TY - JOUR A1 - Artmann, Gerhard A1 - Zang, Werner T1 - Vollautomatische Messung rheologischer Parameter roter Blutzellen JF - Biomedizinische Technik / Biomedical Engineering Y1 - 1990 SN - 0013-5585 VL - 35 IS - S3 SP - 94 EP - 96 ER - TY - CHAP A1 - Lanzl, I. A1 - Seidova, S.-F. A1 - Dühring, C. von A1 - Kotliar, Konstantin ED - Erb, Carl T1 - Befunde der dynamischen Gefäßanalyse am Auge bei Gesunden und Glaukom-Patienten mit praxisrelevanter Bedeutung T2 - Mikrozirkulation beim Glaukom Y1 - 2009 N1 - Search on Glaucoma SP - 33 EP - 39 PB - Elsevier CY - Amsterdam ER - TY - THES A1 - Kotliar, Konstantin T1 - Pathophysiologische Beurteilung und hämodynamische Analyse von mikrostrukturellen Veränderungen des retinalen Gefäßlängsschnittsprofils Y1 - 2012 N1 - Moskau, Habil.-Schr. ,Russ. Univ., Med. Fakultät, 2012. Originaltitel in Russisch. ER - TY - JOUR A1 - Feucht, Nikolaus A1 - Schönbach, Etienne Michael A1 - Lanzl, Ines A1 - Kotliar, Konstantin A1 - Lohmann, Chris Patrick A1 - Maier, Mathias T1 - Changes in the foveal microstructure after intravitreal bevacizumab application in patients with retinal vascular disease JF - Clinical Ophthalmology Y1 - 2013 SN - 1177-5483 VL - 7 SP - 173 EP - 178 PB - Dove Medical Press CY - Auckland, New Zealand ER - TY - JOUR A1 - Murgan, Ilina A1 - Beyer, Sonja A1 - Kotliar, Konstantin A1 - Weber, Lutz A1 - Bechtold-Dalla Pozza, Susanne A1 - Dalla Pozza, Robert A1 - Wegner, Aharon A1 - Sitnikova, Diana A1 - Stock, Konrad A1 - Heemann, Uwe A1 - Schmaderer, Christoph A1 - Baumann, M. T1 - Arterial and Retinal Vascular Changes in Hypertensive and Prehypertensive Adolescents JF - American Journal of Hypertension Y1 - 2013 SN - 1941-7225 VL - 26 IS - 3 SP - 400 EP - 408 PB - Oxford University Press CY - Oxford ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Hanssen, Henner A1 - Eberhardt, Karla A1 - Vilser, Walthard A1 - Schmaderer, Christoph A1 - Halle, Martin A1 - Heemann, Uwe A1 - Baumann, M. T1 - Retinal pulse wave velocity in young male normotensive and mildly hypertensive subjects JF - Microcirculation Y1 - 2013 SN - 1549-8719 N1 - Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.) PB - Wiley CY - Malden ER - TY - JOUR A1 - Reisert, Steffen A1 - Schneider, Benno A1 - Geissler, Hanno A1 - Gompel, Matthias van A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Multi-sensor chip for the investigation of different types of metal oxides for the detection of H2O2 in the ppm range JF - physica status solidi (a) N2 - In this work, a multi-sensor chip for the investigation of the sensing properties of different types of metal oxides towards hydrogen peroxide in the ppm range is presented. The fabrication process and physical characterization of the multi-sensor chip are described. Pure SnO2 and WO3 as well as Pd- and Pt-doped SnO2 films are characterized in terms of their sensitivity to H2O2. The sensing films have been prepared by drop-coating of water-dispensed nano-powders. A physical characterization, including scanning electron microscopy and X-ray diffraction analysis of the deposited metal-oxide films, was done. From the measurements in hydrogen peroxide atmosphere, it could be shown, that all of the tested metal oxide films are suitable for the detection of H2O2 in the ppm range. The highest sensitivity and reproducibility was achieved using Pt-doped SnO2. Calibration plot of a SnO2, WO3, Pt-, and Pd-doped SnO2 gas sensor for H2O2 concentrations in the ppm range. Y1 - 2013 SN - 1862-6319 VL - 210 IS - 5 SP - 898 EP - 904 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Hennemann, Jörg A1 - Kohl, Claus-Dieter A1 - Reisert, Steffen A1 - Kirchner, Patrick A1 - Schöning, Michael Josef T1 - Copper oxide nanofibres for detection of hydrogen peroxide vapour at high