TY - JOUR A1 - Mühl, Thomas A1 - Binnebösel, Marcel A1 - Klinge, Uwe A1 - Goedderz, Thomas T1 - New objective measurement to characterize the porosity of textile implants JF - Journal of Biomedical Materials Research Part B: Applied Biomaterials. 84B (2008), H. 1 Y1 - 2008 SN - 1552-4981 SP - 176 EP - 183 ER - TY - JOUR A1 - Staat, Manfred A1 - Trenz, Eva A1 - Lohmann, Philipp A1 - Frotscher, Ralf A1 - Klinge, Uwe A1 - Tabaza, Ruth A1 - Kirschner-Hermanns, Ruth T1 - New measurements to compare soft tissue anchoring systems in pelvic floor surgery JF - Journal of Biomedical Materials Research Part B: Applied Biomaterials N2 - Suburethral slings as well as different meshes are widely used treating stress urinary incontinence and prolaps in women. With the development of MiniSlings and special meshes using less alloplastic material anchorage systems become more important to keep devices in place and to put some tension especially on the MiniSlings. To date, there are many different systems of MiniSlings of different companies on the market which differ in the structure of the used meshes and anchors. A new objective measurement method to compare different properties of MiniSling systems (mesh and anchor) is presented in this article. Ballistic gelatine acts as soft tissue surrogate. Significant differences in parameters like pull-out strength of anchors or shrinkage of meshes under loading conditions have been determined. The form and size of the anchors as well as the structural stability of the meshes are decisive for a proper integration. The tested anchorings sytems showed markedly different mechanical function at their respective load bearing capacity. As the stable fixation of the device in tissue is a prerequisite for a permanet reinforcement, the proposed test system permits further optimisation of anchor and mesh devices to improve the success of the surgical treatment Y1 - 2012 U6 - http://dx.doi.org/10.1002/jbm.b.32654 SN - 1552-4981 VL - 100B IS - 4 SP - 924 EP - 933 PB - Wiley CY - Hoboken, NJ ER - TY - JOUR A1 - Klinge, Uwe A1 - Wilke, Ralf A1 - Mühl, Thomas T1 - Auswahl der Herniennetze nach der “effektiven Porosität” - warum das Gewicht weniger wichtig ist JF - Chirurgische Allgemeine : CHAZ ; Zeitung für Klinik und Praxis Y1 - 2012 SN - 1615-5378 VL - 13 IS - 12 SP - 297 EP - 301 PB - Kaden CY - Mannheim ER - TY - JOUR A1 - Jens, Otto A1 - Kaldenhoff, E. A1 - Kirschner-Hermanns, R. A1 - Mühl, Thomas A1 - Klinge, Uwe T1 - Elongation of textile pelvic floor implants under load is related to complete loss of effective porosity, thereby favoring incorporation in scar plates JF - Journal of biomedical materials research. Part A N2 - Use of textile structures for reinforcement of pelvic floor structures has to consider mechanical forces to the implant, which are quite different to the tension free conditions of the abdominal wall. Thus, biomechanical analysis of textile devices has to include the impact of strain on stretchability and effective porosity. Prolift® and Prolift + M®, developed for tension free conditions, were tested by measuring stretchability and effective porosity applying mechanical strain. For comparison, we used Dynamesh-PR4®, which was designed for pelvic floor repair to withstand mechanical strain. Prolift® at rest showed moderate porosity with little stretchability but complete loss of effective porosity at strain of 4.9 N/cm. Prolift + M® revealed an increased porosity at rest, but at strain showed high stretchability, with subsequent loss of effective porosity at strain of 2.5 N/cm. Dynamesh PR4® preserved its high porosity even under strain, but as consequence of limited stretchability. Though in tension free conditions Prolift® and Prolift + M® can be considered as large pore class I meshes, application of mechanical strain rapidly lead to collapse of pores. The loss of porosity at mechanical stress can be prevented by constructions with high structural stability. Assessment of porosity under strain was found helpful to define requirements for pelvic floor devices. Clinical studies have to prove whether devices with high porosity as well as high structural stability can improve the patients' outcome. Y1 - 2014 U6 - http://dx.doi.org/10.1002/jbm.a.34767 SN - 1552-4965 VL - 102 IS - 4 SP - 1079 EP - 1084 PB - Wiley CY - New York ER - TY - JOUR A1 - Anding, Ralf A1 - Tabaza, Ruth A1 - Staat, Manfred A1 - Trenz, Eva A1 - Lohmann, Philipp A1 - Klinge, Uwe A1 - Kirschner-Hermanns, Ruth T1 - Introducing a method of in vitro testing of different anchoring systems used for female incontinence and prolapse surgery JF - BioMed research international Y1 - 2013 SN - 1110-7251 (E-Journal); 2314-6141 (E-Journal); 1110-7243 (Print); 2314-6133 (Print) VL - Vol. 2013 SP - Article ID 401417 ER - TY - JOUR A1 - Klinge, Uwe A1 - Otto, Jens A1 - Mühl, Thomas T1 - High Structural Stability of Textile Implants Prevents Pore Collapse and Preserves Effective Porosity at Strain JF - BioMed Research International Y1 - 2015 U6 - http://dx.doi.org/10.1155/2015/953209 SN - 2314-6133 (Print) SN - 2314-6141 (Online) N1 - Article ID: 953209 VL - 2015 ER -