TY  - GEN
A1  - Kowollik, Silvia
A1  - Schnitzler, Thomas
A1  - Biselli, Manfred
A1  - Krueger, R.
A1  - Zang, Werner
A1  - Peuscher, A.
A1  - Schillberg, S.
A1  - Fischer, R.
T1  - Die Rolle des Respirationsquotienten in der Zellkulturfermentation
T2  - Chemie Ingenieur Technik
N2  - In der biopharmazeutischen Industrie werden rekombinante Proteine und monoklonale Antikörper in Zellkulturfermentationen produziert, da nur humane oder tierische Zelllinien über die Fähigkeit der Glykosylierung verfügen. Um hohe Produktausbeuten in ausgezeichneter Qualität zu erzielen, ist eine funktionstüchtige Prozesskontrolle unerlässlich. Hierzu wurde in Kooperation mit der Firma Hitec Zang GmbH die HiSense�  Präzisionsabgasanalytik entwickelt, die auf Basis der vollautomatischen Ermittlung des Respirationsquotienten (RQ; Verhältnis vonKohlendioxidbildungsrate (CER) zu Sauerstoffaufnahmerate (OTR)) einen Fermentationsprozess nicht-invasiv überwacht. Der RQ kann in Hybridoma- und CHO-Zellen (s. Abb.) in sowohl serumhaltigen als auch serumfreien Medien erfolgreich ermittelt werden. Hier spiegeln die CER und die OTR das Wachstumsverhalten der kultivierten CHO-Zellen wider. Der RQ nimmt dabei Werte zwischen 0,9 und 1,2 an. Dies lässt auf verschiedene Stoffwechselaktivitäten schließen. Da die momentane industrielle Prozesskontrolle auf gemessenen Sauerstoffaufnahmeraten oder entsprechende Offline-Analytiken der Metaboliten basieren, soll durch die vollautomatische RQ-Ermittlung ein neues Verfahren zur Fermentationsüberwachung etabliert werden. Bisher war diese, in bakteriellen Kultivierungen standardisierte Methode, aufgrund der schwierigen CER-Berechnung bei Zellkulturen keine adäquate Alternative.
Y1  - 2010
SN  - Chemie Ingenieur Tec
U6  - https://doi.org/10.1002/cite.201050393
N1  - ProcessNet-Jahrestagung 2010 und 28. Jahrestagung der Biotechnologen, 21. – 23. September 2010, Eurogress Aachen
VL  - 82
IS  - 9
SP  - 1505
EP  - 1506
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Werner, Frederik
A1  - Miyamoto, Ko-ichiro
A1  - Ackermann, Hans-Josef
A1  - Yoshinobu, Tatsuo
A1  - Schöning, Michael Josef
T1  - FPGA-based LAPS device for the flexible design of sensing sites on functional interfaces
JF  - Physica Status Solidi (A)
N2  - The development of new interfaces for (bio-)chemical sensors requires comprehensive analyses and testing. The light-addressable potentiometric sensor (LAPS) can be used as a platform to investigate the sensitivity of a newly developed interface towards (bio-)chemical agents. LAPS measurements are spatially resolved by utilisation of focused light beams to define individual measurement spots. In this work, a new digitally modulated LAPS set-up based on an FPGA design will be introduced to increase the number of measurement spots, to shorten the measurement time and to improve the measurement accuracy.
Y1  - 2010
U6  - https://doi.org/10.1002/pssa.200983320
SN  - 1862-6300
N1  - Special Issue: Engineering of Functional Interfaces EnFI 2009
VL  - 207
IS  - 4
SP  - 844
EP  - 849
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Fredebeul-Krein, Markus
T1  - Wirtschaftskrise : Staatliche Förderung von glasfaserbasierten Breitbandnetzen?
JF  - Wirtschaftsdienst
N2  - Glasfaserbasierte Breitbandnetze werden in Deutschland auch aufgrund der Wirtschaftskrise nur sehr zögerlich ausgebaut. Markus Fredebeul-Krein hält eine staatliche Subventionierung der Breitbandnetze nur bedingt für gerechtfertigt. Private Investoren benötigen jedoch dringend Planungssicherheit durch verlässliche Regulierungsvorschriften.
Y1  - 2010
SN  - 0043-6275
VL  - 90
IS  - 2
SP  - 113
EP  - 117
PB  - ZBW
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Fredebeul-Krein, Markus
T1  - Die Abschaffung der Studiengebühren ist der falsche Weg!
JF  - Der Ordnungspolitische Kommentar
Y1  - 2010
N1  - Herausgegeben vom Institut für Wirtschaftspolitik an der Universität zu Köln sowie dem Otto-Wolff-Institut für Wirtschaftsordnung
ER  - 
TY  - JOUR
A1  - Fredebeul-Krein, Markus
A1  - Knoben, Werner
T1  - Long term risk sharing contracts as an approach to establish public–private partnerships for investment into next generation access networks
JF  - Telecommunications Policy
N2  - This paper develops an investment/pricing model for the deployment of basic broadband networks which, along with other applications, is applicable to public–private partnership projects. In particular, a new investment model is suggested to be used for finance deployment over a longer term by enabling both private and public investors to participate in the roll-out of next generation access (NGA) infrastructure. This so-called “long-term risk sharing concept” has several notable benefits compared with the traditional regulatory approach. Above all, the model enables both private operators and public authorities to share the risk of investing in NGA infrastructure. Thus the model offers a way for public authorities to achieve a timely and countrywide roll-out of NGA networks, including in areas where NGA investment would otherwise not occur.
Y1  - 2010
U6  - https://doi.org/10.1016/j.telpol.2010.07.011
SN  - 0308-5961
N1  - Part of special issue "Public–private interplay in next generation communications"
VL  - 34
IS  - 9
SP  - 528
EP  - 539
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Fredebeul-Krein, Markus
T1  - Studiengebühren sind sozial gerecht
JF  - INSM-Ökonomenblog
Y1  - 2010
PB  - INSM
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Fredebeul-Krein, Markus
ED  - Bartoldus, Beate
ED  - John-Ohnesorg, Marei
T1  - Sollen die Studiengebühren wieder abgeschafft werden?
T2  - Bildungsgerechtigkeit in der Begabtenförderung. Ein Widerspruch in sich?
