TY  - CHAP
A1  - Raman, Aravind Hariharan
A1  - Jung, Alexander
A1  - Horváth, András
A1  - Becker, Nadine
A1  - Staat, Manfred
ED  - Staat, Manfred
ED  - Erni, Daniel
T1  - Modification of a computer model of human stem cell-derived cardiomyocyte electrophysiology based on Patch-Clamp measurements
T2  - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen
N2  - Human induced pluripotent stem cells (hiPSCs) have shown to be promising in disease studies and drug screenings [1]. Cardiomyocytes derived from hiPSCs have been extensively investigated using patch-clamping and optical methods to compare their electromechanical behaviour relative to fully matured adult cells. Mathematical models can be used for translating findings on hiPSCCMs to adult cells [2] or to better understand the mechanisms of various ion channels when a drug is applied [3,4]. Paci et al. (2013) [3] developed the first model of hiPSC-CMs, which they later refined based on new data [3]. The model is based on iCells® (Fujifilm Cellular Dynamics, Inc. (FCDI), Madison WI, USA) but major differences among several cell lines and even within a single cell line have been found and motivate an approach for creating sample-specific models. We have developed an optimisation algorithm that parameterises the conductances (in S/F=Siemens/Farad) of the latest Paci et al. model (2018) [5] using current-voltage data obtained in individual patch-clamp experiments derived from an automated patch clamp system (Patchliner, Nanion Technologies GmbH, Munich).
Y1  - 2019
SN  - 978-3-940402-22-6
U6  - http://dx.doi.org/10.17185/duepublico/48750
SP  - 10
EP  - 11
PB  - Universität Duisburg-Essen
CY  - Duisburg
ER  - 
TY  - CHAP
A1  - Hunker, Jan
A1  - Jung, Alexander
A1  - Goßmann, Matthias
A1  - Linder, Peter
A1  - Staat, Manfred
ED  - Staat, Manfred
ED  - Erni, Daniel
T1  - Development of a tool to analyze the conduction speed in microelectrode array measurements of cardiac tissue
T2  - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen
N2  - The discovery of human induced pluripotent stem cells reprogrammed from somatic cells [1] and their ability to differentiate into cardiomyocytes (hiPSC-CMs) has provided a robust platform for drug screening [2]. Drug screenings are essential in the development of new components, particularly for evaluating the potential of drugs to induce life-threatening pro-arrhythmias. Between 1988 and 2009, 14 drugs have been removed from the market for this reason [3]. The microelectrode array (MEA) technique is a robust tool for drug screening as it detects the field potentials (FPs) for the entire cell culture. Furthermore, the propagation of the field potential can be examined on an electrode basis. To analyze MEA measurements in detail, we have developed an open-source tool.
Y1  - 2019
SN  - 978-3-940402-22-6
U6  - http://dx.doi.org/10.17185/duepublico/48750
SP  - 7
EP  - 8
PB  - Universität Duisburg-Essen
CY  - Duisburg
ER  - 
TY  - CHAP
A1  - Schmidts, Oliver
A1  - Kraft, Bodo
A1  - Siebigteroth, Ines
A1  - Zündorf, Albert
T1  - Schema Matching with Frequent Changes on Semi-Structured Input Files: A Machine Learning Approach on Biological Product Data
T2  - Proceedings of the 21st International Conference on Enterprise Information Systems - Volume 1: ICEIS
Y1  - 2019
SN  - 978-989-758-372-8
U6  - http://dx.doi.org/10.5220/0007723602080215
SP  - 208
EP  - 215
ER  - 
TY  - CHAP
A1  - Birkl, Josef
A1  - Diendorfer, Gerhard
A1  - Kern, Alexander
A1  - Thern, Stephan
T1  - Extremely high lightning peak currents
T2  - 34th International Conference on Ligntning Protection, 02-07 September 2018
Y1  - 2018
