TY  - JOUR
A1  - Wedrowski, M.
A1  - Bruyndonckx, P.
A1  - Tavernier, S.
A1  - Zhi, L.
A1  - Dang, J.
A1  - Mendes, P. R.
A1  - Perez, J. M.
A1  - Ziemons, Karl
T1  - Robustness of neural networks algorithm for gamma detection in monolithic block detector, positron emission tomography
JF  - 2009 IEEE Nuclear Science Symposium Conference Record (NSS/MIC)
N2  - The monolithic scintillator block approach for gamma detection in the Positron Emission Tomography (PET) avoids estimating Depth of Interaction (DOI), reduces dead zones in detector and diminishes costs of detector production. Neural Networks (NN) are very efficient to determine the entrance point of a gamma incident on a scintillator block. This paper presents results on the robustness of the spatial resolution as a function of the random fraction in the data, temperature and HV fluctuations. This is important when implementing the method in a real scanner. Measurements were done with two Hamamatsu S8550 APD arrays, glued on a 20 × 20 × 10 mm3 monolithic LSO crystal block.
Y1  - 2009
SN  - 1082-3654
SP  - 2625
EP  - 2628
ER  - 
TY  - JOUR
A1  - Weemstra, Monique
A1  - Eilmann, Britta
A1  - Sass-Klaassen, Ute G. W.
A1  - Sterck, Frank J.
T1  - Summer droughts limit tree growth across 10 temperate species on a productive forest site
JF  - Forest Ecology and Management
Y1  - 2013
U6  - https://doi.org/doi:10.1016/j.foreco.2013.06.007
SN  - 0378-1127 (Print)
SN  - 1872-7042  (Online)
VL  - 2013
IS  - 306
SP  - 142
EP  - 149
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wegmann, Kilian
A1  - Hackl, Michael
A1  - Staat, Manfred
A1  - Mayer, Katharina
A1  - Müller, Lars-Peter
T1  - Double plate osteosynthesis of proximal ulna fractures: biomechanical and clinical results
JF  - Knee surgery, sports traumatology, arthroscopy
N2  - While plate fixation of proximal ulna fractures might lead to superior clinical results compared to tension band wiring, regular plates represent an established risk factor for wound complications. The olecranon double plates (Medartis, Basel, CH) might decrease complications related to the osteosynthesis because of their low profile and better anatomical fit. This study aimed to evaluate the biomechanical performance and clinical results of the olecranon double plates.
Y1  - 2016
U6  - https://doi.org/10.1007/s00167-016-4079-0
SN  - 0942-2056
VL  - Volume 24
IS  - Supplement 1
SP  - 58
EP  - 59
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Wegner, Lena
A1  - von Arx, Georg
A1  - Sass-Klaassen, Ute G. W.
A1  - Eilmann, Britta
T1  - ROXAS – an efficient and accurate tool to detect vessels in diffuse-porous species
JF  - IAWA Journal / International Association of Wood Anatomists
Y1  - 2013
U6  - https://doi.org/10.1163/22941932-00000034
SN  - 0928-1541 (Print)
SN  - 2294-1932 (Online)
VL  - 34
IS  - 4
SP  - 425
EP  - 432
PB  - Brill
CY  - Leiden
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
T1  - Optimale Maschinenjustierung
JF  - Technische Hochschule <Ilmenau> / Bibliothek: Wissenschaftliche Zeitschrift. 37 (1991)
Y1  - 1991
SN  - 0043-6917
SP  - 167
EP  - 175
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
T1  - A Solution to the Scheduling Problem Taking into Account Quality
JF  - Operations research '91 : extended abstracts of the 16th Symposium on Operations Research held at the University of Trier at September 9 - 11, 1991 / [GMÖOR]. Peter Gritzmann ... (eds.)
Y1  - 1991
SN  - 3790806080
N1  - Symposium on Operations Research ; (16, 1991, Trier)
SP  - 373
EP  - 375
PB  - Physica-Verl.
CY  - Heidelberg
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
T1  - Optimal Adjustment Policies
JF  - Proceedings of the First Umeå-Würzburg Conference in Statistics : Kronlund Conference Center and University of Umeå, September 10 - 14, 1990 / ed. by Kurt Brännäs
Y1  - 1990
SN  - 91-7174-564-5
N1  - Umeå-Würzburg Conference in Statistics <1, 1990>
SP  - 147
EP  - 158
PB  - Univ. of Umeå
CY  - Umeå
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
T1  - Technically Optimal Inspection Policy with Arithmetical Adaption
JF  - IMA Journal of Management Mathematics. 14 (2003), H. 4
Y1  - 2003
SN  - 1471-678X
N1  - weitere ISSN 1471-6798 (E)
SP  - 357
EP  - 371
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
T1  - Economically Optimal Inspection Policy with Geometrical Adaption
JF  - Journal of Applied Statistics. 30 (2003), H. 5
Y1  - 2003
SN  - 0266-4763
N1  - weitere ISSN 1360-0532 (E)
SP  - 555
EP  - 569
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
T1  - Economically Optimal Inspection Policy with Arithmetical Adaption
JF  - Applied stochastic models and data analysis / [10th International Symposium on Applied Stochastic Models and Analysis, June 12-15 2001, Université Technologique de Compiègne] ; editors Gérard Govaert, Jacques Janssen, Nikolaos Limnios.
Y1  - 2001
N1  - ASDMA 2001
SP  - 1010
EP  - 1015
PB  - Université Technologique de Compiègne
CY  - Compiègne
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
T1  - Economically Optimal Adaptive Inspection Policies
JF  - Economic Quality Control. 15 (2000), H. 1/2
Y1  - 2000
SN  - 0940-5151
N1  - Printausgabe vorhanden: 43 Z 711
SP  - 55
EP  - 77
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
T1  - Economic Machine Adjustment in the Case of Product Screening .E.v.Collani, Ch. Weigand
JF  - Statistical Papers. 33 (1992)
Y1  - 1992
SP  - 171
EP  - 184
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
T1  - On the Effects of SPC on Production Time
JF  - Economic Quality Control. 8 (1993)
Y1  - 1993
SN  - 0940-5151
SP  - 23
EP  - 61
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
T1  - A new Approach for Optimal Control of a Production process
JF  - Economic Quality Control. 7 (1992)
Y1  - 1992
SN  - 0940-5151
SP  - 225
EP  - 251
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
T1  - Optimal Production Schedule for a K Products Single Machine Problem
JF  - Economic Quality Control. 9 (1994)
Y1  - 1994
SN  - 0940-5151
SP  - 91
EP  - 101
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
T1  - Statistical Tests Based on Reliability and Precision
JF  - Economic Quality Control : EQC ; international journal for quality and reliability
N2  - The construction of a statistical test is investigated which is based only on “reliability” and “precision” as quality criteria. The reliability of a statistical test is quantifiedin a straightforward way by the probability that the decision of the test is correct.  However, the quantification of the precision of a statistical test is not at all evident.  Thereforethe paper presents and discusses several approaches.  Moreover the distinction of “nullhypothesis” and “alternative hypothesis” is not necessary any longer.
Y1  - 2012
U6  - https://doi.org/10.1515/eqc-2012-0002
SN  - 1869-6147
VL  - 27
IS  - 1
SP  - 43
EP  - 64
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
T1  - Defining Precisions for Reliable Measurement and Estimation Procedures
JF  - Economic Quality Control. 24 (2009), H. 1
Y1  - 2009
SN  - 0940-5151
SP  - 5
EP  - 33
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
A1  - Collani, E. v.
A1  - Saniga, E.M.
T1  - Economic Adjustment Design for -Control Charts. E.v.Collani, E.M. Saniga, Ch. Weigand
JF  - IIE Transactions / Institute of Industrial Engineers. 26 (1994), H. 6
Y1  - 1994
SN  - 0569-5554
ER  - 
TY  - JOUR
A1  - Weihe, Stefan
A1  - Ansgar, Ernst
A1  - Röth, Thilo
A1  - Proksch, Johannes
T1  - Leichtmetall-Stahl-Verbundguss im Nutzfahrzeugbau
JF  - Lightweight Design
N2  - In modernen Fahrzeugkarosserien der Großserie kommen zunehmend Materialmischbauweisen
zur Anwendung. In Zusammenarbeit der Daimler AG, der Tower Automotive Holding
GmbH, der Imperia GmbH sowie der Partnerunternehmen KSM Castings GmbH und Schaufler
Tooling GmbH & Co. KG wird das Leichtbaupotenzial von Stahlblech-AluminiumverbundgussHybriden
am Beispiel des vorderen Dachquerträgers des Mercedes-Benz Viano/Vito ausführlich
untersucht.
