TY  - RPRT
A1  - Nagl, Manfred
A1  - Kraft, Bodo
T1  - Graphbasierte Werkzeuge zur Unterstützung des konzeptuellen Gebäude-Entwurfs : Bericht über den 2. Förderzeitraum des Schwerpunktprogramms : DFG-Schwerpunktprogramm 1103 : Vernetzt-kooperative Planungsprozesse im Konstruktiven Ingenieurbau. - Auch unter dem Titel: Neue Software-Werkzeuge zur Unterstützung des konzeptuellen Gebäudeentwurfs
N2  - Der konstruktive Entwurf wird in derzeitigen CAD-Systemen gut unterstützt, nicht aber der konzeptuelle Gebäude-Entwurf. Dieser abstrahiert von konstruktiven Elementen wie Linie, Wand oder Decke, um auf die Konzepte, d.h. die eigentlichen Funktionen, heraus zu arbeiten. Diese abstraktere, funktionale Sichtweise auf ein Gebäude ist während der frühen Entwurfsphase essentiell, um Struktur und Organisation des gesamten Gebäudes zu erfassen. Bereits in dieser Phase muss Fachwissen (z. B. rechtliche, ökonomische und technische Bestimmungen) berücksichtigt werden. Im Rahmen des vorliegenden Projekts werden Software-Werkzeuge integriert in industrielle CAD-Systeme entwickelt, die den konzeptuellen Gebäude-Entwurf ermöglichen und diesen gegen Fachwissen prüfen. Das Projekt ist in zwei Teile gegliedert. Im Top-Down-Ansatz werden Datenstrukturen und Methoden zur Strukturierung, Repräsentation und Evaluation von gebäudespezifischem Fachwissen erarbeitet. Dieser Teil baut auf den graphbasierten Werkzeugen PROGRES und UPGRADE des Lehrstuhls auf. Der Bottom-Up-Ansatz ist industriell orientiert und hat zum Ziel, das kommerzielle CAD-System ArchiCAD zu erweitern. Hierbei soll der frühe, konzeptuelle Gebäude-Entwurf in einem CAD-System ermöglicht werden. Der Entwurf kann darüber hinaus gegen das definierte Fachwissen geprüft werden. Im Rahmen des graphbasierten Top-Down-Ansatzes wurde zunächst eine neue Spezifikationsmethode für die Sprache PROGRES entwickelt. Das PROGRES-System erlaubt die Spezifikation von Werkzeugen in deklarativer Form. Üblicherweise wird domänenspezifisches Fachwissen in der PROGRES-Spezifikation codiert, das daraus generierte visuelle Werkzeug stellt dann die entsprechende Funktionalität zur Verfügung. Mit dieser Methode sind am Lehrstuhl für Informatik III Werkzeuge für verschie-dene Anwendungsdomänen entstanden. In unserem Fall versetzen wir einen Domänen-Experten, z. B. einen erfahrenen Architekten, in die Lage, Fachwissen zur Laufzeit einzugeben, dieses zu evaluieren, abzuändern oder zu ergänzen. Im Rahmen der bisherigen Arbeit wurde dazu eine parametrisierte PROGRES-Spezifikation und zwei darauf aufbauende Werkzeuge entwickelt, welche die dynamische Eingabe von gebäude-technisch relevantem Fachwissen erlauben und einen graphbasierten, konzeptuellen Gebäude-Entwurf ermöglichen. In diesem konzeptuellen Gebäude-Entwurf wird von Raumgrößen und Positionen abstrahiert, um die funktionale Struktur eines Gebäudes zu beschreiben. Das Fachwissen kann von einem Architekten visuell definiert werden. Es können semantische Einheiten, im einfachsten Fall Räume, nach verschiedenen Kriterien kategorisiert und klassifiziert werden. Mit Hilfe von Attributen und Relationen können die semantischen Einheiten präziser beschrieben und in Beziehung zueinander gesetzt werden. Die in PROGRES spezifizierten Konsistenz-Analysen erlauben die Prüfung eines graphbasierten konzeptuellen Gebäude-Entwurfs gegen das dynamisch eingefügte Fachwissen. Im zweiten Teil des Forschungsprojekts, dem Bottom-Up-Ansatz, wird das CAD-System ArchiCAD erweitert, um den integrierten konzeptuellen Gebäude-Entwurf zu ermöglichen. Der Architekt erhält dazu neue Entwurfselemente, die Raumobjekte, welche die relevanten semantischen Einheiten während der frühen Entwurfsphase repräsentieren. Mit Hilfe der Raumobjekte kann der Architekt in ArchiCAD den Grundriss und das Raumprogramm eines Gebäudes entwerfen, ohne von konstruktiven Details in seiner Kreativität eingeschränkt zu werden. Die Arbeitsweise mit Raumobjekten entspricht dem informellen konzeptuellen Entwurf auf einer Papierskizze und ist daher für den Architekten intuitiv und einfach zu verwenden. Durch die Integration in ArchiCAD ergibt sich eine weitere Unterstützung: Das im Top-Down-Ansatz spezifizierte Fach-wissen wird verwendet, um den konzeptuellen Gebäude-Entwurf des Architekten auf Regelverletzungen zu überprüfen. Entwurfsfehler werden angezeigt. Zum Abschluss des konzeptuellen Gebäude-Entwurfs mit Raumobjekten wird durch ein weiteres neu entwickeltes Werkzeug eine initiale Wandstruktur automatisch erzeugt, die als Grundlage für die folgenden konstruktiven Entwurfsphasen dient. Alle beschriebenen Erwei-terungen sind in ArchiCAD integriert, sie sind für den Architekten daher leicht zu erlernen und einfach zu bedienen.
KW  - CAD
KW  - CAD
KW  - Bauingenieurwesen
KW  - CAD
KW  - civil engineering
Y1  - 2004
ER  - 
TY  - CHAP
A1  - Kraft, Bodo
A1  - Retkowitz, Daniel
T1  - Graph Transformations for Dynamic Knowledge Processing
N2  - In: Proceedings of the 39th Annual Hawaii International Conference on System Sciences, 2006. HICSS '06 http://dx.doi.org/10.1109/HICSS.2006.200 The conceptual design phase at the beginning of the building construction process is not adequately supported by any CAD-tool. Conceptual design support needs regarding two aspects: first, the architect must be able to develop conceptual sketches that provide abstraction from constructive details. Second, conceptually relevant knowledge should be available to check these conceptual sketches. The paper deals with knowledge to formalize for conceptual design. To enable domain experts formalizing knowledge, a graph-based specification is presented that allows the development of a domain ontology and design rules specific for one class of buildings at runtime. The provided tool support illustrates the introduced concepts and demonstrates the consistency analysis between knowledge and conceptual design.
KW  - CAD
KW  - CAD
KW  - Bauingenieurwesen
KW  - CAD
KW  - civil engineering
Y1  - 2006
ER  - 
TY  - CHAP
A1  - Kraft, Bodo
A1  - Meyer, Oliver
A1  - Nagl, Manfred
T1  - Graph technology support for conceptual design in civil engineering
N2  - In: Advances in intelligent computing in engineering : proceedings of the 9.International EG-ICE Workshop ; Darmstadt, (01 - 03 August) 2002 / Martina Schnellenbach-Held ... (eds.) . - Düsseldorf: VDI-Verl., 2002 .- Fortschritt-Berichte VDI, Reihe 4, Bauingenieurwesen ; 180 ; S. 1-35 The paper describes a novel way to support conceptual design in civil engineering. The designer uses semantical tools guaranteeing certain internal structures of the design result but also the fulfillment of various constraints. Two different approaches and corresponding tools are discussed: (a) Visually specified tools with automatic code generation to determine a design structure as well as fixing various constraints a design has to obey. These tools are also valuable for design knowledge specialist. (b) Extensions of existing CAD tools to provide semantical knowledge to be used by an architect. It is sketched how these different tools can be combined in the future. The main part of the paper discusses the concepts and realization of two prototypes following the two above approaches. The paper especially discusses that specific graphs and the specification of their structure are useful for both tool realization projects.