N2  - In den letzten Jahren haben in Deutschland mehrere Bundesländer Studiengebühren eingeführt. Seitdem wird in der Politik heftig über das Für und Wider diskutiert. Von den Gegnern wird häufig das Argument vorgebracht, Studiengebühren seien sozial ungerecht und würden insbesondere einkommensschwache Bevölkerungsschichten von einem Studium abhalten. Bestätigt werden sie von den Zahlen aus Umfragen, denen zufolge über 70 Prozent derjenigen, die sich gegen ein Studium entscheiden, finanzielle Gründe für einen Studienverzicht anführen. Befürworter halten dem entgegen, Studiengebühren seien angesichts knapper öffentlicher Kassen unbedingt notwendig, da nur so die Qualität der Lehre aufrechterhalten bzw. verbessert werden könne. Zudem würden Studiengebühren die sozialen Bildungsbarrieren keineswegs erhöhen, was auch daran erkennbar sei, dass infolge der Studiengebühren die Zahl der Studierenden nicht zurückgegangen ist. Der vorliegende Artikel leistet einen Beitrag zu dieser Debatte, indem er die an einer Hochschule in Nordrhein-Westfalen gesammelten Erfahrungen mit Studiengebühren auswertet
Y1  - 2010
SN  - 978-3-86872-423-3
SP  - 124
EP  - 129
PB  - Friedrich-Ebert-Stiftung
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Ritz, Thomas
A1  - Strauch, Jakob
ED  - Bick, Markus
T1  - „Offline Strategie"-Patterns für mobile SOA Prozesse
T2  - Mobile und ubiquitäre Informationssysteme : Technologien, Anwendungen und Dienste zur Unterstützung von mobiler Kollaboration ; Proceedings zur 5. Konferenz Mobile und Ubiquitäre Informationssysteme (MMS 2010) ; 23. - 25. Februar 2010 in Göttingen, Germany. - (GI-Edition : Proceedings ; 163)
Y1  - 2010
SN  - 978-3-88579-257-4
SP  - 174
EP  - 180
PB  - Gesellschaft für Informatik
CY  - Bonn
ER  - 
TY  - CHAP
A1  - Schmitt, Robert
A1  - Scholl, Ingrid
A1  - Cai, Yu
A1  - Xia, Ji
A1  - Dziwoki, Paul
A1  - Harding, Martin
A1  - Pavim, Alberto
T1  - Machine vision system for inline inspection in carbide insert production
T2  - Proceedings of the 36th International MATADOR Conference
N2  - In steps of the production chain of carbide inserts, such as unloading or packaging, the conformity test of the insert type is done manually, which causes a statistic increase of errors due to monotony and fatigue of the worker and the wide variety of the insert types. A machine vision system is introduced that captures digital frames of the inserts in the production line, analyses inspects automatically and measures four quality features: coating colour, edge radius, plate shape and chip-former geometry. This new method has been tested on several inserts of different types and has shown that the prevalent insert types can be inspected and robustly classified in real production environment and therefore improves the manufacturing automation.
Y1  - 2010
SN  - 978-1-84996-431-9
U6  - https://doi.org/10.1007/978-1-84996-432-6_77
N1  - 36th MATADOR Conference, University of Manchester, July 2010
SP  - 339
EP  - 342
PB  - Springer
CY  - Berlin
ER  - 
TY  - BOOK
A1  - Timme, Michael
T1  - BGB Crashkurs : der sichere Weg durch die Prüfung ; [Fall für Fall durch das Privatrecht]
Y1  - 2010
SN  - 978-3-406-60803-2
N1  - Beck kompakt
PB  - Beck
CY  - München
ER  - 
TY  - JOUR
A1  - Scholz, A.
A1  - Ley, Wilfried
A1  - Dachwald, Bernd
A1  - Miau, J. J.
A1  - Juang, J. C.
T1  - Flight results of the COMPASS-1 picosatellite mission
JF  - Acta Astronautica
N2  - The mission of the COMPASS-1 picosatellite is to take pictures of the earth, to validate a space-borne GPS receiver developed by the German Aerospace Center, and to verify the proper operation of the magnetic attitude control system in orbit. The spacecraft was launched on April 28, 2008 from the Indian space port Sriharikota, as part of the PSLV-C9 world record launch that simultaneously brought ten satellites into orbit. The mission operations were carried out from the ground stations in Aachen and Tainan. Arising difficulties in the communication link were overcome with the support of individuals from the amateur radio community. After several months of mission operation, abundant housekeeping and mission data has been commanded, received and analyzed and is presented in this paper.
Y1  - 2010
U6  - https://doi.org/10.1016/j.actaastro.2010.06.040
SN  - 0094-5765
VL  - 76
IS  - 9-10
SP  - 1289
EP  - 1298
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Hirschfeld, Julian A.
A1  - Lustfeld, Hans
A1  - Reißel, Martin
A1  - Steffen, Bernhard
T1  - A novel scheme for precise diagnostics and effective stabilization of currents in a fuel cell stack
JF  - International Journal of Energy Research
N2  - A novel scheme for detecting inhomogeneous internal currents in a fuel cell stack is presented. In this paper the scheme is investigated for the case that the flow field plates consist of graphite. Then plates of high conductivity, e.g. aluminium between the flow field plates together with small slits in these plates have three effects: (a) Whenever a local inhomogeneity of the electric current occurs at a particular cell in the stack, this will induce a surface current close to that cell perpendicular to the averaged current. This current can be detected. (b) The plates of high conductivity completely prevent the inhomogeneities from spreading to neighbouring cells. (c) Even at the particular cell the inhomogeneity is suppressed as far as possible. Thus this scheme leads to much better diagnostic possibilities and at the same time reduces electric instabilities to an extent, where they probably become harmless. This scheme will first be explained for a simple model to clarify the idea. However, very precise three dimensional computations using realistic parameters are presented, corroborating the results of the simple model.
Y1  - 2010
U6  - https://doi.org/10.1002/er.1662
SN  - 0363-907X
VL  - 34
IS  - 3
SP  - 293
EP  - 301
PB  - Wiley
CY  - London
ER  - 
TY  - JOUR
A1  - Hirschfeld, Julian A.
A1  - Lustfeld, Hans
A1  - Reißel, Martin
A1  - Steffen, Bernhard
T1  - Tomographic diagnostics of current distributions in a fuel cell stack
JF  - International Journal of Energy Research
N2  - A novel tomographic scheme for analysing the state of any single membrane electrode assembly (MEA) in a stack is suggested. Plates of very high conductivity placed between every fuel cell and slitted in an appropriate manner cause surface currents at well-defined locations of the stack. We show that knowing these surface currents, information about anomalies of the currents in a MEA can be obtained using the methods of tomography. The results are mathematically not unique. However, when assuming plausible defect structures, one can exclude improbable deficiencies by applying a special form of simulated annealing. We present numerical calculations of typical examples demonstrating that the essential defects of the MEA in any single cell of the stack can be detected and their extent can be determined.
