TY  - CHAP
A1  - Bozakov, Zdravko
A1  - Sander, Volker
T1  - OpenFlow: A Perspective for Building Versatile Networks
T2  - Network-Embedded Management and Applications
Y1  - 2013
SN  - 978-1-4419-6769-5
U6  - http://dx.doi.org/10.1007/978-1-4419-6769-5_11
SP  - 217
EP  - 245
PB  - Springer
CY  - New York, NY
ER  - 
TY  - JOUR
A1  - Quittmann, Oliver J.
A1  - Meskemper, Joshua
A1  - Abel, Thomas
A1  - Albracht, Kirsten
A1  - Foitschik, Tina
A1  - Rojas-Vega, Sandra
A1  - Strüder, Heiko K.
T1  - Kinematics and kinetics of handcycling propulsion at increasing workloads in able-bodied subjects
JF  - Sports Engineereing
N2  - In Paralympic sports, biomechanical optimisation of movements and equipment seems to be promising for improving performance. In handcycling, information about the biomechanics of this sport is mainly provided by case studies. The aim of the current study was (1) to examine changes in handcycling propulsion kinematics and kinetics due to increasing workloads and (2) identify parameters that are associated with peak aerobic performance. Twelve non-disabled male competitive triathletes without handcycling experience voluntarily participated in the study. They performed an initial familiarisation protocol and incremental step test until exhaustion in a recumbent racing handcycle that was attached to an ergometer. During the incremental test, tangential crank kinetics, 3D joint kinematics, blood lactate and ratings of perceived exertion (local and global) were identified. As a performance criterion, the maximal power output during the step test (Pmax) was calculated and correlated with biomechanical parameters. For higher workloads, an increase in crank torque was observed that was even more pronounced in the pull phase than in the push phase. Furthermore, participants showed an increase in shoulder internal rotation and abduction and a decrease in elbow flexion and retroversion. These changes were negatively correlated with performance. At high workloads, it seems that power output is more limited by the transition from pull to push phase than at low workloads. It is suggested that successful athletes demonstrate small alterations of their kinematic profile due to increasing workloads. Future studies should replicate and expand the test spectrum (sprint and continuous loads) as well as use methods like surface electromyography (sEMG) with elite handcyclists.
Y1  - 2018
U6  - http://dx.doi.org/10.1007/s12283-018-0269-y
SN  - 1460-2687
VL  - 21
IS  - 21
SP  - 283
EP  - 294
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - JOUR
A1  - Conzen, Catharina
A1  - Albanna, Walid
A1  - Weiss, Miriam
A1  - Kürten, David
A1  - Vilser, Walthard
A1  - Kotliar, Konstantin
A1  - Zäske, Charlotte
A1  - Clusmann, Hans
A1  - Schubert, Gerrit Alexander
T1  - Vasoconstriction and Impairment of Neurovascular Coupling after Subarachnoid Hemorrhage: a Descriptive Analysis of Retinal Changes
JF  - Translational Stroke Research
N2  - Impaired cerebral autoregulation and neurovascular coupling (NVC) contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH). Retinal vessel analysis (RVA) allows non-invasive assessment of vessel dimension and NVC hereby demonstrating a predictive value in the context of various neurovascular diseases. Using RVA as a translational approach, we aimed to assess the retinal vessels in patients with SAH. RVA was performed prospectively in 24 patients with acute SAH (group A: day 5–14), in 11 patients 3 months after ictus (group B: day 90 ± 35), and in 35 age-matched healthy controls (group C). Data was acquired using a Retinal Vessel Analyzer (Imedos Systems UG, Jena) for examination of retinal vessel dimension and NVC using flicker-light excitation. Diameter of retinal vessels—central retinal arteriolar and venular equivalent—was significantly reduced in the acute phase (p < 0.001) with gradual improvement in group B (p < 0.05). Arterial NVC of group A was significantly impaired with diminished dilatation (p < 0.001) and reduced area under the curve (p < 0.01) when compared to group C. Group B showed persistent prolonged latency of arterial dilation (p < 0.05). Venous NVC was significantly delayed after SAH compared to group C (A p < 0.001; B p < 0.05). To our knowledge, this is the first clinical study to document retinal vasoconstriction and impairment of NVC in patients with SAH. Using non-invasive RVA as a translational approach, characteristic patterns of compromise were detected for the arterial and venous compartment of the neurovascular unit in a time-dependent fashion. Recruitment will continue to facilitate a correlation analysis with clinical course and outcome.
