TY  - JOUR
A1  - Grieger, Niklas
A1  - Schwabedal, Justus T. C.
A1  - Wendel, Stefanie
A1  - Ritze, Yvonne
A1  - Bialonski, Stephan
T1  - Automated scoring of pre-REM sleep in mice with deep learning
JF  - Scientific Reports
N2  - Reliable automation of the labor-intensive manual task of scoring animal sleep can facilitate the analysis of long-term sleep studies. In recent years, deep-learning-based systems, which learn optimal features from the data, increased scoring accuracies for the classical sleep stages of Wake, REM, and Non-REM. Meanwhile, it has been recognized that the statistics of transitional stages such as pre-REM, found between Non-REM and REM, may hold additional insight into the physiology of sleep and are now under vivid investigation. We propose a classification system based on a simple neural network architecture that scores the classical stages as well as pre-REM sleep in mice. When restricted to the classical stages, the optimized network showed state-of-the-art classification performance with an out-of-sample F1 score of 0.95 in male C57BL/6J mice. When unrestricted, the network showed lower F1 scores on pre-REM (0.5) compared to the classical stages. The result is comparable to previous attempts to score transitional stages in other species such as transition sleep in rats or N1 sleep in humans. Nevertheless, we observed that the sequence of predictions including pre-REM typically transitioned from Non-REM to REM reflecting sleep dynamics observed by human scorers. Our findings provide further evidence for the difficulty of scoring transitional sleep stages, likely because such stages of sleep are under-represented in typical data sets or show large inter-scorer variability. We further provide our source code and an online platform to run predictions with our trained network.
Y1  - 2021
U6  - http://dx.doi.org/10.1038/s41598-021-91286-0
SN  - 2045-2322
N1  - Corresponding author: Stephan Bialonski
VL  - 11
IS  - Art. 12245
PB  - Springer Nature
CY  - London
ER  - 
TY  - JOUR
A1  - Jildeh, Zaid B.
A1  - Wagner, Patrick H.
A1  - Schöning, Michael Josef
T1  - Sterilization of Objects, Products, and Packaging Surfaces and Their Characterization in Different Fields of Industry: The Status in 2020
JF  - physica status solidi (a) applications and materials science
N2  - The treatment method to deactivate viable microorganisms from objects or products is termed sterilization. There are multiple forms of sterilization, each intended to be applied for a specific target, which depends on—but not limited to—the thermal, physical, and chemical stability of that target. Herein, an overview on the currently used sterilization processes in the global market is provided. Different sterilization techniques are grouped under a category that describes the method of treatment: radiation (gamma, electron beam, X-ray, and ultraviolet), thermal (dry and moist heat), and chemical (ethylene oxide, ozone, chlorine dioxide, and hydrogen peroxide). For each sterilization process, the typical process parameters as defined by regulations and the mode of antimicrobial activity are summarized. Finally, the recommended microorganisms that are used as biological indicators to validate sterilization processes in accordance with the rules that are established by various regulatory agencies are summarized.
KW  - bioburdens
KW  - sterility tests
KW  - sterilization efficacy
KW  - sterilization methods
KW  - validation methods
Y1  - 2021
U6  - http://dx.doi.org/10.1002/pssa.202000732
SN  - 1862-6319
N1  - Corresponding author: Michael J. Schöning
VL  - 218
IS  - 13
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Jablonski, Melanie
A1  - Münstermann, Felix
A1  - Nork, Jasmina
A1  - Molinnus, Denise
A1  - Muschallik, Lukas
A1  - Bongaerts, Johannes
A1  - Wagner, Torsten
A1  - Keusgen, Michael
A1  - Siegert, Petra
A1  - Schöning, Michael Josef
T1  - Capacitive field‐effect biosensor applied for the detection of acetoin in alcoholic beverages and fermentation broths
JF  - physica status solidi (a) applications and materials science
N2  - An acetoin biosensor based on a capacitive electrolyte–insulator–semiconductor (EIS) structure modified with the enzyme acetoin reductase, also known as butane-2,3-diol dehydrogenase (Bacillus clausii DSM 8716ᵀ), is applied for acetoin detection in beer, red wine, and fermentation broth samples for the first time. The EIS sensor consists of an Al/p-Si/SiO₂/Ta₂O₅ layer structure with immobilized acetoin reductase on top of the Ta₂O₅ transducer layer by means of crosslinking via glutaraldehyde. The unmodified and enzyme-modified sensors are electrochemically characterized by means of leakage current, capacitance–voltage, and constant capacitance methods, respectively.
KW  - acetoin
KW  - acetoin reductase
KW  - alcoholic beverages
KW  - biosensors
KW  - capacitive field-effect sensors
Y1  - 2021
U6  - http://dx.doi.org/10.1002/pssa.202000765
SN  - 1862-6319
VL  - 218
IS  - 13
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Özsoylu, Dua
A1  - Kizildag, Sefa
A1  - Schöning, Michael Josef
A1  - Wagner, Torsten
T1  - Effect of plasma treatment on the sensor properties of a light‐addressable potentiometric sensor (LAPS)
JF  - physica status solidi a : applications and materials sciences
N2  - A light-addressable potentiometric sensor (LAPS) is a field-effect-based (bio-) chemical sensor, in which a desired sensing area on the sensor surface can be defined by illumination. Light addressability can be used to visualize the concentration and spatial distribution of the target molecules, e.g., H+ ions. This unique feature has great potential for the label-free imaging of the metabolic activity of living organisms. The cultivation of those organisms needs specially tailored surface properties of the sensor. O2 plasma treatment is an attractive and promising tool for rapid surface engineering. However, the potential impacts of the technique are carefully investigated for the sensors that suffer from plasma-induced damage. Herein, a LAPS with a Ta2O5 pH-sensitive surface is successfully patterned by plasma treatment, and its effects are investigated by contact angle and scanning LAPS measurements. The plasma duration of 30 s (30 W) is found to be the threshold value, where excessive wettability begins. Furthermore, this treatment approach causes moderate plasma-induced damage, which can be reduced by thermal annealing (10 min at 300 °C). These findings provide a useful guideline to support future studies, where the LAPS surface is desired to be more hydrophilic by O2 plasma treatment.