Y1  - 2010
U6  - https://doi.org/10.1002/er.1634
SN  - 0363-907X
VL  - 34
IS  - 3
SP  - 284
EP  - 292
PB  - Wiley
CY  - London
ER  - 
TY  - JOUR
A1  - Schneider, Bettina
A1  - Schneider, Wilhelm
T1  - Die Konzernrechnungslegung
JF  - Das Wirtschaftsstudium : WISU ; Zeitschrift für Ausbildung, Examen und Weiterbildung
Y1  - 2010
SN  - 0340-3084
VL  - 39
IS  - 7
SP  - 938
EP  - 942
PB  - Lange
CY  - Düsseldorf
ER  - 
TY  - CHAP
A1  - Schermutzki, Margret
ED  - Terbuyken, Gregor
T1  - In Modulen lehren, lernen und prüfen
T2  - In Modulen lehren, lernen und prüfen. Herausforderungen an die Hochschuldidaktik
Y1  - 2010
SN  - 978-3-8172-7809-1
N1  - Dokumentation einer Tagung der Evangelischen Akademie Loccum vom 14. bis 16. Dezember 2009 in Kooperation mit der ZEvA Hannover und der Universität Hannover.
SP  - 81
EP  - 106
PB  - Evangelische Akademie Loccum
CY  - Rehburg-Loccum
ER  - 
TY  - JOUR
A1  - Frings, Michael
T1  - Das neue Recht der Zahlungsdienste
JF  - NWB Steuer- und Wirtschaftsrecht
Y1  - 2010
SN  - 0028-3460
SP  - 1151
EP  - 1159
PB  - NWB-Verlag
CY  - Herne
ER  - 
TY  - JOUR
A1  - Frings, Michael
T1  - Das neue Recht des Verbraucherkredits
JF  - NWB Steuer- und Wirtschaftsrecht
Y1  - 2010
SN  - 0028-3460
IS  - 20
SP  - 1608
EP  - 1617
PB  - NWB-Verlag
CY  - Herne
ER  - 
TY  - BOOK
A1  - Timme, Michael
T1  - WEG - Wohnungeigentumsgesetz / Hrsg. von Michael Timme . Stand 15.02.2010 ; Edition: 5
Y1  - 2010
N1  - Beck´scher Online-Kommentar
ER  - 
TY  - BOOK
A1  - Timme, Michael
A1  - Batschari, Alexander [Bearb.]
T1  - Wohnungseigentumsgesetz : Gesetz über das Wohnungseigentum und das Dauerwohnrecht ; Kommentar / hrsg. von Michael Timme. Bearb. von Alexander Batschari ...
Y1  - 2010
SN  - 978-3-406-60452-2
PB  - Beck
CY  - München
ER  - 
TY  - CHAP
A1  - Staat, Manfred
A1  - Sponagel, Stefan
A1  - Nguyen, Nhu Huynh
T1  - Experiment and material model for soft tissue materials
T2  - Constitutive  models for rubber VI
N2  - Biomechanics studies biological soft tissue materials (growth, remodeling) in vivo. For this objective, the detailed information of material properties must be well defined to construct reliable constitutive models. In the paper, the bulge test is carried out with elastomers in order to develop a test method. Then, application of the test for soft tissue materials is straightforward due to the similarities between elastomers with soft tissue materials as proved in Holzapfel 2005, Ogden 2009. It means, after the preliminary experiments and parameter identification with rubber materials has been setup, experiments on soft tissue materials can be similarly carried out. Elastomers have a complex behavior which strongly depends on the largest previous load cycle. For simplicity we consider only the first loading.
Y1  - 2010
SN  - 9780429206597 (eBook)
U6  - https://doi.org/10.1201/NOE0415563277-90
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Hoffmann, Ulrich
A1  - Schermutzki, Margret
A1  - Winckelmann-Schlieper, Katja
T1  - Kompetenzbasierte Verzahnung von berufspraktischem und wissenschaftlichem Lernen : Der Studiengang Prozesstechnik der FH Aachen
JF  - Berufsbildung in Wissenschaft und Praxis
N2  - Durch rapide gesellschaftliche Veränderungen und neue Anforderungen auf dem Arbeitsmarkt gewinnt die akademische berufliche Weiterbildung zunehmend an Bedeutung. Die Nachfrage nach entsprechenden Angeboten ist sowohl seitens der Unternehmen als auch der Arbeitnehmer/-innen hoch. Die Hochschulen sind aufgefordert, darauf zu reagieren und Wege für lebenslanges Lernen aufzuzeigen, indem sie außerhalb der Hochschule erworbene Kenntnisse auf Hochschulabschlüsse anerkennen und Möglichkeiten schaffen, diese Kenntnisse mit dem Ziel weiterzuentwickeln, einen akademischen Abschluss zu erreichen. Dieser Beitrag stellt einen Studiengang vor, der es Berufstätigen ermöglicht, durch die Anrechnung beruflich erworbener Kompetenzen bis zu 50 Prozent der zu erbringenden Studienleistung abzugelten.
Y1  - 2010
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0035-bwp-10232-7
SN  - 0341-4515
VL  - 39
IS  - 2
SP  - 32
EP  - 36
PB  - Bundesinstitut für Berufsbildung (BiBB)
CY  - Bonn
ER  - 
TY  - PAT
A1  - Jeromin, Günter Erich
T1  - Immobilisierung von Alkoholdehydrogenasen und deren Coenzyme sowie Verwendung des Immobilisats : Offenlegungsschrift : DE 102008038326 A1 Offenlegungstag: 25.02.2010
Y1  - 2010
PB  - Deutsches Patent- und Markenamt
CY  - München
ER  - 
TY  - JOUR
A1  - Balakrishnan, Karthikeyan
A1  - Andrei-Selmer, Luminita-Cornelia
A1  - Selmer, Thorsten
A1  - Bacher, Michael
A1  - Dodel, Richard
T1  - Comparison of intravenous immunoglobulins for naturally occurring autoantibodies against amyloid-β
JF  - Journal of Alzheimer's Disease
N2  - Intravenous immunoglobulins (IVIG) are currently used for therapeutic purposes in autoimmune disorders. Recently, we demonstrated the presence of naturally occurring antibodies against amyloid- β (nAbs-Aβ) within the pool of IVIG. In this study, we compared different brands of IVIG for nAbs-Aβ and have found differences in the specificity of the nAbs-Aβ towards Aβ1–40 and Aβ1–42 . We analyzed the influence of a pH-shift over the course of antibody storage using ELISA and investigated antibody dimerization at acidic and neutral pH as well as differences in the IgG subclass distributions among the IVIG using both HPLC and a nephelometric assay. Furthermore, we investigated the epitope region of purified nAbs-Aβ. The differences found in Aβ specificity are not directly proportionate to the binding nature of these antibodies when administered in vivo. This information, however, may serve as a guide when choosing the commercial source of IVIG for therapeutic applications in Alzheimer's disease
Y1  - 2010
U6  - https://doi.org/10.3233/JAD-2010-1353
SN  - 1387-2877
VL  - 20
IS  - 1
SP  - 135
EP  - 143
PB  - IOS Press
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Alexopoulos, Spiros
A1  - Hoffschmidt, Bernhard
T1  - Solar tower power plant in Germany and future perspectives of the development of the technology in Greece and Cyprus
JF  - Renewable Energy
N2  - Since the 80s power production with solar thermal power plants has been a way to substitute fossil fuels. By concentrating direct solar radiation from heliostats very high temperatures of a thermal fluid can be reached. The resulting heat is converted to mechanical energy in a steam cycle which generates electricity.