Y1  - 2018
U6  - http://dx.doi.org/10.1007/s12975-017-0585-8
SN  - 1868-601X
IS  - 9
SP  - 284
EP  - 293
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - JOUR
A1  - Stulpe, Werner
T1  - Pairwise coexistence of effects versus coexistence
JF  - Journal of Physics: Conference Series
Y1  - 2020
U6  - http://dx.doi.org/10.1088/1742-6596/1638/1/012004
SN  - 1742-6596
VL  - 1638
IS  - 012004
SP  - 1
EP  - 21
PB  - IOP
CY  - Bristol
ER  - 
TY  - CHAP
A1  - Iomdina, Elena N.
A1  - Kiseleva, Anna A.
A1  - Kotliar, Konstantin
A1  - Luzhnov, Petr V.
T1  - Quantification of Choroidal Blood Flow Using the OCT-A System Based on Voxel Scan Processing
T2  - 2020 International Conference on Biomedical Innovations and Applications (BIA)
Y1  - 2020
SN  - 978-1-7281-7073-2
U6  - http://dx.doi.org/10.1109/BIA50171.2020.9244511
SP  - 41
EP  - 44
ER  - 
TY  - BOOK
A1  - Yoshinobu, Tatsuo
A1  - Schöning, Michael Josef
ED  - Yoshinobu, Tatsuo
ED  - Schöning, Michael Josef
T1  - Light-addressing and chemical imaging technologies for electrochemical sensing
Y1  - 2020
SN  - 978-3-03943-029-1
U6  - http://dx.doi.org/10.3390/books978-3-03943-029-1
N1  - This book is a printed edition of the Special Issue Light-Addressing and Chemical Imaging Technologies for Electrochemical Sensing that was published in Sensors
PB  - MDPI
CY  - Basel
ER  - 
TY  - CHAP
A1  - Sildatke, Michael
A1  - Karwanni, Hendrik
A1  - Kraft, Bodo
A1  - Schmidts, Oliver
A1  - Zündorf, Albert
T1  - Automated Software Quality Monitoring in Research Collaboration Projects
T2  - ICSEW'20: Proceedings of the IEEE/ACM 42nd International Conference on Software Engineering Workshops
Y1  - 2020
U6  - http://dx.doi.org/10.1145/3387940.3391478
SP  - 603
EP  - 610
ER  - 
TY  - JOUR
A1  - Malan, Leone
A1  - Hamer, Mark
A1  - Känel, Roland von
A1  - Kotliar, Konstantin
A1  - Wyk, Roelof D. van
A1  - Lambert, Gavin W.
A1  - Vilser, Walthard
A1  - Ziemssen, Tjalf
A1  - Schlaich, Markus P.
A1  - Smith, Wayne
A1  - Magnusson, Martin
A1  - Wentzel, Annemarie
A1  - Myburgh, Carlien E.
A1  - Steyn, Hendrik S.
A1  - Malan, Nico T.
T1  - Delayed retinal vein recovery responses indicate both non-adaptation to stress as well as increased risk for stroke: the SABPA study
JF  - Cardiovascular Journal of Africa
Y1  - 2020
U6  - http://dx.doi.org/10.5830/CVJA-2020-031
SN  - 1680-0745
VL  - 26
IS  - 31
SP  - 1
EP  - 12
PB  - Clinics Cardive Publishing
CY  - Durbanville
ER  - 
TY  - JOUR
A1  - Quittmann, Oliver J.
A1  - Meskemper, Joshua
A1  - Albracht, Kirsten
A1  - Abel, Thomas
A1  - Foitschik, Tina
A1  - Strüder, Heiko K.
