TY - JOUR A1 - Mourzina, Ioulia G. A1 - Yoshinobu, Tatsuo A1 - Ermolenko, Yuri E. A1 - Vlasov, Yuri G. A1 - Schöning, Michael Josef A1 - Iwasaki, H. T1 - Immobilization of urease and cholinesterase on the surface of semiconductor transducer for the development of lightaddressable potentiometric sensors JF - Microchimica Acta. 144 (2004), H. 1-3 Y1 - 2004 SN - 0026-3672 SP - 41 EP - 50 ER - TY - JOUR A1 - Bogoyavlenskiy, A. P. A1 - Berezin, V. E. A1 - Ogneva, A. V. A1 - Tolmacheva, V. P. A1 - Digel, Ilya A1 - Khudyakova, S. S. T1 - Immunostimulating activity of a saponin-containing extract of Saponaria officinalis JF - Voprosy virusologii Y1 - 1999 SN - 0507-4088 VL - 44 IS - 5 SP - 229 EP - 232 ER - TY - CHAP A1 - Kahmann, Stephanie A1 - Hackl, Michael A1 - Wegmann, Kilian A1 - Müller, Lars-Peter A1 - Staat, Manfred ED - Erni, Daniel T1 - Impact of a proximal radial shortening osteotomy on the distribution of forces and the stability of the elbow T2 - 1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen N2 - The human arm consists of the humerus (upper arm), the medial ulna and the lateral radius (forearm). The joint between the humerus and the ulna is called humeroulnar joint and the joint between the humerus and the radius is called humeroradial joint. Lateral and medial collateral ligaments stabilize the elbow. Statistically, 2.5 out of 10,000 people suffer from radial head fractures [1]. In these fractures the cartilage is often affected. Caused by the injured cartilage, degenerative diseases like posttraumatic arthrosis may occur. The resulting pain and reduced range of motion have an impact on the patient’s quality of life. Until now, there has not been a treatment which allows typical loads in daily life activities and offers good long-term results. A new surgical approach was developed with the motivation to reduce the progress of the posttraumatic arthrosis. Here, the radius is shortened by 3 mm in the proximal part [2]. By this means, the load of the radius is intended to be reduced due to a load shift to the ulna. Since the radius is the most important stabilizer of the elbow it has to be confirmed that the stability is not affected. In the first test (Fig. 1 left), pressure distributions within the humeroulnar and humeroradial joints a native and a shortened radius were measured using resistive pressure sensors (I5076 and I5027, Tekscan, USA). The humerus was loaded axially in a tension testing machine (Z010, Zwick Roell, Germany) in 50 N steps up to 400 N. From the humerus the load is transmitted through both the radius and the ulna into the hand which is fixed on the ground. In the second test (Fig. 1 right), the joint stability was investigated using a digital image correlation system to measure the displacement of the ulna. Here, the humerus is fixed with a desired flexion angle and the unconstrained forearm lies on the ground. A rope connects the load actuator with a hook fixed in the ulna. A guide roller is used so that the rope pulls the ulna horizontally when a tensile load is applied. This creates a moment about the elbow joint with a maximum value of 7.5 Nm. Measurements were performed with varying flexion angles (0°, 30°, 60°, 90°, 120°). For both tests and each measurement, seven specimens were used. Student ́s t-test was employed to determine whether the mean values of the measurements in native specimen and operated specimens differ significantly. Y1 - 2016 U6 - http://dx.doi.org/10.17185/duepublico/40821 SP - 7 EP - 8 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - JOUR A1 - Weber, Hans-Joachim A1 - Hekmat, K. A1 - Zimmermann, T. A1 - Kampe, S. T1 - Impact of tranexamic acid vs. aprotinin on blood loss and transfusion requirements after cardiopulmonary bypass: a prospective, randomised, double-blind trial / Hekmat, K. ; Zimmermann, T. ; Kampe, S. ; Kasper, S. M. ; Weber, H. J. ; Geissler, H. J. ; Meh JF - Current Medical Research and Opinion. 20 (2004), H. 1 Y1 - 2004 SN - 0300-7995 SP - 121 EP - 126 ER - TY - JOUR A1 - Poghossian, Arshak A1 - Mai, D.-T. A1 - Mourzina, Y. A1 - Schöning, Michael Josef T1 - Impedance effect of an ion-sensitive membrane: characterisation of an EMIS sensor by impedance spectroscopy, capacitance-voltage and constant-capacitance method JF - Sensors and Actuators B. 103 (2004), H. 1-2 Y1 - 2004 SN - 0925-4005 SP - 423 EP - 428 ER - TY - JOUR A1 - Schusser, Sebastian A1 - Leinhos, Marcel A1 - Bäcker, Matthias A1 - Poghossian, Arshak A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Impedance spectroscopy: A tool for real-time in situ monitoring of the degradation of biopolymers JF - Physica Status Solidi (A) N2 - Investigation of the degradation kinetics of biodegradable polymers is essential for the development of implantable biomedical devices with predicted biodegradability. In this work, an impedimetric sensor has been applied for real-time and in situ monitoring of degradation processes of biopolymers. The sensor consists of two platinum thin-film electrodes covered by a polymer film to be studied. The benchmark biomedical polymer poly(D,L-lactic acid) (PDLLA) was used as a model system. PDLLA films were deposited on the sensor structure from a polymer solution by using the spin-coating method. The degradation kinetics of