High efficiencies and fast start-up are reached by using air as a heat medium, as well as using porous ceramic materials as solar receiver of the concentrated sunlight.

In Germany the construction of a 1.5 MWe solar tower power plant began in 2008. It is operational since December 2008 and started production of electricity in the spring of 2009.

In Greece and Cyprus, countries with high solar potential, the development of this competitive solar thermal technology is imperative, since it has already been implemented in other Mediterranean countries.
Y1  - 2010
U6  - https://doi.org/10.1016/j.renene.2009.11.003
SN  - 0960-1481
VL  - 35
IS  - 7
SP  - 1352
EP  - 1356
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Pham, Phu Tinh
A1  - Vu, Khoi Duc
A1  - Tran, Thanh Ngoc
A1  - Staat, Manfred
T1  - A primal-dual algorithm for shakedown analysis of elastic-plastic bounded linearly kinematic hardening bodies
Y1  - 2010
N1  - 4th European Conference on Computational Mechanics (Solids, Structures and Coupled Problems in Engineering), ECCOMAS ECCM 2010, Paris, France, May 17 – 21, 2010
ER  - 
TY  - CHAP
A1  - Nguyen, N.-H.
A1  - Raatschen, Hans-Jürgen
A1  - Staat, Manfred
T1  - A hyperelastic model of biological tissue materials in tubular organs
Y1  - 2010
N1  - 4th European Conference on Computational Mechanics (Solids, Structures and Coupled Problems in Engineering), ECCOMAS ECCM 2010, Paris, France, May 17 – 21, 2010
ER  - 
TY  - CHAP
A1  - Tran, Thanh Ngoc
A1  - Staat, Manfred
T1  - Shakedown analysis of two dimensional structures by an edge-based smoothed finite element method
Y1  - 2010
N1  - 4th European Conference on Computational Mechanics (Solids, Structures and Coupled Problems in Engineering), ECCOMAS ECCM 2010, Paris, France, May 17 – 21, 2010
ER  - 
TY  - JOUR
A1  - Bäcker, Matthias
A1  - Poghossian, Arshak
A1  - Abouzar, Maryam H.
A1  - Wenmackers, Sylvia
A1  - Janssens, Stoffel D.
A1  - Haenen, Ken
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Capacitive field-effect (bio-)chemical sensors based on nanocrystalline diamond films
JF  - MRS Online Proceedings Library
N2  - Capacitive field-effect electrolyte-diamond-insulator-semiconductor (EDIS) structures with O-terminated nanocrystalline diamond (NCD) as sensitive gate material have been realized and investigated for the detection of pH, penicillin concentration, and layer-by-layer adsorption of polyelectrolytes. The surface oxidizing procedure of NCD thin films as well as the seeding and NCD growth process on a Si-SiO2 substrate have been improved to provide high pH-sensitive, non-porous thin films without damage of the underlying SiO2 layer and with a high coverage of O-terminated sites. The NCD surface topography, roughness, and coverage of the surface groups have been characterized by SEM, AFM and XPS methods. The EDIS sensors with O-terminated NCD film treated in oxidizing boiling mixture for 45 min show a pH sensitivity of about 50 mV/pH. The pH-sensitive properties of the NCD have been used to develop an EDIS-based penicillin biosensor with high sensitivity (65-70 mV/decade in the concentration range of 0.25-2.5 mM penicillin G) and low detection limit (5 μM). The results of label-free electrical detection of layer-by-layer adsorption of charged polyelectrolytes are presented, too.
Y1  - 2010
SN  - 1946-4274
VL  - 1203
PB  - MRS
CY  - Warrendale
ER  - 
TY  - JOUR
A1  - Beging, Stefan
A1  - Mlynek, Daniela
A1  - Hataihimakul, Sudkanung
A1  - Poghossian, Arshak
A1  - Baldsiefen, Gerhard
A1  - Busch, Heinz
A1  - Laube, Norbert
A1  - Kleinen, Lisa
A1  - Schöning, Michael Josef
T1  - Field-effect calcium sensor for the determination of the risk of urinary stone  formation
JF  - Sensors and Actuators B: Chemical
N2  - Urinary stone formation has been evolved to a widespread disease during the last years. The reason for the formation of urinary stones are little crystals, mostly composed of calcium oxalate, which are formed in human kidneys. The early diagnosis of the risk for urinary stone formation of patients can be determined by the “Bonn-Risk-Index” method based on the potentiometric detection of the Ca2+-ion concentration and an optical determination of the triggered crystallisation of calcium oxalate in unprocessed urine. In this work, miniaturised capacitive field-effect EMIS (electrolyte-membrane-insulator-semiconductor) sensors have been developed for the determination of the Ca2+-ion concentration in human native urine. The Ca2+-sensitive EMIS sensors have been systematically characterised by impedance spectroscopy, capacitance–voltage and constant–capacitance method in terms of sensitivity, signal stability and response time in both CaCl2 solutions and in native urine. The obtained results demonstrate the suitability of EMIS sensors for the measurement of the Ca2+-ion concentration in native urine of patients.
Y1  - 2010
U6  - https://doi.org/10.1016/j.snb.2008.12.012
SN  - 0925-4005
N1  - 22nd International Conference on Eurosensors: Dresden, Germany, 7-10 September 2008
VL  - 144
IS  - 2
SP  - 374
EP  - 379
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Reisert, Steffen
A1  - Henkel, Hartmut
A1  - Schneider, Andreas
A1  - Schäfer, Daniel
A1  - Friedrich, Peter
A1  - Berger, Jörg
A1  - Schöning, Michael Josef
T1  - Development of a handheld sensor system for the online measurement of hydrogen peroxide in aseptic filling systems
JF  - Physica Status Solidi (A)
N2  - A handheld sensor system for the online measurement of hydrogen peroxide (H2O2) in aseptic sterilisation processes has been developed. It is based on a calorimetric-type gas sensor that consists of a differential set-up of two temperature sensors, of which one is catalytically activated and the second one is passivated and used as reference. The sensor principle relies in detecting a rise in temperature on the active sensor due to the exothermic reaction of H2O2 on the catalytic surface. To characterise the sensor system towards H2O2 sensitivity and other influencing factors, measurements have been carried out both at an experimental set-up and a manufacturer's sterilisation machine. Physical sensor characterisation was done by means of the optical microscopy.