KW  - CAD
KW  - CAD ;
KW  - CAD
KW  - civil engineering
Y1  - 2002
SN  - 3-18-318004-9
ER  - 
TY  - JOUR
A1  - Richter, Charlotte
A1  - Braunstein, Björn
A1  - Stäudle, Benjamin
A1  - Attias, Julia
A1  - Süss, Alexander
A1  - Weber, Tobias
A1  - Mileva, Katya N.
A1  - Rittweger, Jörn
A1  - Green, David A.
A1  - Albracht, Kirsten
T1  - Gastrocnemius medialis contractile behavior during running differs between simulated Lunar and Martian gravities
JF  - Scientific reports
N2  - The international partnership of space agencies has agreed to proceed forward to the Moon sustainably. Activities on the Lunar surface (0.16 g) will allow crewmembers to advance the exploration skills needed when expanding human presence to Mars (0.38 g). Whilst data from actual hypogravity activities are limited to the Apollo missions, simulation studies have indicated that ground reaction forces, mechanical work, muscle activation, and joint angles decrease with declining gravity level. However, these alterations in locomotion biomechanics do not necessarily scale to the gravity level, the reduction in gastrocnemius medialis activation even appears to level off around 0.2 g, while muscle activation pattern remains similar. Thus, it is difficult to predict whether gastrocnemius medialis contractile behavior during running on Moon will basically be the same as on Mars. Therefore, this study investigated lower limb joint kinematics and gastrocnemius medialis behavior during running at 1 g, simulated Martian gravity, and simulated Lunar gravity on the vertical treadmill facility. The results indicate that hypogravity-induced alterations in joint kinematics and contractile behavior still persist between simulated running on the Moon and Mars. This contrasts with the concept of a ceiling effect and should be carefully considered when evaluating exercise prescriptions and the transferability of locomotion practiced in Lunar gravity to Martian gravity.
KW  - Bone quality and biomechanics
KW  - Environmental impact
KW  - Skeletal muscle
KW  - Tendons
KW  - Ultrasound
Y1  - 2021
U6  - http://dx.doi.org/10.1038/s41598-021-00527-9
SN  - 2045-2322
N1  - Corresponding author: Charlotte Richter
VL  - 11
IS  - Article number: 22555
PB  - Springer Nature
CY  - London
ER  - 
TY  - CHAP
A1  - Wagner, Thorsten
A1  - Kohl, Claus-Dieter
A1  - Fröba, Michael
A1  - Tiemann, Michael
T1  - Gas sensing properties of ordered mesoporous SnO2
N2  - We report on the synthesis and CO gas-sensing properties of mesoporous tin(IV) oxides (SnO2). For the synthesis cetyltrimethylammonium bromide (CTABr) was used as a structure-directing agent; the resulting SnO2 powders were applied as films to commercially available sensor substrates by drop coating. Nitrogen physisorption shows specific surface areas up to 160 m2·g-1 and mean pore diameters of about 4 nm, as verified by TEM. The film conductance was measured in dependence on the CO concentration in humid synthetic air at a constant temperature of 300 °C. The sensors show a high sensitivity at low CO concentrations and turn out to be largely insensitive towards changes in the relative humidity. We compare the materials with commercially available SnO2-based sensors.
KW  - Biosensor
KW  - Tin oxide
KW  - sensing properties
KW  - CO
KW  - humidity
Y1  - 2006
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:a96-opus-1422
ER  - 
TY  - CHAP
A1  - Staat, Manfred
A1  - Ballmann, J.
T1  - Fundamental aspects of numerical methods for the propagation of multi-dimensional nonlinear waves in solids
T2  - Nonlinear hyperbolic equations : theory, computations methods, and applications ; proceedings of the 2nd International Conference on Nonlinear Hyperbolic Problems, Aachen
N2  - The nonlinear scalar constitutive equations of gases lead to a change in sound speed from point to point as would be found in linear inhomogeneous (and time dependent) media. The nonlinear tensor constitutive equations of solids introduce the additional local effect of solution dependent anisotropy. The speed of a wave passing through a point changes with propagation direction and its rays are inclined to the front. It is an open question whether the widely used operator splitting techniques achieve a dimensional splitting with physically reasonable results for these multi-dimensional problems. May be this is the main reason why the theoretical and numerical investigations of multi-dimensional wave propagation in nonlinear solids are so far behind gas dynamics. We hope to promote the subject a little by a discussion of some fundamental aspects of the solution of the equations of nonlinear elastodynamics. We use methods of characteristics because they only integrate mathematically exact equations which have a direct physical interpretation.
KW  - Nichtlineare Welle
KW  - Nichtlineare Gleichung
KW  - Festkörper
KW  - Elastodynamik
KW  - Multi-dimensional wave propagation
KW  - nonlinear solids
KW  - nonlinear tensor constitutive equation
Y1  - 1989
SP  - 574
EP  - 588
ER  - 
TY  - CHAP
A1  - Poghossian, Arshak
A1  - Schumacher, Kerstin
A1  - Kloock, Joachim P.
A1  - Rosenkranz, Christian
A1  - Schultze, Joachim W.
A1  - Müller-Veggian, Mattea
A1  - Schöning, Michael Josef
T1  - Functional testing and characterisation of ISFETs on wafer level by means of a micro-droplet cell
N2  - A wafer-level functionality testing and characterisation system for ISFETs (ionsensitive field-effect transistor) is realised by means of integration of a specifically designed capillary electrochemical micro-droplet cell into a commercial wafer prober-station. The developed system allows the identification and selection of “good” ISFETs at the earliest stage and to avoid expensive bonding, encapsulation and packaging processes for nonfunctioning ISFETs and thus, to decrease costs, which are wasted for bad dies. The developed system is also feasible for wafer-level characterisation of ISFETs in terms of sensitivity, hysteresis and response time. Additionally, the system might be also utilised for wafer-level testing of further electrochemical sensors.
KW  - Biosensor
KW  - Biosensorik
KW  - ISFET
KW  - Wafer
KW  - ISFET
KW  - wafer-level testing
KW  - capillary micro-droplet cell
Y1  - 2006
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:a96-opus-1259
ER  - 
TY  - CHAP
A1  - Tran, Thanh Ngoc
A1  - Staat, Manfred
A1  - Kreißig, R.
T1  - Finite element shakedown and limit reliability analysis of thin shells
N2  - A procedure for the evaluation of the failure probability of elastic-plastic thin shell structures is presented. The procedure involves a deterministic limit and shakedown analysis for each probabilistic iteration which is based on the kinematical approach and the use the exact Ilyushin yield surface. Based on a direct definition of the limit state function, the non-linear problems may be efficiently solved by using the First and Second Order Reliabiblity Methods (Form/SORM). This direct approach reduces considerably the necessary knowledge of uncertain technological input data, computing costs and the numerical error. In: Computational plasticity / ed. by Eugenio Onate. Dordrecht: Springer 2007. VII, 265 S. (Computational Methods in Applied Sciences ; 7) (COMPLAS IX. Part 1 . International Center for Numerical Methods in Engineering (CIMNE)). ISBN 978-1-402-06576-7  S. 186-189
KW  - Finite-Elemente-Methode
KW  - Limit analysis
KW  - shakedown analysis
KW  - Exact Ilyushin yield surface
KW  - Random variable
KW  - First Order Reliabiblity Method
Y1  - 2007
ER  - 
TY  - CHAP
A1  - Digel, Ilya
A1  - Demirci, Taylan
A1  - Trzewik, Jürgen
A1  - Linder, Peter
A1  - Temiz Artmann, Aysegül
T1  - Fibroblast response to mechanical stress: role of the adhesion substrate : [abstract]
N2  - Mechanical stimulation of the cells resulted in evident changes in the cell morphology, protein composition and gene expression. Microscopically, additional formation of stress fibers accompanied by cell re-arrangements in a monolayer was observed. Also, significant activation of p53 gene was revealed as compared to control. Interestingly, the use of CellTech membrane coating induced cell death after mechanical stress had been applied. Such an effect was not detected when fibronectin had been used as an adhesion substrate.
