TY  - JOUR
A1  - Meliß, Michael
A1  - Späte, Frank
T1  - The solar heating system with seasonal storage at the Solar-Campus Jülich
JF  - Solar energy. Vol. 69 (2000), iss. 6
Y1  - 2000
SN  - 0038-092X
SP  - 525
EP  - 533
ER  - 
TY  - CHAP
A1  - Repschläger, Horst
A1  - Hafner, Bernd
A1  - Meliß, Michael
A1  - Philippi, Helga
A1  - Späte, Frank
T1  - Vergleich verschiedener Netzvarianten am Beispiel des geplanten solaren Nahwärmesystems für den Solar-Campus Jülich
T2  - 8. Symposium Thermische Solarenergie : Ort: Bildungszentrum der Hanns-Seidel-Stiftung, Kloster Banz, Staffelstein. Termin: 13. - 15. Mai 1998 / OTTI, Technologie-Kolleg
Y1  - 1998
SP  - 310
EP  - 314
PB  - OTTI
CY  - Regensburg
ER  - 
TY  - CHAP
A1  - Späte, Frank
A1  - Wollscheid, Georg
A1  - Meliß, Michael
T1  - Erdreichwärmetauscher im Solar-Campus Jülich
T2  - Deutschlands Weg in eine solare Zukunft : Tagungsband; 26. - 30. Juni 1998 Fachhochschule Köln / 11. Internationales Sonnenforum
Y1  - 1998
SP  - 591
EP  - 598
PB  - Solar Promotion
CY  - München
ER  - 
TY  - CHAP
A1  - Späte, Frank
A1  - Hubrich, Jörg
A1  - Keip, Wolfgang
A1  - Meliß, Michael
T1  - Der Solar-Campus Jülich - Stand der Arbeiten
T2  - Deutschlands Weg in eine solare Zukunft : Tagungsband; 26. - 30. Juni 1998 Fachhochschule Köln / 11. Internationales Sonnenforum
Y1  - 1998
SP  - 666
EP  - 672
PB  - Solar Promotion
CY  - München
ER  - 
TY  - CHAP
A1  - Razen, Manfred
A1  - Späte, Frank
A1  - Meliß, Michael
A1  - Breuer, Maria
A1  - Hubrich, Jörg
A1  - Rischert, Christa
T1  - Aus-, Fort- und Weiterbildung am Solar-Institut Jülich
T2  - Deutschlands Weg in eine solare Zukunft : Tagungsband; 26. - 30. Juni 1998 Fachhochschule Köln / 11. Internationales Sonnenforum
Y1  - 1998
SP  - 1071
EP  - 1078
PB  - Solar Promotion
CY  - München
ER  - 
TY  - CHAP
A1  - Krug, Wolfgang
A1  - Razen, Manfred
A1  - Späte, Frank
A1  - Meliß, Michael
T1  - Solarpraktikum für Feriengäste
T2  - Deutschlands Weg in eine solare Zukunft : Tagungsband; 26. - 30. Juni 1998 Fachhochschule Köln / 11. Internationales Sonnenforum
Y1  - 1998
SP  - 1102
EP  - 1109
PB  - Solar Promotion
CY  - München
ER  - 
TY  - CHAP
A1  - Meliß, Michael
A1  - Späte, Frank
A1  - Lange, Harald
T1  - The Solar-Campus Jülich - an interdisciplinary project
T2  - Building a new century. 5th Conference on Solar Architecture and Design, Bonn, 27th of May 1998. Ed. by Eurosolar e.V. Ed. by Irm Pontenagel.
Y1  - 1999
SN  - 3-933745-03-9
SP  - 382
EP  - 387
PB  - Eurosolar-Verl.