Y1  - 2010
U6  - https://doi.org/10.1002/pssa.200983304
SN  - 1862-6300
N1  - Special Issue: Engineering of Functional Interfaces EnFI 2009
VL  - 207
IS  - 4
SP  - 913
EP  - 918
PB  - Wiley-VCH
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Miyamoto, Ko-ichiro
A1  - Sugawara, Yuri
A1  - Kanoh, Shin´ichiro
A1  - Yoshinobu, Tatsuo
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
T1  - Image correction method for the chemical imaging sensor
JF  - Sensors and Actuators B: Chemical
N2  - The chemical imaging sensor is a semiconductor-based chemical sensor that can visualize the spatial distribution of chemical species. For the practical application of this sensor, artifacts in the chemical images due to defects of the semiconductor substrate and contamination of the sensing surface etc. have been a major problem. An image correction method was developed to eliminate the influence of nonuniformity of individual sensor plate.
Y1  - 2010
U6  - https://doi.org/10.1016/j.snb.2008.10.069
SN  - 0925-4005
N1  - 22nd International Conference on Eurosensors: Dresden, Germany, 7-10 September 2008
VL  - 144
IS  - 2
SP  - 344
EP  - 348
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Siqueira, José R. Jr.
A1  - Oliveira, Osvaldo N. Jr.
A1  - Moritz, Werner
A1  - Schöning, Michael Josef
T1  - Capacitive electrolyte-insulator-semiconductor structures functionalised with a polyelectrolyte/enzyme multilayer: New strategy for enhanced field-effect biosensing
JF  - Physica Status Solidi (A)
N2  - A novel strategy for enhanced field-effect biosensing using capacitive electrolyte–insulator–semiconductor (EIS) structures functionalised with pH-responsive weak polyelectrolyte/enzyme or dendrimer/enzyme multilayers is presented. The feasibility of the proposed approach is exemplarily demonstrated by realising a penicillin biosensor based on a capacitive p-Si–SiO2 EIS structure functionalised with a poly(allylamine hydrochloride) (PAH)/penicillinase and a poly(amidoamine) dendrimer/penicillinase multilayer. The developed sensors response to changes in both the local pH value near the gate surface and the charge of macromolecules induced via enzymatic reaction, resulting in a higher sensitivity. For comparison, an EIS penicillin biosensor with adsorptively immobilised penicillinase has been also studied. The highest penicillin sensitivity of 100 mV/dec has been observed for the EIS sensor functionalised with the PAH/penicillinase multilayer. The lower and upper detection limit was around 20 µM and 10 mM, respectively. In addition, an incorporation of enzymes in a multilayer prepared by layer-by-layer technique provides a larger amount of immobilised enzymes per sensor area, reduces enzyme leaching effects and thus, enhances the biosensor lifetime (the loss of penicillin sensitivity after 2 months was 10–12%).
Y1  - 2010
U6  - https://doi.org/10.1002/pssa.200983317
SN  - 1862-6300
N1  - Special Issue: Engineering of Functional Interfaces EnFI 2009
VL  - 207
IS  - 4
SP  - 884
EP  - 890
PB  - Wiley-VCH
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Kirchner, Patrick
A1  - Ng, Yue Ann
A1  - Spelthahn, Heiko
A1  - Schneider, Andreas
A1  - Henkel, Hartmut
A1  - Friedrich, Peter
A1  - Kolstad, Jens
A1  - Berger, Jörg
A1  - Keusgen, Michael
T1  - Gas sensor investigation based on a catalytically activated thin-film thermopile for H2O2 detection
JF  - Physica Status Solidi (A)
N2  - In aseptic filling systems, hydrogen peroxide vapour is commonly used for the reduction of microbial contaminations in carton packages. In this process, the germicidal efficiency of the vapour depends especially on the H₂O₂ concentration. To monitor the H₂O₂ concentration, a calorimetric H₂O₂ gas sensor based on a catalytically activated thin-film thermopile is investigated. Two different sensor layouts, namely a circular and a linear form, as well as two various material pairs such as tungsten/nickel and gold/nickel, have been examined for the realization of a thin-film thermopile. Additionally, manganese oxide and palladium particles have been compared as responsive catalysts towards H₂O₂. The thin-film sensors have been investigated at various H₂O₂ concentrations, gas temperatures and flow rates.
Y1  - 2010
U6  - https://doi.org/10.1002/pssa.200983309
SN  - 1862-6300
N1  - Special Issue: Engineering of Functional Interfaces EnFI 2009
VL  - 207
IS  - 4
SP  - 787
EP  - 792
PB  - Wiley-VCH
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Buniatyan, Vahe V.
A1  - Abouzar, Maryam H.
A1  - Martirosyan, Norayr W.
A1  - Schubert, Jürgen
A1  - Gevorgian, Spartak
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
T1  - pH-sensitive properties of barium strontium titanate (BST) thin films prepared by pulsed laser deposition technique
JF  - Physica Status Solidi (A)
N2  - pH-sensitive properties of barium strontium titanate (BST) high-k thin films as alternative gate material for field-effect capacitive (bio-)chemical sensors based on an electrolyte-insulator-semiconductor system have been investigated. The BST films of different compositions (Ba0.31Sr0.69TiO3, Ba0.25Sr0.75TiO3 and Mg-doped Ba0.8Sr0.2Mg0.1Ti0.9O3) were deposited by pulsed laser deposition technique from targets fabricated by self-propagating high-temperature synthesis. The realised sensors have been electrochemically characterised by means of impedance-spectroscopy, capacitance–voltage and constant-capacitance method. The sensors possess a Nernstian-like pH sensitivity in the concentration range between pH 3 and 11 with a response time of 5–10 s. An equivalent circuit model for the BST-based capacitive field-effect sensor is discussed.
