TY - JOUR
A1 - Dachwald, Bernd
A1 - Ulamec, Stephan
A1 - Postberg, Frank
A1 - Sohl, Frank
A1 - Vera, Jean-Pierre de
A1 - Christoph, Waldmann
A1 - Lorenz, Ralph D.
A1 - Hellard, Hugo
A1 - Biele, Jens
A1 - Rettberg, Petra
T1 - Key technologies and instrumentation for subsurface exploration of ocean worlds
JF - Space Science Reviews
N2 - In this chapter, the key technologies and the instrumentation required for the subsurface exploration of ocean worlds are discussed. The focus is laid on Jupiter’s moon Europa and Saturn’s moon Enceladus because they have the highest potential for such missions in the near future. The exploration of their oceans requires landing on the surface, penetrating the thick ice shell with an ice-penetrating probe, and probably diving with an underwater vehicle through dozens of kilometers of water to the ocean floor, to have the chance to find life, if it exists. Technologically, such missions are extremely challenging. The required key technologies include power generation, communications, pressure resistance, radiation hardness, corrosion protection, navigation, miniaturization, autonomy, and sterilization and cleaning. Simpler mission concepts involve impactors and penetrators or – in the case of Enceladus – plume-fly-through missions.
Y1 - 2020
U6 - https://doi.org/10.1007/s11214-020-00707-5
SN - 1572-9672
N1 - Corresponding author: Bernd Dachwald
VL - 216
IS - Art. 83
PB - Springer
CY - Dordrecht
ER -
TY - JOUR
A1 - Kern, Alexander
A1 - Krichel, Frank
T1 - Überlegungen zum Blitzschutzkonzept für regenerative Energieanlagen
N2 - Dem Blitzschutz von Anlagen der regenerativen Energien kommt in Zukunft eine steigende Bedeutung zu. Dabei ist es notwendig zu berücksichtigen, dass die Schutzmaßnahmen technisch/wirtschaftlich ausgewogen sind. Erbauer, Besitzer oder Benutzer von netzautarken Hybridanlagen haben zu entscheiden, ob die Anlage einen Schutz braucht oder nicht. Um diese Entscheidung zu fällen, ist eine Risikoanalyse als erster Schritt sinnvoll. Diese muss dabei die für die Hybridanlage relevanten Schadenarten und spezifischen Parameter, Werte und Randbedingungen mit einbeziehen. Dazu ist die Hilfe eines Blitzschutzexperten sehr hilfreich.
KW - Alternative Energiequelle
KW - Energietechnische Anlage
KW - Blitzschutz
KW - Blitzschutz
KW - Regenerative Energieanlagen
KW - Lightning protection
KW - renewable energy
Y1 - 2003
ER -
TY - JOUR
A1 - Kern, Alexander
A1 - Krichel, Frank
T1 - Considerations about the lightning protection system of mains independent renewable energy hybrid-systems - practical experiences
JF - Journal of electrostatics. 60 (2004), H. 2-4
Y1 - 2004
SN - 0304-3886
N1 - ISSN der E-Ausg.: 0304-3886
SP - 257
EP - 263
ER -
TY - JOUR
A1 - Kern, Alexander
A1 - Krichel, Frank
A1 - Neskakis, Apostolos
A1 - Müller, Klaus-Peter (u.a.)
