TY - JOUR A1 - Neu, Eugen A1 - Janser, Frank A1 - Khatibi, Akbar A. A1 - Orifici, Adrian C. T1 - Fully Automated Operational Modal Analysis using multi-stage clustering JF - Mechanical Systems and Signal Processing Y1 - 2017 U6 - https://doi.org/10.1016/j.ymssp.2016.07.031 SN - 0888-3270 VL - Vol. 84, Part A SP - 308 EP - 323 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Mischke, Winfried A1 - Neuß, Frank T1 - Führt die Übernahme der Domain eines anderen Unternehmers zur Haftung für dessen Schulden nach § 25 HGB? JF - Zeitschrift für Vertragsgestaltung, Schuld- und Haftungsrecht : ZGS Y1 - 2009 SN - 1619-7011 VL - 8 SP - 407 EP - 409 PB - ZAP, Verl. f. die Rechts- und Anwaltspraxis CY - Recklinghausen ER - TY - JOUR A1 - Thielemann, Frank A1 - Schaffner, M. T1 - Gemeinsam sind wir stark . Schaffner, M.; Thielemann, F. JF - Print & Produktion. 9 (1996), H. 10 Y1 - 1996 SN - 0944-7482 SP - 28 EP - f. ER - TY - JOUR A1 - Hamm, Laurits A1 - Hartung, Frank T1 - High Quality Visual Communication based on IMS JF - Mobilkommunikation : Technologien und Anwendungen ; Vorträge der 16. ITG-Fachtagung vom 18. bis 19. Mai 2011 in Osnabrück / Veranst.: Informationstechnische Gesellschaft im VDE (ITG) ... Tagungsleitung: Ralf Tönjes. Programmkomitee/Hrsg.: Peter Roer Y1 - 2011 SN - 978-3-8007-3352-1 N1 - ITG-Fachbericht ; 230 ; Fachtagung Mobilkommunikation <16, 2011, Osnabrück> SP - 80 EP - 85 PB - VDE-Verl. CY - Berlin ER - TY - JOUR A1 - Delle, Lotta E. A1 - Huck, Christina A1 - Bäcker, Matthias A1 - Müller, Frank A1 - Grandthyll, Samuel A1 - Jacobs, Karin A1 - Lilischkis, Rainer A1 - Vu, Xuan T. A1 - Schöning, Michael Josef A1 - Wagner, Patrick A1 - Thoelen, Roland A1 - Weil, Maryam A1 - Ingebrandt, Sven T1 - Impedimetric immunosensor for the detection of histamine based on reduced graphene oxide JF - Physica status solidi (a) Y1 - 2015 U6 - https://doi.org/10.1002/pssa.201431863 SN - 1862-6319 VL - 212 IS - 6 SP - 1327 EP - 1334 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Thielemann, Frank A1 - Schaffner, M. T1 - Innovationswiderstände bei der Einführung neuer Tech­nologien. Schaffner, M.; Thielemann, F. JF - Deutscher Drucker. 1992/93 (1993), H. 38 Y1 - 1993 SN - 0012-1096 SP - g12 EP - ff ER - TY - JOUR A1 - Thielemann, Frank A1 - Schaffner, M. T1 - Innovationswiderstände bei der Einführung neuer Tech­nologien. Schaffner, M.; Thielemann, F. JF - Deutscher Drucker. 1992/93 (1993), H. 42 Y1 - 1993 SN - 0012-1096 SP - g15 EP - ff ER - TY - JOUR A1 - Weckesser, Martin A1 - Grießmeier, Martin A1 - Schmidt, Daniela A1 - Sonnenberg, Frank A1 - Ziemons, Karl A1 - Kemna, Lars A1 - Holschbach, Marcus A1 - Langen, Karl-J. A1 - Müller-Gärtner, Hans-W. T1 - Iodine-123 α-methyl tyrosine single-photon emission tomography of cerebral gliomas: standardised evaluation of tumour uptake and extent JF - European Journal of Nuclear Medicine N2 - Single-photon emission tomography (SPET) with the amino acid analogue l-3-[123I]iodo-α-methyl tyrosine (IMT) is helpful in the diagnosis and monitoring of cerebral gliomas. Radiolabelled amino acids seem to reflect tumour infiltration more specifically than conventional methods like magnetic resonance imaging and computed tomography. Automatic tumour delineation based on maximal tumour uptake may cause an overestimation of mean tumour uptake and an underestimation of tumour extension in tumours with circumscribed peaks. The aim of this study was to develop a program for tumour delineation and calculation of mean tumour uptake which takes into account the mean background activity and is thus optimised to the problem of tumour definition in IMT SPET. Using the frequency distribution of pixel intensities of the tomograms a program was developed which automatically detects a reference brain region and draws an isocontour region around the tumour taking into account mean brain radioactivity. Tumour area and tumour/brain ratios were calculated. A three-compartment phantom was simulated to test the program. The program was applied to IMT SPET studies of 20 patients with cerebral gliomas and was compared to the results of manual