TY - JOUR A1 - Weckesser, Martin A1 - Grießmeier, Martin A1 - Schmidt, Daniela A1 - Sonnenberg, Frank A1 - Ziemons, Karl A1 - Kemna, Lars A1 - Holschbach, Marcus A1 - Langen, Karl-J. A1 - Müller-Gärtner, Hans-W. T1 - Iodine-123 α-methyl tyrosine single-photon emission tomography of cerebral gliomas: standardised evaluation of tumour uptake and extent JF - European Journal of Nuclear Medicine N2 - Single-photon emission tomography (SPET) with the amino acid analogue l-3-[123I]iodo-α-methyl tyrosine (IMT) is helpful in the diagnosis and monitoring of cerebral gliomas. Radiolabelled amino acids seem to reflect tumour infiltration more specifically than conventional methods like magnetic resonance imaging and computed tomography. Automatic tumour delineation based on maximal tumour uptake may cause an overestimation of mean tumour uptake and an underestimation of tumour extension in tumours with circumscribed peaks. The aim of this study was to develop a program for tumour delineation and calculation of mean tumour uptake which takes into account the mean background activity and is thus optimised to the problem of tumour definition in IMT SPET. Using the frequency distribution of pixel intensities of the tomograms a program was developed which automatically detects a reference brain region and draws an isocontour region around the tumour taking into account mean brain radioactivity. Tumour area and tumour/brain ratios were calculated. A three-compartment phantom was simulated to test the program. The program was applied to IMT SPET studies of 20 patients with cerebral gliomas and was compared to the results of manual analysis by three different investigators. Activity ratios and chamber extension of the phantom were correctly calculated by the automatic analysis. A method based on image maxima alone failed to determine chamber extension correctly. Manual region of interest analysis in patient studies resulted in a mean inter-observer standard deviation of 8.7%±6.1% (range 2.7%–25.0%). The mean value of the results of the manual analysis showed a significant correlation to the results of the automatic analysis (r = 0.91, P<0.0001 for the uptake ratio; r = 0.87, P<0.0001 for the tumour area). We conclude that the algorithm proposed simplifies the calculation of uptake ratios and may be used for observer-independent evaluation of IMT SPET studies. Three-dimensional tumour recognition and transfer to co-registered morphological images based on this program may be useful for the planning of surgical and radiation treatment. Y1 - 1998 SN - 1619-7089 VL - 25 IS - 2 SP - 150 EP - 156 ER - TY - JOUR A1 - Thielemann, Frank A1 - Staudt, Erich A1 - Kriegesmann, Bernd T1 - Kooperationsverhalten in der Druckindustrie - zwischen Bestandssicherung und Offensive. Staudt, Erich; Kriegesmann, Bernd; Thielemann, Frank JF - Die Betriebswirtschaft. 58 (1998), H. 6 Y1 - 1998 SN - 0342-7064 N1 - unter der Signatur 43 Z 411-1998 in der Bereichsbibliothek Eupener Str. vorhanden SP - 803 EP - 815 ER - TY - BOOK A1 - Thielemann, Frank A1 - Staudt, Erich T1 - Innovation durch strategische Allianzen : ein Wegweiser für die Druck- und Medienbranche . Staudt, Erich; Thielemann, Frank Y1 - 1998 SN - 3-928854-14-3 N1 - Innovation ; 14 PB - IAI, Inst. für Angewandte Innovationsforschung CY - Bochum ER - TY - JOUR A1 - Thielemann, Frank T1 - Mit strategischen Allianzen ins nächste Jahrtausend JF - Druckspiegel. 53 (1998), H. 5 Y1 - 1998 SN - 0012-6500 SP - 21 EP - 24 ER - TY - JOUR A1 - Thielemann, Frank T1 - Druckindustrielle Innovation JF - Der Siebdruck. 47 (1998), H. 4 Y1 - 1998 SN - 0178-2835 SP - 32 EP - ff ER - TY - JOUR A1 - Thielemann, Frank T1 - Mit vereinten Kräften JF - Trockenbau, Akustik : Magazin für Planung und Ausführung. 15 (1998), H. 5 Y1 - 1998 SN - 0179-8006 SP - 60 EP - 68 ER - TY - CHAP A1 - Späte, Frank A1 - Wollscheid, Georg A1 - Meliß, Michael T1 - Erdreichwärmetauscher im Solar-Campus Jülich T2 - Deutschlands Weg in eine solare Zukunft : Tagungsband; 26. - 30. Juni 1998 Fachhochschule Köln / 11. Internationales Sonnenforum Y1 - 1998 SP - 591 EP - 598 PB - Solar Promotion CY - München ER - TY - CHAP A1 - Späte, Frank A1 - Hubrich, Jörg A1 - Keip, Wolfgang A1 - Meliß, Michael T1 - Der Solar-Campus Jülich - Stand der Arbeiten T2 - Deutschlands Weg in eine solare Zukunft : Tagungsband; 26. - 30. Juni 1998 Fachhochschule Köln / 11. Internationales Sonnenforum Y1 - 1998 SP - 666 EP - 672 PB - Solar Promotion CY - München ER - TY - CHAP A1 - Repschläger, Horst A1 - Hafner, Bernd A1 - Meliß, Michael A1 - Philippi, Helga A1 - Späte, Frank T1 - Vergleich verschiedener Netzvarianten am Beispiel des geplanten solaren Nahwärmesystems für den Solar-Campus Jülich T2 - 8. Symposium Thermische Solarenergie : Ort: Bildungszentrum der Hanns-Seidel-Stiftung, Kloster Banz, Staffelstein. Termin: 13. - 15. Mai 1998 / OTTI, Technologie-Kolleg Y1 - 1998 SP - 310 EP - 314 PB - OTTI CY - Regensburg ER - TY - CHAP A1 - Razen, Manfred A1 - Späte, Frank A1 - Meliß, Michael A1 - Breuer, Maria A1 - Hubrich, Jörg A1 - Rischert, Christa T1 - Aus-, Fort- und Weiterbildung am Solar-Institut Jülich T2 - Deutschlands Weg in eine solare Zukunft : Tagungsband; 26. - 30. Juni 1998 Fachhochschule Köln / 11. Internationales Sonnenforum Y1 - 1998 SP - 1071 EP - 1078 PB - Solar Promotion CY - München ER - TY - CHAP A1 - Krug, Wolfgang A1 - Razen, Manfred A1 - Späte, Frank A1 - Meliß, Michael T1 - Solarpraktikum für Feriengäste T2 - Deutschlands Weg in eine solare Zukunft : Tagungsband; 26. - 30. Juni 1998 Fachhochschule Köln / 11. Internationales Sonnenforum Y1 - 1998 SP - 1102 EP - 1109 PB - Solar Promotion CY - München ER -