T1 - Lightning protection design of a renewable energy hybrid-system without power mains connection
Y1 - 2001
N1 - International Conference on Renewable Energies for Islands <2001, Crete>
ER -
TY - JOUR
A1 - Gebhardt, Andreas
A1 - Schmidt, Frank-Michael
T1 - Practical experiences with making and finishing of coloured models using 3D printing
Y1 - 2002
N1 - International Conference on Rapid Prototyping and Manufacturing <2, 2002, Beijing>
ER -
TY - JOUR
A1 - Gebhardt, Andreas
A1 - Brücker, Christoph
A1 - Schmidt, Frank-Michael
T1 - RP gestützte Herstellung komplexer transparenter Hohlräume für die Strömungsanalyse
N2 - Die Berechnung der Durchströmung von Bauteilen ist gegenüber derjenigen von umströmten Bauteilen deutlich im Hintertreffen. Das liegt vor allem an der fehlenden Verfügbarkeit geeigneter optisch transparenter Modellkanäle für die experimentelle Analyse. Der Beitrag stellt ein Verfahren zur Herstellung transparenter durchströmter Geometrien auf der Basis generativ gefertigter Urmodelle vor. Damit können beliebig komplexe Innenströmungen optisch analysiert werden. Anhand von zwei Beispielen aus der Medizin, der Modellierung der oberen Atemwege und des Bronchialbaums, wird das Verfahren vorgeführt. Der generative Bauprozess mittels 3D-Printing wird beschrieben und die Abformung in transparentem Silikon gezeigt. Schließlich werden beispielhaft der Messaufbau und Ergebnisse der Anwendung vorgestellt. Das Verfahren bildet die Grundlage für die Analyse und Berechnung komplexer Innenströmungen und trägt somit zur Verbesserung zahlreicher technischer Anwendungen bei.
N2 - Unlike the flow around technical products the interior flow is not understood very well. That’s mainly because of a lack of suitable transparent investigation tunnels that are needed to apply optical methods. The paper proposes a procedure to make precise complex hollow structures from a highly transparent material using masters from generative or Rapid Prototyping processes. Taking two examples from the medical field, the upper human airways and the bronchial tree, the entire process is shown. The 3D Printing build process is illustrated as well as the silicon casting process. Finally the measuring equipment is demonstrated and sample results are given. The process establishes the basis for the investigation and calculation of complex interior flow pattern and therefore contributes to a better understanding and consequently improvement of appropriate technical products.
KW - Rapid prototyping
KW - Rapid Prototyping
KW - Strömungsanalyse
KW - Innenströmung
KW - Modellkanäle
KW - 3D-Printing
Y1 - 2005
ER -
TY - JOUR
A1 - Späte, Frank
A1 - Faber, Christian
A1 - Schwarzer, Klemens
A1 - Hartz, Thomas
T1 - Comparison of solar hot water systems in solar settlements - decentralized or centralized systems?
JF - Proceedings / organised by: ISES Europe ... [Ed.: Deutsche Gesellschaft für Sonnenenergie e.V. - DGS, Munich ; PSE GmbH - Forschung Entwicklung Marketing, Freiburg]. - Vol. 1
Y1 - 2004
SN - 3-9809656-1-9
N1 - EuroSun <5, 2004, Freiburg, Breisgau> ; Internationales Sonnenforum <14, 2004, Freiburg, Breisgau> ; Deutsche Gesellschaft für Sonnenenergie
SP - 1-666-1-671
PB - PSE
CY - Freiburg [Breisgau]
ER -
TY - JOUR
A1 - Frank, T.
A1 - Buchwald, D.
A1 - Pennekamp, W.
A1 - Reber, D.
A1 - Sponagel, Stefan
A1 - Laszkovics, A.
A1 - Weber, Hans-Joachim
T1 - Röntgenologische Untersuchung der Strömungseigenschaften funktioneller Komponenten der Herz-Lungen-Maschine
JF - Kardiotechnik. 18 (2009), H. 2
Y1 - 2009
SN - 0941-2670
N1 - gedruckt in der Bibliothek unter der Signatur 63 Z 629
SP - 31
EP - 35
ER -
TY - JOUR
A1 - Hartung, Frank
A1 - Rey, J.
A1 - Mathieu, B.
A1 - Lozano, D.
T1 - Media aware overlay routing in Ambient Networks / Rey, J. ; Mathieu, B. ; Lozano, D. ; Herborn, S. ; Ahmed, K. ; Schmid, S. ; Goebbels, S. ; Hartung, F. ; Kampmann, M.