SN  - 978-1-5386-6635-7
ER  - 
TY  - CHAP
A1  - Rieper, Harald
A1  - Gebhardt, Andreas
A1  - Stucker, Brent
T1  - Process parameters for Selective Laser Melting of AgCu7
T2  - DDMC, Fraunhofer Direct Digital Manufacturing Conference, 3
Y1  - 2016
SN  - 978-3-8396-1001-5
N1  - DDMC, 2016, Fraunhofer Direct Digital Manufacturing Conference, 3rd, Berlin, DE, 2016-03-16 - 2016-03-17
SP  - 171
EP  - 176
PB  - Fraunhofer-Verlag
CY  - Stuttgart
ER  - 
TY  - CHAP
A1  - Schildt, Philipp
A1  - Marzocca, Pier
A1  - Braun, Carsten
A1  - Dahmann, Peter
A1  - Keimer, Jona
T1  - Effects of atmospheric excitation on vibration based condition monitoring methods for hybrid-electric aircraft propulsion systems
T2  - AIAC 2018: 18th Australian International Aerospace Congress: HUMS - 11th Defence Science and Technology (DST) International Conference on Health and Usage Monitoring (HUMS 2019): ISSFD - 27th International Symposium on Space Flight Dynamics (ISSFD)
Y1  - 2019
SN  - 9781925627213
SP  - 923
EP  - 928
ER  - 
TY  - CHAP
A1  - Grundmann, Jan Thimo
A1  - Bauer, Waldemar
A1  - Borchers, Kai
A1  - Dumont, Etienne
A1  - Grimm, Christian D.
A1  - Ho, Tra-Mi
A1  - Jahnke, Rico
A1  - Lange, Caroline
A1  - Maiwald, Volker
A1  - Mikulz, Eugen
A1  - Quantius, Dominik
A1  - Reershemius, Siebo
A1  - Renger, Thomas
A1  - Riemann, Johannes
A1  - Sasaki, Kaname
A1  - Seefeldt, Patric
A1  - Spietz, Peter
A1  - Spröwitz, Tom
A1  - Toth, Norbert
A1  - Wejmo, Elisabet
A1  - Biele, Jens
A1  - Krause, Christian
A1  - Cerotti, Matteo
A1  - Peloni, Alessandro
A1  - Dachwald, Bernd
T1  - Small Spacecraft Solar Sailing for Small Solar System Body Multiple Rendezvous and Landing
T2  - 2018 IEEE Aerospace Conference : 3-10 March 2018
Y1  - 2018
SN  - 978-1-5386-2014-4
ER  - 
TY  - CHAP
A1  - Götten, Falk
A1  - Havermann, Marc
A1  - Braun, Carsten
A1  - Gomez, Francisco
A1  - Bil, Cees
T1  - On the Applicability of Empirical Drag Estimation Methods for Unmanned Air Vehicle Design   Read More: https://arc.aiaa.org/doi/10.2514/6.2018-3192
T2  - 2018 Aviation Technology, Integration, and Operations Conference, AIAA AVIATION Forum
Y1  - 2018
U6  - http://dx.doi.org/10.2514/6.2018-3192
SN  - 1533-385X
N1  - AIAA 2018-3192
SP  - Article 3192
ER  - 
TY  - CHAP
A1  - Mataré, Victor
A1  - Schiffer, Stefan
A1  - Ferrein, Alexander
ED  - Steinbauer, Gerald
ED  - Ferrein, Alexander
T1  - golog++ : An integrative system design
T2  - CogRob 2018. Cognitive Robotics Workshop : Proceedings of the 11th Cognitive Robotics Workshop 2018 co-located with 16th International Conference on Principles of Knowledge Representation and Reasoning (KR 2018) Tempe, AZ, USA, October 27th, 2018
Y1  - 2019
SN  - 1613-0073
SP  - 29
EP  - 35
ER  - 
TY  - CHAP
A1  - Rütters, René
A1  - Weinheimer, Marius
A1  - Bragard, Michael
T1  - Teaching Control Theory with a Simplified Helicopter Model and a Classroom Fitting Hardware Test-Bench
T2  - 2018 IEEE 59th International Scientific Conference on Power and Electrical Engineering of Riga Technical University (RTUCON)
Y1  - 2018
SN  - 978-1-5386-6903-7
U6  - http://dx.doi.org/10.1109/RTUCON.2018.8659871
ER  - 
TY  - CHAP
A1  - Bragard, Michael
A1  - Hoek, Hauke van
A1  - Hoegen, Anne von
A1  - Doncker, Rik W. De
T1  - Motivation-based Learning: Teaching Fundamentals of Electrical Engineering with an LED Spinning Top
T2  - 2018 IEEE 59th International Scientific Conference on Power and Electrical Engineering of Riga Technical University (RTUCON)
Y1  - 2018
SN  - 978-1-5386-6903-7
U6  - http://dx.doi.org/10.1109/RTUCON.2018.8659810
SP  - 1
EP  - 6
ER  - 
TY  - CHAP
A1  - Bindzus, Manuel
A1  - Bragard, Michael
