TY - JOUR
A1 - Wert, Stefan
A1 - Iken, Heiko
A1 - Schöning, Michael Josef
A1 - Matysik, Frank-Michael
T1 - Development of a temperature‐pulse enhanced electrochemical glucose biosensor and characterization of its stability via scanning electrochemical microscopy
JF - Electroanalysis
N2 - Glucose oxidase (GOx) is an enzyme frequently used in glucose biosensors. As increased temperatures can enhance the performance of electrochemical sensors, we investigated the impact of temperature pulses on GOx that was drop-coated on flattened Pt microwires. The wires were heated by an alternating current. The sensitivity towards glucose and the temperature stability of GOx was investigated by amperometry. An up to 22-fold increase of sensitivity was observed. Spatially resolved enzyme activity changes were investigated via scanning electrochemical microscopy. The application of short (<100 ms) heat pulses was associated with less thermal inactivation of the immobilized GOx than long-term heating.
Y1 - 2021
U6 - http://dx.doi.org/10.1002/elan.202100089
SN - 1521-4109
IS - Early View
PB - Wiley-VCH
CY - Weinheim
ER -
TY - JOUR
A1 - Weemstra, Monique
A1 - Eilmann, Britta
A1 - Sass-Klaassen, Ute G. W.
A1 - Sterck, Frank J.
T1 - Summer droughts limit tree growth across 10 temperate species on a productive forest site
JF - Forest Ecology and Management
Y1 - 2013
U6 - http://dx.doi.org/doi:10.1016/j.foreco.2013.06.007
SN - 0378-1127 (Print)
SN - 1872-7042 (Online)
VL - 2013
IS - 306
SP - 142
EP - 149
PB - Elsevier
CY - Amsterdam
ER -
TY - JOUR
A1 - Weckesser, Matthias
A1 - Hufnagel, Andreas
A1 - Ziemons, Karl
A1 - Grießmeier, Martin
A1 - Sonnenberg, Frank
A1 - Hackländer, Thomas
A1 - Langen, Karl-J.
A1 - Holschbach, Markus
A1 - Elger, Christian E.
A1 - Müller-Gärtner, Hans-W.
T1 - Effect of partial volume correction on muscarinic cholinergic receptor imaging with single-photon emission tomography in patients with temporal lobe epilepsy
JF - European Journal of Nuclear Medicine
N2 - Animal experiments and preliminary results in humans have indicated alterations of hippocampal muscarinic acetylcholine receptors (mAChR) in temporal lobe epilepsy. Patients with temporal lobe epilepsy often present with a reduction in hippocampal volume. The aim of this study was to investigate the influence of hippocampal atrophy on the quantification of mAChR with single photon emission tomography (SPET) in patients with temporal lobe epilepsy. Cerebral uptake of the muscarinic cholinergic antagonist [123I]4-iododexetimide (IDex) was investigated by SPET in patients suffering from temporal lobe epilepsy of unilateral (n=6) or predominantly unilateral (n=1) onset. Regions of interest were drawn on co-registered magnetic resonance images. Hippocampal volume was determined in these regions and was used to correct the SPET results for partial volume effects. A ratio of hippocampal IDex binding on the affected side to that on the unaffected side was used to detect changes in muscarinic cholinergic receptor density. Before partial volume correction a decrease in hippocampal IDex binding on the focus side was found in each patient. After partial volume no convincing differences remained. Our results indicate that the reduction in hippocampal IDex binding in patients with epilepsy is due to a decrease in hippocampal volume rather than to a decrease in receptor concentration.
Y1 - 1997
SN - 1619-7089
VL - 24
IS - 9
SP - 1156
EP - 1161
ER -
TY - JOUR
A1 - Weckesser, Martin
A1 - Grießmeier, Martin
A1 - Schmidt, Daniela
A1 - Sonnenberg, Frank
A1 - Ziemons, Karl
A1 - Kemna, Lars
A1 - Holschbach, Marcus
A1 - Langen, Karl-J.