JF - 16th IEEE International Symposium on Personal, Indoor and Mobile Radio Communications, 2005. PIMRC 2005. Date:11-14 Sept. 2005 ; Vol. 2
Y1 - 2004
SP - 952
EP - 957
ER -
TY - JOUR
A1 - Hartung, Frank
A1 - Kumwilaisak, W.
T1 - An intraframe error concealment: nonlinear pattern alignment and directional interpolation / Kumwilaisak, W. ; Hartung, F.
JF - Conference on Image Processing, 2004. ICIP '04. 2004 International / Vol. 2 .
Y1 - 2004
N1 - http://dx.doi.org/10.1109/ICIP.2004.1419426
SP - 825
EP - 828
ER -
TY - JOUR
A1 - Hartung, Frank
A1 - Noh, Jeonghun
A1 - Baccichet, Pierpaolo
A1 - Mavlankar, Aditya
T1 - Standford Peer-to-Peer Mulicast (SPPM) - Overview and recent Extensions / Noh, Jeonghun ; Baccichet, Pierpaolo ; Hartung, Frank ; Mavlankar, Aditya ; Girod, Bernd
Y1 - 2009
SN - 978-1-4244-4593-6
N1 - Picture Coding Symposium, 2009. PCS 2009 ; auch unter IEEE: http://dx.doi.org/10.1109/PCS.2009.5167392
SP - 1
EP - 4
ER -
TY - JOUR
A1 - Hartung, Frank
A1 - Horn, Uwe
A1 - Huschke, Jörg
A1 - Kampmann, Markus
T1 - MBMS—IP Multicast/Broadcast in 3G Networks / Hartung, Frank ; Horn, Uwe ; Huschke, Jörg ; Kampmann, Markus ; Lohmar, Thorsten
JF - International Journal of Digital Multimedia Broadcasting. 2009 (2009)
Y1 - 2009
SN - 1687-7586
N1 - Article ID 597848
SP - 1
EP - 25
ER -
TY - JOUR
A1 - Hartung, Frank
A1 - Kampmann, Markus
A1 - Horn, Uwe
A1 - Kritzner, Jan
T1 - Mobile Television / Hartung, Frank ; Kampmann, Markus ; Horn, Uwe ; Kritzner, Jan
JF - Encyclopedia of mobile computing and commerce / David Taniar ; Bd. 2 : Mobile ICT - Z
Y1 - 2007
SN - 978-1-59904-002-8
SP - 611
EP - 615
PB - Information Science Reference
CY - Hershey
ER -
TY - JOUR
A1 - Hartung, Frank
A1 - Horn, Uwe
A1 - Huschke, Jörg
A1 - Kampmann, Markus
T1 - Delivery of Broadcast Services in 3G Networks / Hartung, Frank ; Horn, Uwe ; Jörg Huschke ; Kampmann, Markus ; Lohmar, Thorsten ; Lundevall, Magnus
JF - IEEE Transactions on Broastcasting. 53 (2007), H. 1 Part: 2
Y1 - 2007
SN - 0018-9316
N1 - campusweit: http://dx.doi.org/10.1109/TBC.2007.891711
SP - 188
EP - 199
ER -
TY - JOUR
A1 - Hartung, Frank
A1 - Horn, Uwe
A1 - Huschke, Jörg
A1 - Kampmann, Markus
T1 - Mobile TV Services in 3G Networks / Hartung, Frank ; Horn, Uwe ; Huschke, Jörg ; Kampmann, Markus ; Lohmar, Thorsten
JF - KIVS 2007 : Kommunikation in verteilten Systemen : 15. ITG-GI-Fachtagung vom 26. Februar bis 2. März 2007 in Bern, Schweiz ; Industriebeiträge, Kurzbeiträge und Workshops / T. Braun ... (Hrsg.)