analysis by three different investigators. Activity ratios and chamber extension of the phantom were correctly calculated by the automatic analysis. A method based on image maxima alone failed to determine chamber extension correctly. Manual region of interest analysis in patient studies resulted in a mean inter-observer standard deviation of 8.7%±6.1% (range 2.7%–25.0%). The mean value of the results of the manual analysis showed a significant correlation to the results of the automatic analysis (r = 0.91, P<0.0001 for the uptake ratio; r = 0.87, P<0.0001 for the tumour area). We conclude that the algorithm proposed simplifies the calculation of uptake ratios and may be used for observer-independent evaluation of IMT SPET studies. Three-dimensional tumour recognition and transfer to co-registered morphological images based on this program may be useful for the planning of surgical and radiation treatment. Y1 - 1998 SN - 1619-7089 VL - 25 IS - 2 SP - 150 EP - 156 ER - TY - JOUR A1 - Dachwald, Bernd A1 - Ulamec, Stephan A1 - Postberg, Frank A1 - Sohl, Frank A1 - Vera, Jean-Pierre de A1 - Christoph, Waldmann A1 - Lorenz, Ralph D. A1 - Hellard, Hugo A1 - Biele, Jens A1 - Rettberg, Petra T1 - Key technologies and instrumentation for subsurface exploration of ocean worlds JF - Space Science Reviews N2 - In this chapter, the key technologies and the instrumentation required for the subsurface exploration of ocean worlds are discussed. The focus is laid on Jupiter’s moon Europa and Saturn’s moon Enceladus because they have the highest potential for such missions in the near future. The exploration of their oceans requires landing on the surface, penetrating the thick ice shell with an ice-penetrating probe, and probably diving with an underwater vehicle through dozens of kilometers of water to the ocean floor, to have the chance to find life, if it exists. Technologically, such missions are extremely challenging. The required key technologies include power generation, communications, pressure resistance, radiation hardness, corrosion protection, navigation, miniaturization, autonomy, and sterilization and cleaning. Simpler mission concepts involve impactors and penetrators or – in the case of Enceladus – plume-fly-through missions. Y1 - 2020 U6 - https://doi.org/10.1007/s11214-020-00707-5 SN - 1572-9672 N1 - Corresponding author: Bernd Dachwald VL - 216 IS - Art. 83 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Thielemann, Frank A1 - Staudt, Erich T1 - Kompetenz zur Innovation: Vom Druckbetrieb zum Multimedia-Dienstleister . Staudt, E.; Thielemann, F. JF - News Letter (der Gesellschaft für Wirtschaftsförde­rung Duisburg) (1997) Y1 - 1997 SP - 3 EP - 3 ER - TY - JOUR A1 - Thielemann, Frank A1 - Staudt, Erich A1 - Kriegesmann, Bernd T1 - Kooperation als Erfolgsfak­tor ostdeutscher Unternehmen. Ergebnisse einer empirischen Untersu­chung zur Ko­operationslandschaft in Ost­deutschland. Staudt, E.; Kriegesmann, B.; Thielemann, F. JF - Zeitschrift für Betriebswirtschaft ZfB. 65 (1995), H. 11 Y1 - 1995 SN - 0044-2372 N1 - unter der Signatur 43 Z 366 in der Bibliothek Eupener Str. vorhanden SP - 1209 EP - 1230 ER - TY - JOUR A1 - Thielemann, Frank A1 - Staudt, Erich A1 - Kriegesmann, Bernd T1 - Kooperationsverhalten in der Druckindustrie - zwischen Bestandssicherung und Offensive. Staudt, Erich; Kriegesmann, Bernd; Thielemann, Frank JF - Die Betriebswirtschaft. 58 (1998), H. 6 Y1 - 1998 SN - 0342-7064 N1 - unter der Signatur 43 Z 411-1998 in der Bereichsbibliothek Eupener Str. vorhanden SP - 803 EP - 815 ER - TY - JOUR A1 - Kern, Alexander A1 - Krichel, Frank A1 - Neskakis, Apostolos A1 - Müller, Klaus-Peter (u.a.) T1 - Lightning protection design of a renewable energy hybrid-system without power mains connection Y1 - 2001 N1 - International Conference on Renewable Energies for Islands <2001, Crete> ER - TY - JOUR A1 - Bensberg, Frank A1 - Auth, Gunnar A1 - Czarnecki, Christian ED - Haake, Jörg M. T1 - Literaturanalyse mit Text Mining JF - E-Learning and Education (eleed) N2 - Die Durchführung einer systematischen Literaturrecherche ist eine zentrale Kompetenz