TY  - JOUR
A1  - Yoshinobu, Tatsuo
A1  - Miyamoto, Ko-ichiro
A1  - Werner, Frederik
A1  - Poghossian, Arshak
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
T1  - Light-addressable potentiometric sensors for quantitative spatial imaging of chemical species
JF  - Annual Review of Analytical Chemistry
N2  - A light-addressable potentiometric sensor (LAPS) is a semiconductor-based chemical sensor, in which a measurement site on the sensing surface is defined by illumination. This light addressability can be applied to visualize the spatial distribution of pH or the concentration of a specific chemical species, with potential applications in the fields of chemistry, materials science, biology, and medicine. In this review, the features of this chemical imaging sensor technology are compared with those of other technologies. Instrumentation, principles of operation, and various measurement modes of chemical imaging sensor systems are described. The review discusses and summarizes state-of-the-art technologies, especially with regard to the spatial resolution and measurement speed; for example, a high spatial resolution in a submicron range and a readout speed in the range of several tens of thousands of pixels per second have been achieved with the LAPS. The possibility of combining this technology with microfluidic devices and other potential future developments are discussed.
Y1  - 2017
U6  - http://dx.doi.org/10.1146/annurev-anchem-061516-045158
SN  - 1936-1327
VL  - 10
SP  - 225
EP  - 246
PB  - Annual Reviews
CY  - Palo Alto, Calif.
ER  - 
TY  - CHAP
A1  - Yoshinobu, Tatsuo
A1  - Krause, Steffi
A1  - Miyamoto, Ko-ichiro
A1  - Werner, Frederik
A1  - Poghossian, Arshak
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
T1  - (Bio-)chemical Sensing and Imaging by LAPS and SPIM
T2  - Label-free biosensing: advanced materials, devices and applications
N2  - The light-addressable potentiometric sensor (LAPS) and scanning photo-induced impedance microscopy (SPIM) are two closely related methods to visualise the distributions of chemical species and impedance, respectively, at the interface between the sensing surface and the sample solution. They both have the same field-effect structure based on a semiconductor, which allows spatially resolved and label-free measurement of chemical species and impedance in the form of a photocurrent signal generated by a scanning light beam. In this article, the principles and various operation modes of LAPS and SPIM, functionalisation of the sensing surface for measuring various species, LAPS-based chemical imaging and high-resolution sensors based on silicon-on-sapphire substrates are described and discussed, focusing on their technical details and prospective applications.
KW  - Chemical imaging
KW  - Field-effect device
KW  - Light-addressable potentiometric sensor
KW  - Potentiometry
Y1  - 2018
SN  - 978-3-319-75219-8
SP  - 103
EP  - 132
PB  - Springer
CY  - Cham
ER  -