TY  - JOUR
A1  - Bohrn, U.
A1  - Stütz, E.
A1  - Fuchs, K.
A1  - Fleischer, M.
A1  - Schöning, Michael Josef
A1  - Wagner, P.
T1  - Monitoring of irritant gas using a whole-cell-based sensor system
JF  - Sensors and Actuators B: Chemical
N2  - Cell-based sensors for the detection of gases have long been underrepresented, due to the cellular requirement of being cultured in a liquid environment. In this work we established a cell-based gas biosensor for the detection of toxic substances in air, by adapting a commercial sensor chip (Bionas®), previously used for the measurement of pollutants in liquids. Cells of the respiratory tract (A549, RPMI 2650, V79), which survive at a gas phase in a natural context, are used as biological receptors. The physiological cell parameters acidification, respiration and morphology are continuously monitored in parallel. Ammonia was used as a highly water-soluble model gas to test the feasibility of the sensor system. Infrared measurements confirmed the sufficiency of the medium draining method. This sensor system provides a basis for many sensor applications such as environmental monitoring, building technology and public security.
Y1  - 2012
U6  - http://dx.doi.org/10.1016/j.snb.2012.05.088
SN  - 0925-4005
VL  - 175
SP  - 208
EP  - 217
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Schusser, Sebastian
A1  - Krischer, Maximillian
A1  - Bäcker, Matthias
A1  - Poghossian, Arshak
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Monitoring of the Enzymatically Catalyzed Degradation of Biodegradable Polymers by Means of Capacitive Field-Effect Sensors
JF  - Analytical Chemistry
N2  - Designing novel or optimizing existing biodegradable polymers for biomedical applications requires numerous tests on the effect of substances on the degradation process. In the present work, polymer-modified electrolyte–insulator–semiconductor (PMEIS) sensors have been applied for monitoring an enzymatically catalyzed degradation of polymers for the first time. The thin films of biodegradable polymer poly(d,l-lactic acid) and enzyme lipase were used as a model system. During degradation, the sensors were read-out by means of impedance spectroscopy. In order to interpret the data obtained from impedance measurements, an electrical equivalent circuit model was developed. In addition, morphological investigations of the polymer surface have been performed by means of in situ atomic force microscopy. The sensor signal change, which reflects the progress of degradation, indicates an accelerated degradation in the presence of the enzyme compared to hydrolysis in neutral pH buffer media. The degradation rate increases with increasing enzyme concentration. The obtained results demonstrate the potential of PMEIS sensors as a very promising tool for in situ and real-time monitoring of degradation of polymers.
Y1  - 2015
U6  - http://dx.doi.org/10.1021/acs.analchem.5b00617
SN  - 1520-6882
VL  - 87
IS  - 13
SP  - 6607
EP  - 6613
PB  - ACS Publications
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Kirchner, Patrick
A1  - Oberländer, Jan
A1  - Suco, Henri-Pierre
A1  - Rysstad, Gunnar
A1  - Schöning, Michael Josef
T1  - Monitoring the microbicidal effectiveness of gaseous hydrogen peroxide in sterilisation processes by means of a calorimetric gas sensor
JF  - Food control
N2  - In the present work, a novel method for monitoring sterilisation processes with gaseous H2O2 in combination with heat activation by means of a specially designed calorimetric gas sensor was evaluated. Therefore, the sterilisation process was extensively studied by using test specimens inoculated with Bacillus atrophaeus spores in order to identify the most influencing process factors on its microbicidal effectiveness. Besides the contact time of the test specimens with gaseous H2O2 varied between 0.2 and 0.5 s, the present H2O2 concentration in a range from 0 to 8% v/v (volume percent) had a strong influence on the microbicidal effectiveness, whereas the change of the vaporiser temperature, gas flow and humidity were almost negligible. Furthermore, a calorimetric H2O2 gas sensor was characterised in the sterilisation process with gaseous H2O2 in a wide range of parameter settings, wherein the measurement signal has shown a linear response against the H2O2 concentration with a sensitivity of 4.75 °C/(% v/v). In a final step, a correlation model by matching the measurement signal of the gas sensor with the microbial inactivation kinetics was established that demonstrates its suitability as an efficient method for validating the microbicidal effectiveness of sterilisation processes with gaseous H2O2.
KW  - hydrogen peroxide
KW  - sterilisation
KW  - Bacillus atrophaeus
KW  - calorimetric gas sensor
Y1  - 2012
U6  - http://dx.doi.org/10.1016/j.foodcont.2012.11.048
SN  - 0956-7135
VL  - 31
IS  - 2
SP  - 530
EP  - 538
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Svetlova, O. V.
A1  - Makarov, F. N.
A1  - Zaseeva, M. V.
T1  - Morfologicheskie i funktsional'nye osobennosti resnichnogo poiaska khrustalika kak kliuchevogo ispolnitel'nogo zvena v mekhanizme akkommodatsii glaza cheloveka = Morpho-functional characteristics of lens ciliary body as a key mechanism of accommodation in
JF  - Morfologiia (Saint Petersburg, Russia). 123 (2003), H. 3
Y1  - 2003
SN  - 1026-3543
N1  - Original in Russisch, English abstract
SP  - 7
EP  - 16
PB  - -
ER  - 
TY  - JOUR
A1  - Ackermann, Hans-Josef
T1  - Morphing- und Level-of-Detail-Techniken zur Reduzierung des Darstellungsaufwands bei Echtzeit-Sichtsimulationen
JF  - Digital controls for high resolution display : JESSI Europrojekt No. 3203000, AE-36 ; Abschlußbericht ; Laufzeit u. Berichtszeitraum: 01.01.1995 bis 31.12.1996.
