TY  - CHAP
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Nanomaterial-Modified Capacitive Field-Effect Biosensors
T2  - Springer Series on Chemical Sensors and Biosensors (Methods and Applications)
N2  - The coupling of charged molecules, nanoparticles, and more generally, inorganic/organic nanohybrids with semiconductor field-effect devices based on an electrolyte–insulator–semiconductor (EIS) system represents a very promising strategy for the active tuning of electrochemical properties of these devices and, thus, opening new opportunities for label-free biosensing by the intrinsic charge of molecules. The simplest field-effect sensor is a capacitive EIS sensor, which represents a (bio-)chemically sensitive capacitor. In this chapter, selected examples of recent developments in the field of label-free biosensing using nanomaterial-modified capacitive EIS sensors are summarized. In the first part, we present applications of EIS sensors modified with negatively charged gold nanoparticles for the label-free electrostatic detection of positively charged small proteins and macromolecules, for monitoring the layer-by-layer formation of oppositely charged polyelectrolyte (PE) multilayers as well as for the development of an enzyme-based biomolecular logic gate. In the second part, examples of a label-free detection by means of EIS sensors modified with a positively charged weak PE layer are demonstrated. These include electrical detection of on-chip and in-solution hybridized DNA (deoxyribonucleic acid) as well as an EIS sensor with pH-responsive weak PE/enzyme multilayers for enhanced field-effect biosensing.
KW  - Biomolecular logic gate
KW  - DNA
KW  - Enzyme biosensor
KW  - Field-effect sensor
KW  - Gold nanoparticle
Y1  - 2017
U6  - http://dx.doi.org/10.1007/5346_2017_2
SP  - 1
EP  - 25
PB  - Springer
CY  - Berlin, Heidelberg
ER  - 
TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Ingebrandt, S.
A1  - Poghossian, Arshak
A1  - Zhang, Y.
A1  - Vu, X. T.
A1  - Moritz, W.
A1  - Schöning, Michael Josef
T1  - Nanoplate field-effect capacitive (bio-)chemical sensor array based on SOI structure
JF  - Procedia Chemistry. 1 (2009), H. 1
Y1  - 2009
SN  - 1876-6196
N1  - Proceedings of the Eurosensors XXIII conference ; Eurosensors 23
SP  - 670
EP  - 673
ER  - 
TY  - CHAP
A1  - Poghossian, Arshak
A1  - Weiland, Maryam
A1  - Schöning, Michael Josef
ED  - Lvova, Larisa
ED  - Kirsanov, Dmitry
ED  - di Natale, Corrado
ED  - Legin, Audrey
T1  - Nanoplate field-effect capacitors: a new transducer structure for multiparameter (bio-)chemical sensing
T2  - Multisensor system for chemical analysis : materials and sensors
N2  - An array of electrically isolated nanoplate field-effect silicon-on-insulator (SOI) capacitors as a new transducer structure for multiparameter (bio-)chemical sensing is presented. The proposed approach allows addressable biasing and electrical readout of multiple nanoplate field-effect capacitive (bio-)chemical sensors on the same SOI chip, as well as differential-mode measurements. The realized sensor chip has been applied for pH and penicillin concentration measurements, electrical monitoring of polyelectrolyte multilayer formation, and the label-free electrical detection of consecutive deoxyribonucleic acid (DNA) hybridization and denaturation events.
Y1  - 2014
SN  - 978-981-4411-15-8 ; 978-981-4411-16-5
U6  - http://dx.doi.org/10.1201/b15491-11
SP  - 333
EP  - 373
PB  - Jenny Stanford Publishing
CY  - Singapore
ET  - 1
ER  - 
TY  - JOUR
A1  - Werner, Frederik
A1  - Spelthahn, H.
A1  - Schöning, Michael Josef
A1  - Krumbe, C.
A1  - Wagner, Torsten
A1  - Yoshinobu, T.
A1  - Keusgen, M.
T1  - Neue Ansteuerungselektronik für LAPS-basierte Biosensoren zur gleichzeitig ortsaufgelösten Messung der pH-Konzentration
JF  - Sensoren und Messsysteme 2010 [Elektronische Ressource] : Vorträge der 15. ITG/GMA-Fachtagung vom 18. bis 19. Mai 2010 in Nürnberg / Informationstechnische Gesellschaft im VDE (ITG); VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik (GMA)
Y1  - 2010
SN  - 978-3-8007-3260-9
N1  - Fachtagung Sensoren und Messsysteme 15, 2010, Nürnberg ; Gesellschaft Mess- und Automatisierungstechnik
SP  - 109
EP  - 114
PB  - VDE Verlag
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Lüth, H.
A1  - Thust, M.
T1  - Neue Ansätze für Chemo- und Biosensoren in Siliziumtechnik
JF  - Physikalische Blätter. 53 (1997), H. 5
Y1  - 1997
SN  - 0031-9279
SP  - 423
EP  - 427
ER  - 
TY  - JOUR
A1  - Simonis, A.
