TY - JOUR A1 - Malan, Leone A1 - Hamer, Mark A1 - Känel, Roland von A1 - Kotliar, Konstantin A1 - Wyk, Roelof D. van A1 - Lambert, Gavin W. A1 - Vilser, Walthard A1 - Ziemssen, Tjalf A1 - Schlaich, Markus P. A1 - Smith, Wayne A1 - Magnusson, Martin A1 - Wentzel, Annemarie A1 - Myburgh, Carlien E. A1 - Steyn, Hendrik S. A1 - Malan, Nico T. T1 - Delayed retinal vein recovery responses indicate both non-adaptation to stress as well as increased risk for stroke: the SABPA study JF - Cardiovascular Journal of Africa Y1 - 2020 U6 - https://doi.org/10.5830/CVJA-2020-031 SN - 1680-0745 VL - 26 IS - 31 SP - 1 EP - 12 PB - Clinics Cardive Publishing CY - Durbanville ER - TY - JOUR A1 - Golland, Alexander T1 - Datenschutzrechtliche Fragen personalisierter Preise — Herausforderungen von Algorithmen im Schnittbereich von Ethik, Ökonomie und Datenschutz JF - CR Computer und Recht Y1 - 2020 SN - 2194-4172 U6 - https://doi.org/10.9785/cr-2020-360313 VL - 36 IS - 3 SP - 186 EP - 194 PB - Verlag Dr. Otto Schmidt CY - Köln ER - TY - JOUR A1 - Golland, Alexander T1 - Datenschutzrechtliche Anforderungen an internationale Datentransfers JF - NJW - Neue Juristische Wochenschrift Y1 - 2020 SN - 0341-1915 N1 - Zugleich Anmerkung zu EuGH, Urteil vom 16.7.2020 (C-311/18) VL - 2020 IS - 36 SP - 2593 EP - 2596 PB - Beck CY - München ER - TY - GEN A1 - Ohrtmann, Jan-Peter A1 - Golland, Alexander T1 - Daten- und Privatsphäreschutz im Wandel der 2020er-Jahre Y1 - 2020 SP - 33 EP - 38 ER - TY - CHAP A1 - Paulsen, Svea A1 - Hoffstadt, Kevin A1 - Krafft, Simone A1 - Leite, A. A1 - Zang, J. A1 - Fonseca-Zang, W. A1 - Kuperjans, Isabel T1 - Continuous biogas production from sugarcane as sole substrate T2 - Energy Reports N2 - A German–Brazilian research project investigates sugarcane as an energy plant in anaerobic digestion for biogas production. The aim of the project is a continuous, efficient, and stable biogas process with sugarcane as the substrate. Tests are carried out in a fermenter with a volume of 10 l. In order to optimize the space–time load to achieve a stable process, a continuous process in laboratory scale has been devised. The daily feed in quantity and the harvest time of the substrate sugarcane has been varied. Analyses of the digester content were conducted twice per week to monitor the process: The ratio of inorganic carbon content to volatile organic acid content (VFA/TAC), the concentration of short-chain fatty acids, the organic dry matter, the pH value, and the total nitrogen, phosphate, and ammonium concentrations were monitored. In addition, the gas quality (the percentages of CO₂, CH₄, and H₂) and the quantity of the produced gas were analyzed. The investigations have exhibited feasible and economical production of biogas in a continuous process with energy cane as substrate. With a daily feeding rate of 1.68gᵥₛ/l*d the average specific gas formation rate was 0.5 m3/kgᵥₛ. The long-term study demonstrates a surprisingly fast metabolism of short-chain fatty acids. This indicates a stable and less susceptible process compared to other substrates. Y1 - 2020 U6 - https://doi.org/10.1016/j.egyr.2019.08.035 N1 - 6th International Conference on Energy and Environment Research, ICEER 2019, 22–25 July, University of Aveiro, Portugal VL - 6 IS - Supplement 1 SP - 153 EP - 158 PB - Elsevier ER - TY - CHAP A1 - Leise, Philipp A1 - Simon, Nicolai A1 - Altherr, Lena T1 - Comparison of Piecewise Linearization Techniques to Model Electric Motor Efficiency Maps: A Computational Study T2 - Operations Research Proceedings 2019 N2 - To maximize the travel distances of battery electric vehicles such as cars or buses for a given amount of stored energy, their powertrains are optimized energetically. One key part within optimization models for electric powertrains is the efficiency map of the electric motor. The underlying function is usually highly nonlinear and nonconvex and leads to major challenges within a global optimization process. To enable faster solution times, one possibility is the usage of piecewise linearization techniques to approximate the