Y1  - 1997
CY  - Erlangen
ER  - 
TY  - JOUR
A1  - Herssens, Nolan
A1  - Cowburn, James
A1  - Albracht, Kirsten
A1  - Braunstein, Bjoern
A1  - Cazzola, Dario
A1  - Colyer, Steffi
A1  - Minetti, Alberto E.
A1  - Pavei, Gaspare
A1  - Rittweger, Jörn
A1  - Weber, Tobias
A1  - Green, David A.
ED  - Cattaneo, Luigi
T1  - Movement in low gravity environments (MoLo) programme – the MoLo-L.O.O.P. study protocol
JF  - PLOS ONE / Public Library of Science
N2  - Exposure to prolonged periods in microgravity is associated with deconditioning of the musculoskeletal system due to chronic changes in mechanical stimulation. Given astronauts will operate on the Lunar surface for extended periods of time, it is critical to quantify both external (e.g., ground reaction forces) and internal (e.g., joint reaction forces) loads of relevant movements performed during Lunar missions. Such knowledge is key to predict musculoskeletal deconditioning and determine appropriate exercise countermeasures associated with extended exposure to hypogravity.
Y1  - 2022
U6  - http://dx.doi.org/10.1371/journal.pone.0278051
SN  - 1932-6203
VL  - 17
IS  - 11
PB  - Plos
CY  - San Francisco
ER  - 
TY  - CHAP
A1  - Müller-Veggian, Mattea
A1  - Kops, Elena Rota
A1  - Quin, Peng
A1  - Herzog, Hans
T1  - MRI Based Attenuation Correction for Brain PET Images
T2  - Advances in medical engineering / [3rd RPT - Remagener Physiktage together with the Second Scientific Workshop of Medical Robotics, Navigation and Visualization ... Remagen ... 7.-9. März 2007]. Thorsten M. Buzug (ed.) Part 1.
N2  - This work describes a procedure to yield attenuation maps from MR images which are used for the absorption correction (AC) of brain PET data. Such an approach could be mandatory for future combined PET and MRI scanners, which probably do not include a transmission facility. T1-weighted MR images were segmented into brain tissue, bone, soft tissue, and sinus; attenuation coefficients corresponding to elemental composition and density as well as to 511 keV photon energy were respectively assigned. Attenuation maps containing up to four compartments were created and forward projected into sinograms with attenuation factors which then were used for AC during reconstruction of FDG-PET data. The commonly used AC based on a radioactive (68Ge) transmission scan served as reference. The reconstructed radioactivity values obtained with the MRI-based AC were about 20% lower than those obtained with PET-based AC if the skull was not taken into account. Considering the skull the difference was still about 10%. Our investigations demonstrate the feasibility of a MRI-based AC, but revealed also the necessity of a satisfying delineation of bone thickness which tends to be underestimated in our first approach of T1-weighted MR image segmentation.
Y1  - 2007
SN  - 978-3-540-68763-4
U6  - http://dx.doi.org/10.1007/978-3-540-68764-1_15
N1  - Springer proceedings in physics ; 114
SP  - 93
EP  - 97
PB  - Springer
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Klöser, Lars
A1  - Kohl, Philipp
A1  - Kraft, Bodo
A1  - Zündorf, Albert
T1  - Multi-attribute relation extraction (MARE): simplifying the application of relation extraction
T2  - Proceedings of the 2nd International Conference on Deep Learning Theory and Applications - DeLTA
N2  - Natural language understanding’s relation extraction makes innovative and encouraging novel business concepts possible and facilitates new digitilized decision-making processes. Current approaches allow the extraction of relations with a fixed number of entities as attributes. Extracting relations with an arbitrary amount of attributes requires complex systems and costly relation-trigger annotations to assist these systems. We introduce multi-attribute relation extraction (MARE) as an assumption-less problem formulation with two approaches, facilitating an explicit mapping from business use cases to the data annotations. Avoiding elaborated annotation constraints simplifies the application of relation extraction approaches. The evaluation compares our models to current state-of-the-art event extraction and binary relation extraction methods. Our approaches show improvement compared to these on the extraction of general multi-attribute relations.
Y1  - 2021
SN  - 978-989-758-526-5
U6  - http://dx.doi.org/10.5220/0010559201480156
N1  - Proceedings of the 2nd International Conference on Deep Learning Theory and Applications, DeLTA2021, July 7-9, 2021
SP  - 148
EP  - 156
ER  - 
TY  - JOUR
A1  - Yoshinobu, T.
A1  - Ermelenko, Y.
A1  - Mourzina, Y.
A1  - Schöning, Michael Josef
A1  - Iwasaki, H.
A1  - Vlasov, Y.
T1  - Multi-component analysis based on the light-addressable potentiometric sensor (LAPS)
JF  - Proceedings : 11th international conference Sensor 2003; 13 - 15 May 2003, Exhibition Centre Nuremberg, Germany
Y1  - 2003
N1  - Internationale Messe mit Kongress Sensor <11, 2003, Nürnberg>
SP  - 141
EP  - 144
PB  - AMA Service
CY  - Wunstorf
ER  - 
TY  - CHAP
A1  - Huck, Christina
A1  - Poghossian, Arshak
A1  - Buniatyan, V.
A1  - Schöning, Michael Josef
T1  - Multi-parameter detection for supporting monitoring and control of biogas processes in agriculture
T2  - Sensoren und Messsysteme 2014 ; Beiträge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in Nürnberg. (ITG-Fachbericht ; 250)
Y1  - 2014
SN  - 978-3-8007-3622-5
SP  - 1
EP  - 5
PB  - VDE-Verl.
CY  - Berlin
ER  -