TY  - JOUR
A1  - Stadler, Andreas M.
A1  - Garvey, G. J.
A1  - Bocahut, A.
A1  - Sacquin-Mora, S.
A1  - Digel, Ilya
A1  - Schneider, G. J.
A1  - Natali, F.
A1  - Artmann, Gerhard
A1  - Zaccai, G.
T1  - Thermal fluctuations of haemoglobin from different species : adaptation to temperature via conformational dynamics
JF  - Journal of the Royal Society Interface
N2  - Thermodynamic stability, configurational motions and internal forces of haemoglobin (Hb) of three endotherms (platypus, Ornithorhynchus anatinus; domestic chicken, Gallus gallus domesticus and human, Homo sapiens) and an ectotherm (salt water crocodile, Crocodylus porosus) were investigated using circular dichroism, incoherent elastic neutron scattering and coarse-grained Brownian dynamics simulations. The experimental results from Hb solutions revealed a direct correlation between protein resilience, melting temperature and average body temperature of the different species on the 0.1 ns time scale. Molecular forces appeared to be adapted to permit conformational fluctuations with a root mean square displacement close to 1.2 Å at the corresponding average body temperature of the endotherms. Strong forces within crocodile Hb maintain the amplitudes of motion within a narrow limit over the entire temperature range in which the animal lives. In fully hydrated powder samples of human and chicken, Hb mean square displacements and effective force constants on the 1 ns time scale showed no differences over the whole temperature range from 10 to 300 K, in contrast to the solution case. A complementary result of the study, therefore, is that one hydration layer is not sufficient to activate all conformational fluctuations of Hb in the pico- to nanosecond time scale which might be relevant for biological function. Coarse-grained Brownian dynamics simulations permitted to explore residue-specific effects. They indicated that temperature sensing of human and chicken Hb occurs mainly at residues lining internal cavities in the β-subunits.
Y1  - 2012
U6  - http://dx.doi.org/10.1098/rsif.2012.0364
SN  - 1742-5689
VL  - 9
IS  - 76
SP  - 2845
EP  - 2855
PB  - The Royal Society
CY  - London
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Vogel, A.
A1  - Zink, S.
A1  - Stache, O.
T1  - Entwicklung eines automatisierten, computergesteuerten Permeabilitätsanalysators zur Messung an Endothelzellen / Vogel, A. ; Zinke, S. ; Stache, O. ; Königsfeld, J. ; Artmann, G.
JF  - Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1
Y1  - 2000
SN  - 1862-278X
SP  - 479
EP  - 480
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Stache, O.
A1  - Königsfeld, J.
T1  - Temperaturabhängigkeit der Pseudopodienbildung und Rückbildung von Granulozyten / Stache, O. ; Königsfeld, J. ; Artmann, G. M.
JF  - Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1
Y1  - 2000
SN  - 1862-278X
SP  - 450
EP  - 451
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Trzewik, J.
A1  - Schmid-Schönbein, G. W.
T1  - Investigation on lymphatic endothelial microvalves / Trzewik, J. ; Artmann, G. M. ; Schmid-Schönbein, G. W.
JF  - Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1
Y1  - 2000
SN  - 1862-278X
SP  - 521
EP  - 522
ER  - 
TY  - JOUR
A1  - Bork, M.
A1  - Kelemen, C.
A1  - Biselli, Manfred
A1  - Artmann, Gerhard
T1  - Biophysikalische Charakterisierung ex vivo kultivierter menschlicher Erythrozythen
JF  - Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1
Y1  - 2000
SN  - 1862-278X
SP  - 471
EP  - 472
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
T1  - Cellular engineering - a challenge for engineers? / Artmann, G. M.
JF  - Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1
Y1  - 2000
SN  - 1862-278X
SP  - 449
ER  - 
TY  - JOUR
A1  - Demirci, T.
A1  - Trzewik, J.
A1  - Linder, Peter
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Mechanical Stimulation of 3T3 Fibroblasts Activates Genes: ITGB5 and p53 Responses as Quantified on the mRNA Level
JF  - Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2
Y1  - 2004
SN  - 0932-4666
SP  - 1030
EP  - 1031
ER  - 
TY  - JOUR
A1  - Demirci, T.
A1  - Trzewik, J.
A1  - Linder, Peter
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Mechanical Stimulation of 3T3 Fibroblasts Activates Genes: Real Time PCR Products and Suppliers by Comparison
JF  - Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2
Y1  - 2004
SN  - 0932-4666
SP  - 1046
EP  - 1047
ER  - 
TY  - JOUR
A1  - Sadykov, Rustam
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
A1  - Porst, Dariusz
A1  - Linder, Peter
A1  - Kayser, Peter
A1  - Artmann, Gerhard
A1  - Savitskaya, Irina
A1  - Zhubanova, Azhar
T1  - Oral lead exposure induces dysbacteriosis in rats
JF  - Journal of Occupational Health. 51 (2009) (2009), H. 1
Y1  - 2009
SN  - 1348-9585
SP  - 64
EP  - 73
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Digel, Ilya
A1  - Zerlin, Kay
A1  - Maggakis-Kelemen, Christina
A1  - Linder, Peter
A1  - Porst, Dariusz
A1  - Kayser, Peter
A1  - Stadler, David
A1  - Dikta, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Hemoglobin senses body temperature
JF  - European Biophysics Journal
Y1  - 2009
SN  - 0175-7571
VL  - 38
IS  - 5
SP  - 589
EP  - 600
ER  - 
TY  - JOUR
A1  - Stadler, A.  M.
