TY  - JOUR
A1  - Bouwman, Peter
A1  - Gulden, Hanneke van der
A1  - Heijden, Ingrid van der
A1  - Drost, Rinske
A1  - Klijn, Christiaan N.
A1  - Prasetyanti, Pramudita
A1  - Pieterse, Mark
A1  - Wientjens, Ellen
A1  - Seibler, Jost
A1  - Hogervorst, Frank B. L.
A1  - Jonkers, Jos
T1  - A High-Throughput Functional Complementation Assay for Classification of BRCA1 Missense Variants
JF  - Cancer Discovery
Y1  - 2013
U6  - https://doi.org/10.1158/2159-8290.CD-13-0094
SN  - 2159-8290
IS  - 3
SP  - 1142
EP  - 1152
ER  - 
TY  - JOUR
A1  - Eilmann, Britta
A1  - Sterck, Frank J.
A1  - Wegner, L.
A1  - de Vries, Sven M. G.
A1  - von Arx, G.
A1  - Mohren, Godefridus M. J.
A1  - den Ouden, Jan
A1  - Sass-Klaassen, Ute G. W.
T1  - Wood structural differences between northern and southern beech provenances growing at a moderate site
JF  - Tree Physiology
Y1  - 2014
U6  - https://doi.org/10.1093/treephys/tpu069
SN  - 1758-4469  (Online)
SN  - 0829-318X (Print)
VL  - 34
IS  - 8
SP  - 882
EP  - 893
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - CHAP
A1  - Borchert, Jörg
A1  - Bremen, Frank
T1  - Geschäfts- und Organisationsmodelle für ein Strom- und Gas-Portfoliomanagement
T2  - Optimierte Strom- und Gasbeschaffung in der Energiewirtschaftsbranche
Y1  - 2014
SN  - 978-3-9813142-9-8
SP  - 11
EP  - 28
PB  - KS-Energy-Verl.
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Luisier, Raphaëlle
A1  - Lempiäinen, Harri
A1  - Scherbichler, Nina
A1  - Braeuning, Albert
A1  - Geissler, Miriam
A1  - Dubost, Valerie
A1  - Müller, Arne
A1  - Scheer, Nico
A1  - Chibout, Salah-Dine
A1  - Hara, Hisanori
A1  - Picard, Frank
A1  - Theil, Diethilde
A1  - Couttet, Philippe
A1  - Vitobello, Antonio
A1  - Grenet, Olivier
A1  - Grasl-Kraupp, Bettina
A1  - Ellinger-Ziegelbauer, Heidrung
A1  - Thomson, John P.
A1  - Meehan, Richard R.
A1  - Elcombe, Clifford R.
A1  - Henderson, Colin J.
A1  - Wolf, C. Roland
A1  - Schwarz, Michael
A1  - Moulin, Pierre
A1  - Terranova, Remi
A1  - Moggs, Jonathan G.
T1  - Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors
JF  - Toxicological Sciences
N2  - The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcinogenesis. Here, we have used a humanized CAR/PXR mouse model to examine potential species differences in receptor-dependent mechanisms underlying liver tissue molecular responses to PB. Early and late transcriptomic responses to sustained PB exposure were investigated in liver tissue from double knock-out CAR and PXR (CARᴷᴼ-PXRᴷᴼ), double humanized CAR and PXR (CARʰ-PXRʰ), and wild-type C57BL/6 mice. Wild-type and CARʰ-PXRʰ mouse livers exhibited temporally and quantitatively similar transcriptional responses during 91 days of PB exposure including the sustained induction of the xenobiotic response gene Cyp2b10, the Wnt signaling inhibitor Wisp1, and noncoding RNA biomarkers from the Dlk1-Dio3 locus. Transient induction of DNA replication (Hells, Mcm6, and Esco2) and mitotic genes (Ccnb2, Cdc20, and Cdk1) and the proliferation-related nuclear antigen Mki67 were observed with peak expression occurring between 1 and 7 days PB exposure. All these transcriptional responses were absent in CARᴷᴼ-PXRᴷᴼ mouse livers and largely reversible in wild-type and CARʰ-PXRʰ mouse livers following 91 days of PB exposure and a subsequent 4-week recovery period. Furthermore, PB-mediated upregulation of the noncoding RNA Meg3, which has recently been associated with cellular pluripotency, exhibited a similar dose response and perivenous hepatocyte-specific localization in both wild-type and CARʰ-PXRʰ mice. Thus, mouse livers coexpressing human CAR and PXR support both the xenobiotic metabolizing and the proliferative transcriptional responses following exposure to PB.