T1  - Normalising surface EMG of ten upper-extremity muscles in handcycling: Manual resistance vs. sport-specific MVICs
JF  - Journal of Electromyography and Kinesiology
N2  - Muscular activity in terms of surface electromyography (sEMG) is usually normalised to maximal voluntary isometric contractions (MVICs). This study aims to compare two different MVIC-modes in handcycling and examine the effect of moving average window-size. Twelve able-bodied male competitive triathletes performed ten MVICs against manual resistance and four sport-specific trials against fixed cranks. sEMG of ten muscles [M. trapezius (TD); M. pectoralis major (PM); M. deltoideus, Pars clavicularis (DA); M. deltoideus, Pars spinalis (DP); M. biceps brachii (BB); M. triceps brachii (TB); forearm flexors (FC); forearm extensors (EC); M. latissimus dorsi (LD) and M. rectus abdominis (RA)] was recorded and filtered using moving average window-sizes of 150, 200, 250 and 300 ms. Sport-specific MVICs were higher compared to manual resistance for TB, DA, DP and LD, whereas FC, TD, BB and RA demonstrated lower values. PM and EC demonstrated no significant difference between MVIC-modes. Moving average window-size had no effect on MVIC outcomes. MVIC-mode should be taken into account when normalised sEMG data are illustrated in handcycling. Sport-specific MVICs seem to be suitable for some muscles (TB, DA, DP and LD), but should be augmented by MVICs against manual/mechanical resistance for FC, TD, BB and RA.
Y1  - 2020
U6  - http://dx.doi.org/10.1016/j.jelekin.2020.102402
SN  - 1050-6411
VL  - 51
IS  - Article 102402
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kopp, Alexander
A1  - Schunck, Laura
A1  - Gosau, Martin
A1  - Smeets, Ralf
A1  - Burg, Simon
A1  - Fuest, Sandra
A1  - Kröger, Nadja
A1  - Zinser, Max
A1  - Krohn, Sebastian
A1  - Behbahani, Mehdi
A1  - Köpf, Marius
A1  - Lauts, Lisa
A1  - Rutkowski, Rico
T1  - Influence of the casting concentration on the mechanical and optical properties of Fa/CaCl2-derived silk fibroin membranes
JF  - International Journal of Molecular Sciences
N2  - In this study, we describe the manufacturing and characterization of silk fibroin membranes derived from the silkworm Bombyx mori. To date, the dissolution process used in this study has only been researched to a limited extent, although it entails various potential advantages, such as reduced expenses and the absence of toxic chemicals in comparison to other conventional techniques. Therefore, the aim of this study was to determine the influence of different fibroin concentrations on the process output and resulting membrane properties. Casted membranes were thus characterized with regard to their mechanical, structural and optical assets via tensile testing, SEM, light microscopy and spectrophotometry. Cytotoxicity was evaluated using BrdU, XTT, and LDH assays, followed by live–dead staining. The formic acid (FA) dissolution method was proven to be suitable for the manufacturing of transparent and mechanically stable membranes. The fibroin concentration affects both thickness and transparency of the membranes. The membranes did not exhibit any signs of cytotoxicity. When compared to other current scientific and technical benchmarks, the manufactured membranes displayed promising potential for various biomedical applications. Further research is nevertheless necessary to improve reproducible manufacturing, including a more uniform thickness, less impurity and physiological pH within the membranes.
Y1  - 2020
U6  - http://dx.doi.org/10.3390/ijms21186704
SN  - 1422-0067
N1  - Special issue: Optimization of Biomaterials for Reconstructive and Regenerative Medicine
VL  - 21
IS  - 18 art. no. 6704
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Capacitive field-effect eis chemical sensors and biosensors: A status report
JF  - Sensors
N2  - Electrolyte-insulator-semiconductor (EIS) field-effect sensors belong to a new generation of electronic chips for biochemical sensing, enabling a direct electronic readout. The review gives an overview on recent advances and current trends in the research and development of chemical sensors and biosensors based on the capacitive field-effect EIS structure—the simplest field-effect device, which represents a biochemically sensitive capacitor. Fundamental concepts, physicochemical phenomena underlying the transduction mechanism and application of capacitive EIS sensors for the detection of pH, ion concentrations, and enzymatic reactions, as well as the label-free detection of charged molecules (nucleic acids, proteins, and polyelectrolytes) and nanoparticles, are presented and discussed.