wissenschaftlichen Arbeitens und bildet daher einen festen Ausbildungsbestandteil von Bachelor- und Masterstudiengängen. In entsprechenden Lehrveranstaltungen werden Studierende zwar mit den grundlegenden Hilfsmitteln zur Suche und Verwaltung von Literatur vertraut gemacht, allerdings werden die Potenziale textanalytischer Methoden und Anwendungssysteme (Text Mining, Text Analytics) dabei zumeist nicht abgedeckt. Folglich werden Datenkompetenzen, die zur systemgestützten Analyse und Erschließung von Literaturdaten erforderlich sind, nicht hinreichend ausgeprägt. Um diese Kompetenzlücke zu adressieren, ist an der Hochschule Osnabrück eine Lehrveranstaltung konzipiert und projektorientiert umgesetzt worden, die sich insbesondere an Studierende wirtschaftswissenschaftlicher Studiengänge richtet. Dieser Beitrag dokumentiert die fachliche sowie technische Ausgestaltung dieser Veranstaltung und zeigt Potenziale für die künftige Weiterentwicklung auf. KW - E-Learning KW - Text Mining KW - Text Analytics KW - Literaturrecherche KW - Literaturanalyse Y1 - 2020 SN - 1860-7470 N1 - Volltext, nur online IS - 13 SP - 1 EP - 13 PB - FernUniversität in Hagen CY - Hagen ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Buhl, Eva Miriam A1 - Draack, Sebastian A1 - Viereck, Thilo A1 - Frank, A1 - Schmitz-Rode, Thomas A1 - Slabu, Ioana T1 - Magnetic relaxation of agglomerated and immobilized iron oxide nanoparticles for hyperthermia and imaging applications JF - IEEE Magnetic Letters N2 - Magnetic nanoparticles (MNPs) are used as therapeutic and diagnostic agents for local delivery of heat and image contrast enhancement in diseased tissue. Besides magnetization, the most important parameter that determines their performance for these applications is their magnetic relaxation, which can be affected when MNPs immobilize and agglomerate inside tissues. In this letter, we investigate different MNP agglomeration states for their magnetic relaxation properties under excitation in alternating fields and relate this to their heating efficiency and imaging properties. With focus on magnetic fluid hyperthermia, two different trends in MNP heating efficiency are measured: an increase by up to 23% for agglomerated MNP in suspension and a decrease by up to 28% for mixed states of agglomerated and immobilized MNP, which indicates that immobilization is the dominant effect. The same comparatively moderate effects are obtained for the signal amplitude in magnetic particle spectroscopy. Y1 - 2018 U6 - https://doi.org/10.1109/LMAG.2018.2879034 SN - 1949-307X VL - 9 IS - Article number 8519617 PB - IEEE CY - New York, NY ER - TY - JOUR A1 - Hartung, Frank A1 - Horn, Uwe A1 - Huschke, Jörg A1 - Kampmann, Markus T1 - MBMS—IP Multicast/Broadcast in 3G Networks / Hartung, Frank ; Horn, Uwe ; Huschke, Jörg ; Kampmann, Markus ; Lohmar, Thorsten JF - International Journal of Digital Multimedia Broadcasting. 2009 (2009) Y1 - 2009 SN - 1687-7586 N1 - Article ID 597848 SP - 1 EP - 25 ER - TY - JOUR A1 - Hartung, Frank A1 - Rey, J. A1 - Mathieu, B. A1 - Lozano, D. T1 - Media aware overlay routing in Ambient Networks / Rey, J. ; Mathieu, B. ; Lozano, D. ; Herborn, S. ; Ahmed, K. ; Schmid, S. ; Goebbels, S. ; Hartung, F. ; Kampmann, M. JF - 16th IEEE International Symposium on Personal, Indoor and Mobile Radio Communications, 2005. PIMRC 2005. Date:11-14 Sept. 2005 ; Vol. 2 Y1 - 2004 SP - 952 EP - 957 ER - TY - JOUR A1 - Hartung, Frank A1 - Kampmann, Markus T1 - Media Delivery Based on Service Aware Transport Overlay Networks / Kampmann, Markus ; Hartung, Frank JF - KIVS 2007 : Kommunikation in verteilten Systemen : 15. ITG-GI-Fachtagung vom 26. Februar bis 2. März 2007 in Bern, Schweiz ; Industriebeiträge, Kurzbeiträge und Workshops / T. Braun ... (Hrsg.) Y1 - 2007 SN - 978-3-8007-2980-7 N1 - Communication in Distributed Systems (KiVS), 2007 ITG-GI Conference SP - 9 EP - 10 ER - TY - JOUR A1 - Thielemann, Frank T1 - Mit strategischen Allianzen ins nächste Jahrtausend JF - Druckspiegel. 53 (1998), H. 5 Y1 - 1998 SN - 0012-6500 SP - 21 EP - 24 ER - TY - JOUR A1 - Thielemann, Frank T1 - Mit vereinten Kräften JF - Trockenbau, Akustik : Magazin für Planung und Ausführung. 