TY  - JOUR
A1  - Murib, M. S.
A1  - Yeap, W. S.
A1  - Eurlings, Y.
A1  - Grinsven, B. van
A1  - Boyen, H.-G.
A1  - Conings, B.
A1  - Michiels, L.
A1  - Ameloot, M.
A1  - Carleer, R.
A1  - Warmer, J.
A1  - Kaul, P.
A1  - Haenen, K.
A1  - Schöning, Michael Josef
A1  - Ceuninck, W. de
A1  - Wagner, P.
T1  - Heat-transfer based characterization of DNA on synthetic sapphire chips
JF  - Sensors and Actuators B: Chemical
N2  - In this study, we show that synthetic sapphire (Al₂O₃), an established implant material, can also serve as a platform material for biosensors comparable to nanocrystalline diamond. Sapphire chips, beads, and powder were first modified with (3-aminopropyl) triethoxysilane (APTES), followed by succinic anhydride (SA), and finally single-stranded probe DNA was EDC coupled to the functionalized layer. The presence of the APTES-SA layer on sapphire powders was confirmed by thermogravimetric analyis and Fourier-transform infrared spectroscopy. Using planar sapphire chips as substrates and X-ray photoelectron spectroscopy (XPS) as surface-sensitive tool, the sequence of individual layers was analyzed with respect to their chemical state, enabling the quantification of areal densities of the involved molecular units. Fluorescence microscopy was used to demonstrate the hybridization of fluorescently tagged target DNA to the probe DNA, including denaturation- and re-hybridization experiments. Due to its high thermal conductivity, synthetic sapphire is especially suitable as a chip material for the heat-transfer method, which was employed to distinguish complementary- and non-complementary DNA duplexes containing single-nucleotide polymorphisms. These results indicate that it is possible to detect mutations electronically with a chemically resilient and electrically insulating chip material.
Y1  - 2016
U6  - http://dx.doi.org/10.1016/j.snb.2016.02.027
SN  - 0925-4005
VL  - 230
IS  - 230
SP  - 260
EP  - 271
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Grinsven, Bart van
A1  - Bon, Natalie vanden
A1  - Strauven, Hannelore
A1  - Grieten, Lars
A1  - Murib, Mohammed
A1  - Jiménez Monroy, Kathia L.
A1  - Janssens, Stoffel D.
A1  - Haenen, Ken
A1  - Schöning, Michael Josef
A1  - Vermeeren, Veronique
A1  - Ameloot, Marcel
A1  - Michiels, Luc
A1  - Thoelen, Ronald
A1  - Ceuninck, Ward de
A1  - Wagner, Patrick
T1  - Heat-Transfer Resistance at Solid-Liquid Interfaces: A Tool for The Detection of Single Nucleotide Polymorphisms in DNA.
JF  - ACS Nano
N2  - In this article, we report on the heat-transfer resistance at interfaces as a novel, denaturation-based method to detect single-nucleotide polymorphisms in DNA. We observed that a molecular brush of double-stranded DNA grafted onto synthetic diamond surfaces does not notably affect the heat-transfer resistance at the solid-to-liquid interface. In contrast to this, molecular brushes of single-stranded DNA cause, surprisingly, a substantially higher heat-transfer resistance and behave like a thermally insulating layer. This effect can be utilized to identify ds-DNA melting temperatures via the switching from low- to high heat-transfer resistance. The melting temperatures identified with this method for different DNA duplexes (29 base pairs without and with built-in mutations) correlate nicely with data calculated by modeling. The method is fast, label-free (without the need for fluorescent or radioactive markers), allows for repetitive measurements, and can also be extended toward array formats. Reference measurements by confocal fluorescence microscopy and impedance spectroscopy confirm that the switching of heat-transfer resistance upon denaturation is indeed related to the thermal on-chip denaturation of DNA.
Y1  - 2012
U6  - http://dx.doi.org/10.1021/nn300147e
SN  - 1936-086X
VL  - 6
IS  - 3
SP  - 2712
EP  - 2721
PB  - ACS Publications
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Engelmann, Ulrich M.
A1  - Seifert, Julian
A1  - Mues, Benedikt
A1  - Roitsch, Stefan
A1  - Ménager, Christine
A1  - Schmidt, Annette M.
A1  - Slabu, Ioana
T1  - Heating efficiency of magnetic nanoparticles decreases with gradual immobilization in hydrogels
JF  - Journal of Magnetism and Magnetic Materials
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.jmmm.2018.09.113
SN  - 0304-8853
VL  - 471
IS  - 1
SP  - 486
EP  - 494
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Kloock, Joachim P.
A1  - Schöning, Michael Josef
T1  - Heavy metal detection with semiconductor devices based on PLD-prepared chalcogenide glass thin films
T2  - Armenian Journal of Physics
Y1  - 2007
SN  - 1829-1171
SP  - 95
EP  - 98
ER  - 
TY  - JOUR
A1  - Probst, M.
A1  - Behbahani, Mehdi
A1  - Borrmann, E.
A1  - Elgeti, S.