concentrations JF - physica status solidi (a) N2 - We present a sensor concept based on copper(II)oxide (CuO) nanofibres for the detection of hydrogen peroxide (H2O2) vapour in the percent per volume (% v/v) range. The fibres were produced by using the electrospinning technique. To avoid water condensation in the pores, the fibres were initially modified by an exposure to H2S to get an enclosed surface. By a thermal treatment at 350 °C the fibres were oxidised back to CuO. Thereby, the visible pores disappear which was verified by SEM analysis. The fibres show a decrease of resistance with increasing H2O2 concentration which is due to the fact that hydrogen peroxide is an oxidising gas and CuO a p-type semiconductor. The sensor shows a change of resistance within the minute range to the exposure until the maximum concentration of 6.9% v/v H2O2. At operating temperatures below 450 °C the corresponding sensor response to a concentration of 4.1% v/v increases. The sensor shows a good reproducibility of the signal at different measurements. CuO seems to be a suitable candidate for the detection of H2O2 vapour at high concentrations. Resistance behaviour of the sensor under exposure to H2O2 vapours between 2.3 and 6.9% v/v at an operating temperature of 450 °C. Y1 - 2013 U6 - http://dx.doi.org/10.1002/pssa.201200775 SN - 1862-6319 VL - 210 IS - 5 SP - 859 EP - 863 PB - Wiley CY - Weinheim ER - TY - THES A1 - Schieffer, Andre T1 - Studies on diversity and coexistence in an experimental microbial community N2 - Biodiversity and the coexistence of species have puzzled and fascinated biologists since decades and is a hotspot in todays’ natural sciences. Preserving this biodiversity is a great challenge as habitats and environments underlying tremendous changes like climate change and the loss of natural habitats, which are mainly due to anthropogenic influences. The coexistence of numerous species even in homogeneous environments is a stunning feature of natural communities and has been summarized under the term ‘paradox of plankton’. Up to now, there are several mechanisms discussed, which may contribute to local and global diversity of organisms. Several interspecific trade offs have been identified maintaining the coexistence of species like their abilities regarding competition and predator avoidance, their capability to disperse in space and time, and their ability to exploit variable resources. Further, micro-evolutionary dynamics supporting the coexistence of species have been added to our knowledge, and deriving from theoretical deterministic models, non-linear dynamics which describe the temporal fluctuation of abundances of organisms. Whereas competition and predation seem to be clue structural elements within interacting organisms, the intrinsic dynamic behavior – by means of temporal changes in abundance - plays an important role regarding coexistence within a community. The present work sheds light on different factors affecting the coexistence of species using experimental microbial model systems consisting of a bacterivorous ciliate as the predator and two bacteria strains as prey organism. Additionally, another experimental setup consisting of two up to five bacteria species competing for one limiting resource was investigated. Highly controllable chemostat systems were established to exclude extrinsic disturbances. According to theoretical analyses I was able to show - experimentally and theoretically - that phenotypic plasticity of one species within a microbial one-predator-two-prey food web enlarges the range of possible coexistence of all species under different dynamic conditions, compared to a food web without phenotypic plasticity. This was accompanied by non-linear (chaotic) population dynamics within