15 (1998), H. 5 Y1 - 1998 SN - 0179-8006 SP - 60 EP - 68 ER - TY - JOUR A1 - Thielemann, Frank A1 - Kriegesmann, Bernd A1 - Schaffner, M. T1 - Mit vereinten Kräften die Wettbewerbsfähigkeit steigern - Kooperation als Antwort auf den In­novationsdruck . Kriegesmann, B.; Thielemann, F.; Schaffner, M. JF - Der Druckspiegel. 50 (1995), H. 10 Y1 - 1995 SN - 0012-6500 SP - 931 EP - 935 ER - TY - JOUR A1 - Hartung, Frank T1 - Mobile DRM Introduction: The Need for Mobile DRM JF - Digital Rights Management : Technological, Economic, Legal and Political Aspects / Becker, Eberhard [u.a.] Y1 - 2003 N1 - Lecture Notes in Computer Science ; 2770 SP - 138 EP - 149 PB - Springer CY - Berlin ER - TY - JOUR A1 - Hartung, Frank A1 - Kampmann, Markus A1 - Horn, Uwe A1 - Kritzner, Jan T1 - Mobile Television / Hartung, Frank ; Kampmann, Markus ; Horn, Uwe ; Kritzner, Jan JF - Encyclopedia of mobile computing and commerce / David Taniar ; Bd. 2 : Mobile ICT - Z Y1 - 2007 SN - 978-1-59904-002-8 SP - 611 EP - 615 PB - Information Science Reference CY - Hershey ER - TY - JOUR A1 - Hartung, Frank A1 - Horn, Uwe A1 - Huschke, Jörg A1 - Kampmann, Markus T1 - Mobile TV Services in 3G Networks / Hartung, Frank ; Horn, Uwe ; Huschke, Jörg ; Kampmann, Markus ; Lohmar, Thorsten JF - KIVS 2007 : Kommunikation in verteilten Systemen : 15. ITG-GI-Fachtagung vom 26. Februar bis 2. März 2007 in Bern, Schweiz ; Industriebeiträge, Kurzbeiträge und Workshops / T. Braun ... (Hrsg.) Y1 - 2007 SN - 978-3-8007-2980-7 N1 - Communication in Distributed Systems (KiVS), 2007 ITG-GI Conference SP - 15 EP - 18 ER - TY - JOUR A1 - Slabu, Ioana A1 - Roeth, Anjali A. A1 - Engelmann, Ulrich M. A1 - Wiekhorst, Frank A1 - Buhl, Eva M. A1 - Neumann, Ulf P. A1 - Schmitz-Rode, Thomas T1 - Modeling of magnetoliposome uptake in human pancreatic tumor cells in vitro JF - Nanotechnology Y1 - 2019 U6 - https://doi.org/10.1088/1361-6528/ab033e SN - 1361-6528 VL - 30 IS - 18 SP - 184004 ER - TY - JOUR A1 - Hartung, Frank A1 - Dondeti, L. A1 - Castleford, F. T1 - Multimedia Internet KEYing (MIKEY) General Extension Payload for Open Mobile Alliance BCAST LTKM/STKM Transport / Dondeti, L. ; Castleford, D. ; Hartung, F. Y1 - 2007 SP - 1 EP - 7 ER - TY - JOUR A1 - Hartung, Frank A1 - Schieder, Andreas A1 - Kampmann, Markus A1 - Vorwerk, Marc T1 - Network Supported Media Delivery in Ambient Networks (Netzwerkunterstützte Medienverteilung) / Schieder, Andreas ; Kampmann, Markus ; Hartung, Frank ; Vorwerk, Marc ; Rembarz, René JF - it - Information Technology . 48 (2006), H. 5 Y1 - 2006 SN - 1611-2776 N1 - in der Bereichsbibliothek Eupener Str. unter der Signatur 23 Z 376 vorhanden SP - 264 EP - 273 ER - TY - JOUR A1 - Thielemann, Frank A1 - Staudt, Erich A1 - Kriegesmann, Bernd T1 - Neuformierung von Wertschöpfungsketten: Das Beispiel Druckindustrie . Staudt, Erich; Kriegesmann, Bernd; Thielemann, Frank JF - Zeitschrift Führung und Organisation. 96 (1997), H. 2 Y1 - 1997 SN - 0044-3212 N1 - in der Bereichsbibliothek Eupener Str. unter der Signatur 43 Z 367-1997 vorhanden SP - 75 EP - 80 ER - TY - JOUR A1 - Möhren, Felix A1 - Bergmann, Ole A1 - Janser, Frank A1 - Braun, Carsten T1 - On the influence of elasticity on propeller performance: a parametric study JF - CEAS Aeronautical Journal N2 - The aerodynamic performance of propellers strongly depends on their geometry and, consequently, on aeroelastic deformations. Knowledge of the extent of the impact is crucial for overall aircraft performance. An integrated simulation environment for steady aeroelastic propeller simulations is presented. The simulation environment is applied to determine the impact of elastic deformations on the aerodynamic propeller performance. The aerodynamic module includes a blade element momentum approach to calculate aerodynamic loads. The structural module is based on finite beam elements, according to Timoshenko theory, including moderate deflections. Several fixed-pitch propellers with thin-walled cross sections made of both isotropic and non-isotropic materials are investigated. The