Y1  - 2019
U6  - http://dx.doi.org/10.1002/pssa.201900259
SN  - 1862-6319
N1  - Corresponding author: Torsten Wagner
VL  - 216
IS  - 20
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Jung, Alexander
A1  - Frotscher, Ralf
A1  - Staat, Manfred
T1  - Electromechanical model of hiPSC-derived ventricular cardiomyocytes cocultured with fibroblasts
T2  - 6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), 11-15 June 2018, Glasgow, UK
N2  - The CellDrum provides an experimental setup to study the mechanical effects of fibroblasts co-cultured with hiPSC-derived ventricular cardiomyocytes. Multi-scale computational models based on the Finite Element Method are developed. Coupled electrical cardiomyocyte-fibroblast models (cell level) are embedded into reaction-diffusion equations (tissue level) which compute the propagation of the action potential in the cardiac tissue. Electromechanical coupling is realised by an excitation-contraction model (cell level) and the active stress arising during contraction is added to the passive stress in the force balance, which determines the tissue displacement (tissue level). Tissue parameters in the model can be identified experimentally to the specific sample.
Y1  - 2018
ER  - 
TY  - CHAP
A1  - Schreiber, Marc
A1  - Kraft, Bodo
A1  - Zündorf, Albert
T1  - Metrics Driven Research Collaboration: Focusing on Common Project Goals Continuously
T2  - 39th International Conference on Software Engineering, May 20-28, 2017 - Buenos Aires, Argentina
N2  - Research collaborations provide opportunities for both practitioners and researchers: practitioners need solutions for difficult business challenges and researchers are looking for hard problems to solve and publish. Nevertheless, research collaborations carry the risk that practitioners focus on quick solutions too much and that researchers tackle theoretical problems, resulting in products which do not fulfill the project requirements.
In this paper we introduce an approach extending the ideas of agile and lean software development. It helps practitioners and researchers keep track of their common research collaboration goal: a scientifically enriched software product which fulfills the needs of the practitioner’s business model.
This approach gives first-class status to application-oriented metrics that measure progress and success of a research collaboration continuously. Those metrics are derived from the collaboration requirements and help to focus on a commonly defined goal.
An appropriate tool set evaluates and visualizes those metrics with minimal effort, and all participants will be pushed to focus on their tasks with appropriate effort. Thus project status, challenges and progress are transparent to all research collaboration members at any time.
Y1  - 2017
N1  - Software Engineering in Practice (SEIP).
ICSE2017
Vorabversion der Autoren
ER  - 
TY  - GEN
A1  - Schreiber, Marc
T1  - Mit Maximum-Entropie das Parsing natürlicher Sprache erlernen
N2  - Für die Verarbeitung von natürlicher Sprache ist ein wichtiger Zwischenschritt das Parsing, bei dem für Sätze der natürlichen Sprache Ableitungsbäume bestimmt werden. Dieses Verfahren ist vergleichbar zum Parsen formaler Sprachen, wie z. B. das Parsen eines Quelltextes. Die Parsing-Methoden der formalen Sprachen, z. B. Bottom-up-Parser, können nicht auf das Parsen der natürlichen Sprache übertragen werden, da keine Formalisierung der natürlichen Sprachen existiert [3, 12, 23, 30].
In den ersten Programmen, die natürliche Sprache verarbeiten [32, 41], wurde versucht die natürliche Sprache mit festen Regelmengen zu verarbeiten. Dieser Ansatz stieß jedoch schnell an seine Grenzen, da die Regelmenge nicht vollständig sowie nicht minimal ist und wegen der benötigten Menge an Regeln schwer zu verwalten ist. Die Korpuslinguistik [22] bot die Möglichkeit, die Regelmenge durch Supervised-Machine-Learning-Verfahren [2] abzulösen.
Teil der Korpuslinguistik ist es, große Textkorpora zu erstellen und diese mit sprachlichen Strukturen zu annotieren. Zu diesen Strukturen gehören sowohl die Wortarten als auch die Ableitungsbäume der Sätze. Vorteil dieser Methodik ist es, dass repräsentative Daten zur Verfügung stehen. Diese Daten werden genutzt, um mit Supervised-Machine-Learning-Verfahren die Gesetzmäßigkeiten der natürliche Sprachen zu erlernen.
Das Maximum-Entropie-Verfahren ist ein Supervised-Machine-Learning-Verfahren, das genutzt wird, um natürliche Sprache zu erlernen. Ratnaparkhi [25] nutzt Maximum-Entropie, um Ableitungsbäume für Sätze der natürlichen Sprache zu erlernen. Dieses Verfahren macht es möglich, die natürliche Sprache (abgebildet als Σ∗) trotz einer fehlenden formalen Grammatik zu parsen.
Y1  - 2016
N1  - Aufsatz zu einem Seminar (Theoretische Informatik) an der FH Aachen, 2016.
PB  - FH Aachen
CY  - Aachen
ER  - 
TY  - CHAP
A1  - Staat, Manfred
A1  - Duong, Minh Tuan
T1  - Smoothed Finite Element Methods for Nonlinear Solid Mechanics Problems: 2D and 3D Case Studies
T2  - Proceedings of the National Science and Technology Conference on Mechanical - Transportation Engineering (NSCMET 2016), 13th October 2016, Hanoi, Vietnam, Vol.2
N2  - The Smoothed Finite Element Method (SFEM) is presented as an edge-based and a facebased techniques for 2D and 3D boundary value problems, respectively. SFEMs avoid shortcomings of the standard Finite Element Method (FEM) with lower order elements such as overly stiff behavior, poor stress solution, and locking effects. Based on the idea of averaging spatially the standard strain field of the FEM over so-called smoothing domains SFEM calculates the stiffness matrix for the same number of degrees of freedom (DOFs) as those of the FEM. However, the SFEMs significantly improve accuracy and convergence even for distorted meshes and/or nearly incompressible materials.
Numerical results of the SFEMs for a cardiac tissue membrane (thin plate inflation) and an artery (tension of 3D tube) show clearly their advantageous properties in improving accuracy particularly for the distorted meshes and avoiding shear locking effects.
Y1  - 2016
SP  - 440
EP  - 445
ER  - 
TY  - CHAP
A1  - Duong, Minh Tuan
A1  - Jung, Alexander
A1  - Frotscher, Ralf
A1  - Staat, Manfred
ED  - Papadrakakis, M.