CY  - Bonn
ER  - 
TY  - JOUR
A1  - Meliß, Michael
A1  - Späte, Frank
T1  - Erneuerbare Energien sollen in die Bresche springen. Geld, Kraft und politisches Wollen ist gefragt
JF  - VDI-Nachrichten. Nr. 46 vom 17.11.1995
Y1  - 1995
SN  - 0042-1758
SP  - 33
ER  - 
TY  - JOUR
A1  - Meliß, Michael
A1  - Späte, Frank
T1  - Sonne, Wind und Biomasse zur umweltfreundlichen Energieversorgung
JF  - Wohnung + Gesundheit. Fachzeitschrift für ökologisches Bauen + Leben. 18 (1996), Nr. 79
Y1  - 1996
SN  - 0176-0513
SP  - 47
EP  - 50
ER  - 
TY  - CHAP
A1  - Meliß, Michael
A1  - Späte, Frank
T1  - Berechnung von Sonnenstand und -strahlung
T2  - Regenerative Energiequellen : Praktikum / ed. Michael Meliß
Y1  - 1997
SN  - 3-540-63218-2
U6  - http://dx.doi.org/10.1007/978-3-642-60864-3_2
SP  - 5
EP  - 22
PB  - Springer
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Meliß, Michael
A1  - Späte, Frank
T1  - Auslegung von solarthermischen Anlagen
T2  - Regenerative Energiequellen : Praktikum / ed. Michael Meliß
Y1  - 1997
SN  - 3-540-63218-2
U6  - http://dx.doi.org/10.1007/978-3-642-60864-3_3
SP  - 23
EP  - 47
PB  - Springer
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Meliß, Michael
A1  - Späte, Frank
T1  - Solar-Campus Jülich - an interdisciplinary project
T2  - EuroSun '96 ; 10. Internationales Sonnenforum : proceedings. Bd 3
Y1  - 1996
SP  - 1281
EP  - 1285
PB  - DGS-Sonnenenergie
CY  - München
ER  - 
TY  - CHAP
A1  - Späte, Frank
A1  - Hafner, B.
A1  - Schwarzer, Klemens
T1  - A system for solar process heat for decentralized applications in developing countries
T2  - ISES 1999 Solar World Congress, Jerusalem, Israel, July 4-9, 1999 : conference proceedings / ed. Gershon Grossman. Vol. 3
Y1  - 2000
SN  - 0-080-043895-4
SP  - 236
EP  - 291
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - CHAP
A1  - Kroker, Jan
A1  - Hoffschmidt, Bernhard
A1  - Schwarzer, Klemens
A1  - Späte, Frank
T1  - PTC 1000 modular parabolic trough collector
T2  - Process heat collectors : state of the art within task 33/IV ; IEA SHC-Task 33 and SolarPACES-Task IV: Solar heat for industrial processes : Förderkennzeichen BMBF 0329273A / Solar Heating and Cooling Executive Committee of the International Energy Agency (IEA) ; ed. Werner Weiss
Y1  - 2008
SP  - 45
EP  - 46
PB  - AEE INTEC
CY  - Gleisdorf
ER  - 
TY  - CHAP
A1  - Ziolko, Christoph
A1  - Fricke, Barbara
A1  - Anthrakidis, Anette
A1  - Hoffschmidt, Bernhard
A1  - Dillig, Marius
A1  - Giese, Frank
A1  - Schwarzbözl, Peter
T1  - Ökobilanzielle Aspekte technologischer Entwicklungen des Solarturmkraftwerks
T2  - Forschung und Entwicklung für solarthermische Kraftwerke : 14. Kölner Sonnenkolloquium Mittwoch, 13. Juli 2011, im Auditorium des Campus Jülich der FH Aachen : Kurzfassungen der Vorträge und Poster
Y1  - 2011
SP  - 2 S.
PB  - DLR
CY  - Köln
ER  - 
TY  - CHAP
A1  - Hoffschmidt, Bernhard
A1  - Schwarzer, Klemens
A1  - Späte, Frank
A1  - Kötter, Jens
A1  - Ebert, Miriam
A1  - Sierck, Olaf
T1  - Development of a small modular parabolic trough collector
T2  - 13th International Symposium Concentrated Solar Power and Chemical Energy Technologies : SolarPaces : June 20 - 23, 2006, Seville, Spain
Y1  - 2006
SN  - 8478345191
PB  - SolarPaces
CY  - [o.O.]
ER  - 
TY  - JOUR
A1  - Mischke, Winfried
A1  - Neuß, Frank
T1  - Führt die Übernahme der Domain eines anderen Unternehmers zur Haftung für dessen Schulden nach § 25 HGB?