Y1 - 2007
SN - 978-3-8007-2980-7
N1 - Communication in Distributed Systems (KiVS), 2007 ITG-GI Conference
SP - 15
EP - 18
ER -
TY - JOUR
A1 - Hartung, Frank
A1 - Kampmann, Markus
T1 - Media Delivery Based on Service Aware Transport Overlay Networks / Kampmann, Markus ; Hartung, Frank
JF - KIVS 2007 : Kommunikation in verteilten Systemen : 15. ITG-GI-Fachtagung vom 26. Februar bis 2. März 2007 in Bern, Schweiz ; Industriebeiträge, Kurzbeiträge und Workshops / T. Braun ... (Hrsg.)
Y1 - 2007
SN - 978-3-8007-2980-7
N1 - Communication in Distributed Systems (KiVS), 2007 ITG-GI Conference
SP - 9
EP - 10
ER -
TY - JOUR
A1 - Hartung, Frank
A1 - Kampmann, M.
A1 - Horn, U.
A1 - Huschke, J.
T1 - Delivery of Mobile TV services in 3G cellular networks / Kampmann, M. ; Hartung, F. ; Horn, U. ; Huschke, J. ; Lohmar, T.
JF - Elektronische Medien : Vorträge des 12. Dortmunder Fernsehseminars vom 20. bis 21. März 2007 in Dortmund / Veranst.: ITG-FKTG-Fachbereich 3 ... Wiss. Tagungsleitung: R. Kays
Y1 - 2007
SN - 978-3-8007-3019-3
N1 - ITG-Fachbericht ; 199
SP - 49
EP - 52
PB - VDE-Verl.
CY - Berlin
ER -
TY - JOUR
A1 - Hartung, Frank
A1 - Dondeti, L.
A1 - Castleford, F.
T1 - Multimedia Internet KEYing (MIKEY) General Extension Payload for Open Mobile Alliance BCAST LTKM/STKM Transport / Dondeti, L. ; Castleford, D. ; Hartung, F.
Y1 - 2007
SP - 1
EP - 7
ER -
TY - JOUR
A1 - Hartung, Frank
A1 - Schieder, Andreas
A1 - Kampmann, Markus
A1 - Vorwerk, Marc
T1 - Network Supported Media Delivery in Ambient Networks (Netzwerkunterstützte Medienverteilung) / Schieder, Andreas ; Kampmann, Markus ; Hartung, Frank ; Vorwerk, Marc ; Rembarz, René
JF - it - Information Technology . 48 (2006), H. 5
Y1 - 2006
SN - 1611-2776
N1 - in der Bereichsbibliothek Eupener Str. unter der Signatur 23 Z 376 vorhanden
SP - 264
EP - 273
ER -
TY - JOUR
A1 - Hartung, Frank
A1 - Baldo, N.
A1 - Horn, U.
A1 - Kampmann, M.
T1 - RTCP feedback based transmission rate control for 3G wireless multimedia streaming / Baldo, N. ; Horn, U. ; Kampmann, M. ; Hartung, F. ;
JF - 15th IEEE International Symposium on Personal, Indoor and Mobile Radio Communications, 2004. PIMRC 2004. Date:5-8 Sept. 2004 ; Vol. 3
Y1 - 2004
N1 - http://dx.doi.org/10.1109/PIMRC.2004.1368313
SP - 1817
EP - 1821
ER -
TY - JOUR
A1 - Hartung, Frank
A1 - Horn, U.
T1 - Codierung digitaler Videosignale nach dem MPEG-Standard / Hartung, F. ; Horn, U.
JF - Mikroelektronik + Mikrosystemtechnik. 9 (1995)
Y1 - 1995
N1 - gedruckte Ausgabe in der Bereichsbibliothek Jülich vorhanden
SP - 18
EP - 23
ER -
TY - JOUR
A1 - Hartung, Frank
A1 - Girod, Bernd
A1 - Horn, Uwe
T1 - Subband Image Coding / Girod, Bernd ; Hartung, Frank ; Horn, Uwe
JF - Subband and Wavelet Transforms: Design and Applications / ed. by Ali N. Akansu
Y1 - 1995
SN - 0792396456
SP - 213
EP - 250
PB - Kluwer
CY - Boston
ER -
TY - JOUR
A1 - Hartung, Frank
T1 - Mobile DRM Introduction: The Need for Mobile DRM
JF - Digital Rights Management : Technological, Economic, Legal and Political Aspects / Becker, Eberhard [u.a.]
