TY  - JOUR
A1  - Weckesser, Matthias
A1  - Hufnagel, Andreas
A1  - Ziemons, Karl
A1  - Grießmeier, Martin
A1  - Sonnenberg, Frank
A1  - Hackländer, Thomas
A1  - Langen, Karl-J.
A1  - Holschbach, Markus
A1  - Elger, Christian E.
A1  - Müller-Gärtner, Hans-W.
T1  - Effect of partial volume correction on muscarinic cholinergic receptor imaging with single-photon emission tomography in patients with temporal lobe epilepsy
JF  - European Journal of Nuclear Medicine
N2  - Animal experiments and preliminary results in humans have indicated alterations of hippocampal muscarinic acetylcholine receptors (mAChR) in temporal lobe epilepsy. Patients with temporal lobe epilepsy often present with a reduction in hippocampal volume. The aim of this study was to investigate the influence of hippocampal atrophy on the quantification of mAChR with single photon emission tomography (SPET) in patients with temporal lobe epilepsy. Cerebral uptake of the muscarinic cholinergic antagonist [123I]4-iododexetimide (IDex) was investigated by SPET in patients suffering from temporal lobe epilepsy of unilateral (n=6) or predominantly unilateral (n=1) onset. Regions of interest were drawn on co-registered magnetic resonance images. Hippocampal volume was determined in these regions and was used to correct the SPET results for partial volume effects. A ratio of hippocampal IDex binding on the affected side to that on the unaffected side was used to detect changes in muscarinic cholinergic receptor density. Before partial volume correction a decrease in hippocampal IDex binding on the focus side was found in each patient. After partial volume no convincing differences remained. Our results indicate that the reduction in hippocampal IDex binding in patients with epilepsy is due to a decrease in hippocampal volume rather than to a decrease in receptor concentration.
Y1  - 1997
SN  - 1619-7089
VL  - 24
IS  - 9
SP  - 1156
EP  - 1161
ER  - 
TY  - JOUR
A1  - Geier, Christian
A1  - Bialonski, Stephan
A1  - Elger, Christian E.
A1  - Lehnertz, Klaus
T1  - How important is the seizure onset zone for seizure dynamics?
JF  - Seizure
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.seizure.2014.10.013
SN  - 1059-1311
VL  - 25
SP  - 160
EP  - 166
ER  - 
TY  - JOUR
A1  - Bialonski, Stephan
A1  - Wellmer, Jörg
A1  - Elger, Christian E.
A1  - Lehnertz, Klaus
T1  - Interictal focus localization in neocortical lesional epilepsies with synchronization cluster analysis
JF  - Epilepsia
Y1  - 2006
SN  - 0013-9580
VL  - 47
SP  - 36
ER  - 
TY  - CHAP
A1  - Osterhage, Hannes
A1  - Bialonski, Stephan
A1  - Staniek, Matthäus
A1  - Schindler, Kaspar
A1  - Wagner, Tobias
A1  - Elger, Christian E.
A1  - Lehnertz, Klaus
T1  - Bivariate and multivariate time series analysis techniques and their potential impact for seizure prediction
T2  - Seizure Prediction in Epilepsy: From Basic Mechanisms to Clinical Applications
Y1  - 2008
SN  - 978-3-527-62519-2
U6  - http://dx.doi.org/10.1002/9783527625192.ch15
SP  - 189
EP  - 208
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Schindler, Kaspar A.
A1  - Bialonski, Stephan
A1  - Horstmann, Marie-Therese
A1  - Elger, Christian E.
A1  - Lehnertz, Klaus
T1  - Evolving functional network properties and synchronizability during human epileptic seizures
JF  - Chaos: An Interdisciplinary Journal of Nonlinear Science
Y1  - 2008
U6  - http://dx.doi.org/10.1063/1.2966112
SN  - 1089-7682
VL  - 18
IS  - 3
SP  - 033119
ER  - 
TY  - JOUR
A1  - Lehnertz, Klaus
A1  - Mormann, Florian
A1  - Osterhage, Hannes
A1  - Andy, Müller
A1  - Prusseit, Jens
A1  - Chernihovskyi, Anton
A1  - Staniek, Matthäus
A1  - Krug, Dieter
A1  - Bialonski, Stephan
A1  - Elger, Christian E.
T1  - State-of-the-art of seizure prediction
JF  - Journal of Clinical Neurophysiology
Y1  - 2007
U6  - http://dx.doi.org/10.1097/WNP.0b013e3180336f16
SN  - 1537-1603
VL  - 24
IS  - 2
SP  - 147
EP  - 153
ER  -