KW  - Fibroblast
KW  - Mechanische Beanspruchung
KW  - celldrum technology
Y1  - 2004
ER  - 
TY  - CHAP
A1  - Förster, Arnold
A1  - Stock, Jürgen
A1  - Montanari, Simone
A1  - Lepsa, Mihail Ion
A1  - Lüth, Hans
T1  - Fabrication and characterisation of GaAs Gunn Diode Chips for applications at 77 GHz in automotive industry
N2  - GaAs-based Gunn diodes with graded AlGaAs hot electron injector heterostructures have been developed under the special needs in automotive applications. The fabrication of the Gunn diode chips was based on total substrate removal and processing of integrated Au heat sinks. Especially, the thermal and RF behavior of the diodes have been analyzed by DC, impedance and S-parameter measurements. The electrical investigations have revealed the functionality of the hot electron injector. An optimized layer structure could fulfill the requirements in adaptive cruise control (ACC) systems at 77 GHz with typical output power between 50 and 90 mW.
KW  - Biosensor
KW  - Gunn diode
KW  - microwave generation
KW  - GaAs hot electron injector
Y1  - 2006
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:a96-opus-1462
ER  - 
TY  - JOUR
A1  - Gorissen, P.
A1  - Staat, Manfred
A1  - Laack, Walter van
T1  - Experimentelle Kraftmessungen als Beitrag zur Wirksamkeitsbeurteilung von Schienbeinschonern im Fußballsport
T1  - Experimental measurement of forces as a contribution to evaluate the effectiveness of shin guards in soccer
JF  - OUP Zeitschrift für die orthopädische und unfallchirurgische Praxis
N2  - Diese Studie beschäftigte sich mit der Dämpfungswirkung von Schienbeinschonern, wie sie beim Fußball zum Einsatz kommen. Sie wurde mit Hilfe eines Pendelhammers durchgeführt, der verschiedene Aufschlagkräfte auf die Schoner ermöglichte. Dabei wurde deutlich, dass Schienbeinschoner die beste Wirkung bei Maximalkräften unterhalb von 5kN erreichen können, dass bei größerer Belastung allerdings Verbesserungsbedarf besteht. Hierfür konnte, u.a. durch den Einsatz neuer Materialien, ein guter Ansatzpunkt im „adäquaten Zusammenspiel von Schale und Polsterung“ der Schoner gefunden werden. Die Untersuchung hat weiterhin gezeigt, dass zumindest teilweise eine deutliche Verbesserung der Dämpfungswirkung der Schienbeinschoner in den letzten Jahren erreicht werden konnte.
N2  - This study was conducted to test the damping effects of commercially available soccer shin guards on their damping effects. Therefore a pendulum impact apparatus with varying impact forces was used. It became clear that shin guards show the best effect at maximum forces of less than 5kN. There is however a need for improvement at greater impact forces. A good starting point was found in an „appropriate interaction of shell and padding” of the shin guard. It was further clarified that a significant improvement on the damping effect could be achieved at least partially over the last years.
KW  - Fußball
KW  - Schienbeinschoner
KW  - Aufschlagversuch
Y1  - 2012
U6  - http://dx.doi.org/10.3238/oup.2012.0010-0015
SN  - 2193-5785
VL  - 1
IS  - 1
SP  - 10
EP  - 15
PB  - Deutscher Ärzte-Verlag
CY  - Köln
ER  - 
TY  - CHAP
A1  - Tran, Thanh Ngoc
A1  - Novacek, V.
A1  - Tolba, R.
A1  - Klinge, U.
A1  - Turquier, F.
A1  - Staat, Manfred
T1  - Experimental and Computational approach to study colorectal anastomosis. ISB2011, Proceedings of the XXIII Congress of the International Society of Biomechanics, Brussels, Belgium, July 3-7, 2011
N2  - Summary: This paper presents a methodology to study and understand the mechanics of stapled anastomotic behaviors by combining empirical experimentation and finite element analysis. Performance of stapled anastomosis is studied in terms of leakage and numerical results which are compared to in vitro experiments performed on fresh porcine tissue. Results suggest that leaks occur between the tissue and staple legs penetrating through the tissue.
KW  - Anastomose
KW  - Finite-Elemente-Methode
KW  - Biomechanik
KW  - Anastomosis
KW  - Finite element method
KW  - Biomechanics
Y1  - 2011
ER  - 
TY  - CHAP
A1  - Frotscher, Ralf
A1  - Koch, Jan-Peter
A1  - Raatschen, Hans-Jürgen
A1  - Staat, Manfred
ED  - Onate, E.
T1  - Evaluation of a computational model for drug action on cardiac tissue
T2  - 11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20 - 25, 2014, Barcelona
Y1  - 2014
SP  - 1
EP  - 12
ER  - 
TY  - JOUR
A1  - Alexyuk, Madina
A1  - Bogoyavlenskiy, Andrey
A1  - Alexyuk, Pavel
A1  - Moldakhanov, Yergali
A1  - Berezin, Vladimir
A1  - Digel, Ilya
T1  - Epipelagic microbiome of the Small Aral Sea: Metagenomic structure and ecological diversity
JF  - MicrobiologyOpen
N2  - Microbial diversity studies regarding the aquatic communities that experienced or are experiencing environmental problems are essential for the comprehension of the remediation dynamics. In this pilot study, we present data on the phylogenetic and ecological structure of microorganisms from epipelagic water samples collected in the Small Aral Sea (SAS). The raw data were generated by massive parallel sequencing using the shotgun approach. As expected, most of the identified DNA sequences belonged to Terrabacteria and Actinobacteria (40% and 37% of the total reads, respectively). The occurrence of Deinococcus-Thermus, Armatimonadetes, Chloroflexi in the epipelagic SAS waters was less anticipated. Surprising was also the detection of sequences, which are characteristic for strict anaerobes—Ignavibacteria, hydrogen-oxidizing bacteria, and archaeal methanogenic species. We suppose that the observed very broad range of phylogenetic and ecological features displayed by the SAS reads demonstrates a more intensive mixing of water masses originating from diverse ecological niches of the Aral-Syr Darya River basin than presumed before.
KW  - ecological structure
KW  - metagenomics
KW  - microbial diversity
KW  - shotgun sequencing
KW  - Small Aral Sea
Y1  - 2021
U6  - http://dx.doi.org/10.1002/mbo3.1142
SN  - 2045-8827
VL  - 10
IS  - 1
SP  - 1
EP  - 10
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Preiß, C.
A1  - Linder, Peter
A1  - Wendt, K.
A1  - Krystek, M.
A1  - Digel, Ilya
A1  - Gossmann, Matthias
A1  - Temiz Artmann, Aysegül
A1  - Porst, Dariusz
A1  - Kayser, Peter
A1  - Bassam, Rasha
A1  - Artmann, Gerhard
T1  - Engineering technology for plant physiology and plant stress research
N2  - Plant physiology and plant stress: Plant physiology will be much more important for human mankind because of yield and cultivation limits of crops determined by their resistance to stress. To assess and counteract various stress factors it is necessary to conduct plant research to gain information and results on plant physiology.
KW  - Pflanzenphysiologie
KW  - Pflanzenstress
KW  - Pflanzenscanner
KW  - plant stress
KW  - plant scanner
Y1  - 2011
ER  - 
TY  - GEN
A1  - Staat, Manfred
T1  - Engineering Mechanics. Lecture Notes. 2nd edition, translation of the 3rd corrected and extended German edition of "Technische Mechanik"
N2  - English translation of the corrected lectures notes of Sebastian Krämer. Contents 0 Introduction to Mechanics 1 Statics of Rigid Bodies 2 Elastostatics (Strength of Materials) 3 Kinematics 4 Kinetics Literature
KW  - Technische Mechanik
KW  - Mechanics
KW  - Statics
KW  - Elastostatics
KW  - Kinematics
KW  - Kinetics
Y1  - 2006
ER  - 
TY  - CHAP
A1  - Jung, Alexander
A1  - Frotscher, Ralf
A1  - Staat, Manfred
T1  - Electromechanical model of hiPSC-derived ventricular cardiomyocytes cocultured with fibroblasts
T2  - 6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), 11-15 June 2018, Glasgow, UK
N2  - The CellDrum provides an experimental setup to study the mechanical effects of fibroblasts co-cultured with hiPSC-derived ventricular cardiomyocytes. Multi-scale computational models based on the Finite Element Method are developed. Coupled electrical cardiomyocyte-fibroblast models (cell level) are embedded into reaction-diffusion equations (tissue level) which compute the propagation of the action potential in the cardiac tissue. Electromechanical coupling is realised by an excitation-contraction model (cell level) and the active stress arising during contraction is added to the passive stress in the force balance, which determines the tissue displacement (tissue level). Tissue parameters in the model can be identified experimentally to the specific sample.