A1 - Müller-Gärtner, Hans-W.
T1 - Iodine-123 α-methyl tyrosine single-photon emission tomography of cerebral gliomas: standardised evaluation of tumour uptake and extent
JF - European Journal of Nuclear Medicine
N2 - Single-photon emission tomography (SPET) with the amino acid analogue l-3-[123I]iodo-α-methyl tyrosine (IMT) is helpful in the diagnosis and monitoring of cerebral gliomas. Radiolabelled amino acids seem to reflect tumour infiltration more specifically than conventional methods like magnetic resonance imaging and computed tomography. Automatic tumour delineation based on maximal tumour uptake may cause an overestimation of mean tumour uptake and an underestimation of tumour extension in tumours with circumscribed peaks. The aim of this study was to develop a program for tumour delineation and calculation of mean tumour uptake which takes into account the mean background activity and is thus optimised to the problem of tumour definition in IMT SPET. Using the frequency distribution of pixel intensities of the tomograms a program was developed which automatically detects a reference brain region and draws an isocontour region around the tumour taking into account mean brain radioactivity. Tumour area and tumour/brain ratios were calculated. A three-compartment phantom was simulated to test the program. The program was applied to IMT SPET studies of 20 patients with cerebral gliomas and was compared to the results of manual analysis by three different investigators. Activity ratios and chamber extension of the phantom were correctly calculated by the automatic analysis. A method based on image maxima alone failed to determine chamber extension correctly. Manual region of interest analysis in patient studies resulted in a mean inter-observer standard deviation of 8.7%±6.1% (range 2.7%–25.0%). The mean value of the results of the manual analysis showed a significant correlation to the results of the automatic analysis (r = 0.91, P<0.0001 for the uptake ratio; r = 0.87, P<0.0001 for the tumour area). We conclude that the algorithm proposed simplifies the calculation of uptake ratios and may be used for observer-independent evaluation of IMT SPET studies. Three-dimensional tumour recognition and transfer to co-registered morphological images based on this program may be useful for the planning of surgical and radiation treatment.
Y1 - 1998
SN - 1619-7089
VL - 25
IS - 2
SP - 150
EP - 156
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Staudt, Erich
A1 - Kriegesmann, Bernd
T1 - Kooperation als Erfolgsfaktor ostdeutscher Unternehmen. Ergebnisse einer empirischen Untersuchung zur Kooperationslandschaft in Ostdeutschland. Staudt, E.; Kriegesmann, B.; Thielemann, F.
JF - Zeitschrift für Betriebswirtschaft ZfB. 65 (1995), H. 11
Y1 - 1995
SN - 0044-2372
N1 - unter der Signatur 43 Z 366 in der Bibliothek Eupener Str. vorhanden
SP - 1209
EP - 1230
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Staudt, Erich
A1 - Kriegesmann, Bernd
T1 - Neuformierung von Wertschöpfungsketten: Das Beispiel Druckindustrie . Staudt, Erich; Kriegesmann, Bernd; Thielemann, Frank
JF - Zeitschrift Führung und Organisation. 96 (1997), H. 2
Y1 - 1997
SN - 0044-3212
N1 - in der Bereichsbibliothek Eupener Str. unter der Signatur 43 Z 367-1997 vorhanden
SP - 75
EP - 80
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Staudt, Erich
A1 - Kriegesmann, Bernd
T1 - Kooperationsverhalten in der Druckindustrie - zwischen Bestandssicherung und Offensive. Staudt, Erich; Kriegesmann, Bernd; Thielemann, Frank
JF - Die Betriebswirtschaft. 58 (1998), H. 6
Y1 - 1998
SN - 0342-7064
N1 - unter der Signatur 43 Z 411-1998 in der Bereichsbibliothek Eupener Str. vorhanden
SP - 803
EP - 815
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Staudt, Erich
T1 - Kompetenz zur Innovation: Vom Druckbetrieb zum Multimedia-Dienstleister . Staudt, E.; Thielemann, F.