A1  - Nicolai, M.
A1  - Behr, M.
T1  - Hemodynamic Modeling for Numerical Analysis and Design of Medical Devices
Y1  - 2010
N1  - Posterpresentation ; NIC Symposium 2010 ; 24 - 25 February 2010 Jülich, Germany
ER  - 
TY  - JOUR
A1  - Stadler, A.  M.
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Embs, Jan P.
A1  - Zaccai, Joe
A1  - Büldt, Georg
T1  - Hemoglobin Dynamics in Red Blood Cells: Correlation to Body Temperature
JF  - Biophysical Journal. 95 (2008), H. 11
Y1  - 2008
SN  - 1542-0086
SP  - 5449
EP  - 5461
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Zerlin, Kay
A1  - Digel, Ilya
T1  - Hemoglobin Senses Body Temperature
JF  - Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)
Y1  - 2008
SN  - 978-3-540-75408-4
SP  - 415
EP  - 447
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Digel, Ilya
A1  - Zerlin, Kay
A1  - Maggakis-Kelemen, Christina
A1  - Linder, Peter
A1  - Porst, Dariusz
A1  - Kayser, Peter
A1  - Stadler, David
A1  - Dikta, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Hemoglobin senses body temperature
JF  - European Biophysics Journal
Y1  - 2009
SN  - 0175-7571
VL  - 38
IS  - 5
SP  - 589
EP  - 600
ER  - 
TY  - JOUR
A1  - Li, Anlan
A1  - Shi, Young de
A1  - Landsmann, B.
A1  - Schankowski-Bouvier, P.
A1  - Dikta, Gerhard
A1  - Bauer, U.
A1  - Artmann, Gerhard
T1  - Hemorheology and walking distance of Peripheral Arterial Occlusive Disease patients during treatment with Ginkgo-biloba extract
JF  - Acta Pharmacologica Sinica = ZHONGUO YAOLI XUEBAO. 19 (1998), H. 5
Y1  - 1998
SN  - 1745-7254
N1  - ISSN der parallelen Ausgabe 1671-4083; China-Zs.-Code: CN31-1347 abstract frei unter
SP  - 417
EP  - 421
ER  - 
TY  - CHAP
A1  - Digel, Ilya
A1  - Mansurov, Zulkhair
A1  - Biisenbaev, Makhmut
A1  - Savitskaya, Irina
A1  - Kistaubaeva, Aida
A1  - Akimbekov, Nuraly
A1  - Zhubanova, Azhar
ED  - Hu, Ning
T1  - Heterogeneous Composites on the Basis of Microbial Cells and Nanostructured Carbonized Sorbents
T2  - Composites and Their Applications
N2  - The fact that microorganisms prefer to grow on liquid/solid phase surfaces rather than in the surrounding aqueous phase was noticed long time ago [1]. Virtually any surface – animal, mineral, or vegetable – is a subject for microbial colonization and subsequent biofilm formation. It would be adequate to name just a few notorious examples on microbial colonization of contact lenses, ship hulls, petroleum pipelines, rocks in streams and all kinds of biomedical implants. The propensity of microorganisms to become surface-bound is so profound and ubiquitous that it vindicates the advantages for attached forms over their free-ranging counterparts [2]. Indeed, from ecological and evolutionary standpoints, for many microorganisms the surface-bound state means dwelling in nutritionally favorable, non-hostile environments [3]. Therefore, in most of natural and artificial ecosystems surface-associated microorganisms vastly outnumber organisms in suspension and often organize into complex communities with features that differ dramatically from those of free cells [4].
Y1  - 2012
SN  - 978-953-51-0706-4
U6  - http://dx.doi.org/10.5772/47796
SP  - 249
EP  - 272
PB  - Intech
CY  - London
ER  - 
TY  - BOOK
A1  - Grotendorst, Johannes
T1  - Hierarchical methods for dynamics in complex molecular systems : IAS Winter School, 5 - 9 March 2012, Forschungszentrum Jülich GmbH ; lecture notes / ed. by Johannes Grotendorst, Godehard Sutmann, Gerhard Gompper, Dominik Marx
Y1  - 2012
SN  - 978-3-89336-768-9
N1  - (Schriften des Forschungszentrums Jülich IAS Series 10)
PB  - Forschungszentrum Jülich
CY  - Jülich
ER  - 
TY  - BOOK
A1  - Grotendorst, Johannes
T1  - High performance computing in chemistry : report of the joint research project: High Performance Computing in Chemistry - HPC-Chem ; funded by the Federal Ministry for Education and Research (BMBF) ; period: 1 March 2001 - 29 February 2004 / ed. by Johannes Grotendorst
Y1  - 2004
SN  - 3-00-013618-5
N1  - NIC-Serie ; 25 ; John von Neumann Institute for Computing <Jülich>
PB  - NIC
CY  - Jülich
ER  - 
TY  - JOUR
A1  - Hillen, Walter
T1  - High pT hadron production in photon-photon collisions . TASSO Collaboration
JF  - Physics Letters B. 107 (1982), H. 4
Y1  - 1982
SN  - 0370-2693
SP  - 290
EP  - 296
ER  - 
TY  - JOUR
A1  - Terstegge, Andreas
A1  - Weber, Stefan
A1  - Herzog, H.