Y1  - 2020
U6  - http://dx.doi.org/10.3390/s20195639
SN  - 1424-8220
VL  - 20
IS  - 19
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Muschallik, Lukas
A1  - Kipp, Carina Ronja
A1  - Recker, Inga
A1  - Bongaerts, Johannes
A1  - Pohl, Martina
A1  - Gelissen, Melanie
A1  - Schöning, Michael Josef
A1  - Selmer, Thorsten
A1  - Siegert, Petra
T1  - Synthesis of α-hydroxy ketones and vicinal diols with the Bacillus licheniformis DSM 13T butane-2, 3-diol dehydrogenase
JF  - Journal of Biotechnology
N2  - The enantioselective synthesis of α-hydroxy ketones and vicinal diols is an intriguing field because of the broad applicability of these molecules. Although, butandiol dehydrogenases are known to play a key role in the production of 2,3-butandiol, their potential as biocatalysts is still not well studied. Here, we investigate the biocatalytic properties of the meso-butanediol dehydrogenase from Bacillus licheniformis DSM 13T (BlBDH). The encoding gene was cloned with an N-terminal StrepII-tag and recombinantly overexpressed in E. coli. BlBDH is highly active towards several non-physiological diketones and α-hydroxyketones with varying aliphatic chain lengths or even containing phenyl moieties. By adjusting the reaction parameters in biotransformations the formation of either the α-hydroxyketone intermediate or the diol can be controlled.
Y1  - 2020
SN  - 2590-1559
U6  - http://dx.doi.org/10.1016/j.jbiotec.2020.09.016
VL  - 202
IS  - Vol. 324
SP  - 61
EP  - 70
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Laack, Walter van
T1  - Twee Kanten van één Medaille
T2  - Het Geheim van Elysion : 45 Jaar Studies naar Nabij-de-Dood-Ervaringen over Bewustzijn in Liefde zonder Waarheen
Y1  - 2020
SN  - 978-94-93175-44-0
SP  - 97
EP  - 105
PB  - Van Warven
CY  - Kampen
ER  - 
TY  - JOUR
A1  - Müller, Wolfram
A1  - Jung, Alexander
A1  - Ahammer, Helmut
T1  - Advantages and problems of nonlinear methods applied to analyze physiological time signals: human balance control as an example
JF  - Scientific Reports
Y1  - 2017
SN  - 2045-2322
U6  - http://dx.doi.org/10.1038/s41598-017-02665-5
VL  - 7
IS  - Article number 2464
SP  - 1
EP  - 11
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - JOUR
A1  - Tran, Ngoc Trinh
A1  - Staat, Manfred
T1  - Direct plastic structural design under random strength and random load by chance constrained programming
JF  - European Journal of Mechanics - A/Solids
Y1  - 2021
U6  - http://dx.doi.org/10.1016/j.euromechsol.2020.104106
SN  - 0997-7538
VL  - 85
IS  - Article 104106
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Heinke, Lars N.
A1  - Knicker, Axel J.
A1  - Albracht, Kirsten
T1  - Increased shoulder muscle stretch reflex elicitability in supine subject posture
JF  - Isokinetics and Exercise Science
N2  - BACKGROUND: Muscle stretch reflexes are widely used to examine neural muscle function. The knowledge of reflex response in muscles crossing the shoulder is limited. OBJECTIVE: To quantify reflex modulation according to various subject postures and different procedures of muscle pre-activation steering. METHODS: Thirteen healthy male participants performed two sets of external shoulder rotation stretches in various positions and with different procedures of muscle pre-activation steering on an isokinetic dynamometer over a range of two different pre-activation levels. All stretches were applied with a dynamometer acceleration of 104∘/s2 and a velocity of 150∘/s. Electromyographical response was measured via sEMG. RESULTS: Consistent reflexive response was observed in all tested muscles in all experimental conditions. The reflex elicitation rate revealed a significant muscle main effect (F (5,288) = 2.358, ρ= 0.040; η2= 0.039; f= 0.637) and a significant test condition main effect (F (1,288) = 5.884, ρ= 0.016; η2= 0.020; f= 0.143). Reflex latency revealed a significant muscle pre-activation level main effect (F (1,274) = 5.008, ρ= 0.026; η2= 0.018; f= 0.469). CONCLUSION: Muscular reflexive response was more consistent in the primary internal rotators of the shoulder. Supine posture in combination with visual feedback of muscle pre-activation level enhanced the reflex elicitation rate.