nonlinear efficiency map with linear constraints. Therefore, we evaluate the influence of different piecewise linearization modeling techniques on the overall solution process and compare the solution time and accuracy for methods with and without explicitly used binary variables. KW - MINLP KW - Powertrain KW - Piecewise linearization KW - Efficiency optimization Y1 - 2020 SN - 978-3-030-48439-2 SN - 978-3-030-48438-5 U6 - https://doi.org/10.1007/978-3-030-48439-2_55 N1 - Annual International Conference of the German Operations Research Society (GOR), Dresden, Germany, September 4-6, 2019 SP - 457 EP - 463 PB - Springer CY - Cham ER - TY - CHAP A1 - Finger, Felix A1 - Braun, Carsten A1 - Bil, Cees T1 - Comparative assessment of parallel-hybrid-electric propulsion systems for four different aircraft T2 - AIAA Scitech 2020 Forum N2 - As battery technologies advance, electric propulsion concepts are on the edge of disrupting aviation markets. However, until electric energy storage systems are ready to allow fully electric aircraft, the combination of combustion engine and electric motor as a hybrid-electric propulsion system seems to be a promising intermediate solution. Consequently, the design space for future aircraft is expanded considerably, as serial-hybrid-, parallel-hybrid-, fully-electric, and conventional propulsion systems must all be considered. While the best propulsion system depends on a multitude of requirements and considerations, trends can be observed for certain types of aircraft and certain types of missions. This paper provides insight into some factors that drive a new design towards either conventional or hybrid propulsion systems. General aviation aircraft, VTOL air taxis, transport aircraft, and UAVs are chosen as case studies. Typical missions for each class are considered, and the aircraft are analyzed regarding their take-off mass and primary energy consumption. For these case studies, a high-level approach is chosen, using an initial sizing methodology. Results indicate that hybrid-electric propulsion systems should be considered if the propulsion system is sized by short-duration power constraints (e.g. take-off, climb). However, if the propulsion system is sized by a continuous power requirement (e.g. cruise), hybrid-electric systems offer hardly any benefit. Y1 - 2020 U6 - https://doi.org/10.2514/6.2020-1502 N1 - AIAA Scitech 2020 Forum, Driving aerospace solutions for global challenges, Orlando, 06. - 10. January 2020 ER - TY - JOUR A1 - Finger, Felix A1 - Braun, Carsten A1 - Bil, Cees T1 - Comparative assessment of parallel-hybrid-electric propulsion systems for four different aircraft JF - Journal of Aircraft N2 - Until electric energy storage systems are ready to allow fully electric aircraft, the combination of combustion engine and electric motor as a hybrid-electric propulsion system seems to be a promising intermediate solution. Consequently, the design space for future aircraft is expanded considerably, as serial hybrid-electric, parallel hybrid-electric, fully electric, and conventional propulsion systems must all be considered. While the best propulsion system depends on a multitude of requirements and considerations, trends can be observed for certain types of aircraft and certain types of missions. This Paper provides insight into some factors that drive a new design toward either conventional or hybrid propulsion systems. General aviation aircraft, regional transport aircraft vertical takeoff and landing air taxis, and unmanned aerial vehicles are chosen as case studies. Typical missions for each class are considered, and the aircraft are analyzed regarding their takeoff mass and primary energy consumption. For these case studies, a high-level approach is chosen, using an initial sizing methodology. Only parallel-hybrid-electric powertrains are taken into account. Aeropropulsive interaction effects are neglected. Results indicate that hybrid-electric propulsion systems should be considered if the propulsion system is sized by short-duration power constraints. However, if the