JF - News Letter (der Gesellschaft für Wirtschaftsförderung Duisburg) (1997)
Y1 - 1997
SP - 3
EP - 3
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Staudt, Erich
T1 - Reicht die Kompetenz zur Innovation? Staudt, E.; Thielemann, F.
JF - OP DruckMagazin. 39 (1997), H. 10
Y1 - 1997
SN - 0030-0594
SP - 30
EP - 32
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Schaffner, M.
T1 - Innovationswiderstände bei der Einführung neuer Technologien. Schaffner, M.; Thielemann, F.
JF - Deutscher Drucker. 1992/93 (1993), H. 42
Y1 - 1993
SN - 0012-1096
SP - g15
EP - ff
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Schaffner, M.
T1 - Wie beurteilen die Führungskräfte der Branche den derzeitigen und zukünftigen Innovationsdruck? Expertenmeinung zum Thema Innovationen in der Druckindustrie: M. Schaffner, F. Thielemann
JF - Management im innovatorischen Wandel : Arbeit und Technik in der Druckindustrie / Heinz-Reiner Treichel ; Kurt-Georg Ciesinger
Y1 - 1993
SN - 3-87641-262-5
N1 - Inhaltsverzeichnis
SP - 21
EP - 26
PB - Polygraph-Verl.
CY - Frankfurt am Main
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Schaffner, M.
T1 - Gemeinsam sind wir stark . Schaffner, M.; Thielemann, F.
JF - Print & Produktion. 9 (1996), H. 10
Y1 - 1996
SN - 0944-7482
SP - 28
EP - f.
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Schaffner, M.
T1 - Innovationswiderstände bei der Einführung neuer Technologien. Schaffner, M.; Thielemann, F.
JF - Deutscher Drucker. 1992/93 (1993), H. 38
Y1 - 1993
SN - 0012-1096
SP - g12
EP - ff
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Schaffner, M.
T1 - Vom Einzelkämpfertum zum kooperativen Kundenservice
JF - Polygraph. 49 (1996), H. 23-24
Y1 - 1996
SN - 0032-3842
SP - 40
EP - 42
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Lüdtke, C.
T1 - Balanced Scorecard - Von der Vision zur Strategie
JF - Wirtschafts-Nachrichten. 46 (2001), H. 9
Y1 - 2001
SN - 1436-5588
SP - 10
EP - f.
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Lüdtke, C.
T1 - Einfluß des KonTraG im Unternehmensbereich
JF - Wirtschafts-Nachrichten. 45 (2000), H. 8
Y1 - 2000
SN - 1436-5588
SP - 10
EP - f.
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Lüdtke, C.
T1 - Risikomanagement - Aufbau eines Frühwarnsystems
JF - Wirtschafts-Nachrichten. 45 (2000), H. 12
Y1 - 2000
SN - 1436-5588
SP - 14
EP - ff
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Lüdtke, C.
T1 - Wie sich Logistikunternehmen ihren Platz sichern können
JF - Deutsche Verkehrs-Zeitung (DVZ) (1999)
Y1 - 1999
SN - 0342-166X
SP - 42
EP - 42
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Lang, Franz Peter
T1 - Wissensmanagement und neue Informationstechnologie . Lang, Franz Peter; Thielemann, Frank
JF - Veränderungsmanagement in der Sozialwirtschaft / Bernd Maelicke (Hrsg.)
Y1 - 2000
SN - 3-7890-6738-5
N1 - Inhaltsverzeichnis
SP - 132
EP - 172
PB - Nomos-Verl.-Ges.
CY - Baden-Baden
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Kriegesmann, Bernd
A1 - Schaffner, M.
T1 - Mit vereinten Kräften die Wettbewerbsfähigkeit steigern - Kooperation als Antwort auf den Innovationsdruck . Kriegesmann, B.; Thielemann, F.; Schaffner, M.
JF - Der Druckspiegel. 50 (1995), H. 10
Y1 - 1995
SN - 0012-6500
SP - 931
EP - 935
ER -