A1  - Müller-Gärtner, Hans- W. [u.a.]
T1  - High resolution and better quantification by tube of responsemodelling in 3D PET reconstruction
JF  - Selected papers from the 1996 Nuclear Science Symposium : Marriott Hotel, Anaheim, California, November 3rd - November 9th, 1996
Y1  - 1996
N1  - Nuclear Science Symposium <1996, Anaheim, Calif.> ; (IEEE transactions on nuclear science ; 44,3,1)
SP  - 1603
EP  - 1607
PB  - Inst. of Electrical and Electronic Engineers
CY  - New York
ER  - 
TY  - JOUR
A1  - Bressel, A.
A1  - Schultze, J.W.
A1  - Khan, W.
A1  - Wolfaardt, G. M.
A1  - Rohns, H.-P.
A1  - Irmscher, R.
A1  - Schöning, Michael Josef
T1  - High resolution gravimetric, optical and electrochemical investigations of microbial biofilm formation in aqueous systems
JF  - Electrochimica Acta. 48 (2003), H. 20-22
Y1  - 2003
SN  - 0013-4686
SP  - 3363
EP  - 3372
ER  - 
TY  - JOUR
A1  - Khodaverdi, M.
A1  - Weber, S.
A1  - Streun, M.
A1  - Parl, C.
A1  - Ziemons, Karl
T1  - High resolution imaging with ClearPET™ Neuro - first animal images
JF  - 2005 IEEE Nuclear Science Symposium Conference Record, Vol. 3
N2  - The ClearPET™ Neuro is the first full ring scanner within the Crystal Clear Collaboration (CCC). It consists of 80 detector modules allocated to 20 cassettes. LSO and LuYAP:Ce crystals in phoswich configuration in combination with position sensitive photomultiplier tubes are used to achieve high sensitivity and realize the acquisition of the depth of interaction (DOI) information. The complete system has been tested concerning the mechanical and electronical stability and interplay. Moreover, suitable corrections have been implemented into the reconstruction procedure to ensure high image quality. We present first results which show the successful operation of the ClearPET™ Neuro for artefact free and high resolution small animal imaging. Based on these results during the past few months the ClearPET™ Neuro System has been modified in order to optimize the performance.
Y1  - 2006
SN  - 1082-3654
SP  - 1641
EP  - 1644
ER  - 
TY  - JOUR
A1  - Moritz, W.
A1  - Yoshinobu, T.
A1  - Finger, F.
A1  - Krause, S.
A1  - Martin-Fernandez, M.
A1  - Schöning, Michael Josef
T1  - High resolution LAPS using amorphous silicon as the semiconductor material
JF  - Sensors and Actuators B. 103 (2004), H. 1-2
Y1  - 2004
SN  - 0925-4005
SP  - 436
EP  - 444
ER  - 
TY  - JOUR
A1  - Werner, Frederik
A1  - Wagner, Torsten
A1  - Miyamoto, Ko-ichiro
A1  - Yoshinobu, Tatsuo
A1  - Schöning, Michael Josef
T1  - High speed and high resolution chemical imaging based on a new type of OLED-LAPS set-up
JF  - Sensors and Actuators B: Chemical
N2  - Light-addressable potentiometric sensors (LAPS) are field-effect-based sensors. A modulated light source is used to define the particular measurement spot to perform spatially resolved measurements of chemical species and to generate chemical images. In this work, an organic-LED (OLED) display has been chosen as a light source. This allows high measurement resolution and miniaturisation of the system. A new developed driving method for the OLED display optimised for LAPS-based measurements is demonstrated. The new method enables to define modulation frequencies between 1 kHz and 16 kHz and hence, reduces the measurement time of a chemical image by a factor of 40 compared to the traditional addressing of an OLED display.
Y1  - 2012
U6  - http://dx.doi.org/10.1016/j.snb.2011.12.102
SN  - 0925-4005
N1  - Part of special issue "Selected Papers presented at Eurosensors XXV"
VL  - 175
SP  - 118
EP  - 122
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Werner, Frederik
A1  - Wagner, Torsten
A1  - Miyamoto, Ko-ichiro
A1  - Yoshinobu, Tatsuo
A1  - Schöning, Michael Josef
T1  - High speed and high resolution chemical imaging based on a new type of OLED-LAPS set-up
JF  - Procedia Engineering. 25 (2011)
Y1  - 2011
SN  - 1877-7058
N1  - EurosensorsXXV ; Proc. Eurosensors XXV, September 4-7, 2011, Athens, Greece
SP  - 346
EP  - 349
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Beuscher, H.
A1  - Gono, Y.
T1  - High spin states and isomers in nuclei with neutron number N=80
JF  - Frühjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft (1978)
Y1  - 1978
SP  - 841
EP  - 842
PB  - Physik-Verlag
CY  - Weinheim
ER  -