T1  - A 3D electromechanical FEM-based model for cardiac tissue
T2  - ECCOMAS Congress 2016, VII European Congress on Computational Methods in Applied Sciences and Engineering. Crete Island, Greece, 5–10 June 2016
Y1  - 2016
N1  - revised after the conference
P11367
ER  - 
TY  - CHAP
A1  - Frotscher, Ralf
A1  - Duong, Minh Tuan
A1  - Staat, Manfred
T1  - Simulating beating cardiomyocytes with electromechanical coupling
T2  - II. International Conference on Biomedical Technology : 28-30 October 2015 Hannover, Germany / T. Lenarz, P. Wriggers (Eds.)
Y1  - 2015
SP  - 1
EP  - 2
ER  - 
TY  - CHAP
A1  - Frotscher, Ralf
A1  - Staat, Manfred
ED  - Nithiarasu, Perumal
T1  - Homogenization of a cardiac tissue construct
T2  - CMBE15 : 4th International Conference on Computational & Mathematical Biomedical Engineering ; 29th June - 1st July 2015 ; École Normale Supérieure de Cachan ; Cachan (Paris), France
Y1  - 2015
SN  - 2227-9385
N1  - Konferenzband unter:
http://www.compbiomed.net/getfile.php?type=12/site_documents&id=Proceedings_2227-9385_compressed.pdf
SP  - 645
EP  - 648
PB  - CMBE
CY  - [s.l.]
ER  - 
TY  - CHAP
A1  - Kirchhof, Michael
A1  - Kraft, Bodo
T1  - Dogmatisches „Entweder agil oder klassisch" im Projektmanagement hat ausgedient - die richtige Mischung macht's
T2  - Projekt-Sternstunden : strahlende Erfolge durch Kompetenz
Y1  - 2011
SN  - 978-3-924841-60-7
N1  - PM-Forum <28, 2011, Nürnberg> ; 
PM-Forum 2011, 28. Internationales Deutsches Projektmanagement-Forum ; Nürnberg, 25. - 26.10.2011 ; Tagungsband
SP  - 414
EP  - 425
PB  - GPM
CY  - Nürnberg
ER  - 
TY  - CHAP
A1  - Kraft, Bodo
A1  - Zöll, Axel
ED  - Engstler, Martin
T1  - Von der Langstrecke zum Sprint – Agile Methoden in traditionellen Unternehmen
T2  - Projektmanagement und Vorgehensmodelle 2014 : soziale Aspekte und Standardisierung
Y1  - 2014
SN  - 978-3-88579-630-5
N1  - Gemeinsame Tagung der Fachgruppen Projektmanagement (WI-PM) und Vorgehensmodelle (WI-VM) im Fachgebiet Wirtschaftsinformatik der Gesellschaft für Informatik e.V. ; 16. und 17. Oktober 2014 in Stuttgart ; PVM <1, 2014, Stuttgart>
GI-Edition : Proceedings ; 236
SP  - 35
EP  - 46
PB  - Gesellschaft für Informatik
CY  - Bonn
ER  - 
TY  - CHAP
A1  - Tran, Ngoc Trinh
A1  - Staat, Manfred
A1  - Stavroulakis, G. E.
ED  - Onate, E.
T1  - A multicriteria method for truss optimization
T2  - 11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona
Y1  - 2014
SP  - 1
EP  - 12
ER  - 
TY  - CHAP
A1  - Duong, Minh Tuan
A1  - Staat, Manfred
ED  - Onate, E.
T1  - A face-based smoothed finite element method for hyperelastic models and tissue growth
T2  - 11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona
Y1  - 2014
SP  - 1
EP  - 12
ER  - 
TY  - CHAP
A1  - Tran, Thanh Ngoc
A1  - Staat, Manfred
ED  - Onate, E.
T1  - Uncertain multimode failure and limit analysis of shells
T2  - 11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona
Y1  - 2014
SP  - 1
EP  - 12
ER  - 
TY  - CHAP
A1  - Bhattarai, Aroj
A1  - Frotscher, Ralf
A1  - Sora, M.-C.
A1  - Staat, Manfred
ED  - Onate, E.
T1  - A 3D finite element model of the female pelvic floor for the reconstruction of urinary incontinence
T2  - 11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona
Y1  - 2014
SP  - 1
EP  - 12
ER  - 
TY  - CHAP
A1  - Jung, Alexander
A1  - Staat, Manfred
A1  - Müller, Wolfram
ED  - Onate, E.
T1  - Optimization of the flight style in ski jumping
T2  - 11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20 - 25, 2014, Barcelona
Y1  - 2014
N1  - Das Paper wurde nach der Konferenz überarbeitet.
SP  - 799
EP  - 810
ER  - 
TY  - CHAP
A1  - Frotscher, Ralf
A1  - Koch, Jan-Peter
A1  - Raatschen, Hans-Jürgen
A1  - Staat, Manfred
ED  - Onate, E.
T1  - Evaluation of a computational model for drug action on cardiac tissue
T2  - 11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20 - 25, 2014, Barcelona
Y1  - 2014
SP  - 1
EP  - 12
ER  - 
TY  - CHAP
A1  - Kreyer, Jörg
A1  - Stollenwerk, Dominik
A1  - Schöning, Michael Josef
T1  - Tagung des Forschernachwuchses der FH Aachen 20. November 2013 / ed.: J. Kreyer, D. Stollenwerk, M. J. Schöning
Y1  - 2013
PB  - FH Aachen
CY  - Aachen
ER  - 
TY  - JOUR
A1  - Staat, Manfred
A1  - Heitzer, M.
T1  - Limit and Shakedown Analysis Using a General Purpose Finite Element Code
JF  - Proceedings of NAFEMS World Congress '97 on Design, Simulation & Optimisation : reliability & applicability of computational methods ; Stuttgart, Germany, 9 - 11 April 1997
Y1  - 1997
SN  - 1-87437-620-4
SP  - 522
EP  - 533
PB  - NAFEMS
CY  - Glasgow
ER  - 
TY  - CHAP
A1  - Burgazzi, L.
A1  - Fiorini, F.
A1  - De Magistris, W. (u.a.)