propulsion system is sized by a continuous power requirement, hybrid-electric systems offer hardly any benefit. Y1 - 2020 U6 - https://doi.org/10.2514/1.C035897 SN - 1533-3868 VL - 57 IS - 5 PB - AIAA CY - Reston, Va. ER - TY - JOUR A1 - Knox, Ronald A1 - Bruggemann, Andrea A1 - Gossmann, Matthias A1 - Thomas, Ulrich A1 - Horváth, András A1 - Dragicevic, Elena A1 - Stoelzle-Feix, Sonja A1 - Fertig, Niels A1 - Jung, Alexander A1 - Raman, Aravind Hariharan A1 - Staat, Manfred A1 - Linder, Peter T1 - Combining physiological relevance and throughput for in vitro cardiac contractility measurement JF - Biophysical Journal N2 - Despite increasing acceptance of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in safety pharmacology, controversy remains about the physiological relevance of existing in vitro models for their mechanical testing. We hypothesize that existing signs of immaturity of the cell models result from an improper mechanical environment. We cultured hiPSC-CMs in a 96-well format on hyperelastic silicone membranes imitating their native mechanical environment, resulting in physiological responses to compound stimuli.We validated cell responses on the FLEXcyte 96, with a set of reference compounds covering a broad range of cellular targets, including ion channel modulators, adrenergic receptor modulators and kinase inhibitors. Acute (10 - 30 min) and chronic (up to 7 days) effects were investigated. Furthermore, the measurements were complemented with electromechanical models based on electrophysiological recordings of the used cell types.hiPSC-CMs were cultured on freely-swinging, ultra-thin and hyperelastic silicone membranes. The weight of the cell culture medium deflects the membranes downwards. Rhythmic contraction of the hiPSC-CMs resulted in dynamic deflection changes which were quantified by capacitive distance sensing. The cells were cultured for 7 days prior to compound addition. Acute measurements were conducted 10-30 minutes after compound addition in standard culture medium. For chronic treatment, compound-containing medium was replaced daily for up to 7 days. Electrophysiological properties of the employed cell types were recorded by automated patch-clamp (Patchliner) and the results were integrated into the electromechanical model of the system.Calcium channel agonist S Bay K8644 and beta-adrenergic stimulator isoproterenol induced significant positive inotropic responses without additional external stimulation. Kinase inhibitors displayed cardiotoxic effects on a functional level at low concentrations. The system-integrated analysis detected alterations in beating shape as well as frequency and arrhythmic events and we provide a quantitative measure of these. Y1 - 2020 U6 - https://doi.org/10.1016/j.bpj.2019.11.3104 SN - 0006-3495 N1 - Raman, Arayind Hariharan im Artikel unter dem Namen: Raman, Alexander H. VL - 118 IS - Issue 3, Supplement 1 SP - 570a PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Wollbrink, Moritz A1 - Maslo, Semir A1 - Zimmer, Daniel A1 - Abbas, Karim A1 - Arntz, Kristian A1 - Bergs, Thomas T1 - Clamping and substrate plate system for continuous additive build-up and post-processing of metal parts JF - Procedia CIRP N2 - The manufacturing share of laser powder bed fusion (L-PBF) increases in industrial application, but still many process steps are manually operated. Additionally, it is not possible to achieve tight dimensional tolerances or low surfaces roughness. Hence, a process chain has to be set up to combine additive manufacturing (AM) with further machining technologies. To achieve a continuous workpiece flow as basis for further industrialization of L-PBF, the paper presents a novel substrate system and its application on L-PBF machines and post-processing. The substrate system consists of a zero-point clamping system and a matrix-like interface of contact pins to be substantially connected to the workpiece within the L-PBF process. Y1 - 2020 U6 - https://doi.org/10.1016/j.procir.2020.04.015 SN - 2212-8271 VL - 93 SP - 108 EP - 113 PB - Elsevier CY - Amsterdam ER -