all experimental systems showing phenotypic plasticity. The experiments on the interplay of competition, predation and invasion showed that all aspects have an influence on species coexistence. Under undisturbed controlled conditions all aspects were analyzed in detail and in combination. Populations showed oscillations which were shown by quasi-chaotic attractors in phase space diagrams. Competition experiments with two up to five bacteria species competing for one limiting resource showed that all organisms were able to coexist which was mediated by species oscillations entering a regime of chaos. Besides that fact it was found, that the productivity (biomass) as well as the total cell numbers – under the same nutrition supply – increased by an increasing number of species in the experimental systems. Up to now, the occurrence of non-linear dynamics in well controlled experimental studies has been recognized several times and this phenomenon seemed to be more common in natural systems than generally assumed. N2 - Biodiversität und die Koexistenz von Arten fasziniert und verblüfft Biologen seit Jahr-zehnten und stellen einen Schwerpunkt in der heutigen Umweltforschung dar. Der Schutz und die Konservierung dieser Mannigfaltigkeit stellen eine große Herausfor-derung dar, da die natürlichen Lebensräume sowie die Umwelt enormen Verände-rungen unterworfen sind, welche meist in einem anthropogenen Ursprung wurzeln. Die Koexistenz vieler Arten, auch in relativ homogenen Habitaten ist ein faszinieren-des Charakteristikum natürlicher Lebensgemeinschaften und wird als ‚Paradox des Planktons‘ bezeichnet. Gegenwärtig werden diverse Ursachen diskutiert, welche vermutlich zur lokalen und globalen Diversität von Organismen beitragen. Einige die-ser möglichen Ursachen, die zur Aufrechterhaltung der Koexistenz der Arten beitra-gen, wurden identifiziert: Das Vermögen der Konkurrenz- und Prädationsvermeidung, die Fähigkeit räumlicher sowie zeitlicher Verteilung, sowie das Vermögen variable Ressourcen zu nutzen. Des Weiteren wurden mikro-evolutionäre Phänomene und Dynamiken identifiziert, sowie, von theoretischen deterministischen Modellen ausge-hend, nichtlineare Dynamiken, welche die zeitlichen Schwankungen der Abundanzen von Organismen beschreiben. Diese Aspekte stellen die Schlüsselkomponenten zwi-schen interagierenden Organismen dar, wobei das intrinsiche, nicht lineare dynami-sche Verhalten in Form von zeitlichen Veränderungen in Abundanzen eine zusätzli-che entscheidende Rolle bezüglich der Koexistenz von Arten spielen kann. Einige dieser Aspekte wurden in der vorliegenden Arbeit untersucht. In Anlehnung an theoretische Analysen konnte experimentell sowie theoretisch gezeigt werden, dass phänotypische Plastizität in einer Bakterienart in einem mikrobiellen Ein-Räuber-zwei-Beute-Nahrungsgewebe den Bereich der möglichen Koexistenz unter sich än-dernden experimentellen Bedingungen (Änderungen der Durchflussraten der Chemostate) – im direkten Vergleich zu einem experimentellen Nahrungsgewebe ohne phänotypische Plastizität – erweitern kann. Dies wurde begleitet durch nicht lineare Abundanzschwankungen in den Populationen aller untersuchten Versuchs-ansätze. In weiteren Untersuchungen wurde das Zusammenspiel von Konkurrenz, Prädation und Invasion in einer experimentellen mikrobiellen Gemeinschaft untersucht. Unter kontrollierten Bedingungen konnten diese Aspekte detailliert untersucht werden und es konnten Aufschlüsse darüber gewonnen werden, welche Reaktionen (Interaktionen) innerhalb der untersuchten Gemeinschaften stattfinden. Im Versuchsverlauf wurden Veränderungen in den Abundanzen sowie chaotische Schwankungen der Zellzahlen festgestellt. In Konkurrenzexperimenten von zwei bis zu fünf um eine limitierende Ressource