JF  - Zeitschrift für Vertragsgestaltung, Schuld- und Haftungsrecht : ZGS
Y1  - 2009
SN  - 1619-7011
VL  - 8
SP  - 407
EP  - 409
PB  - ZAP, Verl. f. die Rechts- und Anwaltspraxis
CY  - Recklinghausen
ER  - 
TY  - RPRT
A1  - Dilger, Klaus
A1  - Fischer, Fabian
A1  - Hellmanns, Mark
A1  - Werner, Frank
A1  - Wittor, Björn
T1  - Applikation und Einsatz von faserverstärkten Klebstoffen im Bauwesen (FibrAdh) : Schlussbericht : gefördertes Vorhaben 16.956 B / DVS-Nr. 08.072
Y1  - 2013
ER  - 
TY  - CHAP
A1  - Dylla, Frank
A1  - Ferrein, Alexander
A1  - Lakemeyer, Gerhard
T1  - AllemaniACs 2003 team description
T2  - RoboCup 2003 : Robot Soccer World Cup VII
Y1  - 2003
SP  - 1
EP  - 3
ER  - 
TY  - PAT
A1  - Ahlborn, Kristina
A1  - Gerlach, Frank
A1  - Iken, Heiko
A1  - Schöning, Michael Josef
A1  - Vonau, Winfried
T1  - Miniaturisierte, potentiometrische Indikatorelektrode und Verfahren zu deren Herstellung : Offenlegungsschrift
Y1  - 2012
ER  - 
TY  - JOUR
A1  - Weemstra, Monique
A1  - Eilmann, Britta
A1  - Sass-Klaassen, Ute G. W.
A1  - Sterck, Frank J.
T1  - Summer droughts limit tree growth across 10 temperate species on a productive forest site
JF  - Forest Ecology and Management
Y1  - 2013
U6  - http://dx.doi.org/doi:10.1016/j.foreco.2013.06.007
SN  - 0378-1127 (Print)
SN  - 1872-7042  (Online)
VL  - 2013
IS  - 306
SP  - 142
EP  - 149
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Eilmann, Britta
A1  - Sterck, Frank J.
A1  - Wegner, L.
A1  - de Vries, Sven M. G.
A1  - von Arx, G.
A1  - Mohren, Godefridus M. J.
A1  - den Ouden, Jan
A1  - Sass-Klaassen, Ute G. W.
T1  - Wood structural differences between northern and southern beech provenances growing at a moderate site
JF  - Tree Physiology
Y1  - 2014
U6  - http://dx.doi.org/10.1093/treephys/tpu069
SN  - 1758-4469  (Online)
SN  - 0829-318X (Print)
VL  - 34
IS  - 8
SP  - 882
EP  - 893
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - BOOK
A1  - Altensen, Frank
A1  - Alt, Helmut
A1  - Schumny, Harald
T1  - Kryptologie (HP-41 C/CV) : Chiffrierung, Textverschlüsselung, Datenschutz, Morsealphabet (Vieweg-Programmbibliothek Taschenrechner ; 7) / Helmut Alt ; Harald Schumny [Hrsg.]
Y1  - 1983
SN  - 3-528-04256-7
PB  - Vieweg + Teubner
CY  - Wiesbaden
ER  - 
TY  - CHAP
A1  - Röhrig, Christof
A1  - Großmann, Uwe
A1  - Künemund, Frank
A1  - Gansemer, Sebastian
A1  - Schürmann, Volker
A1  - Wollert, Jörg
T1  - Positionsbestimmung mittels Funktechnologien - Vergleich von Verfahren und Technologien mit exemplarischer Demonstration
T2  - Wireless-Technologies-Kongress 2008 : von der Technologie zur Anwendung / Hrsg. Jörg F. Wollert
Y1  - 2008
SN  - 978-3-89838-608-1
SP  - 337
EP  - 348
PB  - AKA
CY  - Heidelberg
ER  - 
TY  - JOUR
A1  - Bouwman, Peter
A1  - Gulden, Hanneke van der
A1  - Heijden, Ingrid van der
A1  - Drost, Rinske
A1  - Klijn, Christiaan N.
A1  - Prasetyanti, Pramudita
A1  - Pieterse, Mark
A1  - Wientjens, Ellen
A1  - Seibler, Jost
A1  - Hogervorst, Frank B. L.
