TY - CHAP A1 - Scheer, Nico A1 - Chu, Xiaoyan A1 - Salphati, Laurent A1 - Zamek-Gliszczynski, Maciej J. ED - Nicholls, Glynis T1 - Knockout and humanized animal models to study membrane transporters in drug development T2 - Drug Transporters: Volume 1: Role and Importance in ADME and Drug Development Y1 - 2016 SN - 978-1-78262-379-3 U6 - http://dx.doi.org/10.1039/9781782623793-00298 SP - 298 EP - 332 PB - Royal Society of Chemistry CY - Cambridge ER - TY - CHAP A1 - Samuelsson, K. A1 - Scheer, Nico A1 - Wilson, I. A1 - Wolf, C.R. A1 - Henderson, C.J. ED - Chackalamannil, Samuel T1 - Genetically Humanized Animal Models T2 - Comprehensive Medicinal Chemistry III. 3rd Edition N2 - Genetically humanized mice for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging as promising in vivo models for improved prediction of the pharmacokinetic, drug–drug interaction, and safety characteristics of compounds in humans. This is an overview on the genetically humanized and chimeric liver-humanized mouse models, which are illustrated with examples of their utility in drug metabolism and toxicity studies. The models are compared to give guidance for selection of the most appropriate model by highlighting advantages and disadvantages to be carefully considered when used for studies in drug discovery and development. KW - Chimeric liver-humanized mice KW - Drug distribution KW - Drug metabolism KW - Toxicology KW - Knockout mice Y1 - 2017 SN - 978-0-12-803201-5 U6 - http://dx.doi.org/10.1016/B978-0-12-409547-2.12376-5 SP - 130 EP - 149 PB - Elsevier CY - Saint Louis ER - TY - CHAP A1 - Eggert, Mathias T1 - Big Data Research - How to Structure the Changes of the Past Decade? T2 - The Art of Structuring N2 - In the past decade, many IS researchers focused on researching the phenomenon of Big Data. At the same time, the relevance of data protection gets more attention than ever before. In particular, since the enactment of the European General Data Protection Regulation in May 2018 Information Systems research should provide answers for protecting personal data. The article at hand presents a structuring framework for Big Data research outcome and the consideration of data protection. IS Researchers might use the framework in order to structure Big Data literature and to identify research gaps that should be addressed in the future. Y1 - 2019 SN - 978-3-030-06234-7 U6 - http://dx.doi.org/10.1007/978-3-030-06234-7_26 SP - 271 EP - 281 PB - Springer CY - Cham ER - TY - CHAP A1 - Franzen, Julian A1 - Stecken, Jannis A1 - Pfaff, Raphael A1 - Kuhlenkötter, Bernd T1 - Using the Digital Shadow for a Prescriptive Optimization of Maintenance and Operation : The Locomotive in the Context of the Cyber-Physical System T2 - Advances in Production, Logistics and Traffic N2 - In competition with other modes of transport, rail freight transport is looking for solutions to become more attractive. Short-term success can be achieved through the data-driven optimization of operations and maintenance as well as the application of novel strategies such as prescriptive maintenance. After introducing the concept of prescriptive maintenance, this paper aims to prove that vehicle-focused applications of this approach indeed have the potential to increase attractiveness. However, even greater advantages can be activated if data from the horizontal network of the vehicle is available. Drawing on the state of the art in research and technology in the field of cyber-physical systems (CPS) as well as digital twins and shadows, our work serves to design a system of systems for the horizontal interconnection of a rail vehicle and to conceptualize a draft for a digital twin of a locomotive. Y1 - 2019 SN - 978-3-030-13535-5 U6 - http://dx.doi.org/10.1007/978-3-030-13535-5_19 SP - 265 EP - 276 PB - Springer CY - Cham ER - TY - CHAP A1 - Bosse, Elke A1 - Barnat, Miriam ED - Jenert, Tobias ED - Reinmann, Gabi ED - Schmohl, Tobias T1 - Kombination quantitativer und qualitativer Methoden zur Untersuchung der Studieneingangsphase T2 - Hochschulbildungsforschung. Theoretische, methodologische und methodische Denkanstöße für die Hochschuldidaktik Y1 - 2019 SN - 978-3-658-20308-5 SP - 169 EP - 184 PB - Springer VS CY - Wiesbaden ER - TY - CHAP A1 - Drumm, Christian A1 - Lemcke, Jens A1 - Oberle, Daniel T1 - Business Process Management And Semantic Technologies T2 - The Semantic Web Y1 - 2007 SN - 978-0-387-48531-7 U6 - http://dx.doi.org/10.1007/978-0-387-48531-7_10 SP - 207 EP - 239 PB - Springer CY - Boston, MA ER - TY - CHAP A1 - Röth, Thilo A1 - Deutskens, Christoph A1 - Kreisköther, Kai A1 - Heimes, Heiner Hans A1 - Schittny, Bastian A1 - Ivanescu, Sebastian A1 - Kleine Büning, Max A1 - Reinders, Christian A1 - Wessels, Saskia A1 - Haunreiter, Andreas A1 - Reisgen, Uwe A1 - Thiele, Regina A1 - Hameyer, Kay A1 - Doncker, Rik W. de A1 - Sauer, Uwe A1 - Hoek, Hauke van A1 - Hübner, Mareike A1 - Hennen, Martin A1 - Stolze, Thilo A1 - Vetter, Andreas A1 - Hagedorn, Jürgen A1 - Müller, Dirk A1 - Rewitz, Kai A1 - Wesseling, Mark A1 - Flieger, Björn T1 - Entwicklung von elektrofahrzeugspezifischen Systemen T2 - Elektromobilität N2 - Die Batterie ist eine der absolut zentralen Komponenten des Elektrofahrzeugs. Die serielle Entwicklung und Produktion dieser Batterien und die Verbesserung der Leistungen wird entscheidend für den Erfolg der Elektromobilität sein. Die Batterie ist jedoch nicht das einzige elektrofahrzeugspezifische System, das neu entwickelt, umkonzipiert oder verbessert werden muss. So sind ebenso die Entwicklung der neuen Fahrzeugstruktur sowie des elektrifizierten Antriebsstranges Teil dieses Kapitels. Weiterhin wird ein Blick auf das bedeutende Thema des Thermomanagements geworfen. Y1 - 2018 SN - 978-3-662-53137-2 U6 - http://dx.doi.org/10.1007/978-3-662-53137-2_6 SP - 279 EP - 386 PB - Springer Vieweg CY - Berlin, Heidelberg ER - TY - CHAP A1 - Kroll-Ludwigs, Kathrin ED - Calliess, Gralf-Peter T1 - Art. 5 Rom III-Regulation (choice of applicable law by the parties) T2 - Rome Regulations : commentary Y1 - 2015 SN - 9789041147547 PB - Wolters Kluwer ET - 2nd ed. ER - TY - CHAP A1 - Kroll-Ludwigs, Kathrin ED - Colliess, Gralf-Peter T1 - Art. 7 Rome III-Regulation (formal validity) T2 - Rome Regulations : commentary Y1 - 2015 SN - 9789041147547 PB - Wolters Kluwer ET - 2nd ed. ER - TY - CHAP A1 - Calliess, Gralf-Peter A1 - Kroll-Ludwigs, Kathrin T1 - Art. 6 Rome III-Regulation (consent and material validity) T2 - Rome Regulations : commentary Y1 - 2015 SN - 9789041147547 PB - Wolters Kluwer ER -