TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Linder, Peter
A1  - Kayser, Peter
A1  - Digel, Ilya
T1  - NMR in vitro effects on proliferation, apoptosis, and viability of human chondrocytes and osteoblasts
JF  - Methods and findings in Experimental and Clinical Pharmacology. 27 (2005), H. 6
Y1  - 2005
SN  - 0379-0355
SP  - 391
EP  - 394
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Zerlin, Kay
A1  - Digel, Ilya
T1  - Hemoglobin Senses Body Temperature
JF  - Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)
Y1  - 2008
SN  - 978-3-540-75408-4
SP  - 415
EP  - 447
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Digel, Ilya
A1  - Zerlin, Kay
A1  - Maggakis-Kelemen, Christina
A1  - Linder, Peter
A1  - Porst, Dariusz
A1  - Kayser, Peter
A1  - Stadler, David
A1  - Dikta, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Hemoglobin senses body temperature
JF  - European Biophysics Journal
Y1  - 2009
SN  - 0175-7571
VL  - 38
IS  - 5
SP  - 589
EP  - 600
ER  - 
TY  - JOUR
A1  - Stadler, A.  M.
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Embs, Jan P.
A1  - Zaccai, Joe
A1  - Büldt, Georg
T1  - Hemoglobin Dynamics in Red Blood Cells: Correlation to Body Temperature
JF  - Biophysical Journal. 95 (2008), H. 11
Y1  - 2008
SN  - 1542-0086
SP  - 5449
EP  - 5461
ER  - 
TY  - JOUR
A1  - Sadykov, Rustam
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
A1  - Porst, Dariusz
A1  - Linder, Peter
A1  - Kayser, Peter
A1  - Artmann, Gerhard
A1  - Savitskaya, Irina
A1  - Zhubanova, Azhar
T1  - Oral lead exposure induces dysbacteriosis in rats
JF  - Journal of Occupational Health. 51 (2009) (2009), H. 1
Y1  - 2009
SN  - 1348-9585
SP  - 64
EP  - 73
ER  - 
TY  - JOUR
A1  - Stadler, Andreas M.
A1  - Garvey, G. J.
A1  - Bocahut, A.
A1  - Sacquin-Mora, S.
A1  - Digel, Ilya
A1  - Schneider, G. J.
A1  - Natali, F.
A1  - Artmann, Gerhard
A1  - Zaccai, G.
T1  - Thermal fluctuations of haemoglobin from different species : adaptation to temperature via conformational dynamics
JF  - Journal of the Royal Society Interface
N2  - Thermodynamic stability, configurational motions and internal forces of haemoglobin (Hb) of three endotherms (platypus, Ornithorhynchus anatinus; domestic chicken, Gallus gallus domesticus and human, Homo sapiens) and an ectotherm (salt water crocodile, Crocodylus porosus) were investigated using circular dichroism, incoherent elastic neutron scattering and coarse-grained Brownian dynamics simulations. The experimental results from Hb solutions revealed a direct correlation between protein resilience, melting temperature and average body temperature of the different species on the 0.1 ns time scale. Molecular forces appeared to be adapted to permit conformational fluctuations with a root mean square displacement close to 1.2 Å at the corresponding average body temperature of the endotherms. Strong forces within crocodile Hb maintain the amplitudes of motion within a narrow limit over the entire temperature range in which the animal lives. In fully hydrated powder samples of human and chicken, Hb mean square displacements and effective force constants on the 1 ns time scale showed no differences over the whole temperature range from 10 to 300 K, in contrast to the solution case. A complementary result of the study, therefore, is that one hydration layer is not sufficient to activate all conformational fluctuations of Hb in the pico- to nanosecond time scale which might be relevant for biological function. Coarse-grained Brownian dynamics simulations permitted to explore residue-specific effects. They indicated that temperature sensing of human and chicken Hb occurs mainly at residues lining internal cavities in the β-subunits.
Y1  - 2012
U6  - http://dx.doi.org/10.1098/rsif.2012.0364
SN  - 1742-5689
VL  - 9
IS  - 76
SP  - 2845
EP  - 2855
PB  - The Royal Society
CY  - London
ER  - 
TY  - JOUR
A1  - Demirci, Taylan
A1  - Kurulgan Demirci, Eylem
A1  - Trzewik, Jürgen
A1  - Linder, Peter
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Sakizli, Meral
A1  - Temiz Artmann, Aysegül
T1  - Gene expression profile analysis of 3T3/NIH fibroblasts after one hour mechanical stress
JF  - IUBMB Life. 61 (2009), H. 3
Y1  - 2009
SN  - 1521-6543
N1  - Abstracts: Turkish Society of Molecular Medicine, Third International Congress of Molecular Medicine, May 5-8, 2009, Istanbul, Turkey
SP  - 311
EP  - 312
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Linder, Peter
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
A1  - Kayser, Peter
A1  - Porst, Dariusz
A1  - Artmann, Gerhard
T1  - High-throughput testing of mechanical forces generated in thin cell and tissue layers
JF  - Tissue Engineering. 13 (2007), H. 7
Y1  - 2007
SN  - 1076-3279
N1  - Meeting abstract 433
SP  - 1778
EP  - 1778
ER  - 
TY  - JOUR
A1  - Demirci, T.
A1  - Trzewik, J.
A1  - Linder, Peter
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Mechanical Stimulation of 3T3 Fibroblasts Activates Genes: ITGB5 and p53 Responses as Quantified on the mRNA Level
JF  - Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2
Y1  - 2004
SN  - 0932-4666
SP  - 1030
EP  - 1031
ER  - 
TY  - BOOK
A1  - Digel, Ilya
A1  - Zhubanova, Azhar Ahmetovna
A1  - Akimbekov, Nuraly Shardarbekovich
T1  - Visual Virology
Y1  - 2012
SN  - 978-601-247-298-1
N1  - Text kasachisch, russisch, englisch
CY  - Almaty
ER  -