A1  - Lensa, W. von
A1  - Staat, Manfred
A1  - Altes, J.
T1  - Reliability Assessment of Passive Safety Systems
T2  - Proceedings of the 6th International Conference on Nuclear Engineering : ICONE : May 10 - 14, 1998, San Diego, Calif.
Y1  - 1998
N1  - CD-ROM
PB  - American Society of Mechanical Engineers
CY  - New York
ER  - 
TY  - JOUR
A1  - Akimbekov, Nuraly Shardarbekovich
A1  - Mansurov, Zulkhair
A1  - Jandosov, J.
A1  - Digel, Ilya
A1  - Gossmann, Matthias
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
A1  - Zhubanova, Azhar A.
T1  - Wound healing activity of carbonized rice husk
N2  - The carbonized rice husk (CRH) was evaluated for its wound healing activity in rats using excision models. In this study, the influences of CRH on wound healing in rat skin in vivo and cellular behavior of human dermal fibroblasts in vitro were investigated. The obtained results showed that the CRH treatment promoted wound epithelization in rats and exhibited moderate inhibition of cell proliferation in vitro. CRH with lanolin oil treated wounds were found to epithelize faster as compared to controls.
KW  - Wundheilung
KW  - Epithel
KW  - Fibroblast
KW  - carbonized rice husk
KW  - wound healing
KW  - epithelization
KW  - human dermal fibroblasts
Y1  - 2013
PB  - Trans Tech Publications, Switzerland
CY  - Bäch
ER  - 
TY  - CHAP
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
A1  - Nojima, H.
A1  - Artmann, Gerhard
T1  - Some peculiarities of application of cluster ions generated by plasma in respect of indoor air purification :[abstract]
N2  - Recently, the SHARP Corporation, Japan, has developed the world’s first "Plasma Cluster Ions (PCI)" air purification technology using plasma discharge to generate cluster ions. The new plasma cluster device releases positive and negative ions into the air, which are able to decompose and deactivate harmful airborne substances by chemical reactions. Because cluster ions consist of positive and negative ions that normally exist in the natural world, they are completely harmless and safe to humans. The amount of ozone generated by cluster ions is less than 0.01 ppm, which is significantly less than the 0.05-ppm standard for industrial operations and consumer electronics. This amount, thus, has no harming effects whatsoever on the human body. But particular properties and chemical processes in PCI treatment are still under study. It has been shown that PCI in most cases show strongly pronounced irreversible killing effects in respect of airborne microflora due to free-radical induced reactions and can be considered as a potent technology to disinfect both home, medical and industrial appliances.
KW  - Clusterion
KW  - Raumluft
KW  - Luftreiniger
KW  - Plasmacluster ion technology
KW  - Air purification
Y1  - 2003
ER  - 
TY  - CHAP
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
A1  - Nojima, H.
A1  - Artmann, Gerhard
T1  - Effects of plasma generated ions on bacteria : [poster]
N2  - Summary and Conclusions PCIs were clearly effective in terms of their antibacterial effects with the strains tested. This efficacy increased with the time the bacteries were exposed to PCIs. The bactericidal action has proved to be irreversible. PCIs were significantly less effective in shadowed areas. PCI exposure caused multiple protein damages as observed in SDS PAGE studies. There was no single but multiple molecular mechanism causing the bacterial death.
KW  - Clusterion
KW  - Bakterien
KW  - plasma generated ions
Y1  - 2003
ER  - 
TY  - CHAP
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
A1  - Nojima, H.
T1  - Plasma cluster ions (PCI) influence on microbial cells viability : [abstract]
N2  - Recently, SHARP corporation has developed the world’s first “Plasma Cluster Ions (PCI)” air purification technology, which uses plasma discharge to generate cluster ions. The new plasma cluster device releases into the air positive and negative ions, which are harmless to humans and are able to decompose and deactivate airborne substances by chemical reactions. A lot of phenomenological tests of the PCI air purification technology on microbial cells have been conducted. And, in most cases, it has been shown that PCI demonstrate strongly pronounced killing effect. Although, the particular mechanisms of PCI action are still not evident. We studied variations in resistance to PCI among gram-positive airborne microorganisms, as well as some dose-dependent, spatial, cultural and biochemical properties of PCI action in respect of Staphylococcus spp, Enterococcus spp, Micrococcus spp.
KW  - Clusterion
KW  - Raumluft
KW  - Luftreiniger
KW  - Plasmacluster ion technology
KW  - Air purification
Y1  - 2003
ER  - 
TY  - CHAP
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
A1  - Nojima, H.
A1  - Artmann, Gerhard
T1  - Plasma-generated cluster ions' effects on indoor microflora : [abstract]
N2  - Recently, SHARP corporation has developed the world’s first "Plasma Cluster Ions® (PCI)" air purification technology, which uses plasma discharge to generate cluster ions. The new Plasma Cluster Device releases positive and negative ions into the air, which are harmless to humans and are able to decompose and deactivate airborne substances by chemical reactions. In the past, phenomenological tests on the efficacy of the PCI air purification technology on microbial cells have been conducted. In most cases, it has been shown that PCI demonstrated strongly pronounced killing effects on microorganisms. However, the particular mechanisms of PCI action still have to be uncovered.
KW  - Clusterion
KW  - Raumluft
KW  - Luftreiniger
KW  - Plasmacluster ion technology
KW  - Air purification
Y1  - 2003
ER  - 
TY  - CHAP
A1  - Digel, Ilya
A1  - Demirci, Taylan
A1  - Trzewik, Jürgen
A1  - Linder, Peter
A1  - Temiz Artmann, Aysegül
T1  - Fibroblast response to mechanical stress: role of the adhesion substrate : [abstract]
N2  - Mechanical stimulation of the cells resulted in evident changes in the cell morphology, protein composition and gene expression. Microscopically, additional formation of stress fibers accompanied by cell re-arrangements in a monolayer was observed. Also, significant activation of p53 gene was revealed as compared to control. Interestingly, the use of CellTech membrane coating induced cell death after mechanical stress had been applied. Such an effect was not detected when fibronectin had been used as an adhesion substrate.
KW  - Fibroblast
KW  - Mechanische Beanspruchung
KW  - celldrum technology
Y1  - 2004
ER  - 
TY  - CHAP
A1  - Stadler, Andreas M.
