TY - JOUR A1 - Wert, Stefan A1 - Iken, Heiko A1 - Schöning, Michael Josef A1 - Matysik, Frank-Michael T1 - Development of a temperature‐pulse enhanced electrochemical glucose biosensor and characterization of its stability via scanning electrochemical microscopy JF - Electroanalysis N2 - Glucose oxidase (GOx) is an enzyme frequently used in glucose biosensors. As increased temperatures can enhance the performance of electrochemical sensors, we investigated the impact of temperature pulses on GOx that was drop-coated on flattened Pt microwires. The wires were heated by an alternating current. The sensitivity towards glucose and the temperature stability of GOx was investigated by amperometry. An up to 22-fold increase of sensitivity was observed. Spatially resolved enzyme activity changes were investigated via scanning electrochemical microscopy. The application of short (<100 ms) heat pulses was associated with less thermal inactivation of the immobilized GOx than long-term heating. Y1 - 2021 U6 - http://dx.doi.org/10.1002/elan.202100089 SN - 1521-4109 IS - Early View PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Weemstra, Monique A1 - Eilmann, Britta A1 - Sass-Klaassen, Ute G. W. A1 - Sterck, Frank J. T1 - Summer droughts limit tree growth across 10 temperate species on a productive forest site JF - Forest Ecology and Management Y1 - 2013 U6 - http://dx.doi.org/doi:10.1016/j.foreco.2013.06.007 SN - 0378-1127 (Print) SN - 1872-7042 (Online) VL - 2013 IS - 306 SP - 142 EP - 149 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Weckesser, Matthias A1 - Hufnagel, Andreas A1 - Ziemons, Karl A1 - Grießmeier, Martin A1 - Sonnenberg, Frank A1 - Hackländer, Thomas A1 - Langen, Karl-J. A1 - Holschbach, Markus A1 - Elger, Christian E. A1 - Müller-Gärtner, Hans-W. T1 - Effect of partial volume correction on muscarinic cholinergic receptor imaging with single-photon emission tomography in patients with temporal lobe epilepsy JF - European Journal of Nuclear Medicine N2 - Animal experiments and preliminary results in humans have indicated alterations of hippocampal muscarinic acetylcholine receptors (mAChR) in temporal lobe epilepsy. Patients with temporal lobe epilepsy often present with a reduction in hippocampal volume. The aim of this study was to investigate the influence of hippocampal atrophy on the quantification of mAChR with single photon emission tomography (SPET) in patients with temporal lobe epilepsy. Cerebral uptake of the muscarinic cholinergic antagonist [123I]4-iododexetimide (IDex) was investigated by SPET in patients suffering from temporal lobe epilepsy of unilateral (n=6) or predominantly unilateral (n=1) onset. Regions of interest were drawn on co-registered magnetic resonance images. Hippocampal volume was determined in these regions and was used to correct the SPET results for partial volume effects. A ratio of hippocampal IDex binding on the affected side to that on the unaffected side was used to detect changes in muscarinic cholinergic receptor density. Before partial volume correction a decrease in hippocampal IDex binding on the focus side was found in each patient. After partial volume no convincing differences remained. Our results indicate that the reduction in hippocampal IDex binding in patients with epilepsy is due to a decrease in hippocampal volume rather than to a decrease in receptor concentration. Y1 - 1997 SN - 1619-7089 VL - 24 IS - 9 SP - 1156 EP - 1161 ER - TY - JOUR A1 - Weckesser, Martin A1 - Grießmeier, Martin A1 - Schmidt, Daniela A1 - Sonnenberg, Frank A1 - Ziemons, Karl A1 - Kemna, Lars A1 - Holschbach, Marcus A1 - Langen, Karl-J. A1 - Müller-Gärtner, Hans-W. T1 - Iodine-123 α-methyl tyrosine single-photon emission tomography of cerebral gliomas: standardised evaluation of tumour uptake and extent JF - European Journal of Nuclear Medicine N2 - Single-photon emission tomography (SPET) with the amino acid analogue l-3-[123I]iodo-α-methyl tyrosine (IMT) is helpful in the diagnosis and monitoring of cerebral gliomas. Radiolabelled amino acids seem to reflect tumour infiltration more specifically than conventional methods like magnetic resonance imaging and computed tomography. Automatic tumour delineation based on maximal tumour uptake may cause an overestimation of mean tumour uptake and an underestimation of tumour extension in tumours with circumscribed peaks. The aim of this study was to develop a program for tumour delineation and calculation of mean tumour uptake which takes into account the mean background activity and is thus optimised to the problem of tumour definition in IMT SPET. Using the frequency distribution of pixel intensities of the tomograms a program was developed which automatically detects a reference brain region and draws an isocontour region around the tumour taking into account mean brain radioactivity. Tumour area and tumour/brain ratios were calculated. A three-compartment phantom was simulated to test the program. The program was applied to IMT SPET studies of 20 patients with cerebral gliomas and was compared to the results of manual analysis by three different investigators. Activity ratios and chamber extension of the phantom were correctly calculated by the automatic analysis. A method based on image maxima alone failed to determine chamber extension correctly. Manual region of interest analysis in patient studies resulted in a mean inter-observer standard deviation of 8.7%±6.1% (range 2.7%–25.0%). The mean value of the results of the manual analysis showed a significant correlation to the results of the automatic analysis (r = 0.91, P<0.0001 for the uptake ratio; r = 0.87, P<0.0001 for the tumour area). We conclude that the algorithm proposed simplifies the calculation of uptake ratios and may be used for observer-independent evaluation of IMT SPET studies. Three-dimensional tumour recognition and transfer to co-registered morphological images based on this program may be useful for the planning of surgical and radiation treatment. Y1 - 1998 SN - 1619-7089 VL - 25 IS - 2 SP - 150 EP - 156 ER - TY - JOUR A1 - Thielemann, Frank A1 - Staudt, Erich A1 - Kriegesmann, Bernd T1 - Kooperation als Erfolgsfak­tor ostdeutscher Unternehmen. Ergebnisse einer empirischen Untersu­chung zur Ko­operationslandschaft in Ost­deutschland. Staudt, E.; Kriegesmann, B.; Thielemann, F. JF - Zeitschrift für Betriebswirtschaft ZfB. 65 (1995), H. 11 Y1 - 1995 SN - 0044-2372 N1 - unter der Signatur 43 Z 366 in der Bibliothek Eupener Str. vorhanden SP - 1209 EP - 1230 ER - TY - JOUR A1 - Thielemann, Frank A1 - Staudt, Erich A1 - Kriegesmann, Bernd T1 - Neuformierung von Wertschöpfungsketten: Das Beispiel Druckindustrie . Staudt, Erich; Kriegesmann, Bernd; Thielemann, Frank JF - Zeitschrift Führung und Organisation. 96 (1997), H. 2 Y1 - 1997 SN - 0044-3212 N1 - in der Bereichsbibliothek Eupener Str. unter der Signatur 43 Z 367-1997 vorhanden SP - 75 EP - 80 ER - TY - JOUR A1 - Thielemann, Frank A1 - Staudt, Erich A1 - Kriegesmann, Bernd T1 - Kooperationsverhalten in der Druckindustrie - zwischen Bestandssicherung und Offensive. Staudt, Erich; Kriegesmann, Bernd; Thielemann, Frank JF - Die Betriebswirtschaft. 