konkurrierende Bakterienarten konnte gezeigt werden, dass alle Arten – vermittelt durch chaotische Abundanzschwankungen – nebeneinander koexistieren konnten. Begleitend dazu wurde herausgefunden, dass die Produktivität (Biomasse) sowie die Gesamtzellzahl bei gleicher Nahrungsverfügbarkeit der experimentellen Systeme mit steigender Artenzahl zunehmen. Gegenwärtig ist das Auftreten von Chaos in gut kontrollierten experimentellen Studien vereinzelt beobachtet worden, wobei dieses Phänomen jedoch häufiger in der Natur aufzutreten scheint als generell vermutet. Y1 - 2012 N1 - Köln, Univ., Diss., 2012 ER - TY - JOUR A1 - Nomdedeu, Mar Monsonis A1 - Willen, Christine A1 - Schieffer, Andre A1 - Arndt, Hartmut T1 - Temperature-dependent ranges of coexistence in a model of a two-prey-one-predator microbial food web JF - Marine Biology N2 - The objective of our study was to analyze the effects of temperature on the population dynamics of a three-species food web consisting of two prey bacteria (Pedobacter sp. and Acinetobacter johnsonii) and a protozoan predator (Tetrahymena pyriformis) as model organisms. We assessed the effects of temperature on the growth rates of all three species with the objective of developing a model with four differential equations based on the experimental data. The following hypotheses were tested at a theoretical level: Firstly, temperature changes can affect the dynamic behavior of a system by temperature-dependent parameters and interactions and secondly, food web response to temperature cannot be derived from the single species temperature response. The main outcome of the study is that temperature changes affect the parameter range where coexistence is possible within all three species. This has significant consequences on our ideas regarding the evaluation of effects of global warming. Y1 - 2012 U6 - http://dx.doi.org/10.1007/s00227-012-1966-x SN - 1432-1793 VL - 159 IS - 11 SP - 2423 EP - 2430 PB - Springer CY - Berlin ER - TY - JOUR A1 - Heinzel, Alexander A1 - Schäfer, Ralf A1 - Müller, Hans-Wilhelm A1 - Schieffer, Andre A1 - Ingenhag, Ariane A1 - Northoff, Georg A1 - Franz, Matthias A1 - Hautzel, Hubertus T1 - Differential modulation of valence and arousal in high-alexithymic and low-alexithymic individuals JF - Neuroreport N2 - High-alexithymic individuals are characterized by an impaired ability to identify and communicate emotions whereas low-alexithymic individuals have a wide-ranging ability to deal with emotions. This study examined the hypothesis that valence and arousal modifications of emotional stimuli differentially modulate cortical regions in high-alexithymic and low-alexithymic individuals. To this end, 28 high-alexithymic and 25 low-alexithymic individuals were investigated with event-related fMRI using visual emotional stimuli. We found differential neural activations in the dorsal anterior cingulate, the insula and the amygdala. We suggest that these differences may account for the impaired ability of high-alexithymic individuals to appropriately handle emotional stimuli. Y1 - 2010 U6 - http://dx.doi.org/10.1097/WNR.0b013e32833f38e0 SN - 1473-558X VL - 21 IS - 15 SP - 998 EP - 1002 PB - Lippincott Williams & Wilkins CY - London ER - TY - JOUR A1 - Heinzel, Alexander A1 - Schäfer, Ralf A1 - Müller, Hans-Wilhelm A1 - Schieffer, Andre A1 - Ingenhag, Ariane A1 - Eickhoff, Simon B. A1 - Northoff, Georg A1 - Franz, Matthias A1 - Hautzel, Hubertus T1 - Increased Activation of the Supragenual Anterior Cingulate Cortex during Visual Emotional Processing in Male Subjects with High Degrees of Alexithymia: An Event-Related fMRI Study JF - Psychotherapy and Psychosomatics N2 - Background: One of the most prominent neurobiological models of alexithymia assumes an altered function of the