A1  - Embs, Jan P.
A1  - Zerlin, Kay
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Zaccai, Joe
A1  - Büldt, Georg
T1  - Temperature transitions of hemoglobin and cytosolic water diffusion in human red blood cells : [poster]
N2  - Background Hemoglobin interactions in red blood cells Hemoglobin dynamics in human red blood cells Diffusion of H2O in red blood cells
KW  - Erythrozyt
KW  - Hämoglobin
KW  - cytosolic water diffusion
KW  - hemoglobin dynamics
Y1  - 2007
ER  - 
TY  - CHAP
A1  - Mansurov, Zulkhair
A1  - Zhubanova, Azhar A.
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
A1  - Savitskaja, Irina S.
A1  - Kozhalakova, A. A.
A1  - Kistaubaeva, Aida S.
T1  - The sorption of LPS toxic shock by nanoparticles on base of carbonized vegetable raw materials
N2  - Immobilization of lactobacillus on high temperature carbonizated vegetable raw material (rice husk, grape stones) increases their physiological activity and the quantity of the antibacterial metabolits, that consequently lead to increase of the antagonistic activity of lactobacillus. It is implies that the use of the nanosorbents for the attachment of the probiotical microorganisms are highly perspective for decision the important problems, such as the probiotical preparations delivery to the right address and their attachment to intestines mucosa with the following detoxication of gastro-intestinal tract and the normalization of it’s microecology. Besides that, thus, the received carbonizated nanoparticles have peculiar properties – ability to sorption of LPS toxical shock and, hence, to the detoxication of LPS.
KW  - Kohlenstofffaser
KW  - Lipopolysaccharide
KW  - nanostrukturierte carbonisierte Pflanzenteile
KW  - lipopolysaccharides
KW  - nanostructured carbonized plant parts
Y1  - 2008
ER  - 
TY  - CHAP
A1  - Digel, Ilya
A1  - Dachwald, Bernd
A1  - Artmann, Gerhard
A1  - Linder, Peter
A1  - Funke, O.
T1  - A concept of a probe for particle analysis and life detection in icy environments
N2  - A melting probe equipped with autofluorescence-based detection system combined with a light scattering unit, and, optionally, with a microarray chip would be ideally suited to probe icy environments like Europa’s ice layer as well as the polar ice layers of Earth and Mars for recent and extinct live.
KW  - Sonde
KW  - Eisschicht
KW  - Autofluoreszenzverfahren
KW  - Lichtstreuungsbasierte Instrumente
KW  - autofluorescence-based detection system
KW  - light scattering analysis
Y1  - 2009
ER  - 
TY  - CHAP
A1  - Bassam, Rasha
A1  - Digel, Ilya
A1  - Artmann, Gerhard
T1  - Effect of nitric oxide on protein thermal stability : [abstract]
N2  - As a deduction from these results, we can conclude that proteins mainly in vitro, denaturate totally at a temperature between 57°C -62°C, and they also affected by NO and different ions types. In which mainly, NO cause earlier protein denaturation, which means that, NO has a destabilizing effect on proteins, and also different ions will alter the protein denaturation in which, some ions will cause earlier protein denaturation while others not.
KW  - Stickstoffmonoxid
KW  - Proteine
KW  - Hämoglobin
KW  - nitric oxide gas
KW  - protein
KW  - hemoglobin
Y1  - 2009
ER  - 
TY  - CHAP
A1  - O\'Heras, Carlos
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
T1  - Nanostructured carbon-based column for LPS/protein adsorption : [abstract]
N2  - The absence of a general method for endotoxin removal from liquid interfaces gives an opportunity to find new methods and materials to overcome this gap. Activated nanostructured carbon is a promising material that showed good adsorption properties due to its vast pore network and high surface area. The aim of this study is to find the adsorption rates for a carboneous material produced at different temperatures, as well as to reveal possible differences between the performance of the material for each of the adsorbates used during the study (hemoglobin, serum albumin and lipopolysaccharide, LPS).
KW  - Kohlenstofffaser
KW  - Adsorption
KW  - Lipopolysaccharide
KW  - aktivierte nanostrukturierte Kohlenstofffaser
KW  - lipopolysaccharides
KW  - activated nanostructured carbon
Y1  - 2009
ER  - 
TY  - CHAP
A1  - ElBashir, Rasha
A1  - Digel, Ilya
T1  - Effect of nitric oxide gas on hydrogels : [abstract]
N2  - The results support our theory that the NO gas has an influence in increasing the translational diffusion of hydrogels and it accelerates the melting process of the gels.
KW  - Stickstoffmonoxid
KW  - Hydrogel
KW  - nitric oxide gas
KW  - hydrogel
Y1  - 2009
ER  - 
TY  - CHAP
A1  - Arinkin, Vladimir
A1  - Digel, Ilya
T1  - Water bridge phenomenon : [abstract]
N2  - One of interesting but not well known water properties is related to appearance of highly ordered structures in response to strong electrical field. In 1893 Sir William Armstrong placed a cotton thread between two wine glasses filled with chemically pure water. When high DC voltage was applied between the glasses, a connection consisting of water formed, producing a "water bridge"
KW  - Hydrodynamik
KW  - Elektrodynamik
KW  - Wasserbrücke
KW  - water bridge phenomenon
Y1  - 2009
ER  - 
TY  - CHAP
A1  - Digel, Ilya
A1  - Leimena, W.
A1  - Dachwald, Bernd
A1  - Linder, Peter
A1  - Porst, Dariusz
A1  - Kayser, Peter
A1  - Funke, O.
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
T1  - In-situ biological decontamination of an ice melting probe : [abstract]
N2  - The objective of our study was to investigate the efficacy of different in-situ decontamination protocols in the conditions of thermo-mechanical ice-melting.
KW  - Sonde
KW  - Dekontamination
KW  - Wasserstoffperoxid
KW  - Natriumhypochlorit
Y1  - 2010
ER  - 
TY  - CHAP
A1  - Artmann, Gerhard
A1  - Stadler, Andreas M.
A1  - Embs, Jan P.