Y1  - 2018
ER  - 
TY  - CHAP
A1  - Staat, Manfred
A1  - Heitzer, Michael
A1  - Reinders, H.
A1  - Schubert, F.
T1  - Einspielen und Ratchetting bei Zug- und Torsionsbelastung: Analyse und Experimente
T1  - Shakedown and ratchetting under tension-torsion loadings: analysis and experiments
N2  - Traglast- und Einspielanalysen sind vereinfachte doch exakte Verfahren der klassischen Plastizitätstheorie, die neben ausreichender Verformbarkeit keine einschränkenden Voraussetzungen beinhalten. Die Vereinfachungen betreffen die Beschaffung der Daten und Modelle für Details der Lastgeschichte und des Stoffverhaltens. Eine FEM-basierte Traglast- und Einspielanalyse für ideal plastisches Material wurde auf ein kinematisch verfestigendes Materialgesetz erweitert und in das Finite Element Programm PERMAS implementiert. In einem einfachen Zug-Torsionsexperiment wurde eine Hohlprobe mit konstanter Torsion und zyklischer Zugbelastung beansprucht, um die neue Implementierung zu verifizieren. Es konnte gezeigt werden, dass die Einspielanalyse gut mit den experimentellen Ergebnissen übereinstimmt. Bei Verfestigung lassen sich wesentlich größere Sicherheiten nachweisen. Dieses Potential bedarf weiterer experimenteller Absicherung. Parallel dazu ist die Eisnpieltheorie auf fortschrittliche Verfestigungsansätze zu erweitern.
KW  - Zug-Druck-Beanspruchung
KW  - Einspielen <Werkstoff>
KW  - Ratcheting
KW  - Torsion
KW  - Zug-Druck-Belastung
KW  - Torsionsbelastung
KW  - shakedown
KW  - ratchetting
KW  - tension–torsion loading
Y1  - 2001
ER  - 
TY  - CHAP
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
A1  - Nojima, H.
A1  - Artmann, Gerhard
T1  - Effects of plasma generated ions on bacteria : [poster]
N2  - Summary and Conclusions PCIs were clearly effective in terms of their antibacterial effects with the strains tested. This efficacy increased with the time the bacteries were exposed to PCIs. The bactericidal action has proved to be irreversible. PCIs were significantly less effective in shadowed areas. PCI exposure caused multiple protein damages as observed in SDS PAGE studies. There was no single but multiple molecular mechanism causing the bacterial death.
KW  - Clusterion
KW  - Bakterien
KW  - plasma generated ions
Y1  - 2003
ER  - 
TY  - JOUR
A1  - Özsoylu, Dua
A1  - Kizildag, Sefa
A1  - Schöning, Michael Josef
A1  - Wagner, Torsten
T1  - Effect of plasma treatment on the sensor properties of a light‐addressable potentiometric sensor (LAPS)
JF  - physica status solidi a : applications and materials sciences
N2  - A light-addressable potentiometric sensor (LAPS) is a field-effect-based (bio-) chemical sensor, in which a desired sensing area on the sensor surface can be defined by illumination. Light addressability can be used to visualize the concentration and spatial distribution of the target molecules, e.g., H+ ions. This unique feature has great potential for the label-free imaging of the metabolic activity of living organisms. The cultivation of those organisms needs specially tailored surface properties of the sensor. O2 plasma treatment is an attractive and promising tool for rapid surface engineering. However, the potential impacts of the technique are carefully investigated for the sensors that suffer from plasma-induced damage. Herein, a LAPS with a Ta2O5 pH-sensitive surface is successfully patterned by plasma treatment, and its effects are investigated by contact angle and scanning LAPS measurements. The plasma duration of 30 s (30 W) is found to be the threshold value, where excessive wettability begins. Furthermore, this treatment approach causes moderate plasma-induced damage, which can be reduced by thermal annealing (10 min at 300 °C). These findings provide a useful guideline to support future studies, where the LAPS surface is desired to be more hydrophilic by O2 plasma treatment.
Y1  - 2019
U6  - http://dx.doi.org/10.1002/pssa.201900259
SN  - 1862-6319
N1  - Corresponding author: Torsten Wagner
VL  - 216
IS  - 20
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Bassam, Rasha
A1  - Digel, Ilya
A1  - Artmann, Gerhard
T1  - Effect of nitric oxide on protein thermal stability : [abstract]
N2  - As a deduction from these results, we can conclude that proteins mainly in vitro, denaturate totally at a temperature between 57°C -62°C, and they also affected by NO and different ions types. In which mainly, NO cause earlier protein denaturation, which means that, NO has a destabilizing effect on proteins, and also different ions will alter the protein denaturation in which, some ions will cause earlier protein denaturation while others not.
KW  - Stickstoffmonoxid
KW  - Proteine
KW  - Hämoglobin
KW  - nitric oxide gas
KW  - protein
KW  - hemoglobin
Y1  - 2009
ER  - 
TY  - CHAP
A1  - ElBashir, Rasha
A1  - Digel, Ilya
T1  - Effect of nitric oxide gas on hydrogels : [abstract]
N2  - The results support our theory that the NO gas has an influence in increasing the translational diffusion of hydrogels and it accelerates the melting process of the gels.
KW  - Stickstoffmonoxid
KW  - Hydrogel
KW  - nitric oxide gas
KW  - hydrogel
Y1  - 2009
ER  - 
TY  - CHAP
A1  - Kirchhof, Michael
A1  - Kraft, Bodo
T1  - Dogmatisches „Entweder agil oder klassisch" im Projektmanagement hat ausgedient - die richtige Mischung macht's
T2  - Projekt-Sternstunden : strahlende Erfolge durch Kompetenz
Y1  - 2011
SN  - 978-3-924841-60-7
N1  - PM-Forum <28, 2011, Nürnberg> ; 
PM-Forum 2011, 28. Internationales Deutsches Projektmanagement-Forum ; Nürnberg, 25. - 26.10.2011 ; Tagungsband
SP  - 414
EP  - 425
PB  - GPM
CY  - Nürnberg
ER  - 
TY  - CHAP
A1  - Staat, Manfred
A1  - Heitzer, Michael
T1  - Direkte FEM-Berechnung der Tragfähigkeit hochbeanspruchter passiver Komponenten
T1  - Direct FEM-computation of load carrying capacity of highly loaded passive components
N2  - Genaue Kenntnis der Spannungen und Verformungen in passiven Komponenten gewinnt man mit detailierten inelastischen FEM Analysen. Die lokale Beanspruchung läßt sich aber nicht direkt mit einer Beanspruchbarkeit im strukturmechanischen Sinne vergleichen. Konzentriert man sich auf die Frage nach der Tragfähigkeit, dann vereinfacht sich die Analyse. Im Rahmen der Plastizitätstheorie berechnen Traglast- und Einspielanalyse die tragbaren Lasten direkt und exakt. In diesem Beitrag wird eine Implementierung der Traglast- und Einspielsätze in ein allgemeines FEM Programm vorgestellt, mit der die Tragfähigkeit passiver Komponenten direkt berechnet wird. Die benutzten Konzepte werden in Bezug auf die übliche Strukturanalyse erläutert. Beispiele mit lokal hoher Beanspruchung verdeutlichen die Anwendung der FEM basierten Traglast- und Einspielanalysen. Die berechneten Interaktionsdiagramme geben einen guten Überblick über die möglichen Betriebsbereiche passiver Komponenten. Die Traglastanalyse bietet auch einen strukturmechanischen Zugang zur Kollapslast rißbehafteter Komponenten aus hochzähem Material.