Y1  - 2013
SN  - 2192-8738 (Online)
SN  - 1865-4819 (Print)
VL  - 6
IS  - 2
SP  - 38
EP  - 43
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Weihe, Stefan
A1  - Ernst, Ansgar
A1  - Röth, Thilo
A1  - Proksch, Johannes
T1  - Aluminium-Stahl-Verbundguss im Nutzfahrzeugbau
JF  - ATZ - Automobiltechnische Zeitschrift
N2  - In modernen Fahrzeugkarosserien der Großserie kommen zunehmend Materialmischbauweisen zur Anwendung. In Zusammenarbeit der Daimler AG, der Tower Automotive Holding GmbH, der Imperia GmbH sowie der Partnerunternehmen KSM Castings GmbH und Schaufler Tooling GmbH & Co. KG wird das Leichtbaupotenzial von Aluminiumverbundguss-Stahlblech-Hybriden am Beispiel des vorderen Dachquerträgers des Mercedes-Benz Viano/Vito ausführlich untersucht.
Y1  - 2013
SN  - 2192-8800 (Online)
SN  - 0001-2785 (Print)
VL  - 115
IS  - 4
SP  - 312
EP  - 316
PB  - Springer Fachmedien Wiesbaden
ER  - 
TY  - JOUR
A1  - Welden, Melanie
A1  - Poghossian, Arshak
A1  - Vahidpour, Farnoosh
A1  - Wendlandt, Tim
A1  - Keusgen, Michael
A1  - Wege, Christina
A1  - Schöning, Michael Josef
T1  - Towards multi-analyte detection with field-effect capacitors modified with tobacco mosaic virus bioparticles as enzyme nanocarriers
JF  - Biosensors
N2  - Utilizing an appropriate enzyme immobilization strategy is crucial for designing enzyme-based biosensors. Plant virus-like particles represent ideal nanoscaffolds for an extremely dense and precise immobilization of enzymes, due to their regular shape, high surface-to-volume ratio and high density of surface binding sites. In the present work, tobacco mosaic virus (TMV) particles were applied for the co-immobilization of penicillinase and urease onto the gate surface of a field-effect electrolyte-insulator-semiconductor capacitor (EISCAP) with a p-Si-SiO₂-Ta₂O₅ layer structure for the sequential detection of penicillin and urea. The TMV-assisted bi-enzyme EISCAP biosensor exhibited a high urea and penicillin sensitivity of 54 and 85 mV/dec, respectively, in the concentration range of 0.1–3 mM. For comparison, the characteristics of single-enzyme EISCAP biosensors modified with TMV particles immobilized with either penicillinase or urease were also investigated. The surface morphology of the TMV-modified Ta₂O₅-gate was analyzed by scanning electron microscopy. Additionally, the bi-enzyme EISCAP was applied to mimic an XOR (Exclusive OR) enzyme logic gate.
KW  - urease
KW  - enzyme-logic gate
KW  - bi-enzyme biosensor
KW  - capacitive field-effect sensor
KW  - tobacco mosaic virus (TMV)
KW  - penicillinase
Y1  - 2022
U6  - https://doi.org/10.3390/bios12010043
SN  - 2079-6374
N1  - This article belongs to the Special Issue "Biosensors: 10th Anniversary Feature Papers"
VL  - 12
IS  - 1
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Welden, Melanie
A1  - Severins, Robin
A1  - Poghossian, Arshak
A1  - Wege, Christina
A1  - Bongaerts, Johannes
A1  - Siegert, Petra
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Detection of acetoin and diacetyl by a tobacco mosaic virus-assisted field-effect biosensor
JF  - Chemosensors
N2  - Acetoin and diacetyl have a major impact on the flavor of alcoholic beverages such as wine or beer. Therefore, their measurement is important during the fermentation process. Until now, gas chromatographic techniques have typically been applied; however, these require expensive laboratory equipment and trained staff, and do not allow for online monitoring. In this work, a capacitive electrolyte–insulator–semiconductor sensor modified with tobacco mosaic virus (TMV) particles as enzyme nanocarriers for the detection of acetoin and diacetyl is presented. The enzyme acetoin reductase from Alkalihalobacillus clausii DSM 8716ᵀ is immobilized via biotin–streptavidin affinity, binding to the surface of the TMV particles. The TMV-assisted biosensor is electrochemically characterized by means of leakage–current, capacitance–voltage, and constant capacitance measurements. In this paper, the novel biosensor is studied regarding its sensitivity and long-term stability in buffer solution. Moreover, the TMV-assisted capacitive field-effect sensor is applied for the detection of diacetyl for the first time. The measurement of acetoin and diacetyl with the same sensor setup is demonstrated. Finally, the successive detection of acetoin and diacetyl in buffer and in diluted beer is studied by tuning the sensitivity of the biosensor using the pH value of the measurement solution.
Y1  - 2022
U6  - https://doi.org/10.3390/chemosensors10060218
SN  - 2227-9040
N1  - This article belongs to the Special Issue "Nanostructured Devices for Biochemical Sensing"
VL  - 10
IS  - 6
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Welden, Rene
A1  - Jablonski, Melanie
A1  - Wege, Christina
A1  - Keusgen, Michael
A1  - Wagner, Patrick Hermann
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
T1  - Light-Addressable Actuator-Sensor Platform for Monitoring and Manipulation of pH Gradients in Microfluidics: A Case Study with the Enzyme Penicillinase
JF  - Biosensors
N2  - The feasibility of light-addressed detection and manipulation of pH gradients inside an electrochemical microfluidic cell was studied. Local pH changes, induced by a light-addressable electrode (LAE), were detected using a light-addressable potentiometric sensor (LAPS) with different measurement modes representing an actuator-sensor system. Biosensor functionality was examined depending on locally induced pH gradients with the help of the model enzyme penicillinase, which had been immobilized in the microfluidic channel. The surface morphology of the LAE and enzyme-functionalized LAPS was studied by scanning electron microscopy. Furthermore, the penicillin sensitivity of the LAPS inside the microfluidic channel was determined with regard to the analyte’s pH influence on the enzymatic reaction rate. In a final experiment, the LAE-controlled pH inhibition of the enzyme activity was monitored by the LAPS.
KW  - microfluidics
KW  - enzyme kinetics
KW  - actuator-sensor system
KW  - light-addressable electrode
KW  - light-addressable potentiometric sensor
Y1  - 2021
U6  - https://doi.org/10.3390/bios11060171
SN  - 2079-6374
N1  - This article belongs to the Special Issue "Selected Papers from the 1st International Electronic Conference on Biosensors (IECB 2020)"
VL  - 11
IS  - 6
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Welden, Rene
A1  - Scheja, Sabrina
A1  - Schöning, Michael Josef
A1  - Wagner, Patrick
A1  - Wagner, Torsten
T1  - Electrochemical Evaluation of Light‐Addressable Electrodes Based on TiO2 for the Integration in Lab‐on‐Chip Systems
JF  - physica status solidi a : applications and materials sciences
N2  - In lab-on-chip systems, electrodes are important for the manipulation (e.g., cell stimulation, electrolysis) within such systems. An alternative to commonly used electrode structures can be a light-addressable electrode. Here, due to the photoelectric effect, the conducting area can be adjusted by modification of the illumination area which enables a flexible control of the electrode. In this work, titanium dioxide based light-addressable electrodes are fabricated by a sol–gel technique and a spin-coating process, to deposit a thin film on a fluorine-doped tin oxide glass. To characterize the fabricated electrodes, the thickness, and morphological structure are measured by a profilometer and a scanning electron microscope. For the electrochemical behavior, the dark current and the photocurrent are determined for various film thicknesses. For the spatial resolution behavior, the dependency of the photocurrent while changing the area of the illuminated area is studied. Furthermore, the addressing of single fluid compartments in a three-chamber system, which is added to the electrode, is demonstrated.
Y1  - 2018
U6  - https://doi.org/10.1002/pssa.201800150
SN  - 1862-6319
VL  - 215
IS  - 15
SP  - Article number 1800150
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Welden, Rene
A1  - Schöning, Michael Josef
A1  - Wagner, Patrick H.
A1  - Wagner, Torsten
T1  - Light-Addressable Electrodes for Dynamic and Flexible Addressing of Biological Systems and Electrochemical Reactions
JF  - Sensors
N2  - In this review article, we are going to present an overview on possible applications of light-addressable electrodes (LAE) as actuator/manipulation devices besides classical electrode structures. For LAEs, the electrode material consists of a semiconductor. Illumination with a light source with the appropiate wavelength leads to the generation of electron-hole pairs which can be utilized for further photoelectrochemical reaction. Due to recent progress in light-projection technologies, highly dynamic and flexible illumination patterns can be generated, opening new possibilities for light-addressable electrodes. A short introduction on semiconductor–electrolyte interfaces with light stimulation is given together with electrode-design approaches. Towards applications, the stimulation of cells with different electrode materials and fabrication designs is explained, followed by analyte-manipulation strategies and spatially resolved photoelectrochemical deposition of different material types.