T1  - Motivating Intuitive Understanding of the Switched Reluctance Machine in the Education of Undergraduate Students
T2  - 2018 IEEE 59th International Scientific Conference on Power and Electrical Engineering of Riga Technical University (RTUCON)
Y1  - 2018
SN  - 978-1-5386-6903-7
U6  - http://dx.doi.org/10.1109/RTUCON.2018.8659870
SP  - 1
EP  - 6
ER  - 
TY  - CHAP
A1  - Kazuki, Yasuhiro
A1  - Kobayashi, Kaoru
A1  - Hirabayashi, Masumi
A1  - Abe, Satoshi
A1  - Kajitani, Naoyo
A1  - Kazuki, Kanoko
A1  - Takehara, Shoko
A1  - Takiguchi, Masato
A1  - Satoh, Daisuke
A1  - Kuze, Jiro
A1  - Sakuma, Tetsushi
A1  - Kaneko, Takehito
A1  - Mashimo, Tomoji
A1  - Osamura, Minori
A1  - Hashimoto, Mari
A1  - Wakatsuki, Riko
A1  - Hirashima, Rika
A1  - Fujiwara, Ryoichi
A1  - Deguchi, Tsuneo
A1  - Kurihara, Atsushi
A1  - Tsukazaki, Yasuko
A1  - Senda, Naoto
A1  - Yamamoto, Takashi
A1  - Scheer, Nico
A1  - Oshimura, Mitsuo
T1  - Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism
T2  - PNAS Proceedings of the National Academy of Sciences of the United States of America
Y1  - 2019
U6  - http://dx.doi.org/10.1073/pnas.1808255116
SN  - 1091-6490
VL  - 116
IS  - 8
SP  - 3072
EP  - 3081
ER  - 
TY  - CHAP
A1  - Baader, Fabian
A1  - Reiswich, M.
A1  - Bartsch, M.
A1  - Keller, D.
A1  - Tiede, E.
A1  - Keck, G.
A1  - Demircian, A.
A1  - Friedrich, M.
A1  - Dachwald, Bernd
A1  - Schüller, K.
A1  - Lehmann, R.
A1  - Chojetzki, R.
A1  - Durand, C.
A1  - Rapp, L.
A1  - Kowalski, Julia
A1  - Förstner, R.
T1  - VIPER - Student research on extraterrestrical ice penetration technology
T2  - Proceedings of the 2nd Symposium on Space Educational Activities
N2  - Recent analysis of scientific data from Cassini and earth-based observations gave evidence for a global ocean under a surrounding solid ice shell on Saturn's moon Enceladus. Images of Enceladus' South Pole showed several fissures in the ice shell with plumes constantly exhausting frozen water particles, building up the E-Ring, one of the outer rings of Saturn. In this southern region of Enceladus, the ice shell is considered to be as thin as 2 km, about an order of magnitude thinner than on the rest of the moon. Under the ice shell, there is a global ocean consisting of liquid water. Scientists are discussing different approaches the possibilities of taking samples of water, i.e. by melting through the ice using a melting probe. FH Aachen UAS developed a prototype of maneuverable melting probe which can navigate through the ice that has already been tested successfully in a terrestrial environment. This means no atmosphere and or ambient pressure, low ice temperatures of around 100 to 150K (near the South Pole) and a very low gravity of 0,114 m/s^2 or 1100 μg. Two of these influencing measures are about to be investigated at FH Aachen UAS in 2017, low ice temperature and low ambient pressure below the triple point of water. Low gravity cannot be easily simulated inside a large experiment chamber, though. Numerical simulations of the melting process at RWTH Aachen however are showing a gravity dependence of melting behavior. Considering this aspect, VIPER provides a link between large-scale experimental simulations at FH Aachen UAS and numerical simulations at RWTH Aachen. To analyze the melting process, about 90 seconds of experiment time in reduced gravity and low ambient pressure is provided by the REXUS rocket. In this time frame, the melting speed and contact force between ice and probes are measured, as well as heating power and a two-dimensional array of ice temperatures. Additionally, visual and infrared cameras are used to observe the melting process.