Y1 - 2003
N1 - Lecture Notes in Computer Science ; 2770
SP - 138
EP - 149
PB - Springer
CY - Berlin
ER -
TY - JOUR
A1 - Hartung, Frank
A1 - Girod, Bernd
T1 - Copyright protection in video delivery networks by watermarking of pre-compressed video / Hartung, Frank ; Girod, Bernd
JF - Multimedia Applications, Services and Techniques - EMAST ´97 : Second European Conference Milan, Italy, May 21-23, 1997 Proceedings / Fdida, Serge ; Morganti, Michele
Y1 - 1997
N1 - Lecture Notes in Computer Science ; 1242
SP - 423
EP - 436
PB - Springer
CY - Berlin
ER -
TY - JOUR
A1 - Hartung, Frank
A1 - Ramme, F.
T1 - Digital rights management and watermarking of multimedia content for m-commerce applications / Hartung, F. ; Ramme, F.
JF - IEEE Communications Magazine. 38 (2000), H. 11
Y1 - 2000
SN - 0163-6804
N1 - ISS 2000
SP - 78
EP - 84
ER -
TY - JOUR
A1 - Hartung, Frank
A1 - Girod, Bernd
T1 - Statistical optimization of switched two-level quantizers with application to DPCM encoding of color video / Hartung, Frank ; Girod, Bernd
JF - IEEE International Conference on Acoustics, Speech, and Signal Processing, 1996. ICASSP-96. Conference Proceedings., 1996
Y1 - 1996
SN - 0-7803-3192-3
SP - 1974
EP - 1977
ER -
TY - JOUR
A1 - Hartung, Frank
A1 - Niebert, Norbert
A1 - Schieder, Andreas
A1 - Rembarz, René
T1 - Advances in network-supported media delivery in next-generation mobile systems / Hartung, Frank ; Niebert, Norbert ; Schieder, Andreas ; Rembarz, René ; Schmid, Stefan ; Eggert, Lars
JF - IEEE Communications Magazine. 44 (2006), H. 8
Y1 - 2006
SN - 0163-6804
SP - 82
EP - 89
ER -
TY - JOUR
A1 - Hamm, Laurits
A1 - Hartung, Frank
T1 - High Quality Visual Communication based on IMS
JF - Mobilkommunikation : Technologien und Anwendungen ; Vorträge der 16. ITG-Fachtagung vom 18. bis 19. Mai 2011 in Osnabrück / Veranst.: Informationstechnische Gesellschaft im VDE (ITG) ... Tagungsleitung: Ralf Tönjes. Programmkomitee/Hrsg.: Peter Roer
Y1 - 2011
SN - 978-3-8007-3352-1
N1 - ITG-Fachbericht ; 230 ; Fachtagung Mobilkommunikation <16, 2011, Osnabrück>
SP - 80
EP - 85
PB - VDE-Verl.
CY - Berlin
ER -
TY - JOUR
A1 - Hartung, Frank
A1 - Kesici, Sinan
A1 - Catrein, Daniel
T1 - DRM protected Dynamic Adaptive HTTP Streaming
JF - Proceedings of the 2011 ACM Multimedia Systems Conference [Elektronische Ressource] : February 23 - 25, 2011, San Jose, CA, USA / sponsored by: ACM SIGMM
Y1 - 2011
SN - 9781450305181
N1 - ACM Multimedia Systems Conference ; (2 : ; 2011.02.23-25 : ; San Jose, Calif.)