Y1  - 2020
U6  - https://doi.org/10.3390/s20061680
SN  - 1424-8220
VL  - 20
IS  - 6
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Wemhöner, Carsten
A1  - Hafner, Bernd
A1  - Schwarzer, Klemens
T1  - Simulation of solar thermal systems with CARNOT blockset in the environment MATLAB-Simulink
Y1  - 2000
SP  - 1
EP  - 6
ER  - 
TY  - JOUR
A1  - Wendlandt, Tim
A1  - Koch, Claudia
A1  - Britz, Beate
A1  - Liedek, Anke
A1  - Schmidt, Nora
A1  - Werner, Stefan
A1  - Gleba, Yuri
A1  - Vahidpour, Farnoosh
A1  - Welden, Melanie
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Facile Purification and Use of Tobamoviral Nanocarriers for Antibody-Mediated Display of a Two-Enzyme System
JF  - Viruses
N2  - Immunosorbent turnip vein clearing virus (TVCV) particles displaying the IgG-binding domains D and E of Staphylococcus aureus protein A (PA) on every coat protein (CP) subunit (TVCVPA) were purified from plants via optimized and new protocols. The latter used polyethylene glycol (PEG) raw precipitates, from which virions were selectively re-solubilized in reverse PEG concentration gradients. This procedure improved the integrity of both TVCVPA and the wild-type subgroup 3 tobamovirus. TVCVPA could be loaded with more than 500 IgGs per virion, which mediated the immunocapture of fluorescent dyes, GFP, and active enzymes. Bi-enzyme ensembles of cooperating glucose oxidase and horseradish peroxidase were tethered together on the TVCVPA carriers via a single antibody type, with one enzyme conjugated chemically to its Fc region, and the other one bound as a target, yielding synthetic multi-enzyme complexes. In microtiter plates, the TVCVPA-displayed sugar-sensing system possessed a considerably increased reusability upon repeated testing, compared to the IgG-bound enzyme pair in the absence of the virus. A high coverage of the viral adapters was also achieved on Ta2O5 sensor chip surfaces coated with a polyelectrolyte interlayer, as a prerequisite for durable TVCVPA-assisted electrochemical biosensing via modularly IgG-assembled sensor enzymes.
KW  - biosensor
KW  - horseradish peroxidase (HRP)
KW  - glucose oxidase (GOx)
KW  - enzyme cascade
KW  - turnip vein clearing virus (TVCV)
KW  - tobacco mosaic virus (TMV)
Y1  - 2023
U6  - https://doi.org/doi.org/10.3390/v15091951
SN  - 1999-4915
N1  - This article belongs to the Special Issue "Tobamoviruses 2023"
VL  - 9
IS  - 15
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Werfel, Stanislas
A1  - Günthner, Roman
A1  - Hapfelmeier, Alexander
A1  - Hanssen, Henner
A1  - Kotliar, Konstantin
A1  - Heemann, Uwe
A1  - Schmaderer, Christoph
ED  - Guzik, Tomasz J.
T1  - Identification of cardiovascular high-risk groups from dynamic retinal vessel signals using untargeted machine learning
JF  - Cardiovascular Research
N2  - Dynamic retinal vessel analysis (DVA) provides a non-invasive way to assess microvascular function in patients and potentially to improve predictions of individual cardiovascular (CV) risk. The aim of our study was to use untargeted machine learning on DVA in order to improve CV mortality prediction and identify corresponding response alterations.
KW  - Machine learning
KW  - Retinal vessels
KW  - Microcirculation
KW  - Haemodialysis
KW  - Myocardial infarction and cardiac death
Y1  - 2022
U6  - https://doi.org/10.1093/cvr/cvab040
SN  - 0008-6363
VL  - 118
IS  - 2
SP  - 612
EP  - 621
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Werkhausen, Amelie
A1  - Albracht, Kirsten
A1  - Cronin, Neil J
A1  - Paulsen, Gøran
A1  - Bojsen-Møller, Jens
A1  - Seynnes, Olivier R
T1  - Effect of training-induced changes in achilles tendon stiffness on muscle-tendon behavior during landing
JF  - Frontiers in physiology
N2  - During rapid deceleration of the body, tendons buffer part of the elongation of the muscle-tendon unit (MTU), enabling safe energy dissipation via eccentric muscle contraction. Yet, the influence of changes in tendon stiffness within the physiological range upon these lengthening contractions is unknown. This study aimed to examine the effect of training-induced stiffening of the Achilles tendon on triceps surae muscle-tendon behavior during a landing task. Twenty-one male subjects were assigned to either a 10-week resistance-training program consisting of single-leg isometric plantarflexion (n = 11) or to a non-training control group (n = 10). Before and after the training period, plantarflexion force, peak Achilles tendon strain and stiffness were measured during isometric contractions, using a combination of dynamometry, ultrasound and kinematics data. Additionally, testing included a step-landing task, during which joint mechanics and lengths of gastrocnemius and soleus fascicles, Achilles tendon, and MTU were determined using synchronized ultrasound, kinematics and kinetics data collection. After training, plantarflexion strength and Achilles tendon stiffness increased (15 and 18%, respectively), and tendon strain during landing remained similar. Likewise, lengthening and negative work produced by the gastrocnemius MTU did not change detectably. However, in the training group, gastrocnemius fascicle length was offset (8%) to a longer length at touch down and, surprisingly, fascicle lengthening and velocity were reduced by 27 and 21%, respectively. These changes were not observed for soleus fascicles when accounting for variation in task execution between tests. These results indicate that a training-induced increase in tendon stiffness does not noticeably affect the buffering action of the tendon when the MTU is rapidly stretched. Reductions in gastrocnemius fascicle lengthening and lengthening velocity during landing occurred independently from tendon strain. Future studies are required to provide insight into the mechanisms underpinning these observations and their influence on energy dissipation.
KW  - achilles tendon
KW  - energy absorption
KW  - energy dissipation
KW  - mechanical buffer
KW  - stiffness
Y1  - 2018
U6  - https://doi.org/10.3389/fphys.2018.00794
SN  - 1664-042X
IS  - 9
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Werkhausen, Amelie
A1  - Albracht, Kirsten
A1  - Cronin, Neil J.
A1  - Meier, Rahel
A1  - Mojsen-Moeller, Jens
A1  - Seynnes, Olivier R.
T1  - Modulation of muscle-tendon interaction in the human triceps surae during an energy dissipation task
JF  - Journal of Experimental Biology
Y1  - 2017
U6  - https://doi.org/10.1242/jeb.164111
SN  - 0022-0949
VL  - 220
IS  - 22
SP  - 4141
EP  - 4149
ER  - 
TY  - JOUR
A1  - Werkhausen, Amelie
A1  - Cronin, Neil J.
A1  - Albracht, Kirsten
A1  - Bojsen-Møller, Jens
A1  - Seynnes, Olivier R.
T1  - Distinct muscle-tendon interaction during running at different speeds and in different loading conditions
JF  - Journal of Applied Physiology
Y1  - 2019
U6  - https://doi.org/10.1152/japplphysiol.00710.2018
SN  - 1522-1601
VL  - 127
IS  - 1
SP  - 246
EP  - 253
ER  - 
TY  - JOUR
A1  - Werkhausen, Amelie
A1  - Cronin, Neil J.
A1  - Albracht, Kirsten
A1  - Paulsen, Gøran
A1  - Larsen, Askild V.
A1  - Bojsen-Møller, Jens
A1  - Seynnes, Olivier R.
T1  - Training-induced increase in Achilles tendon stiffness affects tendon strain pattern during running
JF  - PeerJ
N2  - Background
During the stance phase of running, the elasticity of the Achilles tendon enables the utilisation of elastic energy and allows beneficial contractile conditions for the triceps surae muscles. However, the effect of changes in tendon mechanical properties induced by chronic loading is still poorly understood. We tested the hypothesis that a training-induced increase in Achilles tendon stiffness would result in reduced tendon strain during the stance phase of running, which would reduce fascicle strains in the triceps surae muscles, particularly in the mono-articular soleus.
Methods 
Eleven subjects were assigned to a training group performing isometric singleleg plantarflexion contractions three times per week for ten weeks, and another ten subjects formed a control group. Before and after the training period, Achilles tendon stiffness was estimated, and muscle-tendon mechanics were assessed during running at preferred speed using ultrasonography, kinematics and kinetics.
Results 
Achilles tendon stiffness increased by 18% (P <0:01) in the training group, but the associated reduction in strain seen during isometric contractions was not statistically significant. Tendon elongation during the stance phase of running was similar after training, but tendon recoil was reduced by 30% (P <0:01), while estimated tendon force remained unchanged. Neither gastrocnemius medialis nor soleus fascicle shortening during stance was affected by training.
Discussion 
These results show that a training-induced increase in Achilles tendon
stiffness altered tendon behaviour during running. Despite training-induced changes in tendon mechanical properties and recoil behaviour, the data suggest that fascicle shortening patterns were preserved for the running speed that we examined. The asymmetrical changes in tendon strain patterns supports the notion that simple inseries models do not fully explain the mechanical output of the muscle-tendon unit during a complex task like running.