A1  - Jonkers, Jos
T1  - A High-Throughput Functional Complementation Assay for Classification of BRCA1 Missense Variants
JF  - Cancer Discovery
Y1  - 2013
U6  - http://dx.doi.org/10.1158/2159-8290.CD-13-0094
SN  - 2159-8290
IS  - 3
SP  - 1142
EP  - 1152
ER  - 
TY  - CHAP
A1  - Borchert, Jörg
A1  - Bremen, Frank
T1  - Geschäfts- und Organisationsmodelle für ein Strom- und Gas-Portfoliomanagement
T2  - Optimierte Strom- und Gasbeschaffung in der Energiewirtschaftsbranche
Y1  - 2014
SN  - 978-3-9813142-9-8
SP  - 11
EP  - 28
PB  - KS-Energy-Verl.
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Delle, Lotta E.
A1  - Huck, Christina
A1  - Bäcker, Matthias
A1  - Müller, Frank
A1  - Grandthyll, Samuel
A1  - Jacobs, Karin
A1  - Lilischkis, Rainer
A1  - Vu, Xuan T.
A1  - Schöning, Michael Josef
A1  - Wagner, Patrick
A1  - Thoelen, Roland
A1  - Weil, Maryam
A1  - Ingebrandt, Sven
T1  - Impedimetric immunosensor for the detection of histamine based on reduced graphene oxide
JF  - Physica status solidi (a)
Y1  - 2015
U6  - http://dx.doi.org/10.1002/pssa.201431863
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1327
EP  - 1334
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Neu, Eugen
A1  - Janser, Frank
A1  - Khatibi, Akbar A.
A1  - Orifici, Adrian C.
T1  - Operational modal analysis of a cantilever in a wind tunnel using optical fiber bragg grating sensors
T2  - 6th International Operational Modal Analysis Conference. IOMAC´15. 2015 May 12-14 Gijon - Spain
Y1  - 2015
U6  - http://dx.doi.org/10.13140/RG.2.1.3753.0324
ER  - 
TY  - JOUR
A1  - Bindal, Gaurav
A1  - Sharma, Sparsh
A1  - Janser, Frank
A1  - Neu, Eugen
T1  - Detailed analysis of variables affecting wing kinematics of bat flight
JF  - SAE International Journal of Aerospace
Y1  - 2013
U6  - http://dx.doi.org/10.4271/2013-01-9003
SN  - 1946-3901
VL  - 6
IS  - 2
SP  - 811
EP  - 818
ER  - 
TY  - CHAP
A1  - Chudoba, Rostislav
A1  - Butenweg, Christoph
A1  - Pfeiffer, Frank
T1  - Textile reinforced concrete. Part I: Process model for collaborative research and development
T2  - Digital proceedings / IKM 2003, proceedings 16th International Conference on the Applications of Computer Science and Mathematics in Architecture and Civil Engineering [Elektronische Ressource : 10. - 12. Juni 2003, Weimar] / Bauhaus-Universität Weimar. Ed.: K. Gürlebeck; L. Hempel; C. Könke
Y1  - 2003
SP  - 1
EP  - 8
PB  - IKM
CY  - Weimar
ER  - 
TY  - JOUR
A1  - Hoeveler, Bastian
A1  - Janser, Frank
A1  - Bindewald, Thorsten
A1  - Gebhardt, Andreas
T1  - Entwurf, Fertigung und Untersuchung eines Windkanalmodells eines innovativen, senkrechtstartenden Kleinflugzeuges
JF  - RTejournal - Forum für Rapid Technologie
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0009-2-42921
SN  - 1614-0923
IS  - 12
SP  - 1
EP  - 5
PB  - Fachhochschule Aachen
CY  - Aachen
ER  - 
TY  - JOUR
A1  - Neu, Eugen
A1  - Janser, Frank
A1  - Khatibi, Akbar A.
A1  - Braun, Carsten
A1  - Orifici, Adrian C.
