TY  - JOUR
A1  - Luisier, Raphaëlle
A1  - Lempiäinen, Harri
A1  - Scherbichler, Nina
A1  - Braeuning, Albert
A1  - Geissler, Miriam
A1  - Dubost, Valerie
A1  - Müller, Arne
A1  - Scheer, Nico
A1  - Chibout, Salah-Dine
A1  - Hara, Hisanori
A1  - Picard, Frank
A1  - Theil, Diethilde
A1  - Couttet, Philippe
A1  - Vitobello, Antonio
A1  - Grenet, Olivier
A1  - Grasl-Kraupp, Bettina
A1  - Ellinger-Ziegelbauer, Heidrung
A1  - Thomson, John P.
A1  - Meehan, Richard R.
A1  - Elcombe, Clifford R.
A1  - Henderson, Colin J.
A1  - Wolf, C. Roland
A1  - Schwarz, Michael
A1  - Moulin, Pierre
A1  - Terranova, Remi
A1  - Moggs, Jonathan G.
T1  - Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors
JF  - Toxicological Sciences
N2  - The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcinogenesis. Here, we have used a humanized CAR/PXR mouse model to examine potential species differences in receptor-dependent mechanisms underlying liver tissue molecular responses to PB. Early and late transcriptomic responses to sustained PB exposure were investigated in liver tissue from double knock-out CAR and PXR (CARᴷᴼ-PXRᴷᴼ), double humanized CAR and PXR (CARʰ-PXRʰ), and wild-type C57BL/6 mice. Wild-type and CARʰ-PXRʰ mouse livers exhibited temporally and quantitatively similar transcriptional responses during 91 days of PB exposure including the sustained induction of the xenobiotic response gene Cyp2b10, the Wnt signaling inhibitor Wisp1, and noncoding RNA biomarkers from the Dlk1-Dio3 locus. Transient induction of DNA replication (Hells, Mcm6, and Esco2) and mitotic genes (Ccnb2, Cdc20, and Cdk1) and the proliferation-related nuclear antigen Mki67 were observed with peak expression occurring between 1 and 7 days PB exposure. All these transcriptional responses were absent in CARᴷᴼ-PXRᴷᴼ mouse livers and largely reversible in wild-type and CARʰ-PXRʰ mouse livers following 91 days of PB exposure and a subsequent 4-week recovery period. Furthermore, PB-mediated upregulation of the noncoding RNA Meg3, which has recently been associated with cellular pluripotency, exhibited a similar dose response and perivenous hepatocyte-specific localization in both wild-type and CARʰ-PXRʰ mice. Thus, mouse livers coexpressing human CAR and PXR support both the xenobiotic metabolizing and the proliferative transcriptional responses following exposure to PB.
Y1  - 2014
U6  - https://doi.org/https://doi.org/10.1093/toxsci/kfu038
SN  - 1094-2025
VL  - 139
IS  - 2
SP  - 501
EP  - 511
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - CHAP
A1  - Kleine, Harald
A1  - Kallweit, Stephan
A1  - Michaux, Frank
A1  - Havermann, Marc
A1  - Olivier, Herbert
T1  - PIV Measurement of Shock Wave Diffraction
T2  - 18th International Symposium on Applications of Laser Techniques to Fluid Mechanics, 2016, Lissabon
Y1  - 2016
SP  - 1
EP  - 14
ER  - 
TY  - JOUR
A1  - Gebhardt, Andreas
A1  - Schmidt, Frank-Michael
T1  - Practical experiences with making and finishing of coloured models using 3D printing
Y1  - 2002
N1  - International Conference on Rapid Prototyping and Manufacturing <2, 2002, Beijing>
ER  - 
TY  - CHAP
A1  - Kroker, Jan
A1  - Hoffschmidt, Bernhard
A1  - Schwarzer, Klemens
A1  - Späte, Frank
T1  - PTC 1000 modular parabolic trough collector
T2  - Process heat collectors : state of the art within task 33/IV ; IEA SHC-Task 33 and SolarPACES-Task IV: Solar heat for industrial processes : Förderkennzeichen BMBF 0329273A / Solar Heating and Cooling Executive Committee of the International Energy Agency (IEA) ; ed. Werner Weiss
Y1  - 2008
SP  - 45
EP  - 46
PB  - AEE INTEC
CY  - Gleisdorf
ER  - 
TY  - JOUR
A1  - Raffeis, Iris
A1  - Adjei-Kyeremeh, Frank
A1  - Vroomen, Uwe
A1  - Westhoff, Elmar
A1  - Bremen, Sebastian
A1  - Hohoi, Alexandru
A1  - Bührig-Polaczek, Andreas
T1  - Qualification of a Ni-Cu alloy for the laser powder bed fusion process (LPBF): Its microstructure and mechanical properties
JF  - Applied Sciences
N2  - As researchers continue to seek the expansion of the material base for additive manufacturing, there is a need to focus attention on the Ni–Cu group of alloys which conventionally has wide industrial applications. In this work, the G-NiCu30Nb casting alloy, a variant of the Monel family of alloys with Nb and high Si content is, for the first time, processed via the laser powder bed fusion process (LPBF). Being novel to the LPBF processes, optimum LPBF parameters were determined, and hardness and tensile tests were performed in as-built conditions and after heat treatment at 1000 °C. Microstructures of the as-cast and the as-built condition were compared. Highly dense samples (99.8% density) were achieved after varying hatch distance (80 µm and 140 µm) with scanning speed (550 mm/s–1500 mm/s). There was no significant difference in microhardness between varied hatch distance print sets. Microhardness of the as-built condition (247 HV0.2) exceeded the as-cast microhardness (179 HV0.2.). Tensile specimens built in vertical (V) and horizontal (H) orientations revealed degrees of anisotropy and were superior to conventionally reported figures. Post heat treatment increased ductility from 20% to 31% (V), as well as from 16% to 25% (H), while ultimate tensile strength (UTS) and yield strength (YS) were considerably reduced.
