TY - JOUR A1 - Vögele, Stefan A1 - Grajewski, Matthias A1 - Govorukha, Kristina A1 - Rübbelke, Dirk T1 - Challenges for the European steel industry: Analysis, possible consequences and impacts on sustainable development JF - Applied Energy N2 - The steel industry in the European Union (EU), important for the economy as a whole, faces various challenges. These are inter alia volatile prices for relevant input factors, uncertainties concerning the regulation of CO₂-emissions and market shocks caused by the recently introduced additional import duties in the US, which is an important sales market. We examine primary and secondary effects of these challenges on the steel industry in the EU and their impacts on European and global level. Developing and using a suitable meta-model, we analyze the competitiveness of key steel producing countries with respect to floor prices depending on selected cost factors and draw conclusions on the impacts in the trade of steel on emissions, energy demand, on the involvement of developing countries in the value chain as well on the need for innovations to avoid relocations of production. Hence, our study contributes to the assessment of sustainable industrial development, which is aimed by the Sustainability Development Goal “Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation countries”. By applying information on country-specific Human Development Indexes (reflecting aspects of life expectancy, education, and per capita income), we show that relocating energy-intensive industries from the EU may not only increase global energy demand and CO₂-emissions, but may also be to the disadvantage of developing countries. Y1 - 2020 U6 - http://dx.doi.org/10.1016/j.apenergy.2020.114633 SN - 0306-2619 VL - 264 IS - Article number: 114633 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Knox, Ronald A1 - Bruggemann, Andrea A1 - Gossmann, Matthias A1 - Thomas, Ulrich A1 - Horváth, András A1 - Dragicevic, Elena A1 - Stoelzle-Feix, Sonja A1 - Fertig, Niels A1 - Jung, Alexander A1 - Raman, Aravind Hariharan A1 - Staat, Manfred A1 - Linder, Peter T1 - Combining physiological relevance and throughput for in vitro cardiac contractility measurement JF - Biophysical Journal N2 - Despite increasing acceptance of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in safety pharmacology, controversy remains about the physiological relevance of existing in vitro models for their mechanical testing. We hypothesize that existing signs of immaturity of the cell models result from an improper mechanical environment. We cultured hiPSC-CMs in a 96-well format on hyperelastic silicone membranes imitating their native mechanical environment, resulting in physiological responses to compound stimuli.We validated cell responses on the FLEXcyte 96, with a set of reference compounds covering a broad range of cellular targets, including ion channel modulators, adrenergic receptor modulators and kinase inhibitors. Acute (10 - 30 min) and chronic (up to 7 days) effects were investigated. Furthermore, the measurements were complemented with electromechanical models based on electrophysiological recordings of the used cell types.hiPSC-CMs were cultured on freely-swinging, ultra-thin and hyperelastic silicone membranes. The weight of the cell culture medium deflects the membranes downwards. Rhythmic contraction of the hiPSC-CMs resulted in dynamic deflection changes which were quantified by capacitive distance sensing. The cells were cultured for 7 days prior to compound addition. Acute measurements were conducted 10-30 minutes after compound addition in standard culture medium. For chronic treatment, compound-containing medium was replaced daily for up to 7 days. Electrophysiological properties of the employed cell types were recorded by automated patch-clamp (Patchliner) and the results were integrated into the electromechanical model of the system.Calcium channel agonist S Bay K8644 and beta-adrenergic stimulator isoproterenol induced significant positive inotropic responses without additional external stimulation. Kinase inhibitors displayed cardiotoxic effects on a functional level at low concentrations. The system-integrated analysis detected alterations in beating shape as well as frequency and arrhythmic events and we provide a quantitative measure of these. Y1 - 2020 U6 - http://dx.doi.org/10.1016/j.bpj.2019.11.3104 SN - 0006-3495 N1 - Raman, Arayind Hariharan im Artikel unter dem Namen: Raman, Alexander H. VL - 118 IS - Issue 3, Supplement 1 SP - 570a PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Grajewski, Matthias A1 - Hron, Jaroslav A1 - Turek, Stefan T1 - Dual weighted a posteriori error estimation for a new nonconforming linear finite element on quadrilaterals JF - Applied Numerical Mathematics N2 - After a short introduction of a new nonconforming linear finite element on quadrilaterals recently developed by Park, we derive a dual weighted residual-based a posteriori error estimator (in the sense of Becker and Rannacher) for this finite element. By computing a corresponding dual solution we estimate the error with respect to a given target error functional. The reliability and efficiency of this estimator is analyzed in several numerical experiments. Y1 - 2005 U6 - http://dx.doi.org/10.1016/j.apnum.2004.09.016 SN - 0168-9274 VL - 54 IS - 3-4 SP - 504 EP - 518 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Grajewski, Matthias A1 - Hron, Jaroslav A1 - Turek, Stefan T1 - Numerical analysis for a new non-conforming linear finite element on quadrilaterals JF - Journal of Computational and Applied Mathematics Y1 - 2006 U6 - http://dx.doi.org/10.1016/j.cam.2005.05.024 SN - 0377-0427 VL - 193 IS - 1 SP - 38 EP - 50 ER - TY - JOUR A1 - Grajewski, Matthias A1 - Köster, Michael A1 - Turek, Stefam T1 - Numerical analysis and implementational aspects of a new multilevel grid deformation method JF - Applied Numerical Mathematics N2 - Recently, we introduced and mathematically analysed a new method for grid deformation (Grajewski et al., 2009) [15] we call basic deformation method (BDM) here. It generalises the method proposed by Liao et al. (Bochev et al., 1996; Cai et al., 2004; Liao and Anderson, 1992) [4], [6], [20]. In this article, we employ the BDM as core of a new multilevel deformation method (MDM) which leads to vast improvements regarding robustness, accuracy and speed. We achieve this by splitting up the deformation process in a sequence of easier subproblems and by exploiting grid hierarchy. Being of optimal asymptotic complexity, we experience speed-ups up to a factor of 15 in our test cases compared to the BDM. This gives our MDM the potential for tackling large grids and time-dependent problems, where possibly the grid must be dynamically deformed once per time step according to the user's needs. Moreover, we elaborate on implementational aspects, in particular efficient grid searching, which is a key ingredient of the BDM. Y1 - 2010 U6 - http://dx.doi.org/10.1016/j.apnum.2010.03.017 SN - 0168-9274 VL - 60 IS - 8 SP - 767 EP - 781 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Grajewski, Matthias A1 - Köster, Michael A1 - Turek, Stefan T1 - Mathematical and Numerical Analysis of a Robust and Efficient Grid Deformation Method in the Finite Element Context JF - SIAM Journal on Scientific Computing Y1 - 2009 U6 - http://dx.doi.org/10.1137/050639387 VL - 31 IS - 2 SP - 1539 EP - 1557 PB - Society for Industrial and Applied Mathematics CY - Philadelphia, Pa. ER - TY - JOUR A1 - Göddeke, Dominik A1 - Strzodka, Robert A1 - Mohd-Yusof, Jamaludin A1 - McCormick, Patrick A1 - Buijssen, Sven H.M. A1 - Grajewski, Matthias A1 - Turek, Stefan T1 - Exploring weak scalability for FEM calculations on a GPU-enhanced cluster JF - Parallel Computing Y1 - 2007 U6 - http://dx.doi.org/10.1016/j.parco.2007.09.002 SN - 0167-8191 VL - 33 IS - 10-11 SP - 685 EP - 699 ER - TY - CHAP A1 - Striegan, Constantin J. D. A1 - Struth, Benjamin A1 - Dickhoff, Jens A1 - Kusterer, Karsten A1 - Funke, Harald A1 - Bohn, Dieter T1 - Numerical Simulations of the Micromix DLN Hydrogen Combustion Technology with LES and Comparison to Results of RANS and Experimental Data T2 - Proceedings of International Gas Turbine Congress 2019 Tokyo, November 17-22, 2019, Tokyo, Japan. Y1 - 2019 SN - 978-4-89111-010-9 N1 - IGCT-2019-147 SP - 1 EP - 9 ER - TY - CHAP A1 - Funke, Harald A1 - Beckmann, Nils T1 - Flexible Fuel Operation of a Dry-Low-Nox Micromix Combustor with Variable Hydrogen Methane Mixtures T2 - Proceedings of International Gas Turbine Congress 2019 Tokyo, November 17-22, 2019, Tokyo, Japan Y1 - 2019 SN - 978-4-89111-010-9 N1 - IGTC-2019-013 ER - TY - CHAP A1 - Horikawa, Atsushi A1 - Okada, Kunio A1 - Uto, Takahiro A1 - Uchiyama, Yuta A1 - Wirsum, Manfred A1 - Funke, Harald A1 - Kusterer, Karsten T1 - Application of Low NOx Micro-mix Hydrogen Combustion to 2MW Class Industrial Gas Turbine Combustor T2 - Proceedings of International Gas Turbine Congress 2019 Tokyo, November 17-22, 2019, Tokyo, Japan Y1 - 2019 SN - 978-4-89111-010-9 N1 - IGTC-2019-129 SP - 1 EP - 6 ER -