A1  - Zaccai, Giuseppe
A1  - Büldt, Georg
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
T1  - The crucial role of water in a phase transition of hemoglobin at body temperature : [abstract]
N2  - The observation of a temperature transition of hemoglobin occurring at a critical temperature close to body temperature
KW  - Hämoglobin
KW  - Erythrozyt
KW  - Körpertemperatur
Y1  - 2010
ER  - 
TY  - CHAP
A1  - Kurulgan Demirci, Eylem
A1  - Linder, Peter
A1  - Demirci, Taylan
A1  - Gierkowski, Jessica R.
A1  - Digel, Ilya
A1  - Gossmann, Matthias
A1  - Temiz Artmann, Aysegül
T1  - rhAPC reduces the endothelial cell permeability via a decrease of cellular mechanical contractile tensions : [abstract]
N2  - In this study, the CellDrum technology quanitfying cellular mechanical tension on a pico-scale was used to investigate the effect of LPS (lipopolysaccharide) on HAoEC (Human Aortic Endothelial Cell) tension.
KW  - Endothelzelle
KW  - Sepsis
KW  - kontraktile Spannung
KW  - rhAPC
KW  - contractile tension
KW  - rhAPC
KW  - celldrum technology
Y1  - 2010
ER  - 
TY  - CHAP
A1  - Dachwald, Bernd
A1  - Xu, Changsheng
A1  - Feldmann, Marco
A1  - Plescher, Engelbert
A1  - Digel, Ilya
A1  - Artmann, Gerhard
T1  - Development and testing of a subsurface probe for detection of life in deep ice : [abstract]
N2  - We present the novel concept of a combined drilling and melting probe for subsurface ice research. This probe, named “IceMole”, is currently developed, built, and tested at the FH Aachen University of Applied Sciences’ Astronautical Laboratory. Here, we describe its first prototype design and report the results of its field tests on the Swiss Morteratsch glacier. Although the IceMole design is currently adapted to terrestrial glaciers and ice shields, it may later be modified for the subsurface in-situ investigation of extraterrestrial ice, e.g., on Mars, Europa, and Enceladus. If life exists on those bodies, it may be present in the ice (as life can also be found in the deep ice of Earth).
KW  - Eisschicht
KW  - Sonde
KW  - subsurface probe
KW  - subsurface ice research
Y1  - 2011
ER  - 
TY  - CHAP
A1  - Artmann, Gerhard
A1  - Digel, Ilya
A1  - Linder, Peter
A1  - Temiz Artmann, Aysegül
T1  - Biophysical and Engineering Contributions to Plant Research
N2  - Tests with palm tree leaves have just started yet and scan data are in the process to be analyzed. The final goal of future project for palm tree gender and species recognition will be to develop optical scanning technology to be applied to date palm tree leaves for in–situ screening purposes. Depending on the software used and the particular requirements of the users the technology potentially shall be able to identify palm tree diseases, palm tree gender, and species of young date palm trees by scanning leaves.
KW  - Pflanzenphysiologie
KW  - Dattel
KW  - Pflanzenscanner
KW  - plant scanner
KW  - date palm tree
Y1  - 2011
ER  - 
TY  - JOUR
A1  - Bogoyavlenskiy, A. P.
A1  - Digel, Ilya
A1  - Berezin, V. E.
T1  - Assessment of dot-blot ELISA sensitivity on membrane sorbent using various peroxidase substrates
N2  - The sensitivity of the peroxidase reaction in dot-blot ELISA significantly depends on the substrate. The highest sensitivity is observed using benzidine and diamine- phenol combinations as the substrates due to the reaction of the coupled oxidation (NADI)
KW  - Enzyme-linked immunosorbent assay
KW  - Peroxidase
KW  - ELISA
KW  - phenols
KW  - naphtols
KW  - aromatic amines
Y1  - 1997
ER  - 
TY  - JOUR
A1  - Zhubanova, Azhar A.
A1  - Digel, Ilya
A1  - Nojima, H.
A1  - Artmann, Gerhard
T1  - The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology
N2  - The most of conventional methods of air purification use the power of a fan to draw in air and pass it through a filter. The problem of bacterial contamination of inner parts of such a type of air conditioners in some cases draws attention towards alternative air-cleaning systems. Some manufacturers offer to use the ozone's bactericidal and deodorizing effects, but the wide spreading of such systems is restricted by the fact that toxic effects of ozone in respect of human beings are well known. In 2000 Sharp Inc. introduced "Plasma Cluster Ions (PCI)" air purification technology, which uses plasma discharge to generate cluster ions (I 0-14 ). This technology has been developed for those customers that are conscious about health and hygiene. In our experiments, we focused on some principal aspects of plasma-generated ions application - time-dependency and irreversibility of bactericidal action, spatial and kinetic characteristics of emitted cluster particles, their chemical targets in the microbial cells.
KW  - Clusterion
KW  - Raumluft
KW  - Luftreiniger
KW  - Plasmacluster ion technology
KW  - Air purification
Y1  - 2007
ER  - 
TY  - JOUR
A1  - Zhubanova, Azhar A.
A1  - Aknazarov, S. K.
A1  - Mansurov, Zulkhair
A1  - Digel, Ilya
A1  - Kozhalakova, A. A.
A1  - Akimbekov, Nuraly Shardarbekovich
A1  - O'Heras, Carlos
A1  - Tazhibayeva, S.
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Adsorption of bacterial Lipopolysaccharides and blood plasma proteins on modified carbonized materials
N2  - Bacterial lipopolysaccharides (endotoxins) show strong biological effects at very low concentrations in human beings and many animals when entering the blood stream. These include affecting structure and function of organs and cells, changing metabolic functions, raising body temperature, triggering the coagulation cascade, modifying hemodynamics and causing septic shock. Because of this toxicity, the removal of even minute amounts is essential for safe parenteral administration of drugs and also for septic shock patients' care. The absence of a general method for endotoxin removal from liquid interfaces urgently requires finding new methods and materials to overcome this gap. Nanostructured carbonized plant parts is a promising material that showed good adsorption properties due to its vast pore network and high surface area. The aim of this study was comparative measurement of endotoxin- and blood proteins-related adsorption rate and adsorption capacity for different carboneous materials produced at different temperatures and under different surface modifications. As a main surface modificator, positively cbarged polymer, polyethileneimine (PEl) was used. Activated carbon materials showed good adsorption properties for LPS and some proteins used in the experiments. During the batch experiments, several techniques (dust removal, autoclaving) were used and optimized for improving the material's adsorption behavior. Also, with the results obtained it was possible to differentiate the materials according to their adsorption capacity and kinetic characteristics. Modification of the surface apparently has not affected hemoglobin binding to the adsorbent's surface. Obtained adsorption isotherms can be used as a powerful tool for designing of future column-based setups for blood purification from LPS, which is especially important for septic shock treatment.