Y1  - 2020
U6  - https://doi.org/10.3390/app10103401
SN  - 2076-3417
N1  - Special Issue Materials Development by Additive Manufacturing Techniques
VL  - 10
IS  - Art. 3401
SP  - 1
EP  - 15
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Hartung, Frank
A1  - Baldo, N.
A1  - Horn, U.
A1  - Kampmann, M.
T1  - RTCP feedback based transmission rate control for 3G wireless multimedia streaming / Baldo, N. ; Horn, U. ; Kampmann, M. ; Hartung, F. ;
JF  - 15th IEEE International Symposium on Personal, Indoor and Mobile Radio Communications, 2004. PIMRC 2004.   Date:5-8 Sept. 2004 ; Vol. 3
Y1  - 2004
N1  - http://dx.doi.org/10.1109/PIMRC.2004.1368313
SP  - 1817
EP  - 1821
ER  - 
TY  - CHAP
A1  - Waldmann, Christoph
A1  - Vera, Jean-Pierre de
A1  - Dachwald, Bernd
A1  - Strasdeit, Henry
A1  - Sohl, Frank
A1  - Hanff, Hendrik
A1  - Kowalski, Julia
A1  - Heinen, Dirk
A1  - Macht, Sabine
A1  - Bestmann, Ulf
A1  - Meckel, Sebastian
A1  - Hildebrandt, Marc
A1  - Funke, Oliver
A1  - Gehrt, Jan-Jöran
T1  - Search for life in ice-covered oceans and lakes beyond Earth
T2  - 2018 IEEE/OES Autonomous Underwater Vehicle Workshop, Proceedings November 2018, Article number 8729761
N2  - The quest for life on other planets is closely connected with the search for water in liquid state. Recent discoveries of deep oceans on icy moons like Europa and Enceladus have spurred an intensive discussion about how these waters can be accessed. The challenge of this endeavor lies in the unforeseeable requirements on instrumental characteristics both with respect to the scientific and technical methods. The TRIPLE/nanoAUV initiative is aiming at developing a mission concept for exploring exo-oceans and demonstrating the achievements in an earth-analogue context, exploring the ocean under the ice shield of Antarctica and lakes like Dome-C on the Antarctic continent.
KW  - Planetary exploration
KW  - Jupiter
KW  - ice moons
KW  - underwater vehicle
KW  - Antarctica
Y1  - 2018
U6  - https://doi.org/10.1109/AUV.2018.8729761
ER  - 
TY  - CHAP
A1  - Galdi, Chiara
A1  - Hartung, Frank
A1  - Dugelay, Jean-Luc
T1  - Socrates: A database of realistic data for source camera recognition on smartphones
T2  - Proceedings of the 8th International Conference on Pattern Recognition Applications and Methods - Volume 1: ICPRAM
Y1  - 2019
SN  - 978-989-758-351-3
U6  - https://doi.org/10.5220/0007403706480655
SP  - 648
EP  - 655
ER  - 
TY  - CHAP
A1  - Meliß, Michael
A1  - Späte, Frank
T1  - Solar-Campus Jülich - an interdisciplinary project
T2  - EuroSun '96 ; 10. Internationales Sonnenforum : proceedings. Bd 3
Y1  - 1996
SP  - 1281
EP  - 1285
PB  - DGS-Sonnenenergie
CY  - München
ER  - 
TY  - JOUR
A1  - Ferrein, Alexander
A1  - Dylla, Frank
A1  - Lakemeyer, Gerhard
T1  - Specifying Multirobot Coordination in ICPGolog - From Simulation towards Real Robots / Dylla, Frank ; Ferrein, Alexander ; Lakemeyer, Gerhard
Y1  - 2003
N1  - AOS-4 at IJCAI-03
SP  - 1
EP  - 10
ER  -