KW  - Finite-Elemente-Methode
KW  - Tragfähigkeit
KW  - FEM-Programm
KW  - FEM-computation
KW  - load carrying capacity
Y1  - 1997
ER  - 
TY  - CHAP
A1  - Staat, Manfred
A1  - Heitzer, Michael
T1  - Direct static FEM approach to limit and shakedown analysis
N2  - Safety and reliability of structures may be assessed indirectly by stress distributions. Limit and shakedown theorems are simplified but exact methods of plasticity that provide safety factors directly in the loading space. These theorems may be used for a direct definition of the limit state function for failure by plastic collapse or by inadaptation. In a FEM formulation the limit state function is obtained from a nonlinear optimization problem. This direct approach reduces considerably the necessary knowledge of uncertain technological input data, the computing time, and the numerical error. Moreover, the direct way leads to highly effective and precise reliability analyses. The theorems are implemented into a general purpose FEM program in a way capable of large-scale analysis.
KW  - Einspielen <Werkstoff>
KW  - Nichtlineare Optimierung
KW  - Shakedown
KW  - Shakedown
KW  - limit load
KW  - lower bound theorem
KW  - nonlinear optimization
KW  - reliability
Y1  - 2000
ER  - 
TY  - JOUR
A1  - Staat, Manfred
T1  - Direct finite element route for design-by-analysis of pressure components
N2  - In the new European standard for unfired pressure vessels, EN 13445-3, there are two approaches for carrying out a Design-by-Analysis that cover both the stress categorization method (Annex C) and the direct route method (Annex B) for a check against global plastic deformation and against progressive plastic deformation. This paper presents the direct route in the language of limit and shakedown analysis. This approach leads to an optimization problem. Its solution with Finite Element Analysis is demonstrated for mechanical and thermal actions. One observation from the examples is that the so-called 3f (3Sm) criterion fails to be a reliable check against progressive plastic deformation. Precise conditions are given, which greatly restrict the applicability of the 3f criterion.
KW  - Einspielen <Werkstoff>
KW  - Plastizität
KW  - Deformation
KW  - Analytischer Zulaessigkeitsnachweis
KW  - Einspiel-Analyse
KW  - fortschreitende plastische Deformation
KW  - alternierend Verformbarkeit
KW  - Einspiel-Kriterium
KW  - Design-by-analysis
KW  - Shakedown analysis
KW  - Progressive plastic deformation
KW  - Alternating plasticity
KW  - Shakedown criterion
Y1  - 2005
ER  - 
TY  - JOUR
A1  - Staat, Manfred
T1  - Direct FEM Limit and Shakedown Analysis with Uncertain Data
N2  - The structural reliability with respect to plastic collapse or to inadaptation is formulated on the basis of the lower bound limit and shakedown theorems. A direct definition of the limit state function is achieved which permits the use of the highly effective first order reliability methods (FORM) is achieved. The theorems are implemented into a general purpose FEM program in a way capable of large-scale analysis. The limit state function and its gradient are obtained from a mathematical optimization problem. This direct approach reduces considerably the necessary knowledge of uncertain technological input data, the computing time, and the numerical error, leading to highly effective and precise reliability analyses.
KW  - Finite-Elemente-Methode
KW  - Einspielen <Werkstoff>
KW  - FEM
KW  - Einspielanalyse
KW  - shakedown
KW  - limit load
KW  - reliability analysis
KW  - FEM
KW  - direct method
Y1  - 2000
ER  - 
TY  - CHAP
A1  - Heitzer, M.
A1  - Staat, Manfred
T1  - Direct FEM approach to design-by-analysis of pressurized components
N2  - Abstracts of the ACHEMA 2000 - International Meeting on Chemical Engineering, Environmental Protection and Biotechnology, May 22 - 27, 2000. Frankfurt am Main. Achema 2000 : special edition / Linde. [Ed.: Linde AG. Red.: Volker R. Leski]. - Wiesbaden : Linde AG, 2000. - 56 p. : Ill., . - pp: 79 - 81
N2  - Abstracts der ACHEMA 2000 - International Meeting on Chemical Engineering, Environmental Protection and Biotechnology, May 22 - 27, 2000. Frankfurt am Main.
KW  - Finite-Elemente-Methode
KW  - Finite-Elemente-Methode
KW  - limit analysis
KW  - shakedown analysis
Y1  - 2000
ER  - 
TY  - CHAP
A1  - Dachwald, Bernd
A1  - Xu, Changsheng
A1  - Feldmann, Marco
A1  - Plescher, Engelbert
A1  - Digel, Ilya
A1  - Artmann, Gerhard
T1  - Development and testing of a subsurface probe for detection of life in deep ice : [abstract]
N2  - We present the novel concept of a combined drilling and melting probe for subsurface ice research. This probe, named “IceMole”, is currently developed, built, and tested at the FH Aachen University of Applied Sciences’ Astronautical Laboratory. Here, we describe its first prototype design and report the results of its field tests on the Swiss Morteratsch glacier. Although the IceMole design is currently adapted to terrestrial glaciers and ice shields, it may later be modified for the subsurface in-situ investigation of extraterrestrial ice, e.g., on Mars, Europa, and Enceladus. If life exists on those bodies, it may be present in the ice (as life can also be found in the deep ice of Earth).
KW  - Eisschicht
KW  - Sonde
KW  - subsurface probe
KW  - subsurface ice research
Y1  - 2011
ER  - 
TY  - JOUR
A1  - Jablonski, Melanie
A1  - Poghossian, Arshak
A1  - Keusgen, Michael
A1  - Wege, Christina
A1  - Schöning, Michael Josef
T1  - Detection of plant virus particles with a capacitive field-effect sensor
JF  - Analytical and Bioanalytical Chemistry
N2  - Plant viruses are major contributors to crop losses and induce high economic costs worldwide. For reliable, on-site and early detection of plant viral diseases, portable biosensors are of great interest. In this study, a field-effect SiO2-gate electrolyte-insulator-semiconductor (EIS) sensor was utilized for the label-free electrostatic detection of tobacco mosaic virus (TMV) particles as a model plant pathogen. The capacitive EIS sensor has been characterized regarding its TMV sensitivity by means of constant-capacitance method. The EIS sensor was able to detect biotinylated TMV particles from a solution with a TMV concentration as low as 0.025 nM. A good correlation between the registered EIS sensor signal and the density of adsorbed TMV particles assessed from scanning electron microscopy images of the SiO2-gate chip surface was observed. Additionally, the isoelectric point of the biotinylated TMV particles was determined via zeta potential measurements and the influence of ionic strength of the measurement solution on the TMV-modified EIS sensor signal has been studied.
KW  - Plant virus
KW  - Capacitive field-effect sensor
KW  - Tobacco mosaic virus (TMV)
KW  - Label-free detection
KW  - Zeta potential
Y1  - 2021
U6  - http://dx.doi.org/10.1007/s00216-021-03448-8
SN  - 1618-2650
N1  - Corresponding authors: Arshak Poghossian & Michael J. Schöning
VL  - 413
SP  - 5669
EP  - 5678
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - CHAP
A1  - Näther, Niko
A1  - Juárez, Leon M.
A1  - Emmerich, Rüdiger
A1  - Berger, Jörg
A1  - Friedrich, Peter
A1  - Schöning, Michael Josef
T1  - Detection of hydrogen peroxide (H2O2) at exposed temperatures for industrial processes
N2  - An H2O2 sensor for the application in industrial sterilisation processes has been developed. Therefore, automated sterilisation equipment at laboratory scale has been constructed using parts from industrial sterilisation facilities. In addition, a software tool has been developed for the control of the sterilisation equipment at laboratory scale. First measurements with the developed sensor set-up as part of the sterilisation equipment have been performed and the sensor has been physically characterised by optical microscopy and SEM.