KW  - Kohlenstofffaser
KW  - Lipopolysaccharide
KW  - nanostrukturierte carbonisierte Pflanzenteile
KW  - lipopolysaccharides
KW  - nanostructured carbonized plant parts
Y1  - 2010
ER  - 
TY  - JOUR
A1  - Seifarth, Volker
A1  - Schehl, D.
A1  - Linder, Peter
A1  - Gossmann, Matthias
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Porst, Dariusz
A1  - Preiß, C.
A1  - Kayser, Peter
A1  - Pack, O.
A1  - Temiz Artmann, Aysegül
T1  - Ureplace: development of a bioreactor for in vitro culturing of cell seeded tubular vessels on collagen scaffolds
N2  - The demand of replacements for inoperable organs exceeds the amount of available organ transplants. Therefore, tissue engineering developed as a multidisciplinary field of research for autologous in-vitro organs. Such three dimensional tissue constructs request the application of a bioreactor. The UREPLACE bioreactor is used to grow cells on tubular collagen scaffolds OPTIMAIX Sponge 1 with a maximal length of 7 cm, in order to culture in vitro an adequate ureter replacement. With a rotating unit, (urothelial) cells can be placed homogeneously on the inner scaffold surface. Furthermore, a stimulation is combined with this bioreactor resulting in an orientation of muscle cells. These culturing methods request a precise control of several parameters and actuators. A combination of a LabBox and the suitable software LabVision is used to set and conduct parameters like rotation angles, velocities, pressures and other important cell culture values. The bioreactor was tested waterproof successfully. Furthermore, the temperature controlling was adjusted to 37 °C and the CO2 - concentration regulated to 5 %. Additionally, the pH step responses of several substances showed a perfect functioning of the designed flow chamber. All used software was tested and remained stable for several days.
KW  - Tissue Engineering
KW  - Bioreaktor
KW  - Organkultur
KW  - Harnleiter
Y1  - 2011
ER  - 
TY  - JOUR
A1  - Preiß, C.
A1  - Linder, Peter
A1  - Wendt, K.
A1  - Krystek, M.
A1  - Digel, Ilya
A1  - Gossmann, Matthias
A1  - Temiz Artmann, Aysegül
A1  - Porst, Dariusz
A1  - Kayser, Peter
A1  - Bassam, Rasha
A1  - Artmann, Gerhard
T1  - Engineering technology for plant physiology and plant stress research
N2  - Plant physiology and plant stress: Plant physiology will be much more important for human mankind because of yield and cultivation limits of crops determined by their resistance to stress. To assess and counteract various stress factors it is necessary to conduct plant research to gain information and results on plant physiology.
KW  - Pflanzenphysiologie
KW  - Pflanzenstress
KW  - Pflanzenscanner
KW  - plant stress
KW  - plant scanner
Y1  - 2011
ER  - 
TY  - JOUR
A1  - Bassam, Rasha
A1  - Artmann, Gerhard
A1  - Hescheler, Jürgen
A1  - Graef, T.
A1  - Temiz Artmann, Aysegül
A1  - Porst, Dariusz
A1  - Linder, Peter
A1  - Kayser, Peter
A1  - Arinkin, Vladimir
A1  - Gossmann, Matthias
A1  - Digel, Ilya
T1  - Alterations in human hemoglobin structure related to red blood cell storage
N2  - The importance of the availability of stored blood or blood cells, respectively, for urgent transfusion cannot be overestimated. Nowadays, blood storage becomes even more important since blood products are used for epidemiological studies, bio-technical research or banked for transfusion purposes. Thus blood samples must not only be processed, stored, and shipped to preserve their efficacy and safety, but also all parameters of storage must be recorded and reported for Quality Assurance. Therefore, blood banks and clinical research facilities are seeking more accurate, automated means for blood storage and blood processing.
KW  - Hämoglobin
KW  - Hämoglobinstruktur
KW  - Blutzellenlagerung
KW  - Hemoglobin structure
KW  - Red blood cell storage
Y1  - 2011
ER  - 
TY  - JOUR
A1  - Gorissen, P.
A1  - Staat, Manfred
A1  - Laack, Walter van
T1  - Experimentelle Kraftmessungen als Beitrag zur Wirksamkeitsbeurteilung von Schienbeinschonern im Fußballsport
T1  - Experimental measurement of forces as a contribution to evaluate the effectiveness of shin guards in soccer
JF  - OUP Zeitschrift für die orthopädische und unfallchirurgische Praxis
N2  - Diese Studie beschäftigte sich mit der Dämpfungswirkung von Schienbeinschonern, wie sie beim Fußball zum Einsatz kommen. Sie wurde mit Hilfe eines Pendelhammers durchgeführt, der verschiedene Aufschlagkräfte auf die Schoner ermöglichte. Dabei wurde deutlich, dass Schienbeinschoner die beste Wirkung bei Maximalkräften unterhalb von 5kN erreichen können, dass bei größerer Belastung allerdings Verbesserungsbedarf besteht. Hierfür konnte, u.a. durch den Einsatz neuer Materialien, ein guter Ansatzpunkt im „adäquaten Zusammenspiel von Schale und Polsterung“ der Schoner gefunden werden. Die Untersuchung hat weiterhin gezeigt, dass zumindest teilweise eine deutliche Verbesserung der Dämpfungswirkung der Schienbeinschoner in den letzten Jahren erreicht werden konnte.
N2  - This study was conducted to test the damping effects of commercially available soccer shin guards on their damping effects. Therefore a pendulum impact apparatus with varying impact forces was used. It became clear that shin guards show the best effect at maximum forces of less than 5kN. There is however a need for improvement at greater impact forces. A good starting point was found in an „appropriate interaction of shell and padding” of the shin guard. It was further clarified that a significant improvement on the damping effect could be achieved at least partially over the last years.