essential parameters are varied: diameter, disc loading, sweep, material, rotational, and flight velocity. The relative change of thrust between rigid and elastic blades quantifies the impact of propeller elasticity. Swept propellers of large diameters or low disc loadings can decrease the thrust significantly. High flight velocities and low material stiffness amplify this tendency. Performance calculations without consideration of propeller elasticity can lead to decreased efficiency. To avoid cost- and time-intense redesigns, propeller elasticity should be considered for swept planforms and low disc loadings. KW - Propeller KW - Finite element method KW - Blade element method KW - Propeller elasticity KW - Aeroelasticity Y1 - 2023 U6 - https://doi.org/10.1007/s13272-023-00649-y SN - 1869-5590 (Online) SN - 1869-5582 (Print) N1 - Corresponding author: Felix Möhren VL - 14 SP - 311 EP - 323 PB - Springer Nature CY - Berlin ER - TY - JOUR A1 - Bergmann, Ole A1 - Möhren, Felix A1 - Braun, Carsten A1 - Janser, Frank T1 - On the influence of elasticity on swept propeller noise JF - AIAA SCITECH 2023 Forum N2 - High aerodynamic efficiency requires propellers with high aspect ratios, while propeller sweep potentially reduces noise. Propeller sweep and high aspect ratios increase elasticity and coupling of structural mechanics and aerodynamics, affecting the propeller performance and noise. Therefore, this paper analyzes the influence of elasticity on forward-swept, backward-swept, and unswept propellers in hover conditions. A reduced-order blade element momentum approach is coupled with a one-dimensional Timoshenko beam theory and Farassat's formulation 1A. The results of the aeroelastic simulation are used as input for the aeroacoustic calculation. The analysis shows that elasticity influences noise radiation because thickness and loading noise respond differently to deformations. In the case of the backward-swept propeller, the location of the maximum sound pressure level shifts forward by 0.5 °, while in the case of the forward-swept propeller, it shifts backward by 0.5 °. Therefore, aeroacoustic optimization requires the consideration of propeller deformation. Y1 - 2023 U6 - https://doi.org/10.2514/6.2023-0210 N1 - Session: Propeller, Open Rotor, and Rotorcraft Noise II AIAA SCITECH 2023 Forum, 23-27 January 2023, National Harbor, MD & Online PB - AIAA CY - Reston, Va. ER - TY - JOUR A1 - Neu, Eugen A1 - Janser, Frank A1 - Khatibi, Akbar A. A1 - Braun, Carsten A1 - Orifici, Adrian C. T1 - Operational Modal Analysis of a wing excited by transonic flow JF - Aerospace Science and Technology N2 - Operational Modal Analysis (OMA) is a promising candidate for flutter testing and Structural Health Monitoring (SHM) of aircraft wings that are passively excited by wind loads. However, no studies have been published where OMA is tested in transonic flows, which is the dominant condition for large civil aircraft and is characterized by complex and unique aerodynamic phenomena. We use data from the HIRENASD large-scale wind tunnel experiment to automatically extract modal parameters from an ambiently excited wing operated in the transonic regime using two OMA methods: Stochastic Subspace Identification (SSI) and Frequency Domain Decomposition (FDD). The system response is evaluated based on accelerometer measurements. The excitation is investigated from surface pressure measurements. The forcing function is shown to be non-white, non-stationary and contaminated by narrow-banded transonic disturbances. All these properties violate fundamental OMA assumptions about the forcing function. Despite this, all physical modes in the investigated frequency range were successfully identified, and in addition transonic pressure waves were identified as physical modes as well. The SSI method showed superior identification capabilities for the investigated case. The investigation shows that complex transonic flows can interfere with OMA. This can make existing approaches for modal tracking unsuitable for their application to aircraft wings operated in the transonic flight regime. Approaches to separate the true physical modes from the transonic disturbances are discussed. Y1 - 2016 U6 - https://doi.org/10.1016/j.ast.2015.11.032 SN - 1270-9638 VL - 49 SP - 73 EP - 79 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Thielemann, Frank A1 - Bock, Jürgen T1 - Organization and management of German-Russian joint ventures. Bock, Jürgen; Thielemann, Frank JF - International journal of technology management. 