KW  - Achilles tendon
KW  - Stiffness
KW  - Running
KW  - Tendon properties
KW  - Architectural gear ratio
Y1  - 2019
U6  - https://doi.org/10.7717/peerj.6764
SN  - 21678359
PB  - Peer
CY  - London
ER  - 
TY  - JOUR
A1  - Werkhausen, Amelie
A1  - Willwacher, Steffen
A1  - Albracht, Kirsten
T1  - Medial gastrocnemius muscle fascicles shorten throughout stance during sprint acceleration
JF  - Scandinavian Journal of Medicine & Science in Sports
N2  - The compliant nature of distal limb muscle-tendon units is traditionally considered suboptimal in explosive movements when positive joint work is required. However, during accelerative running, ankle joint net mechanical work is positive. Therefore, this study aims to investigate how plantar flexor muscle-tendon behavior is modulated during fast accelerations. Eleven female sprinters performed maximum sprint accelerations from starting blocks, while gastrocnemius muscle fascicle lengths were estimated using ultrasonography. We combined motion analysis and ground reaction force measurements to assess lower limb joint kinematics and kinetics, and to estimate gastrocnemius muscle-tendon unit length during the first two acceleration steps. Outcome variables were resampled to the stance phase and averaged across three to five trials. Relevant scalars were extracted and analyzed using one-sample and two-sample t-tests, and vector trajectories were compared using statistical parametric mapping. We found that an uncoupling of muscle fascicle behavior from muscle-tendon unit behavior is effectively used to produce net positive mechanical work at the joint during maximum sprint acceleration. Muscle fascicles shortened throughout the first and second steps, while shortening occurred earlier during the first step, where negative joint work was lower compared with the second step. Elastic strain energy may be stored during dorsiflexion after touchdown since fascicles did not lengthen at the same time to dissipate energy. Thus, net positive work generation is accommodated by the reuse of elastic strain energy along with positive gastrocnemius fascicle work. Our results show a mechanism of how muscles with high in-series compliance can contribute to net positive joint work.
KW  - locomotion
KW  - muscle mechanics
KW  - running
KW  - sprint start
KW  - ultrasonography
Y1  - 2021
U6  - https://doi.org/10.1111/sms.13956
SN  - 0905-7188 (Druckausgabe)
SN  - 1600-0838 (Onlineausgabe)
VL  - 31
IS  - 7
SP  - 1471
EP  - 1480
PB  - Wiley-Blackwell
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Werner, Frederik
A1  - Groebel, Simone
A1  - Krumbe, Christoph
A1  - Wagner, Torsten
A1  - Selmer, Thorsten
A1  - Yoshinobu, Tatsuo
A1  - Baumann, Marcus
A1  - Schöning, Michael Josef
T1  - Nutrient concentration-sensitive microorganism-based biosensor
JF  - Physica Status Solidi (a)
Y1  - 2012
U6  - https://doi.org/10.1002/pssa.201100801
SN  - 1862-6319
VL  - 209
IS  - 5
SP  - 900
EP  - 904
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Werner, Frederik
A1  - Groebel, Simone
A1  - Schuhmacher, K.
A1  - Spelthahn, Heiko
A1  - Wagner, Torsten
A1  - Selmer, Thorsten
A1  - Baumann, Marcus
A1  - Schöning, Michael Josef
T1  - Bestimmung der metabolischen Aktivität von Mikroorganismen während des Biogasbildungsprozesses
JF  - 9. Dresdner Sensor-Symposium : Dresden, 07.-09. Dezember 2009 / Gerlach, Gerald ; Hauptmann, Peter [Hrsg.]
Y1  - 2009
SN  - 978-3-941298-44-6
N1  - Dresdner Sensor-Symposium ; (9, 2009, Dresden)
SP  - 201
EP  - 204
PB  - TUDpress
CY  - Dresden
ER  - 
TY  - JOUR
A1  - Werner, Frederik
A1  - Groebel, Simone
A1  - Wagner, Torsten
A1  - Yoshinobu, Tatsuo
A1  - Selmer, Thorsten
A1  - Baumann, Marcus
A1  - Schöning, Michael Josef
T1  - Überwachung der metabolischen Aktivität von Mikroorganismen zur Kontrolle des biologischen Prozesses im Biogasfermenter
JF  - Biogas 2011 : Energieträger der Zukunft ; 6. Fachtagung, Fachtagung Braunschweig, 08. und 09. Juni 2011 / VDI Energie und Umwelt
Y1  - 2011
SN  - 978-3-18-092121-1
N1  - Gesellschaft Energie und Umwelt ; Fachtagung Biogas ; (6 : ; 2011.06.08-09 : ; Braunschweig) ; 	VDI-Berichte ; 2121
SP  - 285
EP  - 286
PB  - VDI-Verl.
CY  - Düsseldorf
ER  - 
TY  - JOUR
A1  - Werner, Frederik
A1  - Krumbe, Christoph
A1  - Schumacher, Katharina
A1  - Groebel, Simone
A1  - Spelthahn, Heiko
A1  - Stellberg, Michael
A1  - Wagner, Torsten
A1  - Yoshinobu, Tatsuo
A1  - Selmer, Thorsten
A1  - Keusgen, Michael
A1  - Baumann, Marcus
A1  - Schöning, Michael Josef
T1  - Determination of the extracellular acidification of Escherichia coli by a light-addressable potentiometric sensor
JF  - Physica status solidi (a) : applications and material science. 208 (2011), H. 6
Y1  - 2011
SN  - 1862-6319
SP  - 1340
EP  - 1344
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Werner, Frederik
A1  - Miyamoto, Ko-ichiro
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
A1  - Yoshinobu, Tatsuo
T1  - Lateral resolution enhancement of pulse-driven light-addressable potentiometric sensor
JF  - Sensor and Actuators B: Chemical
N2  - To study chemical and biological processes, spatially resolved determination of the concentrations of one or more analyte species is of distinct interest. With a light-addressable potentiometric sensor (LAPS), chemical images can be created, which visualize the concentration distribution above the sensor plate. One important challenge is to achieve a good lateral resolution in order to detect events that take place in a small and limited region. LAPS utilizes a focused light spot to address the measurement region. By moving this light spot along the semiconductor sensor plate, the concentration distribution can be observed. In this study, we show that utilizing a pulse as light excitation instead of a traditionally used continuously modulated light excitation, the lateral resolution can be improved by a factor of 6 or more.
KW  - Chemical images
KW  - LAPS
KW  - Light-addressable potentiometric sensor
Y1  - 2017
U6  - https://doi.org/10.1016/j.snb.2017.02.057
SN  - 0925-4005
VL  - 248
SP  - 961
EP  - 965
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Werner, Frederik
A1  - Schusser, Sebastian
A1  - Spalthahn, Heiko
A1  - Wagner, Torsten
A1  - Yoshinobu, Tatsuo
A1  - Schöning, Michael Josef
T1  - Field-programmable gate array based controller for multi spot light-addressable potentiometric sensors with integrated signal correction mode
JF  - Electrochimica Acta
N2  - A light-addressable potentiometric sensor (LAPS) can measure the concentration of one or several analytes at the sensor surface simultaneously in a spatially resolved manner. A modulated light pointer stimulates the semiconductor structure at the area of interest and a responding photocurrent can be read out. By simultaneous stimulation of several areas with light pointers of different modulation frequencies, the read out can be performed at the same time. With the new proposed controller electronic based on a field-programmable gate array (FPGA), it is possible to control the modulation frequencies, phase shifts, and light brightness of multiple light pointers independently and simultaneously. Thus, it is possible to investigate the frequency response of the sensor, and to examine the analyte concentration by the determination of the surface potential with the help of current/voltage curves and phase/voltage curves. Additionally, the ability to individually change the light intensities of each light pointer is used to perform signal correction.
Y1  - 2011
U6  - https://doi.org/10.1016/j.electacta.2011.03.012
SN  - 0013-4686
VL  - 56
IS  - 26
SP  - 9656
EP  - 9660
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Werner, Frederik
A1  - Spelthahn, H.
A1  - Schöning, Michael Josef
A1  - Krumbe, C.
A1  - Wagner, Torsten
A1  - Yoshinobu, T.
A1  - Keusgen, M.
