TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Lanzl, Ines M.
A1  - Hanssen, Henner
A1  - Eberhardt, Karla
A1  - Vilser, Walthard
A1  - Halle, Martin
A1  - Heemann, Uwe
A1  - Schmidt-Trucksäss, Arno
A1  - Baumann, Marcus
T1  - Does increased blood pressure rather than aging influence retinal pulse wave velocity?
JF  - Investigative Ophthalmology & Visual Science, IOVS
N2  - Purpose: It was demonstrated previously that retinal pulse wave velocity (rPWV) as a measure of retinal arterial stiffness is increased in aged anamnestically healthy volunteers compared with young healthy subjects. Using novel methodology of rPWV assessment this finding was confirmed and investigated whether it might relate to the increased blood pressure usually accompanying the aging process, rather than to the aging itself.

Methods: A total of 12 young 25.5-year-old (24.0–28.8) [median(1st quartile–3rd quartile)] and 12 senior 68.5-year-old (63.8–71.8) anamnestically healthy volunteers; and 12 senior 63.0-year-old (60.8–65.0) validated healthy volunteers and 12 young 33.0-year-old (29.5–35.0) hypertensive patients were examined. Time-dependent alterations of vessel diameter were assessed by the Dynamic Vessel Analyzer in a retinal artery of each subject. The data were filtered and processed using mathematical signal analysis and rPWVs were calculated.

Results: rPWV amounted to 1200 (990-1470) RU (relative units)/s in the hypertensive group and to 1040 (700-2230) RU/s in anamnestically healthy seniors. These differed significantly from rPWVs in young healthy group (410 [280–500] RU/s) and in validated healthy seniors (400 [320–510] RU/s). rPWV associated with age and mean arterial pressure (MAP) in the pooled cohort excluded validated healthy seniors. In a regression model these associations remain when alternately adjusted for MAP and age. When including validated healthy seniors in the pooled cohort only association with MAP remains.

Conclusions: Both aging (with not excluded cardiovascular risk factors) and mild hypertension are associated with elevated rPWV. rPWV increases to a similar extent both in young mildly hypertensive subjects and in aged anamnestically healthy persons. Healthy aging is not associated with increased rPWV.
Y1  - 2012
U6  - http://dx.doi.org/10.1167/iovs.11-8815
SN  - 0146-0404
VL  - 53
IS  - 4
SP  - 2119
EP  - 2126
PB  - ARVO
CY  - Rockville, Md.
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Baumann, Marcus
A1  - Vilser, Walthard
A1  - Lanzl, Ines M.
T1  - Pulse wave velocity in retinal arteries of healthy volunteers
JF  - British Journal of Ophthalmology (eBJO)
Y1  - 2011
SN  - 1468-2079
VL  - 95
IS  - 11
SP  - 675
EP  - 679
PB  - BMJ Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Baumann, Marcus
A1  - Schwarz, Sonja
A1  - Kotliar, Konstantin
A1  - Eynatten, Maximilian von
A1  - Trucksaess, Arno
A1  - Burckhardt, Klaus
A1  - Lutz, Jens
A1  - Heemann, Uwe
A1  - Lanzl, Ines
T1  - Non-diabetic chronic kidney disease influences retinal microvasculature
JF  - Kidney and Blood Pressure Research
Y1  - 2009
SN  - 1423-0143
VL  - 32
IS  - 6
SP  - 428
EP  - 433
PB  - -
ER  - 
TY  - JOUR
A1  - Burkhardt, Klaus
A1  - Schwarz, Sonja
A1  - Pan, Chengrui
A1  - Stelter, Felix
A1  - Kotliar, Konstantin
A1  - Eynatten, Maxilian von
A1  - Sollinger, Daniel
A1  - Lanzl, Ines
A1  - Heemann, Uwe
A1  - Baumann, Marcus
T1  - Myeloid-related protein 8/14 complex describes microcirculatory alterations in patients with type 2 diabetes and nephropathy
JF  - Cardiovascular Diabetology
Y1  - 2009
SN  - 1475-2840
VL  - 8
IS  - 10
SP  - 1
EP  - 8
PB  - -
ER  -