9 (1994), H. 8 Y1 - 1994 SN - 0267-5730 SP - 864 EP - 879 ER - TY - JOUR A1 - Luisier, Raphaëlle A1 - Lempiäinen, Harri A1 - Scherbichler, Nina A1 - Braeuning, Albert A1 - Geissler, Miriam A1 - Dubost, Valerie A1 - Müller, Arne A1 - Scheer, Nico A1 - Chibout, Salah-Dine A1 - Hara, Hisanori A1 - Picard, Frank A1 - Theil, Diethilde A1 - Couttet, Philippe A1 - Vitobello, Antonio A1 - Grenet, Olivier A1 - Grasl-Kraupp, Bettina A1 - Ellinger-Ziegelbauer, Heidrung A1 - Thomson, John P. A1 - Meehan, Richard R. A1 - Elcombe, Clifford R. A1 - Henderson, Colin J. A1 - Wolf, C. Roland A1 - Schwarz, Michael A1 - Moulin, Pierre A1 - Terranova, Remi A1 - Moggs, Jonathan G. T1 - Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors JF - Toxicological Sciences N2 - The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcinogenesis. Here, we have used a humanized CAR/PXR mouse model to examine potential species differences in receptor-dependent mechanisms underlying liver tissue molecular responses to PB. Early and late transcriptomic responses to sustained PB exposure were investigated in liver tissue from double knock-out CAR and PXR (CARᴷᴼ-PXRᴷᴼ), double humanized CAR and PXR (CARʰ-PXRʰ), and wild-type C57BL/6 mice. Wild-type and CARʰ-PXRʰ mouse livers exhibited temporally and quantitatively similar transcriptional responses during 91 days of PB exposure including the sustained induction of the xenobiotic response gene Cyp2b10, the Wnt signaling inhibitor Wisp1, and noncoding RNA biomarkers from the Dlk1-Dio3 locus. Transient induction of DNA replication (Hells, Mcm6, and Esco2) and mitotic genes (Ccnb2, Cdc20, and Cdk1) and the proliferation-related nuclear antigen Mki67 were observed with peak expression occurring between 1 and 7 days PB exposure. All these transcriptional responses were absent in CARᴷᴼ-PXRᴷᴼ mouse livers and largely reversible in wild-type and CARʰ-PXRʰ mouse livers following 91 days of PB exposure and a subsequent 4-week recovery period. Furthermore, PB-mediated upregulation of the noncoding RNA Meg3, which has recently been associated with cellular pluripotency, exhibited a similar dose response and perivenous hepatocyte-specific localization in both wild-type and CARʰ-PXRʰ mice. Thus, mouse livers coexpressing human CAR and PXR support both the xenobiotic metabolizing and the proliferative transcriptional responses following exposure to PB. Y1 - 2014 U6 - https://doi.org/https://doi.org/10.1093/toxsci/kfu038 SN - 1094-2025 VL - 139 IS - 2 SP - 501 EP - 511 PB - Oxford University Press CY - Oxford ER - TY - JOUR A1 - Gebhardt, Andreas A1 - Schmidt, Frank-Michael T1 - Practical experiences with making and finishing of coloured models using 3D printing Y1 - 2002 N1 - International Conference on Rapid Prototyping and Manufacturing <2, 2002, Beijing> ER - TY - JOUR A1 - Raffeis, Iris A1 - Adjei-Kyeremeh, Frank A1 - Vroomen, Uwe A1 - Westhoff, Elmar A1 - Bremen, Sebastian A1 - Hohoi, Alexandru A1 - Bührig-Polaczek, Andreas T1 - Qualification of a Ni-Cu alloy for the laser powder bed fusion process (LPBF): Its microstructure and mechanical properties JF - Applied Sciences N2 - As researchers continue to seek the expansion of the material base for additive manufacturing, there is a need to focus attention on the Ni–Cu group of alloys which conventionally has wide industrial applications. In this work, the G-NiCu30Nb casting alloy, a variant of the Monel family of alloys with Nb and high Si content is, for the first time, processed via the laser powder bed fusion process (LPBF). Being novel to the LPBF processes, optimum LPBF parameters were determined, and hardness and tensile tests were performed in as-built conditions and