T1  - Neue Ansteuerungselektronik für LAPS-basierte Biosensoren zur gleichzeitig ortsaufgelösten Messung der pH-Konzentration
JF  - Sensoren und Messsysteme 2010 [Elektronische Ressource] : Vorträge der 15. ITG/GMA-Fachtagung vom 18. bis 19. Mai 2010 in Nürnberg / Informationstechnische Gesellschaft im VDE (ITG); VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik (GMA)
Y1  - 2010
SN  - 978-3-8007-3260-9
N1  - Fachtagung Sensoren und Messsysteme 15, 2010, Nürnberg ; Gesellschaft Mess- und Automatisierungstechnik
SP  - 109
EP  - 114
PB  - VDE Verlag
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Werner, Frederik
A1  - Takenaga, Shoko
A1  - Taki, Hidenori
A1  - Sawada, Kazuaki
A1  - Schöning, Michael Josef
T1  - Comparison of label-free ACh-imaging sensors based on CCD and LAPS
JF  - Sensors and  Actuators B: Chemical (2012)
N2  - Semiconductor-based chemical imaging sensors, like the light-addressable potentiometric sensor (LAPS) or the pH-imaging sensor based on a charge-coupled device (CCD), are becoming a powerful tool for label-free imaging of biological phenomena. We have proposed a polyion-based enzymatic membrane to develop an acetylcholine (ACh) imaging sensor for neural cell-activity observations. In this study, a CCD-type ACh-imaging sensor and a LAPS-type ACh-imaging sensor were fabricated and the prospect of both sensors was clarified by making a comparison of their basic characteristics.
Y1  - 2013
SN  - 0925-4005
VL  - 177
SP  - 745
EP  - 752
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Werner, Frederik
A1  - Wagner, Torsten
A1  - Miyamoto, Ko-ichiro
A1  - Yoshinobu, Tatsuo
A1  - Schöning, Michael Josef
T1  - High speed and high resolution chemical imaging based on a new type of OLED-LAPS set-up
JF  - Sensors and Actuators B: Chemical
N2  - Light-addressable potentiometric sensors (LAPS) are field-effect-based sensors. A modulated light source is used to define the particular measurement spot to perform spatially resolved measurements of chemical species and to generate chemical images. In this work, an organic-LED (OLED) display has been chosen as a light source. This allows high measurement resolution and miniaturisation of the system. A new developed driving method for the OLED display optimised for LAPS-based measurements is demonstrated. The new method enables to define modulation frequencies between 1 kHz and 16 kHz and hence, reduces the measurement time of a chemical image by a factor of 40 compared to the traditional addressing of an OLED display.
Y1  - 2012
U6  - https://doi.org/10.1016/j.snb.2011.12.102
SN  - 0925-4005
N1  - Part of special issue "Selected Papers presented at Eurosensors XXV"
VL  - 175
SP  - 118
EP  - 122
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Werner, Frederik
A1  - Wagner, Torsten
A1  - Miyamoto, Ko-ichiro
A1  - Yoshinobu, Tatsuo
A1  - Schöning, Michael Josef
T1  - High speed and high resolution chemical imaging based on a new type of OLED-LAPS set-up
JF  - Procedia Engineering. 25 (2011)
Y1  - 2011
SN  - 1877-7058
N1  - EurosensorsXXV ; Proc. Eurosensors XXV, September 4-7, 2011, Athens, Greece
SP  - 346
EP  - 349
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Werner, Frederik
A1  - Wagner, Torsten
A1  - Yoshinobu, Tatsuo
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Frequency behaviour of light-addressable potentiometric sensors
JF  - Physica Status Solidi (A)
N2  - Light-addressable potentiometric sensors (LAPS) are semiconductor-based potentiometric sensors, with the advantage to detect the concentration of a chemical species in a liquid solution above the sensor surface in a spatially resolved manner. The addressing is achieved by a modulated and focused light source illuminating the semiconductor and generating a concentration-depending photocurrent. This work introduces a LAPS set-up that is able to monitor the electrical impedance in addition to the photocurrent. The impedance spectra of a LAPS structure, with and without illumination, as well as the frequency behaviour of the LAPS measurement are investigated. The measurements are supported by electrical equivalent circuits to explain the impedance and the LAPS-frequency behaviour. The work investigates the influence of different parameters on the frequency behaviour of the LAPS. Furthermore, the phase shift of the photocurrent, the influence of the surface potential as well as the changes of the sensor impedance will be discussed.
Y1  - 2013
U6  - https://doi.org/10.1002/pssa.201200929
SN  - 1521-396X ; 0031-8965
VL  - 210
IS  - 5
SP  - 884
EP  - 891
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Wert, Stefan
A1  - Iken, Heiko
A1  - Schöning, Michael Josef
A1  - Matysik, Frank-Michael
T1  - Development of a temperature‐pulse enhanced electrochemical glucose biosensor and characterization of its stability via scanning electrochemical microscopy
JF  - Electroanalysis
N2  - Glucose oxidase (GOx) is an enzyme frequently used in glucose biosensors. As increased temperatures can enhance the performance of electrochemical sensors, we investigated the impact of temperature pulses on GOx that was drop-coated on flattened Pt microwires. The wires were heated by an alternating current. The sensitivity towards glucose and the temperature stability of GOx was investigated by amperometry. An up to 22-fold increase of sensitivity was observed. Spatially resolved enzyme activity changes were investigated via scanning electrochemical microscopy. The application of short (<100 ms) heat pulses was associated with less thermal inactivation of the immobilized GOx than long-term heating.
Y1  - 2021
U6  - https://doi.org/10.1002/elan.202100089
SN  - 1521-4109
IS  - Early View
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Weßling, Matthias
T1  - Der Einsatz fertiger Videofilme in der Personalentwicklung
JF  - Personal – Zeitschrift für Human Resource Management. 50 (1998), H. 3
Y1  - 1998
SN  - 0031-5605
SP  - 128
EP  - 130
ER  - 
TY  - JOUR
A1  - Weßling, Matthias
T1  - Coaching - Literaturreport deutschsprachiger Monographien
JF  - Personal – Zeitschrift für Human Resource Management. 49 (1997), H. 7
Y1  - 1997
SN  - 0031-5605
SP  - 377
EP  - 378
ER  - 
TY  - JOUR
A1  - Weßling, Matthias
T1  - Angewandte Psychologie für (Nachwuchs-) Manager: Die Förderung von Eigenverantwortung und sozialer Handlungskompetenz durch Verhaltenstrainings
JF  - Psychologie an Fachhochschulen / Günther, Ullrich [Hrsg.]
Y1  - 1999
SN  - 3-934252-29-X
SP  - 72
EP  - 92
PB  - Pabst
CY  - Lengerich [u.a.]
ER  - 
TY  - JOUR
A1  - Weßling, Matthias
T1  - Existenzgründung - Intensivtraining macht fit
JF  - DUZ : das unabhängige Hochschulmagazin. 54 (1998), H. 5
Y1  - 1998
SN  - 0936-4501
SP  - 14
EP  - 15
ER  - 
TY  - JOUR
A1  - Weßling, Matthias
T1  - Existenzgründung - ein didaktisch innovatives Fachhochschulseminar
JF  - Die neue Hochschule : Nachrichten, Meinungen, Berichte / Hrsg.: Hochschullehrerbund - Bundesvereinigung - e.V. (hlb). 39 (1998), H. 2
Y1  - 1998
SN  - 0340-448x
SP  - 7
EP  - 9
ER  - 
TY  - JOUR
A1  - Weßling, Matthias
T1  - Existenzgründung - Wege in die Selbständigkeit: Erfahrungsbericht eines neuen Seminars
JF  - Fachblatt / der Rektor der Fachhochschule Aachen (1997)
Y1  - 1997
SN  - 1430-7707
SP  - 6
EP  - 7
ER  - 
TY  - JOUR
A1  - Weßling, Matthias
T1  - Unternehmenskultur
JF  - Ergebnisse empirischer betriebswirtschaftlicher Forschung : zu einer Realtheorie der Unternehmung ; Festschrift für Eberhard Witte / Jürgen Hauschildt ... (Hrsg.)
Y1  - 1993
SN  - 3-7910-0678-9
SP  - 115
EP  - 134
PB  - Schäffer-Poeschel
CY  - Stuttgart
ER  - 
TY  - JOUR
A1  - Weßling, Matthias
T1  - Como lidar com culturas estrangeiras: um treinamento inovador ao base da metodologia de “experiential learning” através Kolb & Fry / Wessling, Matthias
JF  - Revista Nic / Universidade Estadual de Londrina. 1 (2009), H. 2
Y1  - 2009
SN  - 1984-2325
ER  - 
TY  - JOUR
A1  - Weßling, Matthias
T1  - Aktives Nachfolger-Coaching für den Mittelstand setzt früh an. Innovative Idee für Studierende der FH Aachen
JF  - Wirtschaftliche Nachrichten der Industrie- und Handelskammer Aachen / IHK (2008)
Y1  - 2008
SP  - 12
EP  - 13
ER  - 
TY  - JOUR
A1  - Weßling, Matthias
T1  - Von Daniel Düsentrieb zu Dagobert Duck. Trinationale Master Class in High-Tech Entrepreneurship
JF  - Dimensionen : Magazin der Fachhochschule Aachen (2009)
Y1  - 2009
SP  - 46
ER  - 
TY  - JOUR
A1  - Weßling, Matthias
T1  - Innovative Didaktik auf internationalem Niveau
JF  - Dimensionen : Magazin der Fachhochschule Aachen (2008)
Y1  - 2008
SP  - 36
EP  - 37
ER  - 
TY  - JOUR
A1  - Weßling, Matthias
A1  - Runte, Reinhard C.
