TY - JOUR A1 - Thielemann, Frank A1 - Schaffner, M. T1 - Innovationswiderstände bei der Einführung neuer Tech­nologien. Schaffner, M.; Thielemann, F. JF - Deutscher Drucker. 1992/93 (1993), H. 38 Y1 - 1993 SN - 0012-1096 SP - g12 EP - ff ER - TY - JOUR A1 - Thielemann, Frank A1 - Schaffner, M. T1 - Innovationswiderstände bei der Einführung neuer Tech­nologien. Schaffner, M.; Thielemann, F. JF - Deutscher Drucker. 1992/93 (1993), H. 42 Y1 - 1993 SN - 0012-1096 SP - g15 EP - ff ER - TY - JOUR A1 - Weckesser, Martin A1 - Grießmeier, Martin A1 - Schmidt, Daniela A1 - Sonnenberg, Frank A1 - Ziemons, Karl A1 - Kemna, Lars A1 - Holschbach, Marcus A1 - Langen, Karl-J. A1 - Müller-Gärtner, Hans-W. T1 - Iodine-123 α-methyl tyrosine single-photon emission tomography of cerebral gliomas: standardised evaluation of tumour uptake and extent JF - European Journal of Nuclear Medicine N2 - Single-photon emission tomography (SPET) with the amino acid analogue l-3-[123I]iodo-α-methyl tyrosine (IMT) is helpful in the diagnosis and monitoring of cerebral gliomas. Radiolabelled amino acids seem to reflect tumour infiltration more specifically than conventional methods like magnetic resonance imaging and computed tomography. Automatic tumour delineation based on maximal tumour uptake may cause an overestimation of mean tumour uptake and an underestimation of tumour extension in tumours with circumscribed peaks. The aim of this study was to develop a program for tumour delineation and calculation of mean tumour uptake which takes into account the mean background activity and is thus optimised to the problem of tumour definition in IMT SPET. Using the frequency distribution of pixel intensities of the tomograms a program was developed which automatically detects a reference brain region and draws an isocontour region around the tumour taking into account mean brain radioactivity. Tumour area and tumour/brain ratios were calculated. A three-compartment phantom was simulated to test the program. The program was applied to IMT SPET studies of 20 patients with cerebral gliomas and was compared to the results of manual analysis by three different investigators. Activity ratios and chamber extension of the phantom were correctly calculated by the automatic analysis. A method based on image maxima alone failed to determine chamber extension correctly. Manual region of interest analysis in patient studies resulted in a mean inter-observer standard deviation of 8.7%±6.1% (range 2.7%–25.0%). The mean value of the results of the manual analysis showed a significant correlation to the results of the automatic analysis (r = 0.91, P<0.0001 for the uptake ratio; r = 0.87, P<0.0001 for the tumour area). We conclude that the algorithm proposed simplifies the calculation of uptake ratios and may be used for observer-independent evaluation of IMT SPET studies. Three-dimensional tumour recognition and transfer to co-registered morphological images based on this program may be useful for the planning of surgical and radiation treatment. Y1 - 1998 SN - 1619-7089 VL - 25 IS - 2 SP - 150 EP - 156 ER - TY - CHAP A1 - Hartung, Frank A1 - Hillgärtner, Michael A1 - Schmitz, Günter A1 - Schuba, Marko A1 - Adolphs, Fabian A1 - Hoffend, Jens A1 - Theis, Jochen T1 - IT-Sicherheit im Automobil T2 - AmE 2014 : Automotive meets Electronics, Beiträge der 5. GMM-Fachtagung