anterior cingulate cortex (ACC) as the crucial neural correlate of alexithymia. So far functional imaging studies have yielded inconclusive results. Therefore, we tested this hypothesis in healthy alexithymics and nonalexithymics in an event-related fMRI study. Methods: Thirty high- and 30 low-alexithymic right-handed male subjects (selected by the 20-item Toronto Alexithymia Scale, TAS-20) were investigated with event-related fMRI using a picture viewing paradigm. The stimuli consisted of happy, fearful and neutral facial expressions (Ekman-Friesen) as well as positive, negative and neutral pictures from the International Affective Picture System. Results: Contrasting the high-alexithymic with the low-alexithymic group we observed increased activation of the supragenual ACC for different emotional valences as well as for different emotional stimuli. Moreover, there was a positive correlation of the ACC with the individual TAS-20 scores but no correlations with the individual Beck Depression Inventory scores. Additionally, there was no difference in activity of the amygdala. Conclusions: We demonstrated that the supragenual ACC is constantly activated more strongly in alexithymic subjects and that this activation is related to the symptoms of alexithymia and not to associated symptoms such as depression. Therefore, our findings support the hypothesis of an altered function of the ACC in alexithymia. Y1 - 2010 U6 - http://dx.doi.org/10.1159/000320121 SN - 0033-3190 VL - 79 IS - 6 SP - 363 EP - 370 PB - Karger CY - Basel ER - TY - JOUR A1 - Kirchner, Patrick A1 - Oberländer, Jan A1 - Suso, Henri-Pierre A1 - Rysstad, Gunnar A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Towards a wireless sensor system for real-time H2O2 monitoring in aseptic food processes JF - Physica status solidi (a) N2 - A wireless sensor system based on the industrial ZigBee standard for low-rate wireless networking was developed that enables real-time monitoring of gaseous H2O2 during the package sterilization in aseptic food processes. The sensor system consists of a remote unit connected to a calorimetric gas sensor, which was already established in former works, and an external base unit connected to a laptop computer. The remote unit was built up by an XBee radio frequency (RF) module for data communication and a programmable system-on-chip controller to read out the sensor signal and process the sensor data, whereas the base unit is a second XBee RF module. For the rapid H2O2 detection on various locations inside the package that has to be sterilized, a novel read-out strategy of the calorimetric gas sensor was established, wherein the sensor response is measured within the short sterilization time and correlated with the present H2O2 concentration. In an exemplary measurement application in an aseptic filling machinery, the suitability of the new, wireless sensor system was demonstrated, wherein the influence of the gas velocity on the H2O2 distribution inside a package was determined and verified with microbiological tests. KW - calorimetric gas sensor;hydrogen peroxide;wireless sensor system Y1 - 2013 U6 - http://dx.doi.org/10.1002/pssa.201200920 SN - 1862-6319 VL - 210 IS - 5 SP - 877 EP - 883 PB - Wiley CY - Weinheim ER - TY - PAT A1 - Hofbauer, Peter A1 - Härtel, Günter A1 - Lösing, Karl-Heinrich A1 - Dorner, Robert A1 - Simonis, Rainer A1 - Schulte, Erasmus T1 - Brennstoffeinspritzsystem für Brennkraftmaschinen : Offenlegungsschrift DE 3833215 A1 ; Offenlegungstag: 28.12.89 N2 - Es wird ein Brennstoffeinspritzsystem für Brennkraftmaschinen vorgeschlagen, bei dem ein definiertes Teil eines fest vorgegebenen Brennstoffvolumens durch die Druckerhöhung innerhalb einer brennstoffeinschließenden Kammer eine definierte Brennstoffmenge