Y1  - 2020
U6  - http://dx.doi.org/10.3233/IES-192219
SN  - 1878-5913
VL  - 28
IS  - 2
SP  - 139
EP  - 146
PB  - IOS Press
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Akimbekov, Nuraly
A1  - Qiao, Xiaohui
A1  - Digel, Ilya
A1  - Abdieva, Gulzhamal
A1  - Ualieva, Perizat
A1  - Zhubanova, Azhar
T1  - The effect of leonardite-derived amendments on soil microbiome structure and potato yield
JF  - Agriculture
N2  - Humic substances originating from various organic matters can ameliorate soil properties, stimulate plant growth, and improve nutrient uptake. Due to the low calorific heating value, leonardite is rather unsuitable as fuel. However, it may serve as a potential source of humic substances. This study was aimed at characterizing the leonardite-based soil amendments and examining the effect of their application on the soil microbial community, as well as on potato growth and tuber yield. A high yield (71.1%) of humic acid (LHA) from leonardite has been demonstrated. Parental leonardite (PL) and LHA were applied to soil prior to potato cultivation. The 16S rRNA sequencing of soil samples revealed distinct relationships between microbial community composition and the application of leonardite-based soil amendments. Potato tubers were planted in pots in greenhouse conditions. The tubers were harvested at the mature stage for the determination of growth and yield parameters. The results demonstrated that the LHA treatments had a significant effect on increasing potato growth (54.9%) and tuber yield (66.4%) when compared to the control. The findings highlight the importance of amending leonardite-based humic products for maintaining the biogeochemical stability of soils, for keeping their healthy microbial community structure, and for increasing the agronomic productivity of potato plants.
Y1  - 2020
U6  - http://dx.doi.org/10.3390/agriculture10050147
VL  - 10
IS  - Art. 147
SP  - 1
EP  - 17
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Ramoshaba, Nthai E.
A1  - Huisman, Hugo W.
A1  - Lammertyn, Leandi
A1  - Kotliar, Konstantin
A1  - Schutte, Aletta E.
A1  - Smith, Wayne
T1  - Retinal microvasculature and masked hypertension in young adults: the African-PREDICT study
JF  - Hypertension Research
N2  - Masked hypertension is known to induce microvascular complications. However, it is unclear whether early microvascular changes are already occurring in young, otherwise healthy adults. We therefore investigated whether retinal microvascular calibers and acute responses to a flicker stimulus are related to masked hypertension. We used the baseline data of 889 participants aged 20–30 years who were taking part in the African Prospective study on the Early Detection and Identification of Cardiovascular Disease and Hypertension. Clinic and 24-h ambulatory blood pressure were measured. The central retinal artery equivalent (CRAE) and central retinal vein equivalent were calculated from fundus images, and retinal vessel dilation was determined in response to flicker light-induced provocation. A smaller CRAE was observed in those with masked hypertension vs. those with normotension (157.1 vs. 161.2 measuring units, P < 0.001). In forward multivariable-adjusted regression analysis, only CRAE was negatively related to masked hypertension [adjusted R² = 0.267, β = −0.097 (95% CI = −0.165; −0.029), P = 0.005], but other retinal microvascular parameters were not associated with masked hypertension. In multivariable logistic regression analyses, masked hypertension [OR = 2.333, (95% CI = 1.316; 4.241), P = 0.004] was associated with a narrower CRAE. In young healthy adults, masked hypertension was associated with retinal arteriolar narrowing, thereby reflecting early microvascular alterations known to predict cardiovascular outcomes in later life.
