TY  - CHAP
A1  - Artmann, Gerhard
A1  - Meruvu, Haritha
A1  - Kizildag, Sefa
A1  - Temiz Artmann, Aysegül
ED  - Artmann, Gerhard
ED  - Temiz Artmann, Aysegül
ED  - Zhubanova, Azhar A.
ED  - Digel, Ilya
T1  - Functional Toxicology and Pharmacology Test of Cell Induced Mechanical Tensile Stress in 2D and 3D Tissue Cultures
T2  - Biological, Physical and Technical Basics of Cell Engineering
N2  - Mechanical forces/tensile stresses are critical determinants of cellular growth, differentiation and migration patterns in health and disease. The innovative “CellDrum technology” was designed for measuring mechanical tensile stress of cultured cell monolayers/thin tissue constructs routinely. These are cultivated on very thin silicone membranes in the so-called CellDrum. The cell layers adhere firmly to the membrane and thus transmit the cell forces generated. A CellDrum consists of a cylinder which is sealed from below with a 4 μm thick, biocompatible, functionalized silicone membrane. The weight of cell culture medium bulbs the membrane out downwards. Membrane indentation is measured. When cells contract due to drug action, membrane, cells and medium are lifted upwards. The induced indentation changes allow for lateral drug induced mechanical tension quantification of the micro-tissues. With hiPS-induced (human) Cardiomyocytes (CM) the CellDrum opens new perspectives of individualized cardiac drug testing. Here, monolayers of self-beating hiPS-CMs were grown in CellDrums. Rhythmic contractions of the hiPS-cells induce membrane up-and-down deflections. The recorded cycles allow for single beat amplitude, single beat duration, integration of the single beat amplitude over the beat time and frequency analysis. Dose effects of agonists and antagonists acting on Ca2+ channels were sensitively and highly reproducibly observed. Data were consistent with published reference data as far as they were available. The combination of the CellDrum technology with hiPS-Cardiomyocytes offers a fast, facile and precise system for pharmacological and toxicological studies. It allows new preclinical basic as well as applied research in pharmacolgy and toxicology.
Y1  - 2018
SN  - 978-981-10-7904-7
U6  - https://doi.org/10.1007/978-981-10-7904-7_7
SP  - 157
EP  - 192
PB  - Springer
CY  - Singapore
ER  - 
TY  - CHAP
A1  - Lingens, Hans
A1  - Vollmann, Andreas
T1  - Fügetechnik an der FH Aachen - Aus- und Weiterbildung mit Praxisbezug
T2  - Innovation durch Kooperation : wie der Mittelstand durch Zusammenarbeit mit den Hochschulen seine Wettbewerbsfähigkeit steigert : Festschrift für Prof. Dr. rer. nat. Johannes Gartzen / Thomas Gartzen, Ute Gartzen (Hrsg.)
Y1  - 2013
SN  - 978-3-86359-136-6
N1  - Gedruckt in der Bibliothek unter der Signatur: 21 PZI 73
SP  - 123
EP  - 127
PB  - Apprimus Verlag
CY  - Aachen
ER  - 
TY  - CHAP
A1  - Staat, Manfred
A1  - Heitzer, Michael
ED  - Staat, Manfred
ED  - Heitzer, Michael
T1  - Probabilistic limit and shakedown problems
T2  - Numerical methods for limit and shakedown analysis. Deterministic and probabilistic problems
Y1  - 2003
SN  - 3-00-010001-6
N1  - NIC Series
VL  - 15
SP  - 217
EP  - 268
PB  - John von Neumann Institute for Computing (NIC)
CY  - Jülich
ER  - 
TY  - CHAP
A1  - Ulber, Roland
A1  - Muffler, Kai
A1  - Tippkötter, Nils
A1  - Hirth, Thomas
A1  - Sell, Dieter
ED  - Ulber, Roland
ED  - Sell, Dieter
ED  - Hirth, Thomas
T1  - Introduction to Renewable Resources in the Chemical Industry
T2  - Renewable raw materials : new feedstocks for the chemical industry
Y1  - 2011
SN  - 978-3-527-32548-1
SP  - 1
EP  - 6
PB  - Wiley-VCH-Verlag
CY  - Weinheim
ET  - 1. Auflage
ER  - 
TY  - CHAP
A1  - Höhne, Tim
A1  - Narr, Claus
ED  - Schuh, Günther
T1  - Konsequenzen für die überbetriebliche IT-Unterstützung
T2  - Liefertreue im Maschinen- und Anlagenbau
Y1  - 2006
SN  - 3-926690-02-X
N1  - Studie Liefertreue im Maschinen- und Anlagebau; Forschungsinstitut für Rationalisierung FIR an der RWTH Aachen; Fraunhofer-Institut für Produktionstechnik und Automatisierung IPA; Laboratorium für Werkzeugmaschinen und Betriebslehre WZL der RWTH Aachen
ER  - 
TY  - CHAP
A1  - Wilke, Thomas
T1  - Lepautre
T2  - Allgemeines Künstler-Lexikon. Bd. 84
Y1  - 2015
SN  - 978-3-11-023189-2
N1  - unter besonderer Berücksichtigung von Antoine, Jean und Pierre Lepautre;
namentlich gekennzeichneter Lexikon-Eintrag
SP  - 157
EP  - 160
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Wilke, Thomas
T1  - Ranson, Pierre
T2  - Allgemeines Künstler-Lexikon. Online
Y1  - 2017
N1  - namentlich gekennzeichneter Lexikon-Eintrag
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Wilke, Thomas
T1  - Patte, Pierre
T2  - Allgemeines Künstler-Lexikon. Bd. 94
Y1  - 2017
SN  - 978-3-11-023260-8
N1  - namentlich gekennzeichneter Lexikon-Eintrag
SP  - 429
EP  - 430
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Wilke, Thomas
T1  - Peyre, Antoine-Francois
T2  - Allgemeines Künstler-Lexikon. Bd. 95
Y1  - 2017
SN  - 978-3-11-023261-5
N1  - namentlich gekennzeichneter Lexikon-Eintrag
SP  - 300
EP  - 301
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Wilke, Thomas
T1  - Peyre, Marie-Josephe
T2  - Allgemeines Künstler-Lexikon. Bd. 95
Y1  - 2017
SN  - 978-3-11-023261-5
N1  - namentlich gekennzeichneter Lexikon-Eintrag
SP  - 301
EP  - 302
PB  - De Gruyter
CY  - Berlin
ER  -