T1  - Konzept und Praxis unternehmensumfassender Teamentwicklung: Teamentwicklung bei SAINT-GOBAIN GLASS Deutschland / Einhard C. Runte ; Matthias Weßling
JF  - Personal – Zeitschrift für Human Resource Management. 54 (2002), H. 9
Y1  - 2002
SN  - 0031-5605
SP  - 32
EP  - 34
ER  - 
TY  - JOUR
A1  - Weßling, Matthias
A1  - Runte, Reinhard C.
T1  - Konzept und Praxis unternehmensumfassender Teamentwicklung: Vom Leitbild zur gelebten Wirklichkeit / Einhard C. Runte ; Matthias Weßling
JF  - Personal – Zeitschrift für Human Resource Management. 54 (2002), H. 8
Y1  - 2002
SN  - 0031-5605
SP  - 42
EP  - 45
ER  - 
TY  - JOUR
A1  - Whitehead, Mark
A1  - Öhlschläger, Peter
A1  - Almajhdi, Fahad N.
A1  - Alloza, Leonor
A1  - Marzábal, Pablo
A1  - Meyers, Ann E.
A1  - Hitzeroth, Inga I.
A1  - Rybicki, Edward P.
T1  - Human papillomavirus (HPV) type 16 E7 protein bodies cause tumour regression in mice
JF  - BMC cancer
Y1  - 2014
U6  - https://doi.org/10.1186/1471-2407-14-367
SN  - 1471-2407
IS  - 14:367
SP  - 1
EP  - 15
PB  - BioMed Central
CY  - London
ER  - 
TY  - JOUR
A1  - Wiegand, Sandra
A1  - Dietrich, Sascha
A1  - Hertel, Robert
A1  - Bongaerts, Johannes
A1  - Evers, Stefan
A1  - Volland, Sonja
A1  - Daniel, Rolf
A1  - Liesegang, Heiko
T1  - RNA-Seq of Bacillus licheniformis: active regulatory RNA features expressed within a productive fermentation
JF  - BMC genomics
Y1  - 2013
SN  - 1471-2164
VL  - Vol. 14
SP  - 667
PB  - BioMed Central
CY  - London
ER  - 
TY  - JOUR
A1  - Wiegand, Sandra
A1  - Voigt, Birgit
A1  - Albrecht, Dirk
A1  - Bongaerts, Johannes
A1  - Evers, Stefan
A1  - Hecker, Michael
A1  - Daniel, Rolf
A1  - Liesegang, Heiko
T1  - Fermentation stage-dependent adaptations of Bacillus licheniformis during enzyme production
JF  - Microbial Cell Factories
Y1  - 2013
U6  - https://doi.org/10.1186/1475-2859-12-120
SN  - 1475-2859
VL  - 12
SP  - 120
PB  - Biomed Central
CY  - London
ER  - 
TY  - JOUR
A1  - Wiescher, A.
A1  - Kotliar, Konstantin
A1  - Neuhann, T.
A1  - Lanzl, Ines M.
T1  - Rasch progrediente Visusminderung beider Augen bei einem jungen Patienten
JF  - Der Ophthalmologe
N2  - Ein 34-jähriger männlicher Patient stellte sich zur Abklärung einer seit dem 9. Lebensjahr bestehenden und im letzten Jahr rasch progredienten Visusminderung beider Augen bei uns vor. Er beschrieb eine subjektiv zunehmende, im Spiegel für ihn selbst sichtbare, weißliche Trübung in der Pupille beidseits und eine starke Blendempfindlichkeit. Nebenbefundlich gab er rezidivierende Konjunktivitiden und morgens verklebte Lider an. Eine Allergie auf Gräserpollen und eine Unverträglichkeit auf Alkohol sowie mehrere Lebensmittel seien ebenfalls bekannt.

Zusätzlich leidet der Patient an stark ausgeprägtem atopischem Ekzem. Dieses wurde nie systemisch, sondern nur bei Bedarf mit kortisonhaltiger Salbe therapiert.
Y1  - 2010
U6  - https://doi.org/10.1007/s00347-007-1586-x
SN  - 1433-0423
VL  - 105
IS  - 4
SP  - 389
EP  - 392
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Wiesen, Sebastian
A1  - Tippkötter, Nils
A1  - Muffler, Kai
A1  - Suck, Kirstin
A1  - Sohling, Ulrich
A1  - Ruf, Friedrich
A1  - Ulber, Roland
T1  - Adsorption of fatty acids to layered double hydroxides in aqueous systems
JF  - Adsorption
N2  - Due to their anion exchange characteristics, layered double hydroxides (LDHs) are suitable for the detoxification of aqueous, fatty acid containing fermentation substrates. The aim of this study is to examine the adsorption mechanism, using crude glycerol from plant oil esterification as a model system. Changes in the intercalation structure in relation to the amount of fatty acids adsorbed are monitored by X-ray diffraction and infra-red spectroscopy. Additionally, calcination of LDH is investigated in order to increase the binding capacity for fatty acids. Our data propose that, at ambient temperature, fatty acids can be bound to the hydrotalcite by adsorption or in addition by intercalation, depending on fatty acid concentration. The adsorption of fatty acids from crude glycerol shows a BET-like behavior. Above a fatty acid concentration of 3.5 g L−1, intercalation of fatty acids can be shown by the appearance of an increased interlayer spacing. This observation suggests a two phase adsorption process. Calcination of LDHs allows increasing the binding capacity for fatty acids by more than six times, mainly by reduction of structural CO32−.
Y1  - 2015
VL  - 21
IS  - 6-7
SP  - 459
EP  - 466
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Wiesen, Sebastian
A1  - Tippkötter, Nils
A1  - Muffler, Kai
A1  - Suck, Kirstin
A1  - Sohling, Ulrich
A1  - Ruf, Nils
A1  - Ulber, Roland
T1  - Adsorptive Vorbehandlung von Rohglycerin für die 1,3-Propandiol Fermentation mit Clostridium diolis
JF  - Chemie Ingenieur Technik
N2  - Bei der Gewinnung von Fettsäuren aus Pflanzenölen, z. B. zur Herstellung von Biopolymeren, oder bei der Biodiesel- und Seifenproduktion, fällt Glycerin als Nebenprodukt an. Bei der Biokonversion dieses Rohstoffes zu 1,3-Propandiol wird der Produktionsorganismus Clostridium diolis durch Verunreinigungen im Rohglycerin gehemmt. Als inhibierende Substanzen konnten freie Fettsäuren identifiziert werden. Mithilfe eines adsorptiven Aufarbeitungsverfahrens ist es gelungen, die Fettsäuren zu entfernen und die Konversionseffizienz zu 1,3-Propandiol zu erhöhen.
Y1  - 2014
U6  - https://doi.org/10.1002/cite.201300080
N1  - Englischer Titel: Adsorptive Pretreatment of Crude Glycerol Prior to Fermentation to 1,3-Propanediole by Clostridium Diolis
VL  - 86
IS  - 1-2
SP  - 129
EP  - 135
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Wiezorek, E.
A1  - Baumann, Marcus
T1  - Stadtökologie in der Stadtplanung: der "Stadtökologische Beitrag" Aachen
JF  - Wechselwirkung : Wissenschaft & vernetztes Denken
Y1  - 1999
SN  - 0172-1623
VL  - 21
IS  - 97
SP  - 28
EP  - 37
ER  - 
TY  - JOUR
A1  - Wilbring, Daniela
A1  - Enning, Manfred
T1  - Stromversorgung auf Güterwagen - Aktuelle Bemühungen zur Standardisierung
JF  - ETR - Eisenbahntechnische Rundschau
Y1  - 2019
SN  - 0013-2845
VL  - 68
IS  - 11
SP  - 64
EP  - 67
PB  - DVV Media Group
CY  - Hamburg
ER  - 
TY  - JOUR
A1  - Wilbring, Daniela
A1  - Enning, Manfred
A1  - Pfaff, Raphael
A1  - Schmidt, Bernd
T1  - Neue Perspektiven für die Bahn in der Produktions- und Distributionslogistik durch Prozessautomation
JF  - ETR - Eisenbahntechnische Rundschau
Y1  - 2020
SN  - 0013-2845
VL  - 69
IS  - 3
SP  - 15
EP  - 19
ER  - 
TY  - JOUR
A1  - Wild, Dominik
A1  - Schrezenmeier, Johannes
A1  - Czupalla, Markus
A1  - Förstner, Roger
T1  - Thermal Characterization of additive manufactured Integral Structures for Phase Change Applications
JF  - 2020 International Conference on Environmental Systems
N2  - “Infused Thermal Solutions” (ITS) introduces a method for passive thermal control to stabilize structural components thermally without active heating and cooling systems, by using phase change material (PCM) in combination with lattice – both embedded into an additive manufactured integral structure. The technology is currently under development. This paper presents the results of the thermal property measurements performed on additive manufactured ITS breadboards. Within the breadboard campaigns key characteristics of the additive manufactured specimens were derived: Mechanical parameters: specimen impermeability, minimum wall thickness, lattice structure, subsequent heat treatment. Thermal properties: thermo-optical surface properties of the additive manufactured raw material, thermal conductivity and specific heat capacity measurements. As a conclusion the paper introduces an overview of potential ITS hardware applications, expected to increase the thermal performance.