Y1  - 2020
U6  - http://dx.doi.org/10.1038/s41440-020-0487-0
SN  - 1348-4214
IS  - 43
SP  - 1231
EP  - 1238
PB  - Springer Nature
CY  - Osaka
ER  - 
TY  - JOUR
A1  - Akimbekov, Nuraly S.
A1  - Digel, Ilya
A1  - Sherelkhan, Dinara K.
A1  - Lutfor, Afzalunnessa B.
A1  - Razzaque, Mohammed S.
T1  - Vitamin D and the Host-Gut Microbiome: A Brief Overview
JF  - Acta Histochemica et Cytochemica
N2  - There is a growing body of evidence for the effects of vitamin D on intestinal host-microbiome interactions related to gut dysbiosis and bowel inflammation. This brief review highlights the potential links between vitamin D and gut health, emphasizing the role of vitamin D in microbiological and immunological mechanisms of inflammatory bowel diseases. A comprehensive literature search was carried out in PubMed and Google Scholar using combinations of keywords “vitamin D,” “intestines,” “gut microflora,” “bowel inflammation”. Only articles published in English and related to the study topic are included in the review. We discuss how vitamin D (a) modulates intestinal microbiome function, (b) controls antimicrobial peptide expression, and (c) has a protective effect on epithelial barriers in the gut mucosa. Vitamin D and its nuclear receptor (VDR) regulate intestinal barrier integrity, and control innate and adaptive immunity in the gut. Metabolites from the gut microbiota may also regulate expression of VDR, while vitamin D may influence the gut microbiota and exert anti-inflammatory and immune-modulating effects. The underlying mechanism of vitamin D in the pathogenesis of bowel diseases is not fully understood, but maintaining an optimal vitamin D status appears to be beneficial for gut health. Future studies will shed light on the molecular mechanisms through which vitamin D and VDR interactions affect intestinal mucosal immunity, pathogen invasion, symbiont colonization, and antimicrobial peptide expression.
Y1  - 2020
U6  - http://dx.doi.org/10.1267/ahc.20011
SN  - 1347-5800
VL  - 53
IS  - 3
SP  - 33
EP  - 42
PB  - Japan Society of Histochemistry and Cytochemistry
CY  - Osaka
ER  - 
TY  - JOUR
A1  - Choi, Chang-Hoon
A1  - Felder, Tim
A1  - Felder, Jörg
A1  - Tellmann, Lutz
A1  - Hong, Suk-Min
A1  - Wegener, Hans-Peter
A1  - Shah, N Jon
A1  - Ziemons, Karl
T1  - Design, evaluation and comparison of endorectal coils for hybrid MR-PET imaging of the prostate
JF  - Physics in Medicine & Biology
N2  - Prostate cancer is one of the most common cancers among men and its early detection is critical for its successful treatment. The use of multimodal imaging, such as MR-PET, is most advantageous as it is able to provide detailed information about the prostate. However, as the human prostate is flexible and can move into different positions under external conditions, it is important to localise the focused region-of-interest using both MRI and PET under identical circumstances. In this work, we designed five commonly used linear and quadrature radiofrequency surface coils suitable for hybrid MR-PET use in endorectal applications. Due to the endorectal design and the shielded PET insert, the outer face of the coils investigated was curved and the region to be imaged was outside the volume of the coil. The tilting angles of the coils were varied with respect to the main magnetic field direction. This was done to approximate the various positions from which the prostate could be imaged. The transmit efficiencies and safety excitation efficiencies from simulations, together with the signal-to-noise ratios from the MR images were calculated and analysed. Overall, it was found that the overlapped loops driven in quadrature were superior to the other types of coils we tested. In order to determine the effect of the different coil designs on PET, transmission scans were carried out, and it was observed that the differences between attenuation maps with and without the coils were negligible. The findings of this work can provide useful guidance for the integration of such coil designs into MR-PET hybrid systems in the future.
Y1  - 2020
U6  - http://dx.doi.org/10.1088/1361-6560/ab87f8
SN  - 0031-9155
VL  - 65
IS  - 11
PB  - IOP
CY  - Bristol
ER  -