Y1  - 2010
U6  - https://doi.org/10.1002/pssa.200983310
SN  - 1862-6300
N1  - Special Issue: Engineering of Functional Interfaces EnFI 2009
VL  - 207
IS  - 4
SP  - 824
EP  - 830
PB  - Wiley-VCH
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Turek, Monik
A1  - Heiden, Wolfgang
A1  - Guo, Sharon
A1  - Riesen, Alfred
A1  - Schubert, Jürgen
A1  - Zander, Willi
A1  - Krüger, Peter
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Simultaneous detection of cyanide and heavy metals for environmental analysis by means of µISEs
JF  - Physica Status Solidi (A)
N2  - In environmental analysis, cyanide and heavy metals play an important role, because these substances are highly toxic for biological systems. They can lead to chronic and acute diseases. Due to the chemical properties of cyanide it is frequently used for industrial processes such as extraction of silver and gold. Heavy metals can be found as trace elements in nature and are often applied in industries e.g., galvanization processes. Up to now, cyanide and heavy metals can be detected by several sensors separately and their detection is often limited to laboratory investigations. In this publication, with regard to an in situ analysis, a new miniaturized silicon-based sensor system for the simultaneous detection of cyanide and heavy metals in aqueous solutions is presented that is based on chalcogenide glass-based micro ion-selective electrodes (µISEs). The µISEs are incorporated into a specially designed measuring system for the simultaneous detection of heavy metals and cyanide in solutions and validated by simultaneous measurements of Cu2+- and CN−-ions, Cd2+- and CN−- ions and Pb2+- and CN−-ions. The particular sensor system has shown good sensor properties in the µ-molar ion-concentration range. For simultaneous measurements in complex heavy metal and cyanide solutions an intelligent software using fuzzy logic is discussed.
Y1  - 2010
U6  - https://doi.org/10.1002/pssa.200983303
SN  - 1862-6300
N1  - Special Issue: Engineering of Functional Interfaces EnFI 2009
VL  - 207
IS  - 4
SP  - 817
EP  - 823
PB  - Wiley-VCH
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Siqueira, José R. Jr.
A1  - Bäcker, Matthias
A1  - Poghossian, Arshak
A1  - Zucolotto, Valtencir
A1  - Oliveira, Osvaldo N. Jr.
A1  - Schöning, Michael Josef
T1  - Associating biosensing properties with the morphological structure of multilayers containing carbon nanotubes on field-effect devices
JF  - Physica Status Solidi (A)
N2  - The control of molecular architecture provided by the layer-by-layer (LbL) technique has led to enhanced biosensors, in which advantageous features of distinct materials can be combined. Full optimization of biosensing performance, however, is only reached if the film morphology is suitable for the principle of detection of a specific biosensor. In this paper, we report a detailed morphology analysis of LbL films made with alternating layers of single-walled carbon nanotubes (SWNTs) and polyamidoamine (PAMAM) dendrimers, which were then covered with a layer of penicillinase (PEN). An optimized performance to detect penicillin G was obtained with 6-bilayer SWNT/PAMAM LbL films deposited on p-Si-SiO2-Ta2O5 chips, used in biosensors based on a capacitive electrolyte-insulator-semiconductor (EIS) and a light-addressable potentiometric sensor (LAPS) structure, respectively. Field-emission scanning electron microscopy (FESEM) and atomic force microscopy (AFM) images indicated that the LbL films were porous, with a large surface area due to interconnection of SWNT into PAMAM layers. This morphology was instrumental for the adsorption of a larger quantity of PEN, with the resulting LbL film being highly stable. The experiments to detect penicillin were performed with constant-capacitance (ConCap) and constant-current (CC) measurements for EIS and LAPS sensors, respectively, which revealed an enhanced detection signal and sensitivity of ca. 100 mV/decade for the field-effect sensors modified with the PAMAM/SWNT LbL film. It is concluded that controlling film morphology is essential for an enhanced performance of biosensors, not only in terms of sensitivity but also stability and response time.
Y1  - 2010
U6  - https://doi.org/10.1002/pssa.200983301
SN  - 1862-6300
N1  - Special Issue: Engineering of Functional Interfaces EnFI 2009
VL  - 207
IS  - 4
SP  - 781
EP  - 786
PB  - Wiley-VCH
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Gossla, Ulrich
A1  - Buttel, Luc
A1  - Wahrmund, Holger
A1  - Mehlig, Bernd
T1  - Bemessung, Anwendung und Qualitätssicherung von Stahlfaserspritzbeton im Tunnelbau
JF  - Beton- und Stahlbetonbau
N2  - Die Spritzbetonbauweise hat sich im Tunnelbau seit Jahren bewährt. Spritzbeton wird als unbewehrter Beton, in Verbindung mit Bewehrung sowie als Stahlfaserspritzbeton eingesetzt. Bei den meisten Tunnelschalen aus Stahlfaserspritzbeton werden Stahlfasern derzeit nur als konstruktive Bewehrung verwendet. Die Faserzugabe führt zu einer nennenswerten Erhöhung der Bruchenergie und somit zu einer höheren Zähigkeit des sonst spröden Materials und damit zu einer höheren Sicherheit.

Stahlfaserspritzbeton kann auch anstelle von Spritzbeton mit statisch erforderlicher Mattenbewehrung eingesetzt werden. Die Bemessung erfolgt dann unter Berücksichtigung der Nachrisszugfestigkeit. Diese kann wie bei Stahlfaserbeton an Biegebalken ermittelt werden, die aus größeren Proben herausgesägt werden. Anhand von verschiedenen Beispielen werden die unterschiedlichen Anwendungen aufgezeigt und die dafür erforderlichen Prüfungen vorgestellt.
Y1  - 2010
U6  - https://doi.org/10.1002/best.200900688
SN  - 0005-9900
VL  - 105
IS  - 2
SP  - 92
EP  - 101
PB  - Ernst & Sohn
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Ullrich, Sebastian
A1  - Grottke, Oliver
A1  - Rossaint, Rolf
A1  - Staat, Manfred
A1  - Deserno, Thomas M.
A1  - Kuhlen, Torsten
T1  - Virtual Needle Simulation with Haptics for Regional Anaesthesia
Y1  - 2010
N1  - IEEE Virtual Reality 2010, Workshop on Medical Virtual Environments, Waltham, MA, USA, March 21, 2010
ER  - 
TY  - JOUR
A1  - Timme, Michael
T1  - Mietschuldenfreiheitsbescheinigung durch den bisherigen Vermieter?
JF  - MDR Monatsschrift für Deutsches Recht
N2  - Der VIII. Zivilsenat des BGH hat entschieden, dass ein Mieter von seinem ehemaligen Vermieter keine „Mietschuldenfreiheitsbescheinigung‘‘ verlangen kann, die über eine Quittung für die erhaltenen Mietzahlungen hinausgeht. Der folgende Beitrag untersucht die Konsequenzen der aktuellen Entscheidung.