über jeweils ein Rückschlagventil abgespritzt wird. Ein elektronisches Steuergerät berechnet die Dauer und/oder Intensität und gegebenenfalls die Impulsfolge eines zum Beispiel zur Verdampfung einer bestimmten Brennstoffmenge erforderlichen Laserimpulses. Das System kann für Ein- oder Mehrstelleinspritzung Verwendung finden. KW - Brennkraftmaschine KW - Brennstoffeinspritzsystem Y1 - 1989 PB - Deutsches Patent- und Markenamt CY - München ER - TY - BOOK A1 - Simonis, Rainer A1 - Brücher, Heiner T1 - Verhalten von radioaktivem Krypton-85 in der Tiefsee : Abschlußbericht für d. Berichtszeitraum 1.10.1980 - 31.3.1983 KW - Krypton-85 Y1 - 1984 N1 - Spezielle Berichte der Kernforschungsanlage Jülich ; 267 PB - Zentralbibliothek d. Kernforschungsanlage CY - Jülich ER - TY - BOOK A1 - Simonis, Rainer T1 - Experimentelle Darstellung von Kr/Xe-Hydrat bei Drücken bis 160 bar KW - Krypton KW - Xenon KW - krypton xenon hydrate Y1 - 1985 N1 - Zugl.: Aachen, Techn. Hochsch., Diss. N1 - Berichte der Kernforschungsanlage Jülich ; 1995 PB - Zentralbibliothek d. Kernforschungsanlage CY - Jülich ER - TY - CHAP A1 - Duong, Minh Tuan A1 - Nguyen, Nhu Hunyh A1 - Staat, Manfred T1 - Finite Element Implementation of a 3D Fung-type Model T2 - ESMC-2012 - 8th European Solid Mechanics Conference, Graz, Austria, July 9-13, 2012 Y1 - 2012 SN - 978-3-85125-223-1 PB - Verlag d. Technischen Universität Graz CY - Graz ER - TY - CHAP A1 - Frotscher, Ralf A1 - Raatschen, Hans-Jürgen A1 - Staat, Manfred ED - Holzapfel, Gerhard A. T1 - Effectiveness of the edge-based smoothed finite element method applied to soft biological tissues T2 - ESMC-2012 - 8th European Solid Mechanics Conference, Graz, Austria, July 9-13, 2012 Y1 - 2012 SN - 978-3-85125-223-1 PB - Verlag d. Technischen Universität Graz CY - Graz ER - TY - GEN A1 - Rongen, Heinz A1 - Ziemons, Karl A1 - Schiek, Michael A1 - Tass, Alexander T1 - Vorrichtung zur Messung biomedizinischer Daten eines Probanden und Verfahren zur Simulation des Probanden mit in Echtzeit verarbeiteten Daten T1 - Device for measuring biomedical data from a testee and method for stimulating the testee with data processed in real-time N2 - Die Erfindung betrifft eine Vorrichtung zur Messung biomedizinischer Daten eines Probanden, mit einem Messsystem zur Erhebung der Daten sowie einer ersten Hardware-Komponente zur Aufzeichnung der Daten. In einer Verbindungsleitung zur Übertragung der Daten vom Messsystem zur ersten Hardware-Komponente zur Aufzeichnung der Daten ist erfindungsgemäss ein Mittel zur galvanischen Auftrennung der Daten angeordnet. Auf diese Weise ist wenigstens die Duplizierung der Daten für Datenverarbeitungszwecke gewährleistet. Die auf diese Weise verarbeiteten Daten werden für ein Verfahren zur Echtzeit-Stimulation eines Probanden genutzt. Y1 - 2006 N1 - Auch veröffentlicht als EP2007276 ; US2009069662 ; US8301222 ; JP2009535071 ; WO2007118443 ; AT 533401 SP - 1 EP - 12 ER - TY - GEN A1 - Achten, Richard A1 - Bauer, Andreas A1 - Bertram, Walter A1 - Cremer, Markus A1 - Daemen, Jos A1 - Dehnhardt, Markus A1 - Fleischer, Manfred A1 - Kirchner, Peter A1 - Leyendecker, Marco A1 - Pietrzyk, Uwe A1 - Schmitz, Jakob A1 - Ziemons, Karl A1 - Zilles, Karl T1 - Vorrichtung zum Halten eines lebenden Objektes bei physiologischen Messungen N2 - Die vorliegende Erfindung betrifft eine Vorrichtung zum Halten eines lebenden Objektes bei physiologischen Messungen mit einem Basiselement und Mitteln zum Arretieren des lebenden Objektes, die atraumatische Ohrenhalter sowie ein Mundstück aufweisen, das mit einer Aussparung für die Zähne des Lebewesens versehen ist, mit einem Masseanteil von wenigstens 95% an glasfaserverstärktem Kunststoff. Y1 - 2005 N1 - Patent Anmelder : Forschungszentrum Jülich GmbH SP - 1 EP - 17 ER -