vom 18. bis 19. Februar 2014 in Dortmund. (GMM-Fachbericht ; 78) Y1 - 2014 SN - 978-3-8007-3580-8 SP - CD-ROM PB - VDE-Verl. CY - Berlin ER - TY - BOOK A1 - Thielemann, Frank A1 - Staudt, Erich A1 - Kriegesmann, Bernd T1 - Joint-ventures. Staudt, Erich; Kriegesmann, Bernd; Thielemann, Frank Y1 - 1994 N1 - Berichte aus der angewandten Innovationsforschung ; 133 PB - Inst. für Angewandte Innovationsforschung e.V. CY - Bochum ER - TY - JOUR A1 - Dachwald, Bernd A1 - Ulamec, Stephan A1 - Postberg, Frank A1 - Sohl, Frank A1 - Vera, Jean-Pierre de A1 - Christoph, Waldmann A1 - Lorenz, Ralph D. A1 - Hellard, Hugo A1 - Biele, Jens A1 - Rettberg, Petra T1 - Key technologies and instrumentation for subsurface exploration of ocean worlds JF - Space Science Reviews N2 - In this chapter, the key technologies and the instrumentation required for the subsurface exploration of ocean worlds are discussed. The focus is laid on Jupiter’s moon Europa and Saturn’s moon Enceladus because they have the highest potential for such missions in the near future. The exploration of their oceans requires landing on the surface, penetrating the thick ice shell with an ice-penetrating probe, and probably diving with an underwater vehicle through dozens of kilometers of water to the ocean floor, to have the chance to find life, if it exists. Technologically, such missions are extremely challenging. The required key technologies include power generation, communications, pressure resistance, radiation hardness, corrosion protection, navigation, miniaturization, autonomy, and sterilization and cleaning. Simpler mission concepts involve impactors and penetrators or – in the case of Enceladus – plume-fly-through missions. Y1 - 2020 U6 - https://doi.org/10.1007/s11214-020-00707-5 SN - 1572-9672 N1 - Corresponding author: Bernd Dachwald VL - 216 IS - Art. 83 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Thielemann, Frank A1 - Staudt, Erich T1 - Kompetenz zur Innovation: Vom Druckbetrieb zum Multimedia-Dienstleister . Staudt, E.; Thielemann, F. JF - News Letter (der Gesellschaft für Wirtschaftsförde­rung Duisburg) (1997) Y1 - 1997 SP - 3 EP - 3 ER - TY - BOOK A1 - Thielemann, Frank T1 - Kompetenzentwicklung im Mittelstand - das Beispiel Kompetenz-Entwicklungs-Center / hrsg. von Frank Thielemann Y1 - 2000 SN - 3-89275-031-9 N1 - Wirtschaftswissenschaftliche Studien ; 20 PB - MA, Akademie-Verl.- und Druck-Ges. CY - Essen ER - TY - BOOK A1 - Thielemann, Frank A1 - Staudt, Erich A1 - Kriegesmann, Bernd A1 - Behrendt, S. T1 - Kooperation als Erfolgsfaktor ostdeutscher Unternehmen : Ergebnisse einer empirischen Untersuchung zur Kooperationslandschaft in Ostdeutschland / Staudt, E.; Kriegesmann, B.; Thielemann, F.; Behrendt, S.; Chalupsky, J. Y1 - 1994 N1 - Berichte aus der angewandten Innovationsforschung ; 132 ; Inhaltsverzeichnis PB - Inst. für Angewandte Innovationsforschung e.V. CY - Bochum ER - TY - JOUR A1 - Thielemann, Frank A1 - Staudt, Erich A1 - Kriegesmann, Bernd T1 - Kooperation als Erfolgsfak­tor ostdeutscher Unternehmen. Ergebnisse einer empirischen Untersu­chung zur Ko­operationslandschaft in Ost­deutschland. Staudt, E.; Kriegesmann, B.; Thielemann, F. JF - Zeitschrift für Betriebswirtschaft ZfB. 65 (1995), H. 11 Y1 - 1995 SN - 0044-2372 N1 - unter der Signatur 43 Z 366 in der Bibliothek Eupener Str. vorhanden SP - 1209 EP - 1230 ER -