Y1  - 2020
PB  - Texas Tech University
ER  - 
TY  - JOUR
A1  - Wilhelm, Wolff
A1  - Berndt, Heinz
A1  - Brandenburg, Dietrich
T1  - Zur Synthese der Hühnerinsulin-A-Kette, I : Darstellung der Fragmente A1–8, A9–15, A1–7 und A8–15
JF  - Hoppe-Seyler's Zeitschrift für physiologische Chemie
Y1  - 1979
U6  - https://doi.org/10.1515/bchm2.1979.360.2.1559
SN  - 1437-4315
SN  - 0018-4888
VL  - 360
IS  - 2
SP  - 1559
EP  - 1568
ER  - 
TY  - JOUR
A1  - Wilke, Thomas
T1  - Newly found plans for the chapel of the Holy Shroud
JF  - Studi Piemontesi
Y1  - 2017
SN  - 0392-7261
VL  - XLVI
IS  - 1
SP  - 75
EP  - 85
ER  - 
TY  - JOUR
A1  - Wilke, Thomas
T1  - [Rezension zu:] Deutsch, Kristina: Jean Marot. Un graveur d'architecture à l'époque de Louis XIV. (= Ars et Scientia; 12), Berlin; Boston 2015.
JF  - ArtHist.net
Y1  - 2017
ER  - 
TY  - JOUR
A1  - Wilke, Thomas
T1  - [Rezension zu: ] Yvonne Prinzessin von Croÿ: Das Hôtel de Galliffet (1784-1792). Pariser Baupraxis undAusstattungskunst am feudalen Privatbau des ausgehenden Ancien Régime, Hildesheim: Olms 2014
JF  - Sehepunkte
Y1  - 2015
SN  - 1618-6168
VL  - 15
IS  - 9
ER  - 
TY  - JOUR
A1  - Wilke, Thomas
T1  - [Rezension zu: ] Simone Meyder: "Mehr königlich als frei". Robert de Cotte und das Bauen in Straßburgnach 1681, Münster: Waxmann 2010
JF  - Sehepunkte
Y1  - 2011
SN  - 1618-6168
VL  - 11
IS  - 2
ER  - 
TY  - JOUR
A1  - Wilke, Thomas
T1  - [Rezension zu: ] Gundula Lang: Bürgerliche Privatgärten in deutschen Landen um 1800. Fallstudien zu Gestalt, Nutzung und Bedeutung im Kontext des gesellschaftlichen Umbruchs, Worms: Wernersche Verlagsgesellschaft 2007
JF  - Sehepunkte
Y1  - 2008
SN  - 1618-6168
VL  - 8
IS  - 9
ER  - 
TY  - JOUR
A1  - Wilke, Thomas
T1  - Architekturzeichnung als Instrument der Theoriebildung. Lineamenta vs. Portraicture – Architekturdarstellung zwischen Wissenschaft und Öffentlichkeit. Tagung des DFG-Netzwerks-Schnittstelle Bild in Zusammenarbeit mit dem Lehrstuhl für Kunstgeschichte der Universität Regensburg, 28.4.2012.
JF  - Kunstchronik
Y1  - 2012
SN  - 0023-5474
VL  - 65
IS  - 9/10
SP  - 494
EP  - 499
PB  - Fachverlag Hans Carl
CY  - Nürnberg
ER  - 
TY  - JOUR
A1  - Wilke, Thomas
T1  - [Tagungsbericht zu:] Bourbon – Habsburg – Oranien 1700 (Marburg, 19. - 21.10.2006).
JF  - ArtHist.net
Y1  - 2006
ER  - 
TY  - JOUR
A1  - Wilke, Thomas
T1  - Gebaute Geschichte in Turin
JF  - Kunsttexte.de
N2  - Städte sind Stein gewordene Geschichte. Ihre realisierte Form ermöglicht Geschichte zu erleben und die Stadtentwicklung nachzuvollziehen. Besonders in Turin ist ablesbar, wie das Haus Savoyen den Ausbau der neuen Hauptstadt zu einer der führenden Barockmetropolen Europas beeinflusste.
Y1  - 2014
U6  - https://doi.org/10.18452/7197
SN  - 1618-8101
VL  - 2014
IS  - 1
PB  - Humboldt-Universität zu Berlin
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Wilke, Thomas
T1  - Vergessene Planungen – Die Kapelle im Neuen Schloß in Stuttgart
JF  - Zeitschrift für württembergische Landesgeschichte (ZWLG)
Y1  - 2004
SN  - 0044-3786
VL  - 63
SP  - 169
EP  - 201
ER  - 
TY  - JOUR
A1  - Willms, Herbert
T1  - Regelung eines H2/O2-Dampferzeugers mit Hilfe eines modifizierten Zirkondioxid-Sensors
JF  - Chemie Ingenieur Technik
Y1  - 1993
SN  - 0009-286X
VL  - 65
IS  - 8
SP  - 954
EP  - 956
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Willms, Herbert
A1  - Beer, Stefan
T1  - Regelung eines H(IND 2)/O(IND 2)-Dampferzeugers
Y1  - 1992
SN  - 0939-2963
N1  - Report: Regelung eines H(IND 2)/O(IND 2)-Dampferzeugers, Deutsche Forschungsanstalt fuer Luft- und Raumfahrt e.V. (DLR), Hardthausen am Kocher (DE). Inst. fuer Chemische Antriebe und Verfahrenstechnik, Sep 1992, (116 S. Gesamtumfang)
ER  - 
TY  - JOUR
A1  - Willms, Herbert
A1  - Beer, Stefan
A1  - Fröhlke, K.
A1  - Haidn, O.J.
A1  - [u.a.], 
T1  - Regelung eines Wasserstoff-/Sauerstoff-Dampferzeugers mit Hilfe eines modifizierten Zirkondioxid-Sensors
Y1  - 1993
N1  - Report: Deutsche Forschungsanstalt für Luft- und Raumfahrt, EN-CA/E (1993) Seite 1-17 (17 Seiten, 14 Bilder, 2 Tabellen, 14 Quellen)
ER  - 
TY  - JOUR
A1  - Wilming, Anja
A1  - Begemann, Jens
A1  - Kuhne, Stefan
A1  - Regestein, Lars
A1  - Bongaerts, Johannes
A1  - Evers, Stefan
A1  - Maurer, Karl-Heinz
A1  - Büchs, Jochen
T1  - Metabolic studies of γ-polyglutamic acid production in Bacillus licheniformis by small-scale continuous cultivations
JF  - Biochemical engineering journal
Y1  - 2013
SN  - 1873-295X (E-Journal); 1369-703X (Print)
VL  - Vol. 73
SP  - 29
EP  - 37
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wilson, C. E.
A1  - Dickie, A. P.
A1  - Schreiter, K.
A1  - Wehr, R.
A1  - Wilson, E. M.
A1  - Bial, J.
A1  - Scheer, Nico
A1  - Wilson, I. D.
A1  - Riley, R. J.
T1  - The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice
JF  - Archives of Toxicology
N2  - The pharmacokinetics of diclofenac were investigated following single oral doses of 10 mg/kg to chimeric liver humanized and murinized FRG and C57BL/6 mice. In addition, the metabolism and excretion were investigated in chimeric liver humanized and murinized FRG mice. Diclofenac reached maximum blood concentrations of 2.43 ± 0.9 µg/mL (n = 3) at 0.25 h post-dose with an AUCinf of 3.67 µg h/mL and an effective half-life of 0.86 h (n = 2). In the murinized animals, maximum blood concentrations were determined as 3.86 ± 2.31 µg/mL at 0.25 h post-dose with an AUCinf of 4.94 ± 2.93 µg h/mL and a half-life of 0.52 ± 0.03 h (n = 3). In C57BL/6J mice, mean peak blood concentrations of 2.31 ± 0.53 µg/mL were seen 0.25 h post-dose with a mean AUCinf of 2.10 ± 0.49 µg h/mL and a half-life of 0.51 ± 0.49 h (n = 3). Analysis of blood indicated only trace quantities of drug-related material in chimeric humanized and murinized FRG mice. Metabolic profiling of urine, bile and faecal extracts revealed a complex pattern of metabolites for both humanized and murinized animals with, in addition to unchanged parent drug, a variety of hydroxylated and conjugated metabolites detected. The profiles in humanized mice were different to those of both murinized and wild-type animals, e.g., a higher proportion of the dose was detected in the form of acyl glucuronide metabolites and much reduced amounts as taurine conjugates. Comparison of the metabolic profiles obtained from the present study with previously published data from C57BL/6J mice and humans revealed a greater, though not complete, match between chimeric humanized mice and humans, such that the liver humanized FRG model may represent a model for assessing the biotransformation of such compounds in humans.
