TY  - JOUR
A1  - Luisier, Raphaëlle
A1  - Lempiäinen, Harri
A1  - Scherbichler, Nina
A1  - Braeuning, Albert
A1  - Geissler, Miriam
A1  - Dubost, Valerie
A1  - Müller, Arne
A1  - Scheer, Nico
A1  - Chibout, Salah-Dine
A1  - Hara, Hisanori
A1  - Picard, Frank
A1  - Theil, Diethilde
A1  - Couttet, Philippe
A1  - Vitobello, Antonio
A1  - Grenet, Olivier
A1  - Grasl-Kraupp, Bettina
A1  - Ellinger-Ziegelbauer, Heidrung
A1  - Thomson, John P.
A1  - Meehan, Richard R.
A1  - Elcombe, Clifford R.
A1  - Henderson, Colin J.
A1  - Wolf, C. Roland
A1  - Schwarz, Michael
A1  - Moulin, Pierre
A1  - Terranova, Remi
A1  - Moggs, Jonathan G.
T1  - Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors
JF  - Toxicological Sciences
N2  - The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcinogenesis. Here, we have used a humanized CAR/PXR mouse model to examine potential species differences in receptor-dependent mechanisms underlying liver tissue molecular responses to PB. Early and late transcriptomic responses to sustained PB exposure were investigated in liver tissue from double knock-out CAR and PXR (CARᴷᴼ-PXRᴷᴼ), double humanized CAR and PXR (CARʰ-PXRʰ), and wild-type C57BL/6 mice. Wild-type and CARʰ-PXRʰ mouse livers exhibited temporally and quantitatively similar transcriptional responses during 91 days of PB exposure including the sustained induction of the xenobiotic response gene Cyp2b10, the Wnt signaling inhibitor Wisp1, and noncoding RNA biomarkers from the Dlk1-Dio3 locus. Transient induction of DNA replication (Hells, Mcm6, and Esco2) and mitotic genes (Ccnb2, Cdc20, and Cdk1) and the proliferation-related nuclear antigen Mki67 were observed with peak expression occurring between 1 and 7 days PB exposure. All these transcriptional responses were absent in CARᴷᴼ-PXRᴷᴼ mouse livers and largely reversible in wild-type and CARʰ-PXRʰ mouse livers following 91 days of PB exposure and a subsequent 4-week recovery period. Furthermore, PB-mediated upregulation of the noncoding RNA Meg3, which has recently been associated with cellular pluripotency, exhibited a similar dose response and perivenous hepatocyte-specific localization in both wild-type and CARʰ-PXRʰ mice. Thus, mouse livers coexpressing human CAR and PXR support both the xenobiotic metabolizing and the proliferative transcriptional responses following exposure to PB.
Y1  - 2014
U6  - https://doi.org/https://doi.org/10.1093/toxsci/kfu038
SN  - 1094-2025
VL  - 139
IS  - 2
SP  - 501
EP  - 511
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Slabu, Ioana
A1  - Roeth, Anjali A.
A1  - Engelmann, Ulrich M.
A1  - Wiekhorst, Frank
A1  - Buhl, Eva M.
A1  - Neumann, Ulf P.
A1  - Schmitz-Rode, Thomas
T1  - Modeling of magnetoliposome uptake in human pancreatic tumor cells in vitro
JF  - Nanotechnology
Y1  - 2019
U6  - https://doi.org/10.1088/1361-6528/ab033e
SN  - 1361-6528
VL  - 30
IS  - 18
SP  - 184004
ER  - 
TY  - JOUR
A1  - Engelmann, Ulrich M.
A1  - Buhl, Eva Miriam
A1  - Draack, Sebastian
A1  - Viereck, Thilo
A1  - Frank, 
A1  - Schmitz-Rode, Thomas
A1  - Slabu, Ioana
T1  - Magnetic relaxation of agglomerated and immobilized iron oxide nanoparticles for hyperthermia and imaging applications
JF  - IEEE Magnetic Letters
N2  - Magnetic nanoparticles (MNPs) are used as therapeutic and diagnostic agents for local delivery of heat and image contrast enhancement in diseased tissue. Besides magnetization, the most important parameter that determines their performance for these applications is their magnetic relaxation, which can be affected when MNPs immobilize and agglomerate inside tissues. In this letter, we investigate different MNP agglomeration states for their magnetic relaxation properties under excitation in alternating fields and relate this to their heating efficiency and imaging properties. With focus on magnetic fluid hyperthermia, two different trends in MNP heating efficiency are measured: an increase by up to 23% for agglomerated MNP in suspension and a decrease by up to 28% for mixed states of agglomerated and immobilized MNP, which indicates that immobilization is the dominant effect. The same comparatively moderate effects are obtained for the signal amplitude in magnetic particle spectroscopy.