PDLLA films have been studied in alkaline solutions of pH 9 and 12 by means of an impedance spectroscopy (IS) method. Any changes in a polymer capacitance/resistance induced by water uptake and/or polymer degradation will modulate the global impedance of the polymer-covered sensor that can be used as an indicator of the polymer degradation. The degradation rate can be evaluated from the time-dependent impedance spectra. As expected, a faster degradation has been observed for PDLLA films exposed to pH 12 solution. Y1 - 2013 U6 - http://dx.doi.org/10.1002/pssa.201200941 SN - 1521-396X ; 0031-8965 VL - 210 IS - 5 SP - 905 EP - 910 PB - Wiley CY - Weinheim ER - TY - CHAP A1 - Oberländer, Jan A1 - Arreola, Julio A1 - Hansen, Christina A1 - Greeff, Anton A1 - Mayer, Marlena A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Impedimetric Biosensor to Enable Fast Evaluation of Gaseous Sterilization Processes T2 - MDPI Proceedings Y1 - 2017 U6 - http://dx.doi.org/10.3390/proceedings1040435 N1 - Eurosensors 2017 Conference, Paris, France, 3–6 September 2017 VL - 1 IS - 4 ER - TY - JOUR A1 - Riedel, Marc A1 - Kartchemnik, Julia A1 - Schöning, Michael Josef A1 - Lisdat, Fred T1 - Impedimetric DNA detection – steps forward to sensorial application JF - Analytical chemistry N2 - This study describes a label-free impedimetric sensor based on short ssDNA recognition elements for the detection of hybridization events. We concentrate on the elucidation of the influence of target length and recognition sequence position on the sensorial performance. The impedimetric measurements are performed in the presence of the redox system ferri-/ferrocyanide and show an increase in charge transfer resistance upon hybridization of ssDNA to the sensor surface. Investigations on the impedimetric signal stability demonstrate a clear influence of the buffers used during the sensor preparation and the choice of the passivating mercaptoalcanol compound. A stable sensor system has been developed, enabling a reproducible detection of 25mer target DNA in the low nanomolar range. After hybridization, a sensor regeneration can be reached with deionized water by adjustment of effective convection conditions, ensuring a sensor reusability. By investigations of longer targets with overhangs exposed to the solution, we can demonstrate applicability of the impedimetric detection for longer ssDNA. However, a decreasing charge transfer resistance change (ΔRct) is found by extending the overhang. As a strategy to increase the impedance change for longer target strands, the position of the recognition sequence can be designed in a way that a small overhang is exposed to the electrode surface. This is found to result in an increase in the relative Rct change. These results suggest that DNA and consequently negative charge near the electrode possess a larger impact on the impedimetric signal than DNA further away. Y1 - 2014 U6 - http://dx.doi.org/10.1021/ac501800q SN - 1520-6882 (E-Journal); 0003-2700 (Print); 0096-4484 (Print) VL - 86 (2014) IS - 15 SP - 7867 EP - 7874 PB - ACS Publications CY - Columbus ER - TY - JOUR A1 - Delle, Lotta E. A1 - Huck, Christina A1 - Bäcker, Matthias A1 - Müller, Frank A1 - Grandthyll, Samuel A1 - Jacobs, Karin A1 - Lilischkis, Rainer A1 - Vu, Xuan T. A1 - Schöning, Michael Josef A1 - Wagner, Patrick A1 - Thoelen, Roland A1 - Weil, Maryam A1 - Ingebrandt, Sven T1 - Impedimetric immunosensor for the detection of histamine based on reduced graphene oxide JF - Physica status solidi (a) Y1 - 2015 U6 - http://dx.doi.org/10.1002/pssa.201431863 SN - 1862-6319 VL - 212 IS - 6 SP - 1327 EP - 1334 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Schäfer, Horst A1 - Boege, P. A1 - Shanjia, Xu A1 - Xinzhang, Wu (u.a.) T1 - Improved conductivity-measurement of semiconductor epitaxial layers by means of the contactless microwave method JF - Conference digest : 10 - 14 January 1994, San Diego, California / International Conference on Millimeter and Submillimeter Waves and Applications / Mohammed N. Afsar, chair/ed. Y1 - 1994 SN - 0-8194-1558-8 N1 - Serie Proceedings / SPIE, The International Society for Optical Engineering ; 2250 SP - 649 EP - 658 PB - SPIE CY - Bellingham, Wash. ER - TY - JOUR A1 - Miyamoto, Koichiro A1 - Seki, Kosuke A1 - Suto, Takeyuki A1 - Werner, Frederik A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Improved spatial resolution of the chemical imaging sensor with a hybrid illumination that suppresses lateral diffusion of photocarriers JF - Sensor and Actuators B: Chemical N2 - The chemical imaging sensor is a semiconductor-based chemical sensor capable of visualizing pH and ion distributions. The spatial resolution depends on the lateral diffusion of photocarriers generated by illumination of the semiconductor substrate. In this study, two types of optical setups, one based on a bundle of optical fibers and the other based on a binocular tube head, were developed to project a hybrid illumination of a modulated light beam and a ring-shaped constant illumination onto the sensor plate. An improved spatial resolution was realized by the ring-shaped constant illumination, which suppressed lateral diffusion of photocarriers by enhanced recombination due to the increased carrier concentration. Y1 - 2018 U6 - http://dx.doi.org/10.1016/j.snb.2018.07.016 SN - 0925-4005 VL - 273 SP - 1328 EP - 1333 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Grießmeier, M. A1 - Sonnenberg, F. A1 - Weckesser, M. A1 - Ziemons, Karl A1 - Langen, K.