Y1  - 2018
SP  - 1
EP  - 6
ER  - 
TY  - CHAP
A1  - Gierse, Andreas
A1  - Krämer, Stefan
A1  - Daab, Dominique J.
A1  - Hessel, Joana
A1  - Baader, Fabian
A1  - Müller, Brigitte S.
A1  - Wagner, Tobias
A1  - Gdalewitsch, Georg
A1  - Plescher, Engelbert
A1  - Pfützenreuter, Lysan
T1  - Experimental in-flight modal-analysis of a sounding rocket structure
T2  - 21st ESA Symposium on Rocket and Ballon related Research
Y1  - 2013
SN  - 9789290922858
SP  - 341
EP  - 346
ER  - 
TY  - CHAP
A1  - Kunfermann, Philipp
A1  - Drumm, Christian
T1  - Lifting XML schemas to ontologies - the concept finder algorithm
T2  - MEDIATE 2005 First International Workshop on Mediation in Semantic Web Services    Proceedings of the First International Workshop on Mediation in Semantic Web Services (MEDIATE 2005)
Y1  - 2005
SP  - 113
EP  - 122
ER  - 
TY  - CHAP
A1  - Drumm, Christian
A1  - Lemcke, Jens
A1  - Oberle, Daniel
T1  - Integrating Semantic Web Services and Business Process Management: A Real Use Case
T2  - Proceedings of the ESWC 2006 Workshop Semantics for Business Process Management 2006 (SBPM 2006), June 2006
Y1  - 2006
ER  - 
TY  - CHAP
A1  - Weber, Ingo
A1  - Markovic, Ivan
A1  - Drumm, Christian
T1  - A conceptual framework for composition in business process management
T2  - Business Information Systems : 10th International Conference, BIS 2007, Poznan, Poland, April 25-27, 2007. Proceedings
Y1  - 2007
SN  - 978-3-540-72035-5
U6  - http://dx.doi.org/10.1007/978-3-540-72035-5_5
SP  - 54
EP  - 66
PB  - Springer
CY  - Berlin, Heidelberg
ER  - 
TY  - CHAP
A1  - Drumm, Christian
A1  - Schmitt, Matthias
A1  - Do, Hong-Hai
A1  - Rahm, Erhard
T1  - Quickmig: automatic schema matching for data migration projects
T2  - Proceedings of the 2007 ACM Conference on Information and Knowledge Management / CIKM'07, Lisboa, Portugal, Nov. 6 - 10, 2007
Y1  - 2007
SN  - 978-1-59593-803-9
U6  - http://dx.doi.org/10.1145/1321440.1321458
SP  - 107
EP  - 116
ER  - 
TY  - CHAP
A1  - Scholl, Ingrid
A1  - Bartella, Alex
A1  - Moluluo, Cem
A1  - Ertural, Berat
A1  - Laing, Frederic
A1  - Suder, Sebastian
T1  - MedicVR : Acceleration and Enhancement Techniques for Direct Volume Rendering in Virtual Reality
T2  - Bildverarbeitung für die Medizin 2019 : Algorithmen – Systeme – Anwendungen
Y1  - 2019
SN  - 978-3-658-25326-4
U6  - http://dx.doi.org/10.1007/978-3-658-25326-4_32
SP  - 152
EP  - 157
PB  - Springer Vieweg
CY  - Wiesbaden
ER  -