TY  - CHAP
A1  - Hingley, Peter
A1  - Dikta, Gerhard
T1  - Finding a well performing box-jenkins forecasting model for annualised patent filings counts
T2  - International Symposium on Forecasting, Thessaloniki, Greece, June 2019
Y1  - 2019
ER  - 
TY  - JOUR
A1  - Attar, Mandana Hossein Zadeh
A1  - Merk, Hans F.
A1  - Kotliar, Konstantin
A1  - Wurpts, Gerda
A1  - Röseler, Stefani
A1  - Moll-Slodowy, Silke
A1  - Plange, Johann
A1  - Baron, Jens Malte
A1  - Balakirski, Galina
T1  - The CD63 basophil activation test as a diagnostic tool for assessing autoimmunity in patients with chronic spontaneous urticaria
JF  - European Journal of Dermatology
Y1  - 2019
U6  - http://dx.doi.org/10.1684/ejd.2019.3680
VL  - 29
IS  - 6
SP  - 614
EP  - 618
ER  - 
TY  - JOUR
A1  - Malik, A. M.
A1  - Abdieva, G. Zh.
A1  - Ualieva, P. S.
A1  - Zhubanova, A. A.
A1  - Temiz Artmann, Aysegül
T1  - CКPИНИНГ МИКPOOPГAНИЗМOВ-ДECТPУКТOPOВ XЛOРOPГAНИЧECКИX ЗAГPЯЗНИТEЛEЙ
T1  - Screening of microorganisms – destructors of chlororganic pollutants
JF  - Eurasian Journal of Ecology
Y1  - 2019
SN  - 2617-7358
VL  - 61
IS  - 4
SP  - 61
EP  - 71
ER  - 
TY  - JOUR
A1  - Pilas, Johanna
A1  - Selmer, Thorsten
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Screen-printed carbon electrodes modified with graphene oxide for the design of a reagent-free NAD+-dependent biosensor array
JF  - Analytical Chemistry
Y1  - 2019
U6  - http://dx.doi.org/10.1021/acs.analchem.9b04481
VL  - 91
IS  - 23
SP  - 15293
EP  - 15299
PB  - ACS Publications
CY  - Washington
ER  - 
TY  - JOUR
A1  - Roeth, A.A.
A1  - Slabu, I.
A1  - Kessler, A.
A1  - Engelmann, Ulrich M.
T1  - Local treatment of pancreatic cancer with magnetic nanoparticles
JF  - HPB
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.hpb.2019.10.959
SN  - 1365-182X
VL  - 21
IS  - Supplement 3
SP  - S868
EP  - S869
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Eschler, Eric
A1  - Wozniak, Felix
A1  - Richter, Christoph
A1  - Drechsler, Klaus
T1  - Materialanalyse an lokal verstärkten Triaxialgeflechten
T2  - Leichtbau in Forschung und industrieller Anwendung von der Nano- bis zur Makroebene, LLC, Landshuter Leichtbau-Colloquium, 9
Y1  - 2019
SN  - 978-3-9818439-2-7
SP  - 120
EP  - 131
PB  - Leichtbau Cluster
CY  - Landshut
ER  - 
TY  - JOUR
A1  - Baringhaus, Ludwig
A1  - Gaigall, Daniel
T1  - On an asymptotic relative efficiency concept based on expected volumes of confidence regions
JF  - Statistics - A Journal of Theoretical and Applied Statistic
N2  - The paper deals with an asymptotic relative efficiency concept for confidence regions of multidimensional parameters that is based on the expected volumes of the confidence regions. Under standard conditions the asymptotic relative efficiencies of confidence regions are seen to be certain powers of the ratio of the limits of the expected volumes. These limits are explicitly derived for confidence regions associated with certain plugin estimators, likelihood ratio tests and Wald tests. Under regularity conditions, the asymptotic relative efficiency of each of these procedures with respect to each one of its competitors is equal to 1. The results are applied to multivariate normal distributions and multinomial distributions in a fairly general setting.
KW  - Volume of confidence regions
KW  - asymptotic relative efficiency
KW  - likelihood ratio test
KW  - multivariate normal distribution
KW  - multinomial distribution
Y1  - 2019
U6  - http://dx.doi.org/10.1080/02331888.2019.1683560
SN  - 1029-4910
VL  - 53
IS  - 6
SP  - 1396
EP  - 1436
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Gaigall, Daniel
T1  - On a new approach to the multi-sample goodness-of-fit problem
JF  - Communications in Statistics - Simulation and Computation
N2  - Suppose we have k samples X₁,₁,…,X₁,ₙ₁,…,Xₖ,₁,…,Xₖ,ₙₖ with different sample sizes ₙ₁,…,ₙₖ and unknown underlying distribution functions F₁,…,Fₖ as observations plus k families of distribution functions {G₁(⋅,ϑ);ϑ∈Θ},…,{Gₖ(⋅,ϑ);ϑ∈Θ}, each indexed by elements ϑ from the same parameter set Θ, we consider the new goodness-of-fit problem whether or not (F₁,…,Fₖ) belongs to the parametric family {(G₁(⋅,ϑ),…,Gₖ(⋅,ϑ));ϑ∈Θ}. New test statistics are presented and a parametric bootstrap procedure for the approximation of the unknown null distributions is discussed. Under regularity assumptions, it is proved that the approximation works asymptotically, and the limiting distributions of the test statistics in the null hypothesis case are determined. Simulation studies investigate the quality of the new approach for small and moderate sample sizes. Applications to real-data sets illustrate how the idea can be used for verifying model assumptions.