after heat treatment at 1000 °C. Microstructures of the as-cast and the as-built condition were compared. Highly dense samples (99.8% density) were achieved after varying hatch distance (80 µm and 140 µm) with scanning speed (550 mm/s–1500 mm/s). There was no significant difference in microhardness between varied hatch distance print sets. Microhardness of the as-built condition (247 HV0.2) exceeded the as-cast microhardness (179 HV0.2.). Tensile specimens built in vertical (V) and horizontal (H) orientations revealed degrees of anisotropy and were superior to conventionally reported figures. Post heat treatment increased ductility from 20% to 31% (V), as well as from 16% to 25% (H), while ultimate tensile strength (UTS) and yield strength (YS) were considerably reduced. Y1 - 2020 U6 - https://doi.org/10.3390/app10103401 SN - 2076-3417 N1 - Special Issue Materials Development by Additive Manufacturing Techniques VL - 10 IS - Art. 3401 SP - 1 EP - 15 PB - MDPI CY - Basel ER - TY - JOUR A1 - Thielemann, Frank A1 - Staudt, Erich T1 - Reicht die Kompetenz zur Innovation? Staudt, E.; Thielemann, F. JF - OP DruckMagazin. 39 (1997), H. 10 Y1 - 1997 SN - 0030-0594 SP - 30 EP - 32 ER - TY - JOUR A1 - Thielemann, Frank A1 - Lüdtke, C. T1 - Risikomanagement - Aufbau eines Frühwarnsystems JF - Wirtschafts-Nachrichten. 45 (2000), H. 12 Y1 - 2000 SN - 1436-5588 SP - 14 EP - ff ER - TY - JOUR A1 - Gebhardt, Andreas A1 - Brücker, Christoph A1 - Schmidt, Frank-Michael T1 - RP gestützte Herstellung komplexer transparenter Hohlräume für die Strömungsanalyse N2 - Die Berechnung der Durchströmung von Bauteilen ist gegenüber derjenigen von umströmten Bauteilen deutlich im Hintertreffen. Das liegt vor allem an der fehlenden Verfügbarkeit geeigneter optisch transparenter Modellkanäle für die experimentelle Analyse. Der Beitrag stellt ein Verfahren zur Herstellung transparenter durchströmter Geometrien auf der Basis generativ gefertigter Urmodelle vor. Damit können beliebig komplexe Innenströmungen optisch analysiert werden. Anhand von zwei Beispielen aus der Medizin, der Modellierung der oberen Atemwege und des Bronchialbaums, wird das Verfahren vorgeführt. Der generative Bauprozess mittels 3D-Printing wird beschrieben und die Abformung in transparentem Silikon gezeigt. Schließlich werden beispielhaft der Messaufbau und Ergebnisse der Anwendung vorgestellt. Das Verfahren bildet die Grundlage für die Analyse und Berechnung komplexer Innenströmungen und trägt somit zur Verbesserung zahlreicher technischer Anwendungen bei. N2 - Unlike the flow around technical products the interior flow is not understood very well. That’s mainly because of a lack of suitable transparent investigation tunnels that are needed to apply optical methods. The paper proposes a procedure to make precise complex hollow structures from a highly transparent material using masters from generative or Rapid Prototyping processes. Taking two examples from the medical field, the upper human airways and the bronchial tree, the entire process is shown. The 3D Printing build process is illustrated as well as the silicon casting process. Finally the measuring equipment is demonstrated and sample results are given. The process establishes the basis for the investigation and calculation of complex interior flow pattern and therefore contributes to a better understanding and consequently improvement of appropriate technical products. KW - Rapid prototyping KW - Rapid Prototyping KW - Strömungsanalyse KW - Innenströmung KW - Modellkanäle KW - 3D-Printing Y1 - 2005 ER - TY - JOUR A1 - Hartung, Frank A1 - Baldo, N. A1 - Horn, U. A1 - Kampmann, M. T1 - RTCP feedback based transmission rate control for 3G wireless multimedia streaming / Baldo, N. ; Horn, U. ; Kampmann, M. ; Hartung, F. ; JF - 15th IEEE International Symposium on Personal, Indoor and Mobile Radio Communications, 2004. PIMRC 2004. Date:5-8 Sept. 2004 ; Vol. 3 Y1 - 2004 N1 - http://dx.doi.org/10.1109/PIMRC.2004.1368313 SP - 1817 EP - 1821 ER - TY - JOUR A1 - Frank, T. A1 - Buchwald, D. A1 - Pennekamp, W. A1 - Reber, D. A1 - Sponagel, Stefan A1 - Laszkovics, A. A1 - Weber, Hans-Joachim T1 - Röntgenologische Untersuchung der Strömungseigenschaften funktioneller Komponenten der Herz-Lungen-Maschine JF - Kardiotechnik. 