T1  - Operational Modal Analysis of a wing excited by transonic flow
JF  - Aerospace Science and Technology
N2  - Operational Modal Analysis (OMA) is a promising candidate for flutter testing and Structural Health Monitoring (SHM) of aircraft wings that are passively excited by wind loads. However, no studies have been published where OMA is tested in transonic flows, which is the dominant condition for large civil aircraft and is characterized by complex and unique aerodynamic phenomena. We use data from the HIRENASD large-scale wind tunnel experiment to automatically extract modal parameters from an ambiently excited wing operated in the transonic regime using two OMA methods: Stochastic Subspace Identification (SSI) and Frequency Domain Decomposition (FDD). The system response is evaluated based on accelerometer measurements. The excitation is investigated from surface pressure measurements. The forcing function is shown to be non-white, non-stationary and contaminated by narrow-banded transonic disturbances. All these properties violate fundamental OMA assumptions about the forcing function. Despite this, all physical modes in the investigated frequency range were successfully identified, and in addition transonic pressure waves were identified as physical modes as well. The SSI method showed superior identification capabilities for the investigated case. The investigation shows that complex transonic flows can interfere with OMA. This can make existing approaches for modal tracking unsuitable for their application to aircraft wings operated in the transonic flight regime. Approaches to separate the true physical modes from the transonic disturbances are discussed.
Y1  - 2016
U6  - http://dx.doi.org/10.1016/j.ast.2015.11.032
SN  - 1270-9638
VL  - 49
SP  - 73
EP  - 79
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - BOOK
A1  - Janser, Frank
A1  - Havermann, Marc
T1  - Inkompressible Strömungen
Y1  - 2015
SN  - 978-3-86130-446-3
N1  - Strömungslehre
und Aerodynamik ; 1
PB  - Verlagshaus Mainz GmbH
CY  - Aachen
ET  - 3. Aufl.
ER  - 
TY  - CHAP
A1  - Nakagawa, Masaki
A1  - Kallweit, Stephan
A1  - Michaux, Frank
A1  - Hojo, Teppei
T1  - Typical Velocity Fields and Vortical Structures around a Formula One Car, based on Experimental Investigations using Particle Image Velocimetry
T2  - SAE International Journal of Passenger Cars - Mechanical Systems
Y1  - 2016
U6  - http://dx.doi.org/10.4271/2016-01-1611
SN  - 1946-4002
ER  - 
TY  - JOUR
A1  - Neu, Eugen
A1  - Janser, Frank
A1  - Khatibi, Akbar A.
A1  - Orifici, Adrian C.
T1  - Fully Automated Operational Modal Analysis using multi-stage clustering
JF  - Mechanical Systems and Signal Processing
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.ymssp.2016.07.031
SN  - 0888-3270
VL  - Vol. 84, Part A
SP  - 308
EP  - 323
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Neu, Eugen
A1  - Janser, Frank
A1  - Khatibi, Akbar A.
A1  - Orifici, Adrian C.
T1  - Automated modal parameter-based anomaly detection under varying wind excitation
JF  - Structural Health Monitoring
N2  - Wind-induced operational variability is one of the major challenges for structural health monitoring of slender engineering structures like aircraft wings or wind turbine blades. Damage sensitive features often show an even bigger sensitivity to operational variability. In this study a composite cantilever was subjected to multiple mass configurations, velocities and angles of attack in a controlled wind tunnel environment. A small-scale impact damage was introduced to the specimen and the structural response measurements were repeated. The proposed damage detection methodology is based on automated operational modal analysis. A novel baseline preparation procedure is described that reduces the amount of user interaction to the provision of a single consistency threshold. The procedure starts with an indeterminate number of operational modal analysis identifications from a large number of datasets and returns a complete baseline matrix of natural frequencies and damping ratios that is suitable for subsequent anomaly detection. Mahalanobis distance-based anomaly detection is then applied to successfully detect the damage under varying severities of operational variability and with various degrees of knowledge about the present operational conditions. The damage detection capabilities of the proposed methodology were found to be excellent under varying velocities and angles of attack. Damage detection was less successful under joint mass and wind variability but could be significantly improved through the provision of the currently encountered operational conditions.
Y1  - 2016
U6  - http://dx.doi.org/10.1177/1475921716665803
SN  - 1475-9217
VL  - 15
IS  - 6
SP  - 1
EP  - 20
PB  - Sage
CY  - London
ER  - 
TY  - CHAP
A1  - Neu, Eugen
A1  - Janser, Frank
A1  - Khatibi, Akbar A.
A1  - Orifici, Adrian C.