Y1  - 2014
U6  - https://doi.org/https://doi.org/10.1093/toxsci/kfu038
SN  - 1094-2025
VL  - 139
IS  - 2
SP  - 501
EP  - 511
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - CHAP
A1  - Neu, Eugen
A1  - Janser, Frank
A1  - Khatibi, Akbar A.
A1  - Orifici, Adrian C.
T1  - Operational modal analysis of a cantilever in a wind tunnel using optical fiber bragg grating sensors
T2  - 6th International Operational Modal Analysis Conference. IOMAC´15. 2015 May 12-14 Gijon - Spain
Y1  - 2015
U6  - https://doi.org/10.13140/RG.2.1.3753.0324
ER  - 
TY  - JOUR
A1  - Delle, Lotta E.
A1  - Huck, Christina
A1  - Bäcker, Matthias
A1  - Müller, Frank
A1  - Grandthyll, Samuel
A1  - Jacobs, Karin
A1  - Lilischkis, Rainer
A1  - Vu, Xuan T.
A1  - Schöning, Michael Josef
A1  - Wagner, Patrick
A1  - Thoelen, Roland
A1  - Weil, Maryam
A1  - Ingebrandt, Sven
T1  - Impedimetric immunosensor for the detection of histamine based on reduced graphene oxide
JF  - Physica status solidi (a)
Y1  - 2015
U6  - https://doi.org/10.1002/pssa.201431863
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1327
EP  - 1334
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Hoeveler, Bastian
A1  - Janser, Frank
A1  - Bindewald, Thorsten
A1  - Gebhardt, Andreas
T1  - Entwurf, Fertigung und Untersuchung eines Windkanalmodells eines innovativen, senkrechtstartenden Kleinflugzeuges
JF  - RTejournal - Forum für Rapid Technologie
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0009-2-42921
SN  - 1614-0923
IS  - 12
SP  - 1
EP  - 5
PB  - Fachhochschule Aachen
CY  - Aachen
ER  - 
TY  - BOOK
A1  - Janser, Frank
A1  - Havermann, Marc
T1  - Inkompressible Strömungen
Y1  - 2015
SN  - 978-3-86130-446-3
N1  - Strömungslehre
und Aerodynamik ; 1
PB  - Verlagshaus Mainz GmbH
CY  - Aachen
ET  - 3. Aufl.
ER  - 
TY  - CHAP
A1  - Nakagawa, Masaki
A1  - Kallweit, Stephan
A1  - Michaux, Frank
A1  - Hojo, Teppei
T1  - Typical Velocity Fields and Vortical Structures around a Formula One Car, based on Experimental Investigations using Particle Image Velocimetry
T2  - SAE International Journal of Passenger Cars - Mechanical Systems
Y1  - 2016
U6  - https://doi.org/10.4271/2016-01-1611
SN  - 1946-4002
ER  - 
TY  - JOUR
A1  - Neu, Eugen
A1  - Janser, Frank
A1  - Khatibi, Akbar A.
A1  - Braun, Carsten
A1  - Orifici, Adrian C.
T1  - Operational Modal Analysis of a wing excited by transonic flow
JF  - Aerospace Science and Technology
N2  - Operational Modal Analysis (OMA) is a promising candidate for flutter testing and Structural Health Monitoring (SHM) of aircraft wings that are passively excited by wind loads. However, no studies have been published where OMA is tested in transonic flows, which is the dominant condition for large civil aircraft and is characterized by complex and unique aerodynamic phenomena. We use data from the HIRENASD large-scale wind tunnel experiment to automatically extract modal parameters from an ambiently excited wing operated in the transonic regime using two OMA methods: Stochastic Subspace Identification (SSI) and Frequency Domain Decomposition (FDD). The system response is evaluated based on accelerometer measurements. The excitation is investigated from surface pressure measurements. The forcing function is shown to be non-white, non-stationary and contaminated by narrow-banded transonic disturbances. All these properties violate fundamental OMA assumptions about the forcing function. Despite this, all physical modes in the investigated frequency range were successfully identified, and in addition transonic pressure waves were identified as physical modes as well. The SSI method showed superior identification capabilities for the investigated case. The investigation shows that complex transonic flows can interfere with OMA. This can make existing approaches for modal tracking unsuitable for their application to aircraft wings operated in the transonic flight regime. Approaches to separate the true physical modes from the transonic disturbances are discussed.
Y1  - 2016
U6  - https://doi.org/10.1016/j.ast.2015.11.032
SN  - 1270-9638
VL  - 49
SP  - 73
EP  - 79
PB  - Elsevier
CY  - Amsterdam
ER  -