Y1  - 2010
U6  - https://doi.org/10.9785/ovs-mdtr-2010-60
SN  - 0340-1812
VL  - 64
IS  - 2
SP  - 60
EP  - 61
PB  - Verlag Dr. Otto Schmidt
CY  - Köln
ER  - 
TY  - JOUR
A1  - Timme, Michael
A1  - Hülk, Fabian
T1  - Schriftform bei Mietvertrag mit einer Aktiengesellschaft
JF  - Neue Zeitschrift für Gesellschaftsrecht (NZG)
Y1  - 2010
SN  - 1434-9272
VL  - 13
IS  - 5
SP  - 177
EP  - 178
PB  - Beck
CY  - München
ER  - 
TY  - JOUR
A1  - Timme, Michael
T1  - Die Schenkung eines Tieres an einen beschränkt Geschäftsfähigen
JF  - Juristische Arbeitsblätter
Y1  - 2010
SN  - 0720-6356
SP  - 174
EP  - 176
PB  - Beck
CY  - München
ER  - 
TY  - JOUR
A1  - Siqueira, Jose R.
A1  - Maki, Rafael M.
A1  - Paulovich, Fernando V.
A1  - Werner, Frederik
A1  - Poghossian, Arshak
A1  - Oliveira, Maria C. F. de
A1  - Zucolotto, Valtencir
A1  - Oliveira, Osvaldo N. Jr.
A1  - Schöning, Michael Josef
T1  - Use of information visualization methods eliminating cross talk in multiple sensing units investigated for a light-addressable potentiometric sensor
JF  - Analytical Chemistry
N2  - The integration of nanostructured films containing biomolecules and silicon-based technologies is a promising direction for reaching miniaturized biosensors that exhibit high sensitivity and selectivity. A challenge, however, is to avoid cross talk among sensing units in an array with multiple sensors located on a small area. In this letter, we describe an array of 16 sensing units of a light-addressable potentiometric sensor (LAPS), which was made with layer-by-layer (LbL) films of a poly(amidomine) dendrimer (PAMAM) and single-walled carbon nanotubes (SWNTs), coated with a layer of the enzyme penicillinase. A visual inspection of the data from constant-current measurements with liquid samples containing distinct concentrations of penicillin, glucose, or a buffer indicated a possible cross talk between units that contained penicillinase and those that did not. With the use of multidimensional data projection techniques, normally employed in information visualization methods, we managed to distinguish the results from the modified LAPS, even in cases where the units were adjacent to each other. Furthermore, the plots generated with the interactive document map (IDMAP) projection technique enabled the distinction of the different concentrations of penicillin, from 5 mmol L−1 down to 0.5 mmol L−1. Data visualization also confirmed the enhanced performance of the sensing units containing carbon nanotubes, consistent with the analysis of results for LAPS sensors. The use of visual analytics, as with projection methods, may be essential to handle a large amount of data generated in multiple sensor arrays to achieve high performance in miniaturized systems
Y1  - 2010
U6  - https://doi.org/10.1021/ac9024076
SN  - 0003-2700
VL  - 82
IS  - 1
SP  - 61
EP  - 65
PB  - ACS Publications
CY  - Washington
ER  - 
TY  - JOUR
A1  - Grottke, O.
A1  - Braunschweig, T.
A1  - Philippen, B.
A1  - Gatzweiler, Karl-Heinz
A1  - Gronloh, N.
A1  - Staat, Manfred
A1  - Rossaint, R.
A1  - Tolba, R.
T1  - A new model for blunt liver injuries in the swine
JF  - European Surgical Research
N2  - Background: To elaborate the impact of new haemostatic agents we developed an instrument for the pressure-controlled induction of blunt liver injuries in a porcine animal model. Materials and Methods: A dilutional coagulopathy of 80% of animal blood volume was induced in 9 anaesthetized pigs. Animals were randomly assigned to be injured with a force of 112 Newton (N) (n = 1), 224 ± 19 N (n = 4) or 355 ± 35 N (n = 4). The impact of injury was measured by blood loss, survival time and coagulation parameters. Liver histology was obtained to evaluate the degree of liver injury. Results: The profound haemodilution resulted in a significant alteration of all coagulation parameters. After inflicting the injury with 355 ± 35 N, both the survival time (30 ± 9 min; p = 0.006) and blood loss (68 ± 16 ml min–1, p = 0.002) were significantly different as compared to injuries with 224 ± 19 N (survival time: 76 ± 20 min, blood loss: 23 ± 4 ml min–1). In contrast, an injury with 112 N led to an insignificant blood loss of only 239 ml. Conclusion: We developed a pressure-controlled clamp that allows for the induction of blunt liver traumas with highly reproducible injuries with a positive correlation with blood loss and survival.
Y1  - 2010
U6  - https://doi.org/10.1159/000265053
SN  - 1421-9921
VL  - 44
IS  - 2
SP  - 65
EP  - 73
PB  - Karger
CY  - Basel
ER  - 
TY  - BOOK
A1  - Siedenbiedel, Georg
T1  - Organisation
Y1  - 2010
SN  - 978-3-8252-8413-8
N1  - UTB ; 8413 : Betriebswirtschaftslehre
PB  - Lucius & Lucius
CY  - Stuttgart
ER  - 
TY  - CHAP
A1  - Hirschberg, Rainer
T1  - Energetische Bewertung raumlufttechnischer Anlagen. Vereinfachtes Verfahren nach DIN V 18599
T2  - Deutsche Kälte-Klima-Tagung 2010 Magdeburg
N2  - Unter Energieeffizienz wird verstanden, dass ein definiertes Ziel mit möglichst wenig Energie erreicht wird. Im Beitrag wird zunächst eine Formel zur Berechnung der Gesamtenergieeffizienz eines Gebäudes angegeben. Darauf aufbauend wird ein 3-Säulen-Modell zur Energieeinsparung vorgeschlagen. Es beinhaltet vereinfachte Verfahren zur Berechnung der Betriebseigenschaften von Heizanlagen, raumlufttechnischen Anlagen und Kühl- und Kaltwasseranlagen. Am Beispiel einer RLT-Anlage wird die Vorgehensweise der Bewertung näher erläutert. Zusammenfassend wird festgestellt, dass das vereinfachte Verfahren eine schnelle und sichere energetische Bewertung der genannten Anlagen erlaubt,, zu Präsenzwissen führt, die Haupteinflussgrößen aufzeigt und eine Anlagenbewertung ohne Gebäudebewertung gewährleistet. Das vereinfachte Verfahren wird im Frühjahr 2011 verfügbar sein. Es soll Bestandteil der DIN V 18599 werden, und die EnEV 2012 soll darauf Bezug nehmen.