18 (2009), H. 2 Y1 - 2009 SN - 0941-2670 N1 - gedruckt in der Bibliothek unter der Signatur 63 Z 629 SP - 31 EP - 35 ER - TY - JOUR A1 - Meliß, Michael A1 - Späte, Frank T1 - Sonne, Wind und Biomasse zur umweltfreundlichen Energieversorgung JF - Wohnung + Gesundheit. Fachzeitschrift für ökologisches Bauen + Leben. 18 (1996), Nr. 79 Y1 - 1996 SN - 0176-0513 SP - 47 EP - 50 ER - TY - JOUR A1 - Ferrein, Alexander A1 - Dylla, Frank A1 - Lakemeyer, Gerhard T1 - Specifying Multirobot Coordination in ICPGolog - From Simulation towards Real Robots / Dylla, Frank ; Ferrein, Alexander ; Lakemeyer, Gerhard Y1 - 2003 N1 - AOS-4 at IJCAI-03 SP - 1 EP - 10 ER - TY - JOUR A1 - Hartung, Frank A1 - Noh, Jeonghun A1 - Baccichet, Pierpaolo A1 - Mavlankar, Aditya T1 - Standford Peer-to-Peer Mulicast (SPPM) - Overview and recent Extensions / Noh, Jeonghun ; Baccichet, Pierpaolo ; Hartung, Frank ; Mavlankar, Aditya ; Girod, Bernd Y1 - 2009 SN - 978-1-4244-4593-6 N1 - Picture Coding Symposium, 2009. PCS 2009 ; auch unter IEEE: http://dx.doi.org/10.1109/PCS.2009.5167392 SP - 1 EP - 4 ER - TY - JOUR A1 - Hartung, Frank A1 - Girod, Bernd T1 - Statistical optimization of switched two-level quantizers with application to DPCM encoding of color video / Hartung, Frank ; Girod, Bernd JF - IEEE International Conference on Acoustics, Speech, and Signal Processing, 1996. ICASSP-96. Conference Proceedings., 1996 Y1 - 1996 SN - 0-7803-3192-3 SP - 1974 EP - 1977 ER - TY - JOUR A1 - Elsen, Ingo A1 - Hartung, Frank A1 - Horn, Uwe A1 - Kampmann, Markus A1 - Peters, Liliane ED - Voas, Jeffrey T1 - Streaming technology in 3G mobile communication systems JF - Computer : innovative technology for computer professionals N2 - Third-generation mobile communication systems will combine standardized streaming with a range of unique services to provide high-quality Internet content that meets the specific needs of the rapidly growing mobile market. Y1 - 2001 SN - 0018-9162 SN - 1558-0814 VL - 34 IS - 9 Seiten SP - 46 EP - 52 PB - IEEE CY - New York ER - TY - JOUR A1 - Hartung, Frank A1 - Girod, Bernd A1 - Horn, Uwe T1 - Subband Image Coding / Girod, Bernd ; Hartung, Frank ; Horn, Uwe JF - Subband and Wavelet Transforms: Design and Applications / ed. by Ali N. Akansu Y1 - 1995 SN - 0792396456 SP - 213 EP - 250 PB - Kluwer CY - Boston ER - TY - JOUR A1 - Weemstra, Monique A1 - Eilmann, Britta A1 - Sass-Klaassen, Ute G. W. A1 - Sterck, Frank J. T1 - Summer droughts limit tree growth across 10 temperate species on a productive forest site JF - Forest Ecology and Management Y1 - 2013 U6 - https://doi.org/doi:10.1016/j.foreco.2013.06.007 SN - 0378-1127 (Print) SN - 1872-7042 (Online) VL - 2013 IS - 306 SP - 142 EP - 149 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Meliß, Michael A1 - Späte, Frank T1 - The solar heating system with seasonal storage at the Solar-Campus Jülich JF - Solar energy. Vol. 69 (2000), iss. 6 Y1 - 2000 SN - 0038-092X SP - 525 EP - 533 ER - TY - JOUR A1 - Ferrein, Alexander A1 - Dylla, Frank A1 - Lakemeyer, Gerhard A1 - Murray, Jan T1 - Towards a League-Independent Qualitative Soccer Theory for RoboCup / Dylla, Frank ; Ferrein, Alexander ; Lakemeyer, Gerhard ; Murray, Jan ; Obst, Oliver ; Röfer, Thomas ; Stolzenburg, Frieder ; Visser, Ubbo JF - RoboCup 2004: Robot Soccer World Cup VIII / Daniele Nardi ... (ed.). Y1 - 2005 SN - 978-3-540-25046-8 N1 - Lecture Notes in Computer Science ; 3276 SP - 611 EP - 618 PB - Springer CY - Berlin ER - TY - JOUR A1 - Bartella, Alexander K. A1 - Kamal, Mohammad A1 - Scholl, Ingrid A1 - Schiffer, Stefan A1 - Steegmann, Julius A1 - Ketelsen, Dominik A1 - Hölzle, Frank W. A1 - Lethaus, Bernd T1 - Virtual reality in preoperative imaging in maxillofacial surgery: implementation of “the next level”? JF - British Journal of Oral and Maxillofacial Surgery Y1 - 2019 U6 - https://doi.org/10.1016/j.bjoms.2019.02.014 SN - 0266-4356 VL - 57 IS - 7 SP - 644 EP - 648 PB - Elsevier CY - Amsterdam ER -