-J. A1 - Müller-Gärtner, H. W. T1 - Improvement of SPECT quantification in small brain structures by using experiment based recovery-coefficient corrections JF - European Journal of Nuclear Medicine Y1 - 1996 SN - 1619-7089 N1 - Abstracts ; PSu827 VL - 23 IS - 9 SP - 1238 EP - 1238 ER - TY - JOUR A1 - Schroth, P. A1 - Schöning, Michael Josef A1 - Schütz, S. A1 - Epanya, P. A1 - Steffen, A. A1 - Weißbecker, B. A1 - Hummel, Hans E. A1 - Kordos, P. A1 - Lüth, H. T1 - Improving the bioelectronic interface of an antenna/chip biosensor – technological aspects JF - Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. Vol 1. Y1 - 1999 SN - 90-76699-02-X N1 - Eurosensors ; (13, 1999, 's-Gravenhage) ; Eurosensors ; (13 : ; 1999.09.12-15 : ; The Hague) ; European Conference on Solid-State Transducers ; (13 : ; 1999.09.12-15 : ; The Hague) SP - 569 EP - 572 CY - The Hague, The Netherlands ER - TY - JOUR A1 - Thust, M. A1 - Schroth, P. A1 - Töpler, A. A1 - Schöning, Michael Josef A1 - Müller-Veggian, Mattea A1 - Kordos, P. A1 - Lüth, H. T1 - Improving the detection limit of a capacitive sensor by means of a diffusion barrier JF - Eurosensors XII : proceedings of the 12th European Conference on Solid-State Transducers and the 9th UK Conference on Sensors and their Applications, Southampton, UK, 13 - 16 September 1998 / ed. by N. M. White ; Vol. 1 Y1 - 1998 SN - 0-7503-0595-9 N1 - Eurosensors ; (12, 1998, Southampton) ; UK Conference on Sensors and Their Applications ; (9, 1998, Southampton) SP - 507 EP - 510 PB - Inst. of Physics Publ. CY - Bristol [u.a.] ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Resmi, Halil A1 - Akhunlar, Hülya A1 - Güner, Gül T1 - In vitro effects of high glucose concentrations on membrane protein sulfhydryl oxidation, G-actin and deformability of human erythrocytes. Resmi, Halil ; Akhunlar, Hülya ; Temiz Artmann, Aysegül ; Güner, Gül JF - Cell biochemistry and function. 23 (2005), H. 3 Y1 - 2005 SN - 0263-6484 SP - 163 EP - 168 ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Baskurt, O. K. A1 - Edremitlioglu, M. T1 - In vitro effects of in vivo activated leukocytes on red blood cell filterability and lipid peroxidation. Baskurt, O.K.; Edremitlioglu, M.; Temiz, A. JF - Clinical Hemorheology. 14 (1994), H. 4 Y1 - 1994 SP - 591 EP - 596 ER - TY - JOUR A1 - Bleilevens, Christian A1 - Hill, Aileen A1 - Grzanna, Tim A1 - Fechter, Tamara A1 - Bohnen, Melanie A1 - Weber, Hans-Joachim A1 - Beckers, Christian A1 - Borosch, Sebastian A1 - Zayat, Rashad A1 - Benstoem, Carin A1 - Rossaint, Rolf A1 - Goetzenich, Andreas T1 - In vitro head-to-head comparison of anticoagulation properties of two heparin brands in a human blood miniature mock loop JF - Interactive cardiovascular and thoracic surgery Y1 - 2019 U6 - http://dx.doi.org/10.1093/icvts/ivy206 SN - 1569-9285 VL - 28 IS - 1 SP - 120 EP - 127 ER - TY - JOUR A1 - Brockhaus, Moritz K. A1 - Behbahani, Mehdi A1 - Muris, Farina A1 - Jansen, Sebastian V. A1 - Schmitz- Rode, Thomas A1 - Steinseifer, Ulrich A1 - Clauser, Johanna C. T1 - In vitro thrombogenicity testing of pulsatile mechanical circulatory support systems: Design and proof-of-concept JF - Artificial Organs N2 - Thrombogenic complications are a main issue in mechanical circulatory support (MCS). There is no validated in vitro method available to quantitatively assess the thrombogenic performance of pulsatile MCS devices under realistic hemodynamic conditions. The aim of this study is to propose a method to evaluate the thrombogenic potential of new designs without the use of complex in-vivo trials. This study presents a novel in vitro method for reproducible thrombogenicity testing of pulsatile MCS systems using low molecular weight heparinized porcine blood. Blood parameters are continuously measured with full blood thromboelastometry (ROTEM; EXTEM, FIBTEM and a custom-made analysis HEPNATEM). Thrombus formation is optically observed after four hours of testing. The results of three experiments are presented each with two parallel loops. The area of thrombus formation inside the MCS device was reproducible. The implantation of a filter inside the loop catches embolizing thrombi without a measurable increase of platelet activation, allowing conclusions of the place of origin of thrombi inside the device. EXTEM and FIBTEM parameters such as clotting velocity (α) and maximum clot firmness (MCF) show a total decrease by around 6% with a characteristic kink after 180 minutes. HEPNATEM α and MCF rise within the first 180 minutes indicate a continuously increasing activation level of coagulation. After 180 minutes, the consumption of clotting factors prevails, resulting in a decrease of α and MCF. With the designed mock loop and the presented protocol we are able to identify thrombogenic hot spots inside a pulsatile pump and characterize their thrombogenic potential. Y1 - 2021 U6 - http://dx.doi.org/10.1111/aor.14046 SN - 1525-1594 VL - 45 IS - 12 SP - 1513 EP - 1521 PB - Wiley CY - Weinheim ER - TY - CHAP A1 - Weber, Hans-Joachim A1 - Porschen, W. A1 - Dietzel, F. A1 - [u.a.], ED - Streffer, Christian T1 - In vivo analysis of the influence of combined hyperthermia and gamma irradiation on euoxic and hypoxic tumor cells T2 - Cancer therapy by hyperthermia and radiation : [proceedings of the 2. International Symposium on Cancer Therapy by Hyperthermia and Radiation, Essen, 2.