A1  - Lüth, H.
A1  - Wang, J.
A1  - Schöning, Michael Josef
T1  - New concepts of miniaturised reference electrodes in silicon technology for potentiometric sensor systems
JF  - Sensors and Actuators B. 103 (2004), H. 1-2
Y1  - 2004
SN  - 0925-4005
SP  - 429
EP  - 435
ER  - 
TY  - JOUR
A1  - Arida, Hassan A.
A1  - Al-haddad, Ameera
A1  - Schöning, Michael Josef
T1  - New Solid-State Organic Membrane Based Lead-Selective Micro-Electrode
JF  - International Journal of Electrochemical Science. 6 (2011), H. 9
Y1  - 2011
SN  - 1452-3981
SP  - 3858
EP  - 3867
ER  - 
TY  - JOUR
A1  - Karschuck, T. L.
A1  - Filipov, Y.
A1  - Bollella, P.
A1  - Schöning, Michael Josef
A1  - Katz, E.
T1  - Not-XOR (NXOR) logic gate based on an enzyme-catalyzed reaction
JF  - International Journal of Unconventional Computing
N2  - Enzyme-catalyzed reactions have been designed to mimic various Boolean logic gates in the general framework of unconventional biomolecular computing. While some of the logic gates, particularly OR, AND, are easy to realize with biocatalytic reactions and have been reported in numerous publications, some other, like NXOR, are very challenging and have not been realized yet with enzyme reactions. The paper reports on a novel approach to mimicking the NXOR logic gate using the bell-shaped enzyme activity dependent on pH values. Shifting pH from the optimum value to the acidic or basic values by using acid or base inputs (meaning 1,0 and 0,1 inputs) inhibits the enzyme reaction, while keeping the optimum pH (assuming 0,0 and 1,1 input combinations) preserves a high enzyme activity. The challenging part of the present approach is the selection of an enzyme with a well-demonstrated bell-shape activity dependence on the pH value. While many enzymes can satisfy this condition, we selected pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenase as this enzyme has the optimum pH center-located on the pH scale allowing the enzyme activity change by the acidic and basic pH shift from the optimum value corresponding to the highest activity. The present NXOR gate is added to the biomolecular “toolbox” as a new example of Boolean logic gates based on enzyme reactions.
Y1  - 2019
SN  - 1548-7199
VL  - 14
IS  - 3-4
SP  - 235
EP  - 242
PB  - Old City Publishing
CY  - Philadelphia
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
T1  - Novel approaches to design siliconbased field-effect sensors
JF  - Electrochemical Microsystem Technologies, New Trends in Electrochemistry Vol. 2
Y1  - 2002
SP  - 384
EP  - 408
PB  - Taylor & Francis
CY  - London New York
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Miyamoto, Ko-ichiro
A1  - Schöning, Michael Josef
A1  - Yoshinobu, Tatsuo
T1  - Novel combination of digital light processing (DLP) and light-addressable potentiometric sensors (LAPS) for flexible chemical imaging
JF  - Procedia Engineering. 5 (2010)
Y1  - 2010
SN  - 1877-7058
N1  - Eurosensor XXIV Conference
SP  - 520
EP  - 523
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Berndsen, Lars
A1  - Lüth, Hans
A1  - Schöning, Michael Josef
T1  - Novel concepts for flow-rate and flow-direction determination by means of pH-sensitive ISFETs
JF  - Proceedings of SPIE. 4560 (2001)
Y1  - 2001
SP  - 19
EP  - 27
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Lüth, H.
T1  - Novel concepts for silicon-based biosensors
JF  - Physica Status Solidi (A) (2001)
Y1  - 2001
SN  - 0031-8965
SP  - 65
EP  - 77
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Malkoc, Ü.
A1  - Thust, M.
A1  - Steffen, A.
A1  - Kordos, P.
A1  - Lüth, H.
T1  - Novel electrochemical sensors with structured and porous semiconductor/insulator capacitors
JF  - Sensors and Actuators B. 65 (2000), H. 1-3
Y1  - 2000
SN  - 0925-4005
SP  - 288
EP  - 290
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Malkoc, Ü.
A1  - Thust, M.
A1  - Steffen, A.
A1  - Kordos, P.
A1  - Lüth, H.
T1  - Novel electrochemical sensors with structured and porous semiconductor/insulator capacitors
JF  - Proceedings of the Seventh International Meeting on Chemical Sensors : 27 - 30 July, 1998, Beijing, P. R. China / ed. Zhi-Gang Zhou
Y1  - 1998
N1  - International Meeting on Chemical Sensors ; (7, 1998, Beijing) ; International Meeting on Chemical Sensors (IMCS) ; (7 : ; 1998.07.27-30 : ; Beijing)
SP  - 885
EP  - 887
PB  - Elsevier
CY  - Amsterdam [u.a.]