58 (1998), H. 6 Y1 - 1998 SN - 0342-7064 N1 - unter der Signatur 43 Z 411-1998 in der Bereichsbibliothek Eupener Str. vorhanden SP - 803 EP - 815 ER - TY - JOUR A1 - Thielemann, Frank A1 - Staudt, Erich T1 - Kompetenz zur Innovation: Vom Druckbetrieb zum Multimedia-Dienstleister . Staudt, E.; Thielemann, F. JF - News Letter (der Gesellschaft für Wirtschaftsförde­rung Duisburg) (1997) Y1 - 1997 SP - 3 EP - 3 ER - TY - JOUR A1 - Thielemann, Frank A1 - Staudt, Erich T1 - Reicht die Kompetenz zur Innovation? Staudt, E.; Thielemann, F. JF - OP DruckMagazin. 39 (1997), H. 10 Y1 - 1997 SN - 0030-0594 SP - 30 EP - 32 ER - TY - JOUR A1 - Thielemann, Frank A1 - Schaffner, M. T1 - Innovationswiderstände bei der Einführung neuer Tech­nologien. Schaffner, M.; Thielemann, F. JF - Deutscher Drucker. 1992/93 (1993), H. 42 Y1 - 1993 SN - 0012-1096 SP - g15 EP - ff ER - TY - JOUR A1 - Thielemann, Frank A1 - Schaffner, M. T1 - Wie beurteilen die Führungskräfte der Branche den derzeitigen und zukünftigen Innovationsdruck? Expertenmeinung zum Thema Innovationen in der Druckindustrie: M. Schaffner, F. Thielemann JF - Management im innovatorischen Wandel : Arbeit und Technik in der Druckindustrie / Heinz-Reiner Treichel ; Kurt-Georg Ciesinger Y1 - 1993 SN - 3-87641-262-5 N1 - Inhaltsverzeichnis SP - 21 EP - 26 PB - Polygraph-Verl. CY - Frankfurt am Main ER - TY - JOUR A1 - Thielemann, Frank A1 - Schaffner, M. T1 - Gemeinsam sind wir stark . Schaffner, M.; Thielemann, F. JF - Print & Produktion. 9 (1996), H. 10 Y1 - 1996 SN - 0944-7482 SP - 28 EP - f. ER - TY - JOUR A1 - Thielemann, Frank A1 - Schaffner, M. T1 - Innovationswiderstände bei der Einführung neuer Tech­nologien. Schaffner, M.; Thielemann, F. JF - Deutscher Drucker. 1992/93 (1993), H. 38 Y1 - 1993 SN - 0012-1096 SP - g12 EP - ff ER - TY - JOUR A1 - Thielemann, Frank A1 - Schaffner, M. T1 - Vom Einzelkämpfertum zum kooperativen Kundenservice JF - Polygraph. 49 (1996), H. 23-24 Y1 - 1996 SN - 0032-3842 SP - 40 EP - 42 ER - TY - JOUR A1 - Thielemann, Frank A1 - Lüdtke, C. T1 - Balanced Scorecard - Von der Vision zur Strategie JF - Wirtschafts-Nachrichten. 46 (2001), H. 9 Y1 - 2001 SN - 1436-5588 SP - 10 EP - f. ER - TY - JOUR A1 - Thielemann, Frank A1 - Lüdtke, C. T1 - Einfluß des KonTraG im Unternehmensbereich JF - Wirtschafts-Nachrichten. 45 (2000), H. 8 Y1 - 2000 SN - 1436-5588 SP - 10 EP - f. ER - TY - JOUR A1 - Thielemann, Frank A1 - Lüdtke, C. T1 - Risikomanagement - Aufbau eines Frühwarnsystems JF - Wirtschafts-Nachrichten. 45 (2000), H. 12 Y1 - 2000 SN - 1436-5588 SP - 14 EP - ff ER - TY - JOUR A1 - Thielemann, Frank A1 - Lüdtke, C. T1 - Wie sich Logistikunternehmen ihren Platz sichern können JF - Deutsche Verkehrs-Zeitung (DVZ) (1999) Y1 - 1999 SN - 0342-166X SP - 42 EP - 42 ER - TY - JOUR A1 - Thielemann, Frank A1 - Lang, Franz Peter T1 - Wissensmanagement und neue Informationstechnologie . Lang, Franz Peter; Thielemann, Frank JF - Veränderungsmanagement in der Sozialwirtschaft / Bernd Maelicke (Hrsg.) Y1 - 2000 SN - 3-7890-6738-5 N1 - Inhaltsverzeichnis SP - 132 EP - 172 PB - Nomos-Verl.-Ges. CY - Baden-Baden ER - TY - JOUR A1 - Thielemann, Frank A1 - Kriegesmann, Bernd A1 - Schaffner, M. T1 - Mit vereinten Kräften die Wettbewerbsfähigkeit steigern - Kooperation als Antwort auf den In­novationsdruck . Kriegesmann, B.; Thielemann, F.; Schaffner, M. JF - Der Druckspiegel. 50 (1995), H. 10 Y1 - 1995 SN - 0012-6500 SP - 931 EP - 935 ER -