TY  - JOUR
A1  - Goßmann, Matthias
A1  - Frotscher, Ralf
A1  - Linder, Peter
A1  - Bayer, Robin
A1  - Epple, U.
A1  - Staat, Manfred
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
T1  - Mechano-pharmacological characterization of cardiomyocytes derived from human induced pluripotent stem cells
JF  - Cellular physiology and biochemistry
N2  - Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential.
KW  - Inotropic compounds
KW  - Pharmacology
KW  - Ion channels
KW  - CellDrum
KW  - Heart tissue culture
KW  - Induced pluripotent stem cells
KW  - Cardiac myocytes
Y1  - 2016
U6  - http://dx.doi.org/10.1159/000443124
SN  - 1421-9778 (Online)
SN  - 1015-8987 (Print)
VL  - 38
IS  - 3
SP  - 1182
EP  - 1198
PB  - Karger
CY  - Basel
ER  - 
TY  - CHAP
A1  - Peloni, A.
A1  - Ceriotti, M.
A1  - Dachwald, Bernd
T1  - Preliminary trajectory design of a multiple NEO rendezvous mission through solar sailing
T2  - Proceedings of the International Astronautical Congress, IAC, Vol. 8, 2014
Y1  - 2015
SN  - 978-1-63439-986-9
SP  - 5352
EP  - 5366
PB  - Curran
CY  - Red Hook, NY
ER  - 
TY  - JOUR
A1  - Hauser, C.
A1  - Kotliar, Konstantin
A1  - Tholen, S.
A1  - Hasenau, A.
A1  - Suttmann, Y.
A1  - Renders, L.
A1  - Heemann, U.
A1  - Baumann, M.
A1  - Schmaderer, C.
T1  - Dynamische retinale Gefäßreaktion bei Hämodialysepatienten
JF  - Nieren- und Hochdruckkrankheiten
Y1  - 2015
U6  - http://dx.doi.org/10.5414/NHX01743a
SN  - 0300-5224
VL  - 44
IS  - 11
SP  - 480
EP  - 480
PB  - Dustri-Verlag
CY  - Oberhaching
ER  - 
TY  - CHAP
A1  - Digel, Ilya
A1  - Sadykov, R.
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
T1  - Changes in intestinal microflora in rats induced by oral exposure to low lead (II) concentrations
T2  - Lead Exposure and Poisoning: Clinical Symptoms, Medical Management and Preventive Strategies
Y1  - 2015
SN  - 9781634826990
SP  - 75
EP  - 99
PB  - Nova Science Publ.
ER  - 
TY  - CHAP
A1  - Pirovano, Laura
A1  - Seefeldt, Patric
A1  - Dachwald, Bernd
A1  - Noomen, Ron
T1  - Attitude and Orbital Dynamics Modeling for an Uncontrolled Solar-Sail Experiment in Low-Earth Orbit
T2  - 25th International Symposium on Spaceflight Dynamics, 2015, Munich, Germany
Y1  - 2015
ER  - 
TY  - CHAP
A1  - Grundmann, Jan Thimo
A1  - Bauer, Waldemar
A1  - Biele, Jens
A1  - Cordero, Frederico
A1  - Dachwald, Bernd
A1  - Koncz, Alexander
A1  - Krause, Christian
A1  - Mikschl, Tobias
A1  - Montenegro, Sergio
A1  - Quantius, Dominik
A1  - Ruffer, Michael
A1  - Sasaki, Kaname
A1  - Schmitz, Nicole
A1  - Seefeldt, Patric
A1  - Tóth, Norbert
A1  - Wejmo, Elisabet
T1  - From Sail to Soil – Getting Sailcraft Out of the Harbour on a Visit to One of Earth’s Nearest Neighbours
T2  - 4th IAA Planetary Denfense Conference - PDC 2015,  13-17 April 2015, Frascati, Roma, Italy
Y1  - 2015
ER  - 
TY  - JOUR
A1  - Grundmann, Jan Thimo
A1  - Dachwald, Bernd
A1  - Grimm, Christian D.