T1  - In-flight vibration-based structural health monitoring of aircraft wings
T2  - 30th Congress of the internatonal council of the aeronautical sciences : 25.-30. September 2016, Daejeon, Korea
N2  - This work presents a methodology for automated
damage-sensitive feature extraction and anomaly
detection under multivariate operational variability
for in-flight assessment of wings. The
method uses a passive excitation approach, i. e.
without the need for artificial actuation. The
modal system properties (natural frequencies and
damping ratios) are used as damage-sensitive
features. Special emphasis is placed on the use
of Fiber Bragg Grating (FBG) sensing technology
and the consideration of Operational and
Environmental Variability (OEV). Measurements
from a wind tunnel investigation with a composite
cantilever equipped with FBG and piezoelectric
sensors are used to successfully detect an impact
damage. In addition, the feasibility of damage
localisation and severity estimation is evaluated
based on the coupling found between damageand
OEV-induced feature changes.
Y1  - 2016
ER  - 
TY  - BOOK
A1  - Janser, Frank
A1  - Havermann, Marc
A1  - Hoeveler, Bastian
A1  - Hertz, Cyril
T1  - Inkompressible Profil- und Tragflügelaerodynamik
T3  - Strömungslehre und Aerodynamik ; Band 2
Y1  - 2016
SN  - 978-3-8107-0261-6
N1  - Signatur in der Bibliothek: 21 ZSE 118
PB  - Verlagshaus Mainz GmbH
CY  - Aachen
ET  - 1. Auflage
ER  - 
TY  - CHAP
A1  - Hansen, Frank
A1  - Laack, Walter van
T1  - Schnittstelle Tod: Sind Religionen religiös und Wissenschaften wissend?
Y1  - 2018
SN  - 978-3-936624-36-6
N1  - Tagungsband des 5. Seminars mit dem gleichnamigen Titel vom 4. November 2017 in Aachen / Hansen, Frank [Interviewer] ; van Laack, Walter [Herausgeber] ; ...
PB  - van Laack GmbH
CY  - Aachen
ER  - 
TY  - CHAP
A1  - Kleine, Harald
A1  - Kallweit, Stephan
A1  - Michaux, Frank
A1  - Havermann, Marc
A1  - Olivier, Herbert
T1  - PIV Measurement of Shock Wave Diffraction
T2  - 18th International Symposium on Applications of Laser Techniques to Fluid Mechanics, 2016, Lissabon
Y1  - 2016
SP  - 1
EP  - 14
ER  - 
TY  - BOOK
A1  - Jochim, Haldor E.
A1  - Lademann, Frank
T1  - Planung von Bahnanlagen: Grundlagen - Planung - Berechnung
Y1  - 2018
SN  - 978-3-446-44220-7
U6  - http://dx.doi.org/10.3139/9783446448940
PB  - Fachbuchverlag Leipzig im Carl Hanser Verlag
CY  - München
ET  - 2., aktualisierte und erweiterte Auflage
ER  - 
TY  - CHAP
A1  - Hammer, Andreas
A1  - Vieth, Matthias
A1  - Maier, Frank
T1  - Co-Plot as a new multivariate analysis method for operations management research?
T2  - Papers of the 12th International EurOMA Conference on Operational and Global Competitiveness, Budapest, Hungary, June 19-22, 2005 / Editor: Krisztina Demeter
Y1  - 2005
SN  - 963-218-455-6
SP  - 1007
EP  - 1016
ER  - 
TY  - JOUR
A1  - Luisier, Raphaëlle
A1  - Lempiäinen, Harri
A1  - Scherbichler, Nina
A1  - Braeuning, Albert
A1  - Geissler, Miriam
A1  - Dubost, Valerie
A1  - Müller, Arne
A1  - Scheer, Nico
A1  - Chibout, Salah-Dine
A1  - Hara, Hisanori
A1  - Picard, Frank
A1  - Theil, Diethilde
A1  - Couttet, Philippe
A1  - Vitobello, Antonio
A1  - Grenet, Olivier
A1  - Grasl-Kraupp, Bettina
A1  - Ellinger-Ziegelbauer, Heidrung
A1  - Thomson, John P.
A1  - Meehan, Richard R.
A1  - Elcombe, Clifford R.
A1  - Henderson, Colin J.
A1  - Wolf, C. Roland
A1  - Schwarz, Michael
A1  - Moulin, Pierre
A1  - Terranova, Remi
A1  - Moggs, Jonathan G.