Y1  - 2018
U6  - https://doi.org/10.1007/s00204-018-2212-1
SN  - 1432-0738
VL  - 92
IS  - 6
SP  - 1953
EP  - 1967
PB  - Springer
ER  - 
TY  - JOUR
A1  - Wilson, Ian D.
A1  - Wilson, Claire E.
A1  - Scheer, Nico
A1  - Dickie, A.P.
A1  - Schreiter, K.
A1  - Wilson, E. M.
A1  - Riley, R. J.
A1  - Wehr, R.
A1  - Bial, J.
T1  - The Pharmacokinetics and Metabolism of Lumiracoxib in Chimeric Humanized and Murinized FRG Mice
JF  - Biochemical pharmacology
Y1  - 2017
U6  - https://doi.org/10.1016/j.bcp.2017.03.015
SN  - 1873-2968
VL  - Volume 135
SP  - 139
EP  - 150
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wilson, T. L.
A1  - Blome, Hans-Joachim
T1  - The Pioneer anomaly and a rotating Gödel universe
JF  - Advances in Space Research
Y1  - 2009
SN  - 0273-1177
VL  - 44
IS  - 11
SP  - 1345
EP  - 1353
ER  - 
TY  - JOUR
A1  - Wilson, Thomas L
A1  - Blome, Hans-Joachim
A1  - LaFave, Norman
T1  - Astrophysical Cosmology Using a Lunar Ligo
JF  - Engineering, construction, and operations in space V : proceedings of the Fifth International Conference on Space '96, Albuquerque, New Mexico, June 1-6, 1996 / sponsored by Aerospace Division of the American Society of Civil Engineers ... [et al.]; edite
Y1  - 1996
SN  - 0-7844-0177-2
SP  - 861
EP  - 863
PB  - The Society
CY  - New York
ER  - 
TY  - JOUR
A1  - Winckler, Silvia
A1  - Krueger, Rolf
A1  - Schnitzler, Thomas
A1  - Zang, Werner
A1  - Fischer, Rainer
A1  - Biselli, Manfred
T1  - A sensitive monitoring system for mammalian cell cultivation processes: a PAT approach
JF  - Bioprocess and biosystems engineering
N2  - Biopharmaceuticals such as antibodies are produced in cultivated mammalian cells, which must be monitored to comply with good manufacturing practice. We, therefore, developed a fully automated system comprising a specific exhaust gas analyzer, inline analytics and a corresponding algorithm to precisely determine the oxygen uptake rate, carbon dioxide evolution rate, carbon dioxide transfer rate, transfer quotient and respiratory quotient without interrupting the ongoing cultivation, in order to assess its reproducibility. The system was verified using chemical simulation experiments and was able to measure the respiratory activity of hybridoma cells and DG44 cells (derived from Chinese hamster ovary cells) with satisfactory results at a minimum viable cell density of ~2.0 × 10⁵ cells ml⁻¹. The system was suitable for both batch and fed-batch cultivations in bubble-aerated and membrane-aerated reactors, with and without the control of pH and dissolved oxygen.
Y1  - 2014
U6  - https://doi.org/10.1007/s00449-013-1062-8
SN  - 1615-7591 (Print) 1615-7605 (Online)
VL  - 37
IS  - 5
SP  - 901
EP  - 912
PB  - Springer
CY  - Berlin, Heidelberg
ER  - 
TY  - JOUR
A1  - Winkler, Norbert
T1  - Vermessung zur Bauzeit der Zitadelle und heute : Bastion Wilhelmus / von Norbert Winkler
JF  - 4 Bastionen, 4 Aspekte : aktuelle Arbeiten zur Zitadelle Jülich ; Katalog zur Ausstellung im Hexenturm 10.11.95 - 14.02.96 / [Veranst.: Stadtgeschichtliches Museum Jülich]. Mit Beitr. von Guido von Büren ... [Hrsg.: Marcell Perse]
Y1  - 1995
N1  - Führer des Stadtgeschichtlichen Museums Jülich ; 7
SP  - 77
EP  - 115
CY  - Jülich
ER  - 
TY  - JOUR
A1  - Winkler, Norbert
T1  - Vermessung
JF  - Zahlentafeln für den Baubetrieb / Hoffmann, Manfred ; Kuhlmann, Willy [Hrsg.]. 7., vollst. überarb. Aufl.
Y1  - 2006
SN  - 3-519-65220-X
N1  - Kapitel 3
SP  - 147
EP  - 160
PB  - Teubner
CY  - Wiesbaden
ER  - 
TY  - JOUR
A1  - Winkler, Norbert
T1  - Vermessung
JF  - Beispiele für die Baubetriebspraxis / Hoffmann, Manfred ; Kuhlmann, Willy [Hrsg.].
Y1  - 2006
SN  - 978-3-8351-0002-2
N1  - Kapitel 2
SP  - 9
EP  - 34
PB  - Teubner
CY  - Wiesbaden
ER  - 
TY  - JOUR
A1  - Wissen, M.
A1  - Bogdanski, N.
A1  - Scheer, H.-C.
A1  - Bitz, Andreas
A1  - Ahrens, G.
A1  - Gruetzner, G.
T1  - Implication of the light polarisation for UV curing of pre-patterned resists
JF  - Microelectronic Engineering
Y1  - 2005
U6  - https://doi.org/10.1016/j.mee.2004.12.099
SN  - 0167-9317
VL  - 78-79
SP  - 659
EP  - 664
ER  - 
TY  - JOUR
A1  - Wissenbach, U.
A1  - Six, S.
A1  - Bongaerts, Johannes
A1  - Ternes, D.
A1  - Steinwachs, S.
A1  - Unden, G.
T1  - A third periplasmic transport system for l-arginine in Escherichia coli: molecular characterization of the artPIQMJ genes, arginine binding and transport
JF  - Molecular microbiology
Y1  - 1995
SN  - 1365-2958 (E-Journal); 0950-382x (Print)
VL  - Vol. 17
IS  - Iss. 4
SP  - 675
EP  - 686
ER  - 
TY  - JOUR
A1  - Witt, Klaus
A1  - Bogner, D.
T1  - Druckmessung mit zukunftsorientierten Perspektiven
JF  - Sensor Report. 5 (1990), H. 1
Y1  - 1990
SN  - 0179-9592
SP  - 8
EP  - 14
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
T1  - The microgravity User Support Centre
JF  - Space Technology - Industrial and Commercial Applications. 13 (1993), H. 2
Y1  - 1993
SN  - 0892-9270
SP  - 121
EP  - 124
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
T1  - Overview of Space Operations at DLR
Y1  - 2000
N1  - SpaceOps2000 Conference, Toulouse, Frankreich,19-23 June 2000
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
A1  - Bewersdorff, A.
A1  - Görler, G.P.
A1  - Otto, G.
T1  - Solidification of silver-germanium alloys in an amorphous matrix aboard the space station Mir
JF  - Acta Astronautica. 29 (1993), H. 7
Y1  - 1993
SN  - 0094-5765
SP  - 547
EP  - 552
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
A1  - Bibring, J.-P.
A1  - Rosenbauer, H.
A1  - Boehnhardt, H.
T1  - The Rosetta Lander (“Philae”) Investigations  / Bibring, J.-P. ; Rosenbauer, H. ; Boehnhardt, H. ;  [...] Wittmann, K.
JF  - Space Science Reviews. 128 (2007), H. 1-4
Y1  - 2007
SN  - 0038-6308
SP  - 205
EP  - 220
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
A1  - Feuerbacher, B.
A1  - Ulamec, S.
A1  - Rosenbauer, H. (u.a.)
T1  - Rosetta Lander - In Situ Characterisation of a Comet Nucleus
JF  - Acta Astronautica. 45 (1999), H. 4-9
Y1  - 1999
SN  - 0094-5765
SP  - 389
EP  - 395
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
A1  - Fortezza, R.
T1  - Telescience opportunities in the precursor flights
JF  - Space Technology - Industrial and Commercial Applications. 13 (1992), H. 2
Y1  - 1992
SN  - 0892-9270
SP  - 221
EP  - 226
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
A1  - Gillessen, F.
A1  - Otto, G.
A1  - Röstel, R.
T1  - Undercooling and solidification of metallic melts suspended in a non-nucleating matrix: Experiment NUCAL of the German Spacelab Mission D-2
JF  - Acta Astronautica. 38 (1996), H. 1
Y1  - 1996
SN  - 0094-5765
SP  - 63
EP  - 68
ER  -