-4.6.1977] Y1 - 1978 SN - 0-8067-1701-7 SN - 3-541-71701-7 SP - 276 EP - 277 PB - Urban and Schwarzenberg CY - Baltimore ; Munich [u.a.] ER - TY - JOUR A1 - Porschen, W. A1 - Gartzen, J. A1 - Gewehr, K. A1 - Mühlensiepen, H. A1 - Weber, Hans-Joachim A1 - [u.a.], T1 - In vivo assay of the radiation sensitivity of hypoxic tumour cells : influence of γ-rays, cyclotron neutrons, misonidazole, hyperthermia and mixed modalities JF - The British journal of cancer / Supplement N2 - Tumour cell death can be evaluated in the living mouse by externally measuring the rate of loss of tumour-bound DNA tracer. By sequentially labelling the tumour-bearing animals with ¹²⁵IUdR and ¹³¹IUdR 50 h apart, the average tumour cells at the time of the second injection are labelled by ¹²⁵IUdR and the euoxic tumour cells are specifically labelled with ¹³¹IUdR. Tumour treatment at this stage of labelling permits the observation of the reaction of euoxic cells and average tumour cells and finally yields data on hypoxic cells and thus on the oxygen enhancement ratio. This information adds to results from tumour control and growth delay. With this technique effects were analysed of 60-Co γ-rays, cyclotron neutrons (E = 6 MeV), misonidazole (500 mg/kg body wt) and hyperthermia (42°C water-bath), or combinations of these. Misonidazole (15 min before irradiation) altered the oxygen enhancement ratio by a factor of 1·5 for γ-rays and of 1·1 for neutrons; when evaluated from tumour-growth delay and TCD-50 misonidazole gave a dose modifying factor of 1·47 for γ-rays and of 1·2-1·3 for neutrons. Based on percentage tumour regression 100 days after treatment, the enhancement ratio from hyperthermia (after irradiation) was 2·75 for γ-rays (at 10 Gray) and 2·2 for neutrons (at 3·2 Gray). For neutrons combined with misonidazole and hyperthermia the ratio was 2·4. These results demonstrate that effects of neutron irradiation may be modified by electron-affinic substances and/or hyperthermia. Y1 - 1978 SN - 0306-9443 N1 - Section 6: Sensitization and Hypoxic Cytotoxicity: Effects of Hyperthermia and High Let IS - 3 SP - 194 EP - 197 PB - Lewis CY - London ER - TY - CHAP A1 - Richter, Charlotte A1 - Braunstein, Bjoern A1 - Stäudle, Benjamin A1 - Attias, Julia A1 - Suess, Alexander A1 - Weber, T. A1 - Rittweger, Joern A1 - Green, David A. A1 - Albracht, Kirsten T1 - In vivo fascicle length of the gastrocnemius muscle during walking in simulated martian gravity using two different body weight support devices T2 - 23rd Annual Congress of the European College of Sport Science, Dublin, Irland Y1 - 2018 ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Haenni, D. R. A1 - Beuscher, H. A1 - Lieder, R. M. T1 - In-beam studies of ¹⁴⁵ Gd and ¹⁴⁵ Eu JF - Frühjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft (1979) Y1 - 1979 ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Zuber, K. A1 - Gueven, H. T1 - In-beam study of 63 143 Eu 80 JF - Zeitschrift für Physik / A, Hadrons and nuclei. 330 (1988), H. 3 Y1 - 1988 SN - 1431-5831 N1 - 2. ISSN: 0340-2193 ; 3. ISSN 0930-1151 ; 4. ISSN 0939-7922 SP - 343 EP - 344 ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Haenni, D. R. A1 - Beuscher, H. A1 - Lieder, R. M. T1 - In-beam study of levels in ¹⁴⁵ Eu JF - Structure of medium-heavy nuclei, 1979 : proceedings of the 6. European Physical Soc. Nuclear Divisional Conference on the Structure of Medium-Heavy Nuclei held in Rhodes, Greece, 1-4 May 1979 / ed. Committee: G. S. Anagnostatos ... - (Conference series / Institute of Physics London, Bristol ; 49) Y1 - 1980 SN - 0-85498-140-3 N1 - Conference on the Structure of Medium Heavy Nuclei <6, 1979, Rodos> ; European Physical Society / Nuclear Physics Division SP - 131 PB - Inst. of Physics CY - Bristol ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Beuscher, H. A1 - Haenni, D. R. T1 - In-beam study of the light transitional nucleus ¹³⁸ Nd JF - Annual report 1979 / Kernforschungsanlage Jülich Institut für Kernphysik / Hrsg.: A. Fässler. - (Spezielle Berichte der Kernforschungsanlage Jülich ; 72) Y1 - 1980 SP - 45 PB - Kernforschungsanlage CY - Jülich ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Morek, T. A1 - Beuscher, H. A1 - Bochev, B. T1 - In-beam study of the odd-odd nuclei ¹³⁴ La and ¹³⁶ La JF - Nuclear physics / A, Nuclear and hadronic physics. 