TY - JOUR A1 - Poghossian, Arshak A1 - Jablonski, Melanie A1 - Koch, Claudia A1 - Bronder, Thomas A1 - Rolka, David A1 - Wege, Christina A1 - Schöning, Michael Josef T1 - Field-effect biosensor using virus particles as scaffolds for enzyme immobilization JF - Biosensors and Bioelectronics N2 - A field-effect biosensor employing tobacco mosaic virus (TMV) particles as scaffolds for enzyme immobilization is presented. Nanotubular TMV scaffolds allow a dense immobilization of precisely positioned enzymes with retained activity. To demonstrate feasibility of this new strategy, a penicillin sensor has been developed by coupling a penicillinase with virus particles as a model system. The developed field-effect penicillin biosensor consists of an Al-p-Si-SiO₂-Ta₂O₅-TMV structure and has been electrochemically characterized in buffer solutions containing different concentrations of penicillin G. In addition, the morphology of the biosensor surface with virus particles was characterized by scanning electron microscopy and atomic force microscopy methods. The sensors possessed a high penicillin sensitivity of ~ 92 mV/dec in a nearly-linear range from 0.1 mM to 10 mM, and a low detection limit of about 50 µM. The long-term stability of the penicillin biosensor was periodically tested over a time period of about one year without any significant loss of sensitivity. The biosensor has also been successfully applied for penicillin detection in bovine milk samples. Y1 - 2018 U6 - https://doi.org/10.1016/j.bios.2018.03.036 SN - 0956-5663 VL - 110 SP - 168 EP - 174 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schuh, G. A1 - Gottschalk, S. A1 - Höhne, Tim T1 - High Resolution Production Management JF - CIRP Annals Y1 - 2007 U6 - https://doi.org/10.1016/j.cirp.2007.05.105 SN - 0007-8506 VL - 56 IS - 1 SP - 439 EP - 442 ER - TY - CHAP A1 - Schuh, Günther A1 - Gottschalk, Sebastian Friedrich A1 - Narr, Claus A1 - Höhne, Tim ED - Zäh, Michael F. T1 - Adaptive logistics : information management for planning and control of small series assembly T2 - 2nd International Conference on Changeable, Agile, Reconfigurable and Virtual Production (CARV 2007), Toronto, Ontario, Canada, 22-24 July 2007 : Book of Abstracts Y1 - 2007 SN - 978-0-9783187-0-3 SP - 212 EP - 221 ER - TY - CHAP A1 - Schuh, Günther A1 - Gottschalk, Sebastian A1 - Höhne, Tim A1 - Attig, Philipp ED - Mitsuishi, M. T1 - Further Potentials of Smart Logistics T2 - Manufacturing Systems and Technologies for the New Frontier Y1 - 2008 SN - 978-1-84800-267-8 SN - 978-1-84800-266-1 (Printausgabe) U6 - https://doi.org/10.1007/978-1-84800-267-8_18 N1 - The 41St Cirp Conference On Manufacturing Systems, May 26-28, 2008, Tokyo, Japan SP - 93 EP - 96 PB - Springer CY - London ER - TY - CHAP A1 - Funke, Harald A1 - Keinz, Jan A1 - Hendrick, P. T1 - Experimental Evaluation of the Pollutant and Noise Emissions of the GTCP 36-300 Gas Turbine Operated with Kerosene and a Low NOX Micromix Hydrogen Combustor T2 - 7th European Conference for Aeronautics and Space Sciences, EUCASS 2017 Y1 - 2017 U6 - https://doi.org/10.13009/EUCASS2017-125 ER - TY - CHAP A1 - Wilke, Thomas ED - Merlotti, Andrea T1 - Planning Process of the Di Castellamonte’s Chapel of the Holy Shroud T2 - Carlo e Amedeo di Castellamonte : 1571-1683, ingegneri e architetti per i duchi di Savoia Y1 - 2016 SN - 978-88-98229-57-4 N1 - Architettura e potere ; 4 SP - 141 EP - 