KW  - Fußball
KW  - Schienbeinschoner
KW  - Aufschlagversuch
Y1  - 2012
U6  - http://dx.doi.org/10.3238/oup.2012.0010-0015
SN  - 2193-5785
VL  - 1
IS  - 1
SP  - 10
EP  - 15
PB  - Deutscher Ärzte-Verlag
CY  - Köln
ER  - 
TY  - CHAP
A1  - Schöning, Michael Josef
A1  - Abdelghani, Adnane
T1  - Nanoscale Science and Technology (NS&T’12) : Proceedings Book Humboldt Kolleg <2012, Tunisia>  ; Tunisia, 17-19 March, 2012 / ed. by Michael J. Schöning ; Adnane Abdelghani
N2  - Proceedings of the 2nd Humboldt Kolleg, Hammamet, Tunisia Organizer: Alexander von Humboldt Stiftung, Germany. pdf 184 p. Welcome Address Dear Participants, Welcome to the 2nd Humboldt Kolleg in “Nanoscale Science and Technology” (NS&T’12) in Tunisia, sponsored by the "Alexander von Humboldt" foundation. The NS&T’12 multidisciplinary scientific program includes seven "hot" topics dealing with "Nanoscale Science and Technology" covering basic and application-oriented research as well as industrial (market) aspects: - Molecular Biophyics, Spectroscopy Techniques, Imaging Microscopy - Nanomaterials Synthesis for Medicine and Bio-chemical Sensors - Nanostructures, Semiconductors, Photonics and Nanodevices - New Technologies in Market Industry - Environment, Electro-chemistry, Bio-polymers and Fuel Cells - Nanomaterials, Photovoltaic, Modelling, Quantum Physics - Microelectronics, Sensors Networks and Embedded Systems We are deeply indebted to all members of the Scientific Committee and General Chairs for joint Sessions and to all speakers and chairmen, who have dedicated invaluable time and efforts for the realization of this event. On behalf of the Organizing Committee, we are cordially inviting you to join the conference and hope that your stay will be fruitful, rewarding and enjoyable. Prof. Dr. Michael J. Schöning, Prof. Dr. Adnane Abdelghani
KW  - Biosensor
KW  - Nanotechnologie
KW  - Nanomaterial
KW  - Nano Materials
KW  - Bio-Sensors
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:a96-opus-3544
ER  - 
TY  - JOUR
A1  - Levers, A.
A1  - Staat, Manfred
A1  - Laack, Walter van
T1  - Analyse der Langzeitwirkung der MBST® KernspinResonanzTherapie bei Gonarthrose
T1  - Analysis of the Long-term Effect of the MBST® Nuclear Magnetic Resonance Therapy on Gonarthrosis
N2  - Originalausgabe: Orthopädische Praxis Jg. 47. 2011 H. 11; S. 536-543. Mit freundlicher Genehmigung des Verlags Zusammenfassung: Auf der Basis von Patientenabfragen mittels Fragebogen zum Schmerzempfinden und zur Einschränkung bei Aktivitäten des alltäglichen Lebens wird die Langzeitwirkung der MBST® KernspinResonanz-Therapie bei Gonarthrose untersucht. An der Studie nahmen 39 Patienten teil, bei denen die Therapie bis zu vier Jahre zurückliegt. Neben einer Gesamtbetrachtung wird der Erfolg auch in Abhängigkeit von Alter, Geschlecht und sportlicher Aktivität analysiert. Insgesamt weist die Studie auf eine anhaltende Verbesserung des Gesundheitszustands mit zum Teil deutlicher Schmerzlinderung auch noch nach vier Jahren hin, jedoch mit einer leichten Schmerzzunahme gegen Ende des Untersuchungszeitraums von vier Jahren. Eine tendenziell positivere Wirkung bei Frauen, älteren Menschen oder auch sportlich nicht-aktiven Patienten lässt auf eine mögliche Beeinflussung des Erfolgs der Therapie durch (Über-)Belastung im Alltag schließen. Ein zusätzlich positiver Effekt der Therapie auf die Knochendichte ist ebenfalls denkbar, dies bleibt jedoch offen.
N2  - Original edition: Orthopädische Praxis Vol. 47. 2011 Issue 11; P. 536-543. On the friendly authority of the publisher. Abstract: Based upon a questionnaire for patient-queries regarding pain-sensation and activity-restrictions during everyday task, the long-term effect of MBST® nuclear magnetic resonance therapy is studied in osteoarthritis of the knee. 39 patients, whose therapy dates back up to four years, participated in the study. In addition to an overall view, the success of this therapy is also analyzed regarding age, gender and physical activities. Overall, the study pointed out a sustained improvement in the patients´ local health-status with a significant pain-relief even after four years, but also with a slight increase in pain towards the end of that four-year period. There tends to be more positive effect on women, on elderly of also on even non-sports-active patients which suggest a possible influence by daily (over)-stressing on the success of the therapy. An additional positive effect of the therapy on bone density is also conceivable, however, this remains open.
KW  - Kniegelenkarthrose
KW  - Gonarthrose
KW  - MBST
KW  - Arthosetherapie
KW  - gonarthrosis
KW  - MBST
KW  - arthrosis therapy
Y1  - 2011
ER  - 
TY  - CHAP
A1  - Tran, Thanh Ngoc
A1  - Novacek, V.
A1  - Tolba, R.
A1  - Klinge, U.
A1  - Turquier, F.
A1  - Staat, Manfred
T1  - Experimental and Computational approach to study colorectal anastomosis. ISB2011, Proceedings of the XXIII Congress of the International Society of Biomechanics, Brussels, Belgium, July 3-7, 2011
N2  - Summary: This paper presents a methodology to study and understand the mechanics of stapled anastomotic behaviors by combining empirical experimentation and finite element analysis. Performance of stapled anastomosis is studied in terms of leakage and numerical results which are compared to in vitro experiments performed on fresh porcine tissue. Results suggest that leaks occur between the tissue and staple legs penetrating through the tissue.
KW  - Anastomose
KW  - Finite-Elemente-Methode
KW  - Biomechanik
KW  - Anastomosis
KW  - Finite element method
KW  - Biomechanics
Y1  - 2011
ER  -