T1  - Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors
JF  - Toxicological Sciences
N2  - The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcinogenesis. Here, we have used a humanized CAR/PXR mouse model to examine potential species differences in receptor-dependent mechanisms underlying liver tissue molecular responses to PB. Early and late transcriptomic responses to sustained PB exposure were investigated in liver tissue from double knock-out CAR and PXR (CARᴷᴼ-PXRᴷᴼ), double humanized CAR and PXR (CARʰ-PXRʰ), and wild-type C57BL/6 mice. Wild-type and CARʰ-PXRʰ mouse livers exhibited temporally and quantitatively similar transcriptional responses during 91 days of PB exposure including the sustained induction of the xenobiotic response gene Cyp2b10, the Wnt signaling inhibitor Wisp1, and noncoding RNA biomarkers from the Dlk1-Dio3 locus. Transient induction of DNA replication (Hells, Mcm6, and Esco2) and mitotic genes (Ccnb2, Cdc20, and Cdk1) and the proliferation-related nuclear antigen Mki67 were observed with peak expression occurring between 1 and 7 days PB exposure. All these transcriptional responses were absent in CARᴷᴼ-PXRᴷᴼ mouse livers and largely reversible in wild-type and CARʰ-PXRʰ mouse livers following 91 days of PB exposure and a subsequent 4-week recovery period. Furthermore, PB-mediated upregulation of the noncoding RNA Meg3, which has recently been associated with cellular pluripotency, exhibited a similar dose response and perivenous hepatocyte-specific localization in both wild-type and CARʰ-PXRʰ mice. Thus, mouse livers coexpressing human CAR and PXR support both the xenobiotic metabolizing and the proliferative transcriptional responses following exposure to PB.
Y1  - 2014
U6  - http://dx.doi.org/https://doi.org/10.1093/toxsci/kfu038
SN  - 1094-2025
VL  - 139
IS  - 2
SP  - 501
EP  - 511
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - CHAP
A1  - Waldmann, Christoph
A1  - Vera, Jean-Pierre de
A1  - Dachwald, Bernd
A1  - Strasdeit, Henry
A1  - Sohl, Frank
A1  - Hanff, Hendrik
A1  - Kowalski, Julia
A1  - Heinen, Dirk
A1  - Macht, Sabine
A1  - Bestmann, Ulf
A1  - Meckel, Sebastian
A1  - Hildebrandt, Marc
A1  - Funke, Oliver
A1  - Gehrt, Jan-Jöran
T1  - Search for life in ice-covered oceans and lakes beyond Earth
T2  - 2018 IEEE/OES Autonomous Underwater Vehicle Workshop, Proceedings November 2018, Article number 8729761
N2  - The quest for life on other planets is closely connected with the search for water in liquid state. Recent discoveries of deep oceans on icy moons like Europa and Enceladus have spurred an intensive discussion about how these waters can be accessed. The challenge of this endeavor lies in the unforeseeable requirements on instrumental characteristics both with respect to the scientific and technical methods. The TRIPLE/nanoAUV initiative is aiming at developing a mission concept for exploring exo-oceans and demonstrating the achievements in an earth-analogue context, exploring the ocean under the ice shield of Antarctica and lakes like Dome-C on the Antarctic continent.
KW  - Planetary exploration
KW  - Jupiter
KW  - ice moons
KW  - underwater vehicle
KW  - Antarctica
Y1  - 2018
U6  - http://dx.doi.org/10.1109/AUV.2018.8729761
ER  - 
TY  - JOUR
A1  - Bartella, Alexander K.
A1  - Kamal, Mohammad
A1  - Scholl, Ingrid
A1  - Schiffer, Stefan
A1  - Steegmann, Julius
A1  - Ketelsen, Dominik
A1  - Hölzle, Frank W.
A1  - Lethaus, Bernd
T1  - Virtual reality in preoperative imaging in maxillofacial surgery: implementation of “the next level”?