152 PB - Campisano editore CY - Rom ER - TY - JOUR A1 - Liu, Z. A1 - Schaap, K. S. A1 - Ballemans, L. A1 - de Blois, E. A1 - Rohde, M. A1 - Paulßen, Elisabeth T1 - Measurement of reaction kinetics of [177Lu]Lu-DOTA-TATE using a microfluidic system JF - Dalton Transactions Y1 - 2017 U6 - https://doi.org/10.1039/C7DT01830D SN - 1477-9234 VL - 46 IS - 42 SP - 14669 EP - 14676 ER - TY - JOUR A1 - Infantino, Angelo A1 - Paulßen, Elisabeth A1 - Mostacci, Domiziano A1 - Schaffer, Paul A1 - Trinczek, Michael A1 - Hoehr, Cornelia T1 - Assessment of the production of medical isotopes using the Monte Carlo code FLUKA: Simulations against experimental measurements JF - Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms N2 - The Monte Carlo code FLUKA is used to simulate the production of a number of positron emitting radionuclides, ¹⁸F, ¹³N, ⁹⁴Tc, ⁴⁴Sc, ⁶⁸Ga, ⁸⁶Y, ⁸⁹Zr, ⁵²Mn, ⁶¹Cu and ⁵⁵Co, on a small medical cyclotron with a proton beam energy of 13 MeV. Experimental data collected at the TR13 cyclotron at TRIUMF agree within a factor of 0.6 ± 0.4 with the directly simulated data, except for the production of ⁵⁵Co, where the simulation underestimates the experiment by a factor of 3.4 ± 0.4. The experimental data also agree within a factor of 0.8 ± 0.6 with the convolution of simulated proton fluence and cross sections from literature. Overall, this confirms the applicability of FLUKA to simulate radionuclide production at 13 MeV proton beam energy. Y1 - 2016 U6 - https://doi.org/10.1016/j.nimb.2015.10.067 SN - 1872-9584 VL - 366 SP - 117 EP - 123 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Hoehr, Cornelia A1 - Paulßen, Elisabeth A1 - Benard, Francois A1 - Lee, Chris Jaeil A1 - Hou, Xinchi A1 - Badesso, Brian A1 - Ferguson, Simon A1 - Miao, Qing A1 - Yang, Hua A1 - Buckley, Ken A1 - Hanemaayer, Victoire A1 - Zeisler, Stefan A1 - Ruth, Thomas A1 - Celler, Anna A1 - Schaffer, Paul T1 - ⁴⁴ᶢSc production using a water target on a 13 MeV cyclotron JF - Nuclear medicine and biology N2 - Access to promising radiometals as isotopes for novel molecular imaging agents requires that they are routinely available and inexpensive to obtain. Proximity to a cyclotron center outfitted with solid target hardware, or to an isotope generator for the metal of interest is necessary, both of which can introduce significant hurdles in development of less common isotopes. Herein, we describe the production of ⁴⁴Sc (t₁⸝₂ = 3.97 h, Eavg,β⁺ = 1.47 MeV, branching ratio = 94.27%) in a solution target and an automated loading system which allows a quick turn-around between different radiometallic isotopes and therefore greatly improves their availability for tracer development. Experimental yields are compared to theoretical calculations. Y1 - 2014 U6 - https://doi.org/10.1016/j.nucmedbio.2013.12.016 SN - 1872-9614 VL - 41 IS - 5 SP - 401 EP - 406 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Paulßen, Elisabeth A1 - Hoehr, Cornelia A1 - Hou, Xinchi A1 - Hanemaayer, Victoire A1 - Zeisler, Stefan A1 - Adam, Michael J. A1 - Ruth, Thomas J. A1 - Celler, Anna A1 - Buckley, Ken A1 - Benard, Francois A1 - Schaffer, Paul T1 - Production of Y-86 and other radiometals for research purposes using a solution target system JF - Nuclear medicine and biology Y1 - 2015 U6 - https://doi.org/10.1016/j.nucmedbio.2015.06.005 SN - 1872-9614 VL - 42 IS - 11 SP - 842 EP - 849 PB - Elsevier CY - Amsterdam ER -