433 (1985), H. 2 Y1 - 1985 SN - 0375-9474 SP - 159 EP - 180 ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Zuber, K. A1 - Gueven, H. T1 - In-beam study of ¹⁴³ Eu JF - Annual report 1987 / Kernforschungsanlage Jülich Institut für Kernphysik / Grümmer , F. (Hrsg.) . - (Spezielle Berichte der Kernforschungsanlage Jülich ; 442) Y1 - 1988 SP - 44 PB - Verlag des Forschungszentrums Jülich CY - Jülich ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Mariscotti, M. A. J. A1 - Beuscher, H. A1 - Davidson, W. F. T1 - In-beam study of ¹⁴⁴ Gd JF - Proceedings of the International Conference on Nuclear Structure : Tokyo, Sept. 5 - 10, 1977 / ed. by T. Marumori. - Journal of the Physical Society of Japan ; Vol. 44, 1978 : Suppl. Y1 - 1978 N1 - International Conference on Nuclear Structure <1977, Tokyo> SP - 863 PB - Physical Soc. of Japan CY - Tokyo ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Mariscotti, M. A. J. A1 - Beuscher, H. A1 - Davidson, W. F. T1 - In-beam study of ¹⁴⁴ Gd JF - Annual report 1976 / Institut für Kernphysik Kernforschungsanlage Jülich / Ed. board: A. Fäßler ... Y1 - 1977 SP - 37 PB - Kernforschungsanlage CY - Jülich ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Mariscotti, M. A. J. A1 - Beuscher, H. A1 - Davidson, W. F. T1 - In-beam study of ¹⁴⁴ Gd JF - Nuclear physics / A. 311 (1978), H. 3 Y1 - 1978 SN - 0375-9474 SP - 395 EP - 412 ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Haenni, D. R. A1 - Beuscher, H. A1 - Lieder, R. M. T1 - In-beam study of ¹⁴⁵ Gd JF - Annual report 1978 / Kernforschungsanlage Jülich Institut für Kernphysik / Hrsg.: A. Fässler. - (Spezielle Berichte der Kernforschungsanlage Jülich ; 36) Y1 - 1979 SP - 27 PB - Kernforschungsanlage CY - Jülich ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Gono, Y. A1 - Lieder, R. M. T1 - In-beam γ-ray study of ¹⁸⁹,¹⁹¹,¹⁹³ Au JF - Nuclear physics / A. 327 (1979), H. 2 Y1 - 1979 SN - 0375-9474 SP - 269 EP - 287 ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Kreiner, A. J. A1 - Fenzl, M. A1 - Kutschera, W. T1 - In-beam γ-spectroscopic investigation of ¹⁹⁶ Tl JF - Annual report 1977 / Institut für Kernphysik Kernforschungsanlage Jülich Y1 - 1978 N1 - Spezielle Berichte der Kernforschungsanlage Jülich ; 15 SP - 47 EP - 48 PB - Verlag des Forschungszentrums Jülich CY - Jülich ER - TY - JOUR A1 - Digel, Ilya T1 - In-situ biological decontamination of an ice melting probe Y1 - 2010 N1 - 38th COSPAR Scientific Assembly. Held 18-15 July 2010, in Bremen, Germany Abstract unter https://www.cospar-assembly.org/abstractcd/OLD/COSPAR-10/abstracts/data/pdf/abstracts/F36-0013-10.pdf ER - TY - JOUR A1 - Kuhnert, Marie-Therese A1 - Bialonski, Stephan A1 - Noenning, Nina A1 - Mai, Heinke A1 - Hinrichs, Hermann A1 - Helmstaedter, Christoph A1 - Lehnertz, Klaus T1 - Incidental and intentional learning of verbal episodic material differentially modifies functional brain networks JF - Plos one N2 - Learning- and memory-related processes are thought to result from dynamic interactions in large-scale brain networks that include lateral and mesial structures of the temporal lobes. We investigate the impact of incidental and intentional learning of verbal episodic material on functional brain networks that we derive from scalp-EEG recorded continuously from 33 subjects during a neuropsychological test schedule. Analyzing the networks' global statistical properties we observe that intentional but not incidental learning leads to a significantly increased clustering coefficient, and the average shortest path length remains unaffected. Moreover, network modifications correlate with subsequent recall performance: the more pronounced the modifications of the clustering coefficient, the higher the recall performance. Our findings provide novel insights into the relationship between topological aspects of functional brain networks and higher cognitive functions. Y1 - 2013 U6 - http://dx.doi.org/10.1371/journal.pone.0080273 VL - 8 IS - 11 PB - PLOS CY - San Francisco ER - TY - JOUR A1 - Siqueira, Jose R. A1 - Molinnus, Denise A1 - Beging, Stefan A1 - Schöning, Michael Josef T1 - Incorporating a hybrid urease-carbon nanotubes sensitive nanofilm on capacitive field-effect sensors for urea detection JF - Analytical chemistry N2 - The ideal combination among biomolecules and nanomaterials is the key for reaching biosensing units with high sensitivity. The challenge, however, is to find out a stable and sensitive film architecture that can be incorporated on the sensor’s surface. In this paper, we report on the benefits of incorporating a layer-by-layer (LbL) nanofilm of polyamidoamine (PAMAM) dendrimer and carbon nanotubes (CNTs) on capacitive electrolyte-insulator-semiconductor (EIS) field-effect sensors for detecting urea. Three sensor arrangements were studied in order to investigate the adequate film architecture, involving the LbL film with the enzyme urease: (i) urease immobilized directly onto a bare EIS [EIS-urease] sensor; (ii) urease atop the LbL film over the EIS [EIS-(PAMAM/CNT)-urease] sensor; and (iii) urease sandwiched between the LbL film and another CNT layer [EIS-(PAMAM/CNT)-urease-CNT]. The surface morphology of all three urea-based EIS biosensors was investigated by atomic force microscopy (AFM), while the biosensing abilities were studied by means of capacitance–voltage (C/V) and dynamic constant-capacitance (ConCap) measureaments at urea concentrations ranging from 0.1 mM to 100 mM. The EIS-urease and EIS-(PAMAM/CNT)-urease sensors showed similar sensitivity (∼18 mV/decade) and a nonregular signal behavior as the urea concentration increased. On the other hand, the EIS-(PAMAM/CNT)-urease-CNT sensor exhibited a superior output signal performance and higher sensitivity of about 33 mV/decade. The presence of the additional CNT layer was decisive to achieve a urea based EIS sensor with enhanced properties. Such