JF  - British Journal of Oral and Maxillofacial Surgery
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.bjoms.2019.02.014
SN  - 0266-4356
VL  - 57
IS  - 7
SP  - 644
EP  - 648
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Galdi, Chiara
A1  - Hartung, Frank
A1  - Dugelay, Jean-Luc
T1  - Socrates: A database of realistic data for source camera recognition on smartphones
T2  - Proceedings of the 8th International Conference on Pattern Recognition Applications and Methods - Volume 1: ICPRAM
Y1  - 2019
SN  - 978-989-758-351-3
U6  - http://dx.doi.org/10.5220/0007403706480655
SP  - 648
EP  - 655
ER  - 
TY  - JOUR
A1  - Schieren, Mark
A1  - Kleinschmidt, Joris
A1  - Schmutz, Axel
A1  - Loop, Torsten
A1  - Gatzweiler, Karl-Heinz
A1  - Staat, Manfred
A1  - Wappler, Frank
A1  - Defosse, Jerome
T1  - Comparison of forces acting on maxillary incisors during tracheal intubation with different laryngoscopy techniques: a blinded manikin study
JF  - Anaesthesia
Y1  - 2019
SN  - 1365-2044
U6  - http://dx.doi.org/10.1111/anae.14815
N1  - Die Anhänge "Table S1 (Impact of sex and level of training on dental force. Results presented as median (IQR [range]) and n (%))" und 
"Appendix S1 (Measurement technique.)" stehen unter "Supporting Information" zum Download bereit.
VL  - 74
IS  - 12
PB  - Wiley-Blackwell
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Engelmann, Ulrich M.
A1  - Buhl, Eva Miriam
A1  - Draack, Sebastian
A1  - Viereck, Thilo
A1  - Frank, 
A1  - Schmitz-Rode, Thomas
A1  - Slabu, Ioana
T1  - Magnetic relaxation of agglomerated and immobilized iron oxide nanoparticles for hyperthermia and imaging applications
JF  - IEEE Magnetic Letters
N2  - Magnetic nanoparticles (MNPs) are used as therapeutic and diagnostic agents for local delivery of heat and image contrast enhancement in diseased tissue. Besides magnetization, the most important parameter that determines their performance for these applications is their magnetic relaxation, which can be affected when MNPs immobilize and agglomerate inside tissues. In this letter, we investigate different MNP agglomeration states for their magnetic relaxation properties under excitation in alternating fields and relate this to their heating efficiency and imaging properties. With focus on magnetic fluid hyperthermia, two different trends in MNP heating efficiency are measured: an increase by up to 23% for agglomerated MNP in suspension and a decrease by up to 28% for mixed states of agglomerated and immobilized MNP, which indicates that immobilization is the dominant effect. The same comparatively moderate effects are obtained for the signal amplitude in magnetic particle spectroscopy.
Y1  - 2018
U6  - http://dx.doi.org/10.1109/LMAG.2018.2879034
SN  - 1949-307X
VL  - 9
IS  - Article number 8519617
PB  - IEEE
CY  - New York, NY
ER  - 
TY  - JOUR
A1  - Slabu, Ioana
A1  - Roeth, Anjali A.
A1  - Engelmann, Ulrich M.
A1  - Wiekhorst, Frank
A1  - Buhl, Eva M.
A1  - Neumann, Ulf P.
A1  - Schmitz-Rode, Thomas
T1  - Modeling of magnetoliposome uptake in human pancreatic tumor cells in vitro
JF  - Nanotechnology
Y1  - 2019
U6  - http://dx.doi.org/10.1088/1361-6528/ab033e
SN  - 1361-6528
VL  - 30
IS  - 18
SP  - 184004
ER  - 
TY  - BOOK
A1  - Gunnar, Auth
A1  - Barton, Thomas
A1  - Beigel, Stefan
A1  - Bensberg, Frank
A1  - Brehm, Lars
A1  - Wolf, Martin
ED  - Barton, Thomas
ED  - Herrmann, Frank
ED  - Meister, Vera G.
ED  - Müller, Christian
ED  - Seel, Christian
T1  - Prozesse, Technologie, Anwendungen, Systeme und Management 2017
BT  - Angewandte Forschung in der Wirtschaftsinformatik. Tagungsband zur 30. AKWI-Jahrestagung vom 17.09.2017 bis 20.09.2017 an der Hochschule Aschaffenburg / Arbeitskreis Wirtschaftsinformatik an Fachhochschulen (AKWI)
Y1  - 2017
SN  - 978-3-944330-56-3
PB  - Mana-Buch
CY  - Heide
ER  -