KW  - Goodness-of-fit test
KW  - Multi-sample problem
KW  - Parametric bootstrap
Y1  - 2019
U6  - http://dx.doi.org/10.1080/03610918.2019.1618472
SN  - 1532-4141
VL  - 53
IS  - 10
SP  - 2971
EP  - 2989
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - GEN
A1  - Blottner, Dieter
A1  - Hastermann, Maria
A1  - Muckelt, Paul
A1  - Albracht, Kirsten
A1  - Schoenrock, Britt
A1  - Salanova, Michele
A1  - Warner, Martin
A1  - Gunga, Hans-Christian
A1  - Stokes, Maria
T1  - MYOTONES - Inflight muscle health status monitoring during long-duration space missions onboard the International Space Station: a single case study
T2  - IAC Papers Archive
N2  - The MYOTONES experiment is the first to monitor changes in the basic biomechanical properties (tone, elasticity and stiffness) of the resting human myofascial system due to microgravity with a oninvasive, portable device on board the ISS. The MyotonPRO device applies several brief mechanical stimuli to the surface of the skin, and the natural oscillation signals of the tissue beneath are detected and computed by the MyotonPRO. Thus, an objective, quick and easy determination of the state of the underlying tissue is possible.
Two preflight, four inflight and four post flight measurements were performed on a male astronaut using the same 10 measurement points (MP) for each session. MPs were located on the plantar fascia, Achilles tendon, M. soleus, M. gastrocnemius, M. multifidus, M. splenius capitis, M. deltoideus anterior, M. rectus femoris, infrapatellar tendon, M. tibialis anterior. Subcutaneous tissues thickness above the MPs was measured using ultrasound imaging. Magnetic resonance images (MRI) of lower limb muscles and functional tests were also performed pre- and postflight. 
Our first measurements on board the ISS confirmed increased tone and stiffness of the lumbar multifidus muscle, an important trunk stabilizer, dysfunction of which is known to be associated with back pain. Furthermore, reduced tone and stiffness of Achilles tendon and plantar fascia were observed inflight vs. preflight, confirming previous findings from terrestrial analog studies and parabolic 
flights. Unexpectedly, the deltoid showed negative inflight changes in tone and stiffness, and increased elasticity, suggesting a potential risk of muscle atrophy in longer spaceflight that should be addressed by adequate inflight countermeasure protocols. Most values from limb and back MPS showed deflected patterns (in either directions) from inflight shortly after the re-entry phase on the landing day and one week later. Most parameter values then normalized to baseline after 3 weeks likely due to 1G re-adaptation and possible outcome of the reconditioning protocol. No major changes in subcutaneous tissues thickness above the MPs were found inflight vs preflight, suggesting no bias (i.e., fluid shift, extreme tissue thickening or loss). Pre- and postflight MRI and functional tests showed negligible changes in calf muscle size, power and force, which is likely due to training effects from current inflight exercise protocols.
The MYOTONES experiment is currently ongoing to collect data from further crew members. The potential impact of this research is to better understand the effects of microgravity and countermeasures over the time course of an ISS mission cycle. This will enable exercise countermeasures to be tailored
Y1  - 2019
SN  - 00741795
N1  - International Astronautical Congress: space: the power of the past, the promise of the future - Washington DC, USA/Vereinigte Staaten von Amerika
Dauer: 21.10.2019 → 25.10.2019
PB  - Pergamon
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Werkhausen, Amelie
A1  - Cronin, Neil J.
A1  - Albracht, Kirsten
A1  - Paulsen, Gøran
A1  - Larsen, Askild V.
A1  - Bojsen-Møller, Jens
A1  - Seynnes, Olivier R.
T1  - Training-induced increase in Achilles tendon stiffness affects tendon strain pattern during running
JF  - PeerJ
N2  - Background
During the stance phase of running, the elasticity of the Achilles tendon enables the utilisation of elastic energy and allows beneficial contractile conditions for the triceps surae muscles. However, the effect of changes in tendon mechanical properties induced by chronic loading is still poorly understood. We tested the hypothesis that a training-induced increase in Achilles tendon stiffness would result in reduced tendon strain during the stance phase of running, which would reduce fascicle strains in the triceps surae muscles, particularly in the mono-articular soleus.
Methods 
Eleven subjects were assigned to a training group performing isometric singleleg plantarflexion contractions three times per week for ten weeks, and another ten subjects formed a control group. Before and after the training period, Achilles tendon stiffness was estimated, and muscle-tendon mechanics were assessed during running at preferred speed using ultrasonography, kinematics and kinetics.
Results 
Achilles tendon stiffness increased by 18% (P <0:01) in the training group, but the associated reduction in strain seen during isometric contractions was not statistically significant. Tendon elongation during the stance phase of running was similar after training, but tendon recoil was reduced by 30% (P <0:01), while estimated tendon force remained unchanged. Neither gastrocnemius medialis nor soleus fascicle shortening during stance was affected by training.
Discussion 
These results show that a training-induced increase in Achilles tendon
stiffness altered tendon behaviour during running. Despite training-induced changes in tendon mechanical properties and recoil behaviour, the data suggest that fascicle shortening patterns were preserved for the running speed that we examined. The asymmetrical changes in tendon strain patterns supports the notion that simple inseries models do not fully explain the mechanical output of the muscle-tendon unit during a complex task like running.
KW  - Achilles tendon
KW  - Stiffness
KW  - Running
KW  - Tendon properties
KW  - Architectural gear ratio
Y1  - 2019
U6  - http://dx.doi.org/10.7717/peerj.6764
SN  - 21678359
PB  - Peer
CY  - London
ER  -