KW  - Biosensor
KW  - Gas sensor
KW  - hydrogen peroxide
KW  - sterilisation
KW  - catalytic decomposition
Y1  - 2006
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:a96-opus-1418
ER  - 
TY  - JOUR
A1  - Grajewski, Matthias
A1  - Kleefeld, Andreas
T1  - Detecting and approximating decision boundaries in low-dimensional spaces
JF  - Numerical Algorithms
N2  - A method for detecting and approximating fault lines or surfaces, respectively, or decision curves in two and three dimensions with guaranteed accuracy is presented. Reformulated as a classification problem, our method starts from a set of scattered points along with the corresponding classification algorithm to construct a representation of a decision curve by points with prescribed maximal distance to the true decision curve. Hereby, our algorithm ensures that the representing point set covers the decision curve in its entire extent and features local refinement based on the geometric properties of the decision curve. We demonstrate applications of our method to problems related to the detection of faults, to multi-criteria decision aid and, in combination with Kirsch’s factorization method, to solving an inverse acoustic scattering problem. In all applications we considered in this work, our method requires significantly less pointwise classifications than previously employed algorithms.
KW  - MCDA
KW  - Inverse scattering problem
KW  - Fault approximation
KW  - Fault detection
Y1  - 2023
SN  - 1572-9265
N1  - Corresponding author: Matthias Grajewski
VL  - 93
IS  - 4
PB  - Springer Science+Business Media
CY  - Dordrecht
ER  - 
TY  - CHAP
A1  - Staat, Manfred
T1  - Design by Analysis of Pressure Components by non-linear Optimization
N2  - This paper presents the direct route to Design by Analysis (DBA) of the new European pressure vessel standard in the language of limit and shakedown analysis (LISA). This approach leads to an optimization problem. Its solution with Finite Element Analysis is demonstrated for some examples from the DBA-Manual. One observation from the examples is, that the optimisation approach gives reliable and close lower bound solutions leading to simple and optimised design decision.
KW  - Analytischer Zulaessigkeitsnachweis
KW  - FEM
KW  - Einspiel-Analyse
KW  - design-by-analysis
KW  - finite element analysis
KW  - limit and shakedown analysis
Y1  - 2003
ER  - 
TY  - JOUR
A1  - Staat, Manfred
T1  - Cyclic plastic deformation tests to verify FEM-based shakedown analyses
N2  - Fatigue analyses are conducted with the aim of verifying that thermal ratcheting is limited. To this end it is important to make a clear distintion between the shakedown range and the ratcheting range (continuing deformation). As part of an EU-supported research project, experiments were carried out using a 4-bar model. The experiment comprised a water-cooled internal tube, and three insulated heatable outer test bars. The system was subjected to alternating axial forces, superimposed with alternating temperatures at the outer bars. The test parameters were partly selected on the basis of previous shakedown analyses. During the test, temperatures and strains were measured as a function of time. The loads and the resulting stresses were confirmed on an ongoing basis during performance of the test, and after it. Different material models were applied for this incremental elasto-plastic analysis using the ANSYS program. The results of the simulation are used to verify the FEM-based shakedown analysis.
KW  - Materialermüdung
KW  - Einspielen <Werkstoff>
KW  - Materialermüdung
KW  - shakedown analyses
KW  - thermal ratcheting
KW  - fatigue analyses
Y1  - 2001
ER  - 
TY  - JOUR
A1  - Alnemer, Momin Sami Mohammad
A1  - Kotliar, Konstantin
A1  - Neuhaus, Valentin
A1  - Pape, Hans-Christoph
A1  - Ciritsis, Bernhard D.
T1  - Cost-effectiveness analysis of surgical proximal femur fracture prevention in elderly: a Markov cohort simulation model
JF  - Cost Effectiveness and Resource Allocation
N2  - Background
Hip fractures are a common and costly health problem, resulting in significant morbidity and mortality, as well as high costs for healthcare systems, especially for the elderly. Implementing surgical preventive strategies has the potential to improve the quality of life and reduce the burden on healthcare resources, particularly in the long term. However, there are currently limited guidelines for standardizing hip fracture prophylaxis practices.

Methods
This study used a cost-effectiveness analysis with a finite-state Markov model and cohort simulation to evaluate the primary and secondary surgical prevention of hip fractures in the elderly. Patients aged 60 to 90 years were simulated in two different models (A and B) to assess prevention at different levels. Model A assumed prophylaxis was performed during the fracture operation on the contralateral side, while Model B included individuals with high fracture risk factors. Costs were obtained from the Centers for Medicare & Medicaid Services, and transition probabilities and health state utilities were derived from available literature. The baseline assumption was a 10% reduction in fracture risk after prophylaxis. A sensitivity analysis was also conducted to assess the reliability and variability of the results.

Results
With a 10% fracture risk reduction, model A costs between $8,850 and $46,940 per quality-adjusted life-year ($/QALY). Additionally, it proved most cost-effective in the age range between 61 and 81 years. The sensitivity analysis established that a reduction of ≥ 2.8% is needed for prophylaxis to be definitely cost-effective. The cost-effectiveness at the secondary prevention level was most sensitive to the cost of the contralateral side’s prophylaxis, the patient’s age, and fracture treatment cost. For high-risk patients with no fracture history, the cost-effectiveness of a preventive strategy depends on their risk profile. In the baseline analysis, the incremental cost-effectiveness ratio at the primary prevention level varied between $11,000/QALY and $74,000/QALY, which is below the defined willingness to pay threshold.

Conclusion
Due to the high cost of hip fracture treatment and its increased morbidity, surgical prophylaxis strategies have demonstrated that they can significantly relieve the healthcare system. Various key assumptions facilitated the modeling, allowing for adequate room for uncertainty. Further research is needed to evaluate health-state-associated risks.
KW  - Hip fractures
KW  - Prevention
KW  - Geriatric
KW  - Cost-effectiveness
KW  - Prophylaxis
Y1  - 2023
U6  - http://dx.doi.org/10.1186/s12962-023-00482-4
SN  - 1478-7547
N1  - Corresponding author: Momin S. Alnemer
IS  - 21, Article number: 77
PB  - Springer Nature
ER  - 
TY  - JOUR
A1  - Richter, Charlotte
A1  - Braunstein, Bjoern
A1  - Staeudle, Benjamin
A1  - Attias, Julia
A1  - Suess, Alexander
A1  - Weber, Tobias
A1  - Mileva, Katya N.
A1  - Rittweger, Joern
A1  - Green, David A.
A1  - Albracht, Kirsten
T1  - Contractile behavior of the gastrocnemius medialis muscle during running in simulated hypogravity
JF  - npj Microgravity
N2  - Vigorous exercise countermeasures in microgravity can largely attenuate muscular degeneration, albeit the extent of applied loading is key for the extent of muscle wasting. Running on the International Space Station is usually performed with maximum loads of 70% body weight (0.7 g). However, it has not been investigated how the reduced musculoskeletal loading affects muscle and series elastic element dynamics, and thereby force and power generation. Therefore, this study examined the effects of running on the vertical treadmill facility, a ground-based analog, at simulated 0.7 g on gastrocnemius medialis contractile behavior. The results reveal that fascicle−series elastic element behavior differs between simulated hypogravity and 1 g running. Whilst shorter peak series elastic element lengths at simulated 0.7 g appear to be the result of lower muscular and gravitational forces acting on it, increased fascicle lengths and decreased velocities could not be anticipated, but may inform the development of optimized running training in hypogravity. However, whether the alterations in contractile behavior precipitate musculoskeletal degeneration warrants further study.
Y1  - 2021
U6  - http://dx.doi.org/10.1038/s41526-021-00155-7
SN  - 2373-8065
N1  - Corresponding author: Charlotte Richter
VL  - 7
IS  - Article number: 32
PB  - Springer Nature
CY  - New York
ER  - 
TY  - GEN
A1  - Staat, Manfred
A1  - Barry, Steve
T1  - Continuum Mechanics with an Introduction to the Finite Element Method / Steve Barry; Manfred Staat. With extensions by Manfred Staat.