sensitive architecture demonstrates that the incorporation of an adequate hybrid enzyme-nanofilm as sensing unit opens new prospects for biosensing applications using the field-effect sensor platform. Y1 - 2014 U6 - http://dx.doi.org/10.1021/ac500458s SN - 1520-6882 (E-Journal); 0003-2700 (Print); 0096-4484 (Print) VL - 86 IS - 11 SP - 5370 EP - 5375 PB - ACS Publications CY - Columbus ER - TY - JOUR A1 - Heinzel, Alexander A1 - Schäfer, Ralf A1 - Müller, Hans-Wilhelm A1 - Schieffer, Andre A1 - Ingenhag, Ariane A1 - Eickhoff, Simon B. A1 - Northoff, Georg A1 - Franz, Matthias A1 - Hautzel, Hubertus T1 - Increased Activation of the Supragenual Anterior Cingulate Cortex during Visual Emotional Processing in Male Subjects with High Degrees of Alexithymia: An Event-Related fMRI Study JF - Psychotherapy and Psychosomatics N2 - Background: One of the most prominent neurobiological models of alexithymia assumes an altered function of the anterior cingulate cortex (ACC) as the crucial neural correlate of alexithymia. So far functional imaging studies have yielded inconclusive results. Therefore, we tested this hypothesis in healthy alexithymics and nonalexithymics in an event-related fMRI study. Methods: Thirty high- and 30 low-alexithymic right-handed male subjects (selected by the 20-item Toronto Alexithymia Scale, TAS-20) were investigated with event-related fMRI using a picture viewing paradigm. The stimuli consisted of happy, fearful and neutral facial expressions (Ekman-Friesen) as well as positive, negative and neutral pictures from the International Affective Picture System. Results: Contrasting the high-alexithymic with the low-alexithymic group we observed increased activation of the supragenual ACC for different emotional valences as well as for different emotional stimuli. Moreover, there was a positive correlation of the ACC with the individual TAS-20 scores but no correlations with the individual Beck Depression Inventory scores. Additionally, there was no difference in activity of the amygdala. Conclusions: We demonstrated that the supragenual ACC is constantly activated more strongly in alexithymic subjects and that this activation is related to the symptoms of alexithymia and not to associated symptoms such as depression. Therefore, our findings support the hypothesis of an altered function of the ACC in alexithymia. Y1 - 2010 U6 - http://dx.doi.org/10.1159/000320121 SN - 0033-3190 VL - 79 IS - 6 SP - 363 EP - 370 PB - Karger CY - Basel ER - TY - JOUR A1 - Heinke, Lars N. A1 - Knicker, Axel J. A1 - Albracht, Kirsten T1 - Increased shoulder muscle stretch reflex elicitability in supine subject posture JF - Isokinetics and Exercise Science N2 - BACKGROUND: Muscle stretch reflexes are widely used to examine neural muscle function. The knowledge of reflex response in muscles crossing the shoulder is limited. OBJECTIVE: To quantify reflex modulation according to various subject postures and different procedures of muscle pre-activation steering. METHODS: Thirteen healthy male participants performed two sets of external shoulder rotation stretches in various positions and with different procedures of muscle pre-activation steering on an isokinetic dynamometer over a range of two different pre-activation levels. All stretches were applied with a dynamometer acceleration of 104∘/s2 and a velocity of 150∘/s. Electromyographical response was measured via sEMG. RESULTS: Consistent reflexive response was observed in all tested muscles in all experimental conditions. The reflex elicitation rate revealed a significant muscle main effect (F (5,288) = 2.358, ρ= 0.040; η2= 0.039; f= 0.637) and a significant test condition main effect (F (1,288) = 5.884, ρ= 0.016; η2= 0.020; f= 0.143). Reflex latency revealed a significant muscle pre-activation level main effect (F (1,274) = 5.008, ρ= 0.026; η2= 0.018; f= 0.469). CONCLUSION: Muscular reflexive response was more consistent in the primary internal rotators of the shoulder. Supine posture in combination with visual feedback of muscle pre-activation level enhanced the reflex elicitation rate. Y1 - 2020 U6 - http://dx.doi.org/10.3233/IES-192219 SN - 1878-5913 VL - 28 IS - 2 SP - 139 EP - 146 PB - IOS Press CY - Amsterdam ER - TY - JOUR A1 - Kraft, Bodo A1 - Heer, Thomas A1 - Retkowitz, Daniel T1 - Incremental Ontology Integration / Heer, Thomas ; Retkowitz, Daniel ; Kraft, Bodo JF - Proceedings of the 10th International Conference on Enterprise Information Systems : Barcelona, Spain, June 12 - 16, 2008 / organized by INSTICC, Institute for Systems and Technologies of Information, Control and Communication ... [Ed. by José Cordeiro ...] Y1 - 2008 N1 - International Conference on Enterprise Information Systems ; (10 : ; 2008.06.12-16 : ; Barcelona) ; ICEIS ; (10 : ; 2008.06.12-16 : ; Barcelona) SP - 13 EP - 28 PB - INSTICC CY - Setubal ER - TY - BOOK A1 - Bialonski, Stephan T1 - Inferring complex networks from time series of dynamical systems: Pitfalls, misinterpretations, and possible solutions Y1 - 2012 N1 - Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Diss., 2012 PB - Universitäts- und Landesbibliothek Bonn CY - Bonn ER - TY - JOUR A1 - Nguyen, Nhu Huynh A1 - Duong, Minh Tuan A1 - Tran, Thanh Ngoc A1 - Pham, Phu Tinh A1 - Grottke, O. A1 - Tolba, R. A1 - Staat, Manfred T1 - Influence of a freeze–thaw cycle on the stress–stretch curves of tissues of porcine abdominal organs JF - Journal of Biomechanics N2 - The paper investigates both fresh porcine spleen and liver and the possible decomposition of these organs under a freeze–thaw cycle. The effect of tissue preservation condition is an important factor which should be taken into account for protracted biomechanical tests. In this work, tension tests were conducted for a large number of tissue specimens from twenty pigs divided into two groups of 10. Concretely, the first group was tested in fresh state; the other one was tested after a freeze-thaw cycle which simulates the conservation conditions before biomechanical experiments. A modified Fung model for isotropic behavior was adopted for the curve fitting of each kind of tissues. Experimental results show strong effects of the realistic freeze–thaw cycle on the capsule of elastin-rich spleen but negligible effects on the liver which virtually contains no elastin. This different behavior could be explained by the autolysis of elastin by elastolytic enzymes during the warmer period after thawing. Realistic biomechanical properties of elastin-rich organs can only be expected if really fresh tissue is tested. The observations are supported by tests of intestines. KW - Autolysis KW - Decomposition KW - Freeze–thaw process KW - Spleen KW - Liver Y1 - 2012 U6 - http://dx.doi.org/10.1016/j.jbiomech.2012.07.008 SN - 1873-2380 VL - 45 IS - 14 SP - 2382 EP - 2386 PB - Elsevier CY - Amsterdam ER - TY - THES A1 - Albracht, Kirsten T1 - Influence of mechanical properties of the leg extensor muscletendon units on running economy Y1 - 2010 N1 - Cologne, German Sport Univ., Diss., 2010 PB - Deutsche Sporthochschule Köln CY - Köln ER - TY - JOUR A1 - Artmann, Gerhard A1 - Schmid-Schönbein, H. A1 - Schröder, Susanne A1 - Grebe, R. [u.a.] T1 - Influence of Moxaverine-HCL on Membrane Curvature and Microsieve Filterability of Red Cells after Exposure to Hyperosmolarity and Lactacidosis. Schmid-Schönbein, H.; Schröder, Susanne; Grebe, R.; Artmann, Gerhard Michael, Eschweiler, H; Teitel, P. JF - Arzneimittelforschung. 38 (1988), H. 5 Y1 - 1988 SN - 0004-4172 SP - 710 EP - 716 ER - TY - JOUR A1 - Duong, Minh Tuan A1 - Nguyen, Nhu Huynh A1 - Tran, Thanh Ngoc A1 - Tolba, R. H. A1 - Staat, Manfred T1 - Influence of refrigerated storage on tensile mechanical properties of porcine liver and spleen JF - International biomechanics Y1 - 2015 U6 - http://dx.doi.org/10.1080/23335432.2015.1049295 SN - 2333-5432 VL - Vol. 2 IS - Iss. 1 SP - 79 EP - 88 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Lenz, Maximilian A1 - Kahmann, Stephanie Lucina A1 - Behbahani, Mehdi A1 - Pennig, Lenhard A1 - Hackl, Michael A1 - Leschinger, Tim A1 - Müller, Lars Peter A1 - Wegmann, Kilian T1 - Influence of rotator cuff preload on fracture configuration in proximal humerus fractures: a proof of concept for fracture simulation JF - Archives of Orthopaedic and Trauma Surgery N2 - Introduction In regard of surgical training, the reproducible simulation of life-like proximal humerus fractures in human cadaveric specimens is desirable. The aim of the present study was to develop a technique that allows simulation of realistic proximal humerus fractures and to analyse the influence of rotator cuff preload on the generated lesions in regards of fracture configuration. Materials and methods Ten cadaveric specimens (6 left, 4 right) were fractured using a custom-made drop-test bench, in two groups. Five specimens were fractured without rotator cuff preload, while the other five were fractured with the tendons of the rotator cuff preloaded with 2 kg each. The humeral shaft and the shortened scapula were potted. The humerus was positioned at 90° of abduction and 10° of internal rotation to simulate a fall on the elevated arm. In two specimens of each group, the emergence of the fractures was documented with high-speed video imaging. Pre-fracture radiographs were taken to evaluate the deltoid-tuberosity index as a measure of bone density. Post-fracture X-rays and CT scans were performed to define the exact fracture configurations. Neer’s classification was used to analyse the fractures. Results In all ten cadaveric specimens life-like proximal humerus fractures were achieved. Two III-part and three IV-part fractures resulted in each group. The preloading of the rotator cuff muscles had no further influence on the fracture configuration. High-speed videos of the fracture simulation revealed identical fracture mechanisms for both groups. We observed a two-step fracture mechanism, with initial impaction of the head segment against the glenoid followed by fracturing of the head and the tuberosities and then with further impaction of the shaft against the acromion, which lead to separation of the tuberosities. Conclusion A high energetic axial impulse can reliably induce realistic proximal humerus fractures in cadaveric specimens. The preload of the rotator cuff muscles had no influence on initial fracture configuration. Therefore, fracture simulation in the proximal humerus is less elaborate. Using the presented technique, pre-fractured specimens are available for real-life surgical education. KW - Proximal humerus fracture KW - Biomechanical simulation KW - Fracture configuration KW - Fracture simulation KW - Rotator cuff Y1 - 2022 U6 - http://dx.doi.org/10.1007/s00402-022-04471-9 SN - 1434-3916 PB - Springer CY - Berlin, Heidelberg ER - TY - JOUR A1 - Bertz, Morten A1 - Schöning, Michael Josef A1 - Molinnus, Denise A1 - Homma, Takayuki T1 - Influence of temperature, light, and H₂O₂ concentration on microbial spore inactivation: in-situ Raman spectroscopy combined with optical trapping JF - Physica status solidi (a) applications and materials science N2 - To gain insight on chemical sterilization processes, the influence of temperature (up to 70 °C), intense green light, and hydrogen peroxide (H₂O₂) concentration (up to 30% in aqueous solution) on microbial spore inactivation is evaluated by in-situ Raman spectroscopy with an optical trap. Bacillus atrophaeus is utilized as a model organism. Individual spores are isolated and their chemical makeup is monitored under dynamically changing conditions (temperature, light, and H₂O₂ concentration) to mimic industrially relevant process parameters for sterilization in the field of aseptic food processing. While isolated spores in water are highly stable, even at elevated temperatures of 70 °C, exposure to H₂O₂ leads to a loss of spore integrity characterized by the release of the key spore biomarker dipicolinic acid (DPA) in a concentration-dependent manner, which indicates damage to the inner membrane of the spore. Intensive light or heat, both of which accelerate the decomposition of H₂O₂ into reactive oxygen species (ROS), drastically shorten the spore lifetime, suggesting the formation of ROS as a rate-limiting step during sterilization. It is concluded that Raman spectroscopy can deliver mechanistic insight into the mode of action of H₂O₂-based sterilization and reveal the individual contributions of different sterilization methods acting in tandem. KW - hydrogen peroxide KW - optical spore trapping KW - Raman spectroscopy KW - sterilization conditions KW - temperature Y1 - 2024 U6 - http://dx.doi.org/10.1002/pssa.202300866 SN - 1862-6319 (Online) SN - 1862-6300 (Print) IS - Early View PB - Wiley-VCH CY - Berlin ER - TY - JOUR A1 - Kopp, Alexander A1 - Schunck, Laura A1 - Gosau, Martin A1 - Smeets, Ralf A1 - Burg, Simon A1 - Fuest, Sandra A1 - Kröger, Nadja A1 - Zinser, Max A1 - Krohn, Sebastian A1 - Behbahani, Mehdi A1 - Köpf, Marius A1 - Lauts, Lisa A1 - Rutkowski, Rico T1 - Influence of the casting concentration on the mechanical and optical properties of Fa/CaCl2-derived silk fibroin membranes JF - International Journal of Molecular Sciences N2 - In this study, we describe the manufacturing and characterization of silk fibroin membranes derived from the silkworm Bombyx mori. To date, the dissolution process used in this study has only been researched to a limited extent, although it entails various potential advantages, such as reduced expenses and the absence of toxic chemicals in comparison to other conventional techniques. Therefore, the aim of this study was to determine the influence of different fibroin concentrations on the process output and resulting membrane properties. Casted membranes were thus characterized with regard to their mechanical, structural and optical assets via tensile testing, SEM, light microscopy and spectrophotometry. Cytotoxicity was evaluated using BrdU, XTT, and LDH assays, followed by live–dead staining. The formic acid (FA) dissolution method was proven to be suitable for the manufacturing of transparent and mechanically stable membranes. The fibroin concentration affects both thickness and transparency of the membranes. The membranes did not exhibit any signs of cytotoxicity. When compared to other current scientific and technical benchmarks, the manufactured membranes displayed promising potential for various biomedical applications. Further research is nevertheless necessary to improve reproducible manufacturing, including a more uniform thickness, less impurity and physiological pH within the membranes. Y1 - 2020 U6 - http://dx.doi.org/10.3390/ijms21186704 SN - 1422-0067 N1 - Special issue: Optimization of Biomaterials for Reconstructive and Regenerative Medicine VL - 21 IS - 18 art. no. 6704 PB - MDPI CY - Basel ER - TY - JOUR A1 - Albracht, Kirsten A1 - Arampatzis, Adamantios T1 - Influence of the mechanical properties of the muscle-tendon unit on force generation in runners with different running economy JF - Biological Cybernetics Y1 - 2006 U6 - http://dx.doi.org/10.1007/s00422-006-0070-z SN - 1432-0770 VL - 95 IS - 1 SP - 87 EP - 96 ER - TY - JOUR A1 - Stulpe, Werner A1 - Singer, Matthias T1 - Informational Incompleteness of the Observables Sx,Sy,Sz for Spin-1 Systems. Singer, Matthias; Stulpe, W. JF - Foundations of Physics. 20 (1990), H. 4 Y1 - 1990 SN - 1572-9516 SP - 471 EP - 472 ER - TY - JOUR A1 - Artmann, Gerhard A1 - Zhou-Stache, J. A1 - Buettner, R. A1 - Mittermayer, C. [u.a.] T1 - Inhibition of TNF-alpha induced cell death in HUVEC and Jurkat cells by protocatechuic acid. Zhou-Stache, J.; Buettner, R.; Artmann, Gerhard Michael; Mittermayer, C.; Bosserhoff, A. K. JF - Medical and Biological Engineering and Computing. 40 (2002), H. 6 Y1 - 2002 SN - 0140-0118 SP - 698 EP - 703 ER -