIO), Baltimore, USA, May 27-29, 2010
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Tran, L.
A1  - Jockenhövel, S.
A1  - Behr, M.
A1  - Mottaghy, K.
T1  - Numerical prediction of thrombocyte reactions for application to a vascular flow model
JF  - British Journal of Surgery
Y1  - 2011
SN  - 1365-2168
N1  - 46th Congress of the European Society for Surgical Research, Aachen, Germany, 25-28 May 2011 ; ESSR Abstracts 2011 ; Oral Sessions OP10-5
VL  - 98
IS  - S5
SP  - S17
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Tran, L.
A1  - Waluga, C.
A1  - Behr, M.
A1  - Oedekoven, B.
A1  - Mottaghy, K.
T1  - Model-based Numerical Analysis of Platelet Adhesion, Thrombus Growth and Aggregation for Assist Devices
JF  - The International Journal of Artificial Organs. 32 (2009), H. 7
Y1  - 2009
SN  - 0391-3988
N1  - Abstracts - Oral Presentations: XXXVI Annual ESAO Congress, 2-5 September 2009, Compiègne - France; European Society of Artificial Organs (ESAO), Compiegne, France, September 2-5, 2009
SP  - 398
EP  - 398
ER  - 
TY  - JOUR
A1  - Steinseifer, Ulrich
A1  - Kashefi, Ali
A1  - Hormes, Marcus
A1  - Schoberer, Mark
A1  - Orlikowsky, Thorsten
A1  - Behbahani, Mehdi
A1  - Behr, Marek
A1  - Schmitz-Rode, Thomas
T1  - Miniaturization of ECMO Systems : Engineering Challenges and Methods
JF  - Artificial Organs. 33 (2009), H. 5
Y1  - 2009
SN  - 1525-1594
N1  - Fifth International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion Abstracts <May 28, 2009>
SP  - A55
EP  - A55
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Probst, M.
A1  - Mai, A.
A1  - Tran, L.
A1  - Vonderstein, K.
A1  - Keschenau, P.
A1  - Linde, T.
A1  - Steinseifer, U.
A1  - Behr, M.
A1  - Mottaghy, K.
T1  - The influence of high shear on thrombosis and hemolysis in artificial organs
JF  - Artificial Organs
Y1  - 2010
SN  - 0391-3988
N1  - Special Issue: SI ; Meeting abstract
VL  - 33
IS  - 7
SP  - 426
EP  - 426
ER  -