N2  - Contents: 1 Introduction 2 One Dimensional Continuum Mechanics 3 Tensors 4 Three Dimensional Stress and Strain 5 Conservation Laws 6 Contiunuum Modelling 7 Plain Problems 8 Questions 9 Reference Information
KW  - Technische Mechanik
KW  - Finite-Elemente-Methode
Y1  - 2006
ER  - 
TY  - CHAP
A1  - Kraft, Bodo
T1  - Conceptual design tools for civil engineering
N2  - Applications of Graph Transformations with Industrial Relevance Lecture Notes in Computer Science, 2004, Volume 3062/2004, 434-439, DOI: http://dx.doi.org/10.1007/978-3-540-25959-6_33 This paper gives a brief overview of the tools we have developed to support conceptual design in civil engineering. Based on the UPGRADE framework, two applications, one for the knowledge engineer and another for architects allow to store domain specific knowledge and to use this knowledge during conceptual design. Consistency analyses check the design against the defined knowledge and inform the architect if rules are violated.
KW  - CAD
KW  - CAD
KW  - Bauingenieurwesen
KW  - CAD
KW  - civil engineering
Y1  - 2004
ER  - 
TY  - JOUR
A1  - Kraft, Bodo
T1  - Conceptual design mit ArchiCAD 8 : Forschungsprojekt an der RWTH Aachen
N2  - Projektbericht in GraphisoftNews - Architektur und Bauen in einer vernetzten Welt 3/2003 4 Seiten
KW  - CAD
KW  - CAD
KW  - Bauingenieurwesen
KW  - Architektur
KW  - CAD
KW  - civil engineering
KW  - architecture
Y1  - 2003
ER  - 
TY  - JOUR
A1  - Staat, Manfred
A1  - Ballmann, J.
T1  - Computation of impacts on elastic solids by methods of bicharacteristics
JF  - Computational Mechanics '88 : theory and applications ; proceedings of the International Conference on Computational Engineering Science April 10-14, 1988, Atlanta, GA, USA ; vol. 2
N2  - Shock waves, explosions, impacts or cavitation bubble collapses may generate stress waves in solids causing cracks or unexpected dammage due to focussing, physical nonlinearity or interaction with existing cracks. There is a growing interest in wave propagation, which poses many novel problems to experimentalists and theorists.
KW  - Bicharakteristikenverfahren
KW  - Elastizität
KW  - elastic solids
KW  - bicharacteristics
Y1  - 1988
SP  - 1719
EP  - 1722
ER  - 
TY  - JOUR
A1  - Jablonski, Melanie
A1  - Münstermann, Felix
A1  - Nork, Jasmina
A1  - Molinnus, Denise
A1  - Muschallik, Lukas
A1  - Bongaerts, Johannes
A1  - Wagner, Torsten
A1  - Keusgen, Michael
A1  - Siegert, Petra
A1  - Schöning, Michael Josef
T1  - Capacitive field‐effect biosensor applied for the detection of acetoin in alcoholic beverages and fermentation broths
JF  - physica status solidi (a) applications and materials science
N2  - An acetoin biosensor based on a capacitive electrolyte–insulator–semiconductor (EIS) structure modified with the enzyme acetoin reductase, also known as butane-2,3-diol dehydrogenase (Bacillus clausii DSM 8716ᵀ), is applied for acetoin detection in beer, red wine, and fermentation broth samples for the first time. The EIS sensor consists of an Al/p-Si/SiO₂/Ta₂O₅ layer structure with immobilized acetoin reductase on top of the Ta₂O₅ transducer layer by means of crosslinking via glutaraldehyde. The unmodified and enzyme-modified sensors are electrochemically characterized by means of leakage current, capacitance–voltage, and constant capacitance methods, respectively.
KW  - acetoin
KW  - acetoin reductase
KW  - alcoholic beverages
KW  - biosensors
KW  - capacitive field-effect sensors
Y1  - 2021
U6  - http://dx.doi.org/10.1002/pssa.202000765
SN  - 1862-6319
VL  - 218
IS  - 13
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Tran, Thanh Ngoc
A1  - Staat, Manfred
A1  - Kreißig, R.
T1  - Calculation of load carrying capacity of shell structures with elasto-plastic material by direct methods
N2  - Proceedings of the International Conference on Material Theory and Nonlinear Dynamics. MatDyn. Hanoi, Vietnam, Sept. 24-26, 2007, 8 p. In this paper, a method is introduced to determine the limit load of general shells using the finite element method. The method is based on an upper bound limit and shakedown analysis with elastic-perfectly plastic material model. A non-linear constrained optimisation problem is solved by using Newton’s method in conjunction with a penalty method and the Lagrangean dual method. Numerical investigation of a pipe bend subjected to bending moments proves the effectiveness of the algorithm.
KW  - Finite-Elemente-Methode
Y1  - 2007
ER  - 
TY  - JOUR
A1  - Heel, Mareike van
A1  - Dikta, Gerhard
A1  - Braekers, Roel
T1  - Bootstrap based goodness‑of‑fit tests for binary multivariate regression models
JF  - Journal of the Korean Statistical Society
N2  - We consider a binary multivariate regression model where the conditional expectation of a binary variable given a higher-dimensional input variable belongs to a parametric family. Based on this, we introduce a model-based bootstrap (MBB) for higher-dimensional input variables. This test can be used to check whether a sequence of independent and identically distributed observations belongs to such a parametric family. The approach is based on the empirical residual process introduced by Stute (Ann Statist 25:613–641, 1997). In contrast to Stute and Zhu’s approach (2002) Stute & Zhu (Scandinavian J Statist 29:535–545, 2002), a transformation is not required. Thus, any problems associated with non-parametric regression estimation are avoided. As a result, the MBB method is much easier for users to implement. To illustrate the power of the MBB based tests, a small simulation study is performed. Compared to the approach of Stute & Zhu (Scandinavian J Statist 29:535–545, 2002), the simulations indicate a slightly improved power of the MBB based method. Finally, both methods are applied to a real data set.
Y1  - 2021
U6  - http://dx.doi.org/10.1007/s42952-021-00142-4
SN  - 2005-2863 (Online)
SN  - 1226-3192 (Print)
N1  - Corresponding author: Mareike van Heel
VL  - 51
PB  - Springer Nature
CY  - Singapur
ER  - 
TY  - CHAP
A1  - Lei, Yu
A1  - Mulchandani, Priti
A1  - Chen, Wilfred
A1  - Mulchandani, Ashok
T1  - Biosensor for direct determination of fenitrothion and EPN using recombinant Pseudomonas putida JS444 with surface expressed organophosphorus hydrolase. 1. modified clark oxygen electrode
N2  - This paper reports a first microbial biosensor for rapid and cost-effective determination of organophosphorus pesticides fenitrothion and EPN. The biosensor consisted of recombinant PNP-degrading/oxidizing bacteria Pseudomonas putida JS444 anchoring and displaying organophosphorus hydrolase (OPH) on its cell surface as biological sensing element and a dissolved oxygen electrode as the transducer. Surfaceexpressed OPH catalyzed the hydrolysis of fenitrothion and EPN to release 3-methyl-4-nitrophenol and p-nitrophenol, respectively, which were oxidized by the enzymatic machinery of Pseudomonas putida JS444 to carbon dioxide while consuming oxygen, which was measured and correlated to the concentration of organophosphates. Under the optimum operating conditions, the biosensor was able to measure as low as 277 ppb of fenitrothion and 1.6 ppm of EPN without interference from phenolic compounds and other commonly used pesticides such as carbamate pesticides, triazine herbicides and organophosphate pesticides without nitrophenyl substituent. The applicability of the biosensor to lake water was also demonstrated.
KW  - Biosensor
KW  - Organophosphorus
KW  - fenitrothion
KW  - EPN
KW  - biosensor
KW  - Pseudomonas putida
Y1  - 2006
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:a96-opus-1573
ER  - 
TY  - JOUR
A1  - Oliveira, Danilo A.