Y1  - 2018
U6  - https://doi.org/10.1109/LMAG.2018.2879034
SN  - 1949-307X
VL  - 9
IS  - Article number 8519617
PB  - IEEE
CY  - New York, NY
ER  - 
TY  - CHAP
A1  - Neu, Eugen
A1  - Janser, Frank
A1  - Khatibi, Akbar A.
A1  - Orifici, Adrian C.
T1  - In-flight vibration-based structural health monitoring of aircraft wings
T2  - 30th Congress of the internatonal council of the aeronautical sciences : 25.-30. September 2016, Daejeon, Korea
N2  - This work presents a methodology for automated
damage-sensitive feature extraction and anomaly
detection under multivariate operational variability
for in-flight assessment of wings. The
method uses a passive excitation approach, i. e.
without the need for artificial actuation. The
modal system properties (natural frequencies and
damping ratios) are used as damage-sensitive
features. Special emphasis is placed on the use
of Fiber Bragg Grating (FBG) sensing technology
and the consideration of Operational and
Environmental Variability (OEV). Measurements
from a wind tunnel investigation with a composite
cantilever equipped with FBG and piezoelectric
sensors are used to successfully detect an impact
damage. In addition, the feasibility of damage
localisation and severity estimation is evaluated
based on the coupling found between damageand
OEV-induced feature changes.
Y1  - 2016
ER  - 
TY  - CHAP
A1  - Kleine, Harald
A1  - Kallweit, Stephan
A1  - Michaux, Frank
A1  - Havermann, Marc
A1  - Olivier, Herbert
T1  - PIV Measurement of Shock Wave Diffraction
T2  - 18th International Symposium on Applications of Laser Techniques to Fluid Mechanics, 2016, Lissabon
Y1  - 2016
SP  - 1
EP  - 14
ER  - 
TY  - CHAP
A1  - Dinghofer, Kai
A1  - Hartung, Frank
T1  - Analysis of Criteria for the Selection of Machine Learning Frameworks
T2  - 2020 International Conference on Computing, Networking and Communications (ICNC)
N2  - With the many achievements of Machine Learning in the past years, it is likely that the sub-area of Deep Learning will continue to deliver major technological breakthroughs [1]. In order to achieve best results, it is important to know the various different Deep Learning frameworks and their respective properties. This paper provides a comparative overview of some of the most popular frameworks. First, the comparison methods and criteria are introduced and described with a focus on computer vision applications: Features and Uses are examined by evaluating papers and articles, Adoption and Popularity is determined by analyzing a data science study. Then, the frameworks TensorFlow, Keras, PyTorch and Caffe are compared based on the previously described criteria to highlight properties and differences. Advantages and disadvantages are compared, enabling researchers and developers to choose a framework according to their specific needs.
Y1  - 2020
U6  - https://doi.org/10.1109/ICNC47757.2020.9049650
N1  - 2020 International Conference on Computing, Networking and Communications (ICNC), 17-20 February 2020, Big Island, HI, USA
SP  - 373
EP  - 377
PB  - IEEE
CY  - New York, NY
ER  - 
TY  - CHAP
A1  - Jordan, Frank
A1  - Katz, Christiane
A1  - Pieper, Martin
T1  - Online-Kollaboration in der Mathematik: Ein Design-Based-Research-Projekt
T2  - Forschungsimpulse für hybrides Lehren und Lernen an Hochschulen
N2  - Die Studie erörtert anhand eines Fallbeispiels aus der Mathematik für Ingenieur*innen, wie didaktische Gestaltungsprinzipien für Soziale Präsenz, Kollaboration und das Lösen von praxisnahen Problemen mit mathematischem Denken in einer Online-Umgebung aussehen können. Hierfür zieht der
Beitrag den forschungsmethodologischen Rahmen Design-Based Research (DBR) hinzu und berichtet über Zwischenergebnisse. DBR wird an dieser Stelle als eine systematische Herangehensweise an kurzfristige Lehrveränderungen und als Chance auf dem Weg zu einer neuen Hochschullehre nach der COVID-19-Pandemie dargestellt, die theoretische und empirische Erkenntnisse mit Praxisverknüpfung und -relevanz vereint.