ER  - 
TY  - JOUR
A1  - Guo, Yuanyuan
A1  - Seki, Kosuke
A1  - Miyamoto, Ko-ichiro
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
A1  - Yoshinobu, Tatsuo
T1  - Novel photoexcitation method for light-addressable potentiometric sensor with higher spatial resolution
JF  - Applied physics express : APEX
N2  - A novel photoexcitation method for the light-addressable potentiometric sensor (LAPS) is proposed to achieve a higher spatial resolution of chemical images. The proposed method employs a combined light source that consists of a modulated light probe, which generates the alternating photocurrent signal, and a ring of constant illumination surrounding it. The constant illumination generates a sheath of carriers with increased concentration which suppresses the spread of photocarriers by enhanced recombination. A device simulation was carried out to verify the effect of constant illumination on the spatial resolution, which demonstrated that a higher spatial resolution can be obtained.
Y1  - 2014
U6  - http://dx.doi.org/10.7567/APEX.7.067301
SN  - 1882-0786 (E-Journa); 1882-0778 (Print)
VL  - 7
IS  - 6
SP  - 067301-4
PB  - IOP
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Iken, Heiko
A1  - Kirsanov, D.
A1  - Legin, A.
A1  - Schöning, Michael Josef
T1  - Novel Thin-Film Polymeric Materials for the Detection of Heavy Metals
JF  - Procedia Engineering
N2  - A variety of transition metals, e.g., copper, zinc, cadmium, lead, etc. are widely used in industry as components for wires, coatings, alloys, batteries, paints and so on. The inevitable presence of transition metals in industrial processes implies the ambition of developing a proper analytical technique for their adequate monitoring. Most of these elements, especially lead and cadmium, are acutely toxic for biological organisms. Quantitative determination of these metals at low activity levels in different environmental and industrial samples is therefore a vital task. A promising approach to achieve an at-side or on-line monitoring on a miniaturized and cost efficient way is the combination of a common potentiometric sensor array with heavy metal-sensitive thin-film materials, like chalcogenide glasses and polymeric materials, respectively.
Y1  - 2012
U6  - http://dx.doi.org/10.1016/j.proeng.2012.09.148
SN  - 1877-7058
N1  - Part of special issue "26th European Conference on Solid-State Transducers, EUROSENSOR 2012"
IS  - 47
SP  - 322
EP  - 325
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Werner, Frederik
A1  - Groebel, Simone
A1  - Krumbe, Christoph
A1  - Wagner, Torsten
A1  - Selmer, Thorsten
A1  - Yoshinobu, Tatsuo
A1  - Baumann, Marcus
A1  - Schöning, Michael Josef
T1  - Nutrient concentration-sensitive microorganism-based biosensor
JF  - Physica Status Solidi (a)
Y1  - 2012
U6  - http://dx.doi.org/10.1002/pssa.201100801
SN  - 1862-6319
VL  - 209
IS  - 5
SP  - 900
EP  - 904
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Huck, Christina
A1  - Jolly, Christina
A1  - Wagner, Patrick
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - One-chip integrated dual amperometric/field-effect sensor for the detection of dissolved hydrogen
JF  - Procedia Engineering. 25 (2011)
Y1  - 2011
SN  - 1877-7058
N1  - EurosensorsXXV ; Proc. Eurosensors XXV, September 4-7, 2011, Athens, Greece
SP  - 1161
EP  - 1164
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Beging, Stefan
A1  - Rotter, L.
A1  - Poghossian, Arshak
A1  - Biselli, Manfred
A1  - Zang, Werner
A1  - Schöning, Michael Josef
T1  - Online-Messsysteme für die automatisierte Charakterisierung von feldeffektbasierten Biosensoren
JF  - 8. Dresdner Sensor-Symposium : Sensoren für Umwelt, Klima und Sicherheit, Biosensoren und Biosysteme, Sensoren und Sensorsysteme für die Prozesstechnik, Trends in der Sensortechnik, Materialentwicklung für die Sensorik; 8. Dresdner Sensor-Symposium, 10. - 12. Dezember 2007, Dresden / Gerald Gerlach ... (Hg.)
Y1  - 2007
SN  - 978-3-940046-45-1
N1  - Dresdner Sensor-Symposium <8, 2007, Dresden> ; Dresdner Beiträge zur Sensorik ; 29
SP  - 257
EP  - 260
PB  - TUDpress, Verl. der Wissenschaften
CY  - Dresden
ER  - 
TY  - JOUR
A1  - Kirchner, Patrick
A1  - Oberländer, Jan
A1  - Friedrich, Peter
A1  - Berger, Jörg
A1  - Suso, Henri-Pierre
A1  - Kupyna, Andriy
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Optimisation and fabrication of a calorimetric gas sensor built up on a polyimide substrate for H2O2 monitoring
JF  - Physica status solidi (a) : applications and material science. 208 (2011), H. 6
Y1  - 2011
SN  - 1862-6319
SP  - 1235
EP  - 1240
PB  - Wiley
CY  - Weinheim
ER  -