A1  - Molinnus, Denise
A1  - Beging, Stefan
A1  - Siqueira Jr, José R.
A1  - Schöning, Michael Josef
T1  - Biosensor Based on Self-Assembled Films of Graphene Oxide and Polyaniline Using a Field-Effect Device Platform
JF  - physica status solidi (a) applications and materials science
N2  - A new functionalization method to modify capacitive electrolyte–insulator–semiconductor (EIS) structures with nanofilms is presented. Layers of polyallylamine hydrochloride (PAH) and graphene oxide (GO) with the compound polyaniline:poly(2-acrylamido-2-methyl-1-propanesulfonic acid) (PANI:PAAMPSA) are deposited onto a p-Si/SiO2 chip using the layer-by-layer technique (LbL). Two different enzymes (urease and penicillinase) are separately immobilized on top of a five-bilayer stack of the PAH:GO/PANI:PAAMPSA-modified EIS chip, forming a biosensor for detection of urea and penicillin, respectively. Electrochemical characterization is performed by constant capacitance (ConCap) measurements, and the film morphology is characterized by atomic force microscopy (AFM) and scanning electron microscopy (SEM). An increase in the average sensitivity of the modified biosensors (EIS–nanofilm–enzyme) of around 15% is found in relation to sensors, only carrying the enzyme but without the nanofilm (EIS–enzyme). In this sense, the nanofilm acts as a stable bioreceptor onto the EIS chip improving the output signal in terms of sensitivity and stability.
KW  - capacitive electrolyte–insulator–semiconductor sensors
KW  - graphene oxide
KW  - layer-by-layer technique
KW  - nanomaterials
KW  - polyaniline
Y1  - 2021
U6  - http://dx.doi.org/10.1002/pssa.202000747
SN  - 1862-6319
N1  - Corresponding author: José R. Siqueira Jr & Michael J. Schöning
VL  - 218
IS  - 13
SP  - 1
EP  - 9
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Artmann, Gerhard
A1  - Digel, Ilya
A1  - Linder, Peter
A1  - Temiz Artmann, Aysegül
T1  - Biophysical and Engineering Contributions to Plant Research
N2  - Tests with palm tree leaves have just started yet and scan data are in the process to be analyzed. The final goal of future project for palm tree gender and species recognition will be to develop optical scanning technology to be applied to date palm tree leaves for in–situ screening purposes. Depending on the software used and the particular requirements of the users the technology potentially shall be able to identify palm tree diseases, palm tree gender, and species of young date palm trees by scanning leaves.
KW  - Pflanzenphysiologie
KW  - Dattel
KW  - Pflanzenscanner
KW  - plant scanner
KW  - date palm tree
Y1  - 2011
ER  - 
TY  - JOUR
A1  - Staat, Manfred
T1  - Basis Reduction for the Shakedown Problem for Bounded Kinematic Hardening Material
N2  - Limit and shakedown analysis are effective methods for assessing the load carrying capacity of a given structure. The elasto–plastic behavior of the structure subjected to loads varying in a given load domain is characterized by the shakedown load factor, defined as the maximum factor which satisfies the sufficient conditions stated in the corresponding static shakedown theorem. The finite element dicretization of the problem may lead to very large convex optimization. For the effective solution a basis reduction method has been developed that makes use of the special problem structure for perfectly plastic material. The paper proposes a modified basis reduction method for direct application to the two-surface plasticity model of bounded kinematic hardening material. The considered numerical examples show an enlargement of the load carrying capacity due to bounded hardening.
KW  - Finite-Elemente-Methode
KW  - Einspielen <Werkstoff>
KW  - Basis Reduktion
KW  - konvexe Optimierung
KW  - FEM
KW  - Druckgeräte
KW  - Basis reduction
KW  - Convex optimization
KW  - FEM
KW  - Shakedown analysis
Y1  - 2000
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Akimbekov, Nuraly
A1  - Rogachev, Evgeniy
A1  - Pogorelova, Natalia
T1  - Bacterial cellulose produced by Medusomyces gisevii on glucose and sucrose: biosynthesis and structural properties
JF  - Cellulose
N2  - In this work, the effects of carbon sources and culture media on the production and structural properties of bacterial cellulose (BC) synthesized by Medusomyces gisevii have been studied. The culture medium was composed of different initial concentrations of glucose or sucrose dissolved in 0.4% extract of plain green tea. Parameters of the culture media (titratable acidity, substrate conversion degree etc.) were monitored daily for 20 days of cultivation. The BC pellicles produced on different carbon sources were characterized in terms of biomass yield, crystallinity and morphology by field emission scanning electron microscopy (FE-SEM), atomic force microscopy and X-ray diffraction. Our results showed that Medusomyces gisevii had higher BC yields in media with sugar concentrations close to 10 g L−1 after a 18–20 days incubation period. Glucose in general lead to a higher BC yield (173 g L−1) compared to sucrose (163.5 g L−1). The BC crystallinity degree and surface roughness were higher in the samples synthetized from sucrose. Obtained FE-SEM micrographs show that the BC pellicles synthesized in the sucrose media contained densely packed tangles of cellulose fibrils whereas the BC produced in the glucose media displayed rather linear geometry of the BC fibrils without noticeable aggregates.
KW  - Bacterial cellulose
KW  - Medusomyces gisevi
KW  - Carbon sources
KW  - Culture media
KW  - Cellulose nanostructure
Y1  - 2023
U6  - http://dx.doi.org/10.1007/s10570-023-05592-z
SN  - 1572-882X (Online)
SN  - 0969-0239 (Print)
N1  - Corresponding author: Ilya Digel
PB  - Springer Science + Business Media
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Grieger, Niklas
A1  - Schwabedal, Justus T. C.
A1  - Wendel, Stefanie
A1  - Ritze, Yvonne
A1  - Bialonski, Stephan
T1  - Automated scoring of pre-REM sleep in mice with deep learning
JF  - Scientific Reports
N2  - Reliable automation of the labor-intensive manual task of scoring animal sleep can facilitate the analysis of long-term sleep studies. In recent years, deep-learning-based systems, which learn optimal features from the data, increased scoring accuracies for the classical sleep stages of Wake, REM, and Non-REM. Meanwhile, it has been recognized that the statistics of transitional stages such as pre-REM, found between Non-REM and REM, may hold additional insight into the physiology of sleep and are now under vivid investigation. We propose a classification system based on a simple neural network architecture that scores the classical stages as well as pre-REM sleep in mice. When restricted to the classical stages, the optimized network showed state-of-the-art classification performance with an out-of-sample F1 score of 0.95 in male C57BL/6J mice. When unrestricted, the network showed lower F1 scores on pre-REM (0.5) compared to the classical stages. The result is comparable to previous attempts to score transitional stages in other species such as transition sleep in rats or N1 sleep in humans. Nevertheless, we observed that the sequence of predictions including pre-REM typically transitioned from Non-REM to REM reflecting sleep dynamics observed by human scorers. Our findings provide further evidence for the difficulty of scoring transitional sleep stages, likely because such stages of sleep are under-represented in typical data sets or show large inter-scorer variability. We further provide our source code and an online platform to run predictions with our trained network.
Y1  - 2021
U6  - http://dx.doi.org/10.1038/s41598-021-91286-0
SN  - 2045-2322
N1  - Corresponding author: Stephan Bialonski
VL  - 11
IS  - Art. 12245
PB  - Springer Nature
CY  - London
ER  - 
TY  - JOUR
A1  - Bogoyavlenskiy, A. P.
A1  - Digel, Ilya
A1  - Berezin, V. E.
T1  - Assessment of dot-blot ELISA sensitivity on membrane sorbent using various peroxidase substrates
N2  - The sensitivity of the peroxidase reaction in dot-blot ELISA significantly depends on the substrate. The highest sensitivity is observed using benzidine and diamine- phenol combinations as the substrates due to the reaction of the coupled oxidation (NADI)
KW  - Enzyme-linked immunosorbent assay
KW  - Peroxidase
KW  - ELISA
KW  - phenols
KW  - naphtols
KW  - aromatic amines
Y1  - 1997
ER  -