A1  - Kahle, Ralph
A1  - Koch, Aaron Dexter
A1  - Krause, Christian
A1  - Lange, Caroline
A1  - Quantius, Dominik
A1  - Ulamec, Stephan
T1  - Spacecraft for Hypervelocity Impact Research – An Overview of Capabilities, Constraints and the Challenges of Getting There
JF  - Procedia Engineering
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.proeng.2015.04.021
SN  - 1877-7058
N1  - Proceedings of the 2015 Hypervelocity Impact Symposium (HVIS 2015)
VL  - Vol. 103
SP  - 151
EP  - 158
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kowalski, Julia
A1  - Linder, Peter
A1  - Zierke, S.
A1  - Wulfen, B. van
A1  - Clemens, J.
A1  - Konstantinidis, K.
A1  - Ameres, G.
A1  - Hoffmann, R.
A1  - Mikucki, J.
A1  - Tulaczyk, S.
A1  - Funke, O.
A1  - Blandfort, D.
A1  - Espe, Clemens
A1  - Feldmann, Marco
A1  - Francke, Gero
A1  - Hiecker, S.
A1  - Plescher, Engelbert
A1  - Schöngarth, Sarah
A1  - Dachwald, Bernd
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Eliseev, D.
A1  - Heinen, D.
A1  - Scholz, F.
A1  - Wiebusch, C.
A1  - Macht, S.
A1  - Bestmann, U.
A1  - Reineking, T.
A1  - Zetzsche, C.
A1  - Schill, K.
A1  - Förstner, R.
A1  - Niedermeier, H.
A1  - Szumski, A.
A1  - Eissfeller, B.
A1  - Naumann, U.
A1  - Helbing, K.
T1  - Navigation technology for exploration of glacier ice with maneuverable melting probes
JF  - Cold Regions Science and Technology
N2  - The Saturnian moon Enceladus with its extensive water bodies underneath a thick ice sheet cover is a potential candidate for extraterrestrial life. Direct exploration of such extraterrestrial aquatic ecosystems requires advanced access and sampling technologies with a high level of autonomy. A new technological approach has been developed as part of the collaborative research project Enceladus Explorer (EnEx). The concept is based upon a minimally invasive melting probe called the IceMole. The force-regulated, heater-controlled IceMole is able to travel along a curved trajectory as well as upwards. Hence, it allows maneuvers which may be necessary for obstacle avoidance or target selection. Maneuverability, however, necessitates a sophisticated on-board navigation system capable of autonomous operations. The development of such a navigational system has been the focal part of the EnEx project. The original IceMole has been further developed to include relative positioning based on in-ice attitude determination, acoustic positioning, ultrasonic obstacle and target detection integrated through a high-level sensor fusion. This paper describes the EnEx technology and discusses implications for an actual extraterrestrial mission concept.
Y1  - 2016
U6  - http://dx.doi.org/10.1016/j.coldregions.2015.11.006
SN  - 0165-232X
IS  - 123
SP  - 53
EP  - 70
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Duong, Minh Tuan
A1  - Nguyen, Nhu Huynh
A1  - Staat, Manfred
T1  - Physical response of hyperelastic models for composite materials and soft tissues
JF  - Asia pacific journal on computational engineering
Y1  - 2015
U6  - http://dx.doi.org/10.1186/s40540-015-0015-x
SN  - 2196-1166
VL  - 2
IS  - 3 (December 2015)
SP  - 1
EP  - 18
ER  - 
TY  - CHAP
A1  - Peloni, Alessandro
A1  - Ceriotti, Matteo
A1  - Dachwald, Bernd
T1  - Solar-Sailing Trajectory Design for Close-up NEA Observations Mission
T2  - 4th IAA Planetary Defense Conference - PDC 2015, 13-17 April 2015, Frascati, Roma, Italy
Y1  - 2015
N1  - IAA-PDC-15-P-19
ER  -