Y1  - 2010
SN  - 978-3-932715-46-4
N1  - DKV-Tagung 2010, 37. Deutsche Kälte-Klima-Tagung, Magdeburg, DE, 17.-19. Nov, 2010
PB  - DKV
CY  - Hannover
ER  - 
TY  - CHAP
A1  - Digel, Ilya
A1  - Leimena, W.
A1  - Dachwald, Bernd
A1  - Linder, Peter
A1  - Porst, Dariusz
A1  - Kayser, Peter
A1  - Funke, O.
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
T1  - In-situ biological decontamination of an ice melting probe : [abstract]
N2  - The objective of our study was to investigate the efficacy of different in-situ decontamination protocols in the conditions of thermo-mechanical ice-melting.
KW  - Sonde
KW  - Dekontamination
KW  - Wasserstoffperoxid
KW  - Natriumhypochlorit
Y1  - 2010
ER  - 
TY  - CHAP
A1  - Artmann, Gerhard
A1  - Stadler, Andreas M.
A1  - Embs, Jan P.
A1  - Zaccai, Giuseppe
A1  - Büldt, Georg
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
T1  - The crucial role of water in a phase transition of hemoglobin at body temperature : [abstract]
N2  - The observation of a temperature transition of hemoglobin occurring at a critical temperature close to body temperature
KW  - Hämoglobin
KW  - Erythrozyt
KW  - Körpertemperatur
Y1  - 2010
ER  - 
TY  - CHAP
A1  - Kurulgan Demirci, Eylem
A1  - Linder, Peter
A1  - Demirci, Taylan
A1  - Gierkowski, Jessica R.
A1  - Digel, Ilya
A1  - Gossmann, Matthias
A1  - Temiz Artmann, Aysegül
T1  - rhAPC reduces the endothelial cell permeability via a decrease of cellular mechanical contractile tensions : [abstract]
N2  - In this study, the CellDrum technology quanitfying cellular mechanical tension on a pico-scale was used to investigate the effect of LPS (lipopolysaccharide) on HAoEC (Human Aortic Endothelial Cell) tension.
KW  - Endothelzelle
KW  - Sepsis
KW  - kontraktile Spannung
KW  - rhAPC
KW  - contractile tension
KW  - rhAPC
KW  - celldrum technology
Y1  - 2010
ER  - 
TY  - JOUR
A1  - Zhubanova, Azhar A.
A1  - Aknazarov, S. K.
A1  - Mansurov, Zulkhair
A1  - Digel, Ilya
A1  - Kozhalakova, A. A.
A1  - Akimbekov, Nuraly S.
A1  - O'Heras, Carlos
A1  - Tazhibayeva, S.
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Adsorption of bacterial Lipopolysaccharides and blood plasma proteins on modified carbonized materials
N2  - Bacterial lipopolysaccharides (endotoxins) show strong biological effects at very low concentrations in human beings and many animals when entering the blood stream. These include affecting structure and function of organs and cells, changing metabolic functions, raising body temperature, triggering the coagulation cascade, modifying hemodynamics and causing septic shock. Because of this toxicity, the removal of even minute amounts is essential for safe parenteral administration of drugs and also for septic shock patients' care. The absence of a general method for endotoxin removal from liquid interfaces urgently requires finding new methods and materials to overcome this gap. Nanostructured carbonized plant parts is a promising material that showed good adsorption properties due to its vast pore network and high surface area. The aim of this study was comparative measurement of endotoxin- and blood proteins-related adsorption rate and adsorption capacity for different carboneous materials produced at different temperatures and under different surface modifications. As a main surface modificator, positively cbarged polymer, polyethileneimine (PEl) was used. Activated carbon materials showed good adsorption properties for LPS and some proteins used in the experiments. During the batch experiments, several techniques (dust removal, autoclaving) were used and optimized for improving the material's adsorption behavior. Also, with the results obtained it was possible to differentiate the materials according to their adsorption capacity and kinetic characteristics. Modification of the surface apparently has not affected hemoglobin binding to the adsorbent's surface. Obtained adsorption isotherms can be used as a powerful tool for designing of future column-based setups for blood purification from LPS, which is especially important for septic shock treatment.
KW  - Kohlenstofffaser
KW  - Lipopolysaccharide
KW  - nanostrukturierte carbonisierte Pflanzenteile
KW  - lipopolysaccharides
KW  - nanostructured carbonized plant parts
Y1  - 2010
ER  - 
TY  - RPRT
T1  - Forschungsbericht 2010
N2  - Forschungsbericht / Themenheft : Energie, Mobilität, Luft- und Raumfahrt. 72 S. : Ill., graph. Darst. gedruckte Ausgabe unter der Signatur 91 AKN 100-2010 Inhaltsverzeichnis: 4 Grußworte Prorektorin Prof. Dr. rer. nat. Christiane Vaeßen 6 Highlightprojekte 10 Solar-Institut-Jülich 11 Aquasol und CuveWaters 13 PaRiKo 14 Science College Overbach 15 Summer School Renewable Energy 16 Solarturm Jülich 18 Hochtemperatur-Wanderbett-Wärmeübertrager 20 Stromversorgung mit einem hohen Anteil erneuerbarer Energieerzeuger 21 Standards für solare Prozesswäre 22 Solarturmtechnik (viCERP) 24 Novum-Institut 25 MAK-Energie 26 Exbrut 27 Biogasversuchsanlage 28 MiProBa 30 Elektrotechnik 30 Ultrakompakte Leuchtstofflampe 32 ITP Mobilität 34 Elektromobilität 34 E_bike 37 Konzept-Elektrofahrzeug 4e4 40 Elektromobilitätskonzepte 43 Mobilität und Verkehr 43 Mobiliätskonzept für FH Aachen 44 Luft- und Raumfahrt, Automotive 44 Sonnensegel 46 COMPASS 48 Antriebe für Werkzeugmaschinen und Fahrzeuge 50 SAAE 52 Wasserstoff-Gasturbine 53 HyDI 54 Bioethanol als Flugbenzin 56 Zertifizierung von Luftfahrtantrieben 58 Hydrostatischer Probellerantrieb 59 Hybridantrieb und Flugzeug 61 Mix-SCR 62 Abgasnachbehandlung 3D-Keramik 63 VisMut 64 WING 68 Silent Structure 70 Entwicklungspotenzial bei variablen Kfz-Ölpumpen 72 Kunststoff-Rotationsmesser
T3  - Forschungsbericht / FH Aachen - 2010 
KW  - Forschungsbericht
KW  - Aachen / Fachhochschule Aachen
KW  - Fachhochschule Aachen
KW  - Forschungsbericht
KW  - Aachen University of Applied Sciences
KW  - Research Report
Y1  - 2010
ER  -