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:832-cos4-9465
SP  - 245
EP  - 261
PB  - TH Köln
CY  - Köln
ER  - 
TY  - CHAP
A1  - Auth, Gunnar
A1  - Czarnecki, Christian
A1  - Bensberg, Frank
ED  - Draude, Claude
ED  - Lange, Martin
ED  - Sick, Bernhard
ED  - Gesellschaft für Informatik e.V. (GI), 
T1  - Impact of robotic process automation on enterprise architectures
T2  - GI Edition Proceedings Band 295 INFORMATIK 2019, Workshop-Beiträge
N2  - The initial idea of Robotic Process Automation (RPA) is the automation of business processes through the presentation layer of existing application systems. For this simple emulation of user input and output by software robots, no changes of the systems and architecture is required. However, considering strategic aspects of aligning business and technology on an enterprise level as well as the growing capabilities of RPA driven by artificial intelligence, interrelations between RPA and Enterprise Architecture (EA) become visible and pose new questions. In this paper we discuss the relationship between RPA and EA in terms of perspectives and implications. As workin- progress we focus on identifying new questions and research opportunities related to RPA and EA.
KW  - Robotic Process Automation
KW  - Enterprise Architecture
KW  - Software Robots
Y1  - 2019
SN  - 9783885796893
U6  - https://doi.org/10.18420/inf2019_ws05
SN  - 1617-5468
N1  - 50 Jahre Gesellschaft für Informatik – Informatik für Gesellschaft. 16. September, Kassel
SP  - 59
EP  - 65
PB  - Köllen
CY  - Bonn
ER  - 
TY  - CHAP
A1  - Bensberg, Frank
A1  - Auth, Gunnar
A1  - Czarnecki, Christian
A1  - Wörndle, Christopher
ED  - Kemal İlter, H.
T1  - Transforming literature-intensive research processes through text analytics – design, implementation and lessons learned
N2  - The continuing growth of scientific publications raises the question how research processes can be digitalized and thus realized more productively. Especially in information technology fields, research practice is characterized by a rapidly growing volume of publications. For the search process various information systems exist. However, the analysis of the published content is still a highly manual task. Therefore, we propose a text analytics system that allows a fully digitalized analysis of literature sources. We have realized a prototype by using EBSCO Discovery Service in combination with IBM Watson Explorer and demonstrated the results in real-life research projects. Potential addressees are research institutions, consulting firms, and decision-makers in politics and business practice.
KW  - Text analytics
KW  - Text mining
KW  - Literature review
KW  - Research process
Y1  - 2018
U6  - https://doi.org/10.6084/m9.figshare.7582073.v1
N1  - 5th International Management Information Systems Conference.
October 24-26 2018, Ankara
ER  - 
TY  - JOUR
A1  - Czarnecki, Christian
A1  - Bensberg, Frank
A1  - Auth, Gunnar
T1  - Die Rolle von Softwarerobotern für die zukünftige Arbeitswelt
JF  - HMD Praxis der Wirtschaftsinformatik
N2  - Im Rahmen der Digitalisierung ist die zunehmende Automatisierung von bisher manuellen Prozessschritten ein Aspekt, der massive Auswirkungen auf die zukünftige Arbeitswelt haben wird. In diesem Kontext werden an den Einsatz von Softwarerobotern zur Prozessautomatisierung hohe Erwartungen geknüpft. Bei den Implementierungsansätzen wird die Diskussion aktuell insbesondere durch Robotic Process Automation (RPA) und Chatbots geprägt. Beide Ansätze verfolgen das gemeinsame Ziel einer 1:1-Automatisierung von menschlichen Handlungen und dadurch ein direktes Ersetzen von Mitarbeitern durch Maschinen. Bei RPA werden Prozesse durch Softwareroboter erlernt und automatisiert ausgeführt. Dabei emulieren RPA-Roboter die Eingaben auf der bestehenden Präsentationsschicht, so dass keine Änderungen an vorhandenen Anwendungssystemen notwendig sind. Am Markt werden bereits unterschiedliche RPA-Lösungen als Softwareprodukte angeboten. Durch Chatbots werden Ein- und Ausgaben von Anwendungssystemen über natürliche Sprache realisiert. Dadurch ist die Automatisierung von unternehmensexterner Kommunikation (z. B. mit Kunden) aber auch von unternehmensinternen Assistenztätigkeiten möglich. Der Beitrag diskutiert die Auswirkungen von Softwarerobotern auf die Arbeitswelt anhand von Anwendungsbeispielen und erläutert die unternehmensindividuelle Entscheidung über den Einsatz von Softwarerobotern anhand von Effektivitäts- und Effizienzzielen.
KW  - Robotic Process Automation
KW  - Chatbots
KW  - Prozessautomatisierung
KW  - Arbeit 4.0
KW  - Digitalisierung
Y1  - 2019
U6  - https://doi.org/10.1365/s40702-019-00548-z
SN  - 2198-2775
VL  - 56
IS  - 4
SP  - 795
EP  - 808
PB  - Springer
CY  - Cham
ER  -