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Embs, Jan P.
A1  - Zaccai, Joe
A1  - Büldt, Georg
T1  - Hemoglobin Dynamics in Red Blood Cells: Correlation to Body Temperature
JF  - Biophysical Journal. 95 (2008), H. 11
Y1  - 2008
SN  - 1542-0086
SP  - 5449
EP  - 5461
ER  - 
TY  - JOUR
A1  - Kaul, D. K.
A1  - Koshkaryev, A.
A1  - Artmann, Gerhard
A1  - Barshtein, G.
A1  - Yedgar, S.
T1  - Additive effect of red blood cell rigidity and adherence to endothelial cells in inducing vascular resistance
JF  - American Journal of Physiology : Heart and Circulation Physiology . 295 (2008), H. 4
Y1  - 2008
SN  - 1522-1539
VL  - 295
IS  - 4
SP  - H1788
EP  - H1793
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Zerlin, Kay
A1  - Digel, Ilya
T1  - Hemoglobin Senses Body Temperature
JF  - Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)
Y1  - 2008
SN  - 978-3-540-75408-4
SP  - 415
EP  - 447
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Hueck, Isgard S.
A1  - Rossiter, Katharine
A1  - Schmid-Schönbein, Geert W.
T1  - Fluid Shear Attenuates Endothelial Pseudopodia Formation into the Capillary Lumen / Hueck, Isgard S. ; Rossiter, Katharine ; Artman, Gerhard M. ; Schmid-Schönbein, Geert W.
JF  - Microcirculation. 15 (2008), H. 6
Y1  - 2008
SN  - 1549-8719
SP  - 531
EP  - 542
ER  - 
TY  - JOUR
A1  - Maggakis-Kelemen, C.
A1  - Bork, M.
A1  - Kayser, Peter
A1  - Biselli, Manfred
A1  - Artmann, Gerhard
T1  - Biological and mechanical quality of red blood cells cultured from human umbilical cord blood stem cells
JF  - Medical and biological engineering and computing. 41 (2003), H. 3
Y1  - 2003
SN  - 0140-0118
SP  - 350
EP  - 356
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Keller, U.
A1  - Haas, J.
A1  - Amort, U.
A1  - Zang, Werner
A1  - Karschies, S.
T1  - Technik und ausgewählte Applikationen eines Membranbioassays roter Blutzellen
JF  - Biomedizinische Technik = Biomedical engineering. 36 (1991)
Y1  - 1991
SN  - 0013-5585
VL  - 36
IS  - S1
SP  - 450
EP  - 451
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Montanus, M.
A1  - Teitel, P.
T1  - Die photometrische Kapillaraggregation- ein neues Verfahren zur Messung der Erythrozytenaggregation. Montanus, M.; Artmann, Gerhard Michael; Teitel, P.
JF  - Biomedizinische Technik = Biomedical engineering. 36 (1991)
Y1  - 1991
SN  - 0013-5585
SP  - 213
EP  - 215
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Witte, Ch.
T1  - Expertensystem für Personal Computer zur Strukturbestimmung des Circulus Arteriosus Willisii mittels transkranieller Dopplersonografie. Witte, Ch.; Artmann, Gerhard Michael
JF  - Biomedizinische Technik = Biomedical engineering. 36 (1991)
Y1  - 1991
SN  - 0013-5585
SP  - 228
EP  - 230
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Teitel, P.
A1  - Schmid-Schönbein, H.
T1  - Variable rheologische Antwort der Erythrozyten auf den Einfluß von Xantinderivaten (Coffein): Experimentelle Differenzierung von "Responders" und "Nonresponders"
JF  - 11. Jahrestagung der Gesellschaft für Mikrozirkulation
Y1  - 1987
SP  - 100
EP  - 105
PB  - Karger [u.a.]
CY  - Basel [u.a.]
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Grebe, R.
A1  - Homrighausen, A.
A1  - Wolff, H.
A1  - [u.a.], 
T1  - Response of normal and diabetic erythrocytes to membrane deformation by chemical and mechanical forces. Artmann, Gerhard Michael; Grebe, R.; Homrighausen, A.; Wolff, H.; Teitel, P.; Schmid-Schönbein, H.
JF  - 12. Jahrestagung der Gesellschaft für Mikrozirkulation
Y1  - 1988
SP  - 196
EP  - 200
PB  - Karger [u.a.]
CY  - Basel [u.a.]
ER  -