SP - 277
EP - 282
PB - ACM
CY - New York, NY
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Bock, Jürgen
T1 - Aufbau und Management deutsch-russischer Joint-ventures. Bock Jürgen; Thielemann, Frank
JF - Mit Innovation vom Plan zum Markt
Y1 - 1993
SP - 111
EP - 135
CY - Bochum
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Bock, Jürgen
T1 - Organization and management of German-Russian joint ventures. Bock, Jürgen; Thielemann, Frank
JF - International journal of technology management. 9 (1994), H. 8
Y1 - 1994
SN - 0267-5730
SP - 864
EP - 879
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Kriegesmann, Bernd
A1 - Schaffner, M.
T1 - Mit vereinten Kräften die Wettbewerbsfähigkeit steigern - Kooperation als Antwort auf den Innovationsdruck . Kriegesmann, B.; Thielemann, F.; Schaffner, M.
JF - Der Druckspiegel. 50 (1995), H. 10
Y1 - 1995
SN - 0012-6500
SP - 931
EP - 935
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Schaffner, M.
T1 - Gemeinsam sind wir stark . Schaffner, M.; Thielemann, F.
JF - Print & Produktion. 9 (1996), H. 10
Y1 - 1996
SN - 0944-7482
SP - 28
EP - f.
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Schaffner, M.
T1 - Innovationswiderstände bei der Einführung neuer Technologien. Schaffner, M.; Thielemann, F.
JF - Deutscher Drucker. 1992/93 (1993), H. 38
Y1 - 1993
SN - 0012-1096
SP - g12
EP - ff
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Schaffner, M.
T1 - Innovationswiderstände bei der Einführung neuer Technologien. Schaffner, M.; Thielemann, F.
JF - Deutscher Drucker. 1992/93 (1993), H. 42
Y1 - 1993
SN - 0012-1096
SP - g15
EP - ff
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Schaffner, M.
T1 - Wie beurteilen die Führungskräfte der Branche den derzeitigen und zukünftigen Innovationsdruck? Expertenmeinung zum Thema Innovationen in der Druckindustrie: M. Schaffner, F. Thielemann
JF - Management im innovatorischen Wandel : Arbeit und Technik in der Druckindustrie / Heinz-Reiner Treichel ; Kurt-Georg Ciesinger
Y1 - 1993
SN - 3-87641-262-5
N1 - Inhaltsverzeichnis
SP - 21
EP - 26
PB - Polygraph-Verl.
CY - Frankfurt am Main
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Staudt, Erich
A1 - Kriegesmann, Bernd
T1 - Kooperation als Erfolgsfaktor ostdeutscher Unternehmen. Ergebnisse einer empirischen Untersuchung zur Kooperationslandschaft in Ostdeutschland. Staudt, E.; Kriegesmann, B.; Thielemann, F.
JF - Zeitschrift für Betriebswirtschaft ZfB. 65 (1995), H. 11
Y1 - 1995
SN - 0044-2372
N1 - unter der Signatur 43 Z 366 in der Bibliothek Eupener Str. vorhanden
SP - 1209
EP - 1230
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Staudt, Erich
T1 - Kompetenz zur Innovation: Vom Druckbetrieb zum Multimedia-Dienstleister . Staudt, E.; Thielemann, F.
JF - News Letter (der Gesellschaft für Wirtschaftsförderung Duisburg) (1997)
Y1 - 1997
SP - 3
EP - 3
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Staudt, Erich
T1 - Reicht die Kompetenz zur Innovation? Staudt, E.; Thielemann, F.
JF - OP DruckMagazin. 39 (1997), H. 10
Y1 - 1997
SN - 0030-0594
SP - 30
EP - 32
ER -
TY - JOUR
A1 - Thielemann, Frank
T1 - Chancen durch Online-Dienste?
JF - OP DruckMagazin. 39 (1997), H. 1-2
Y1 - 1997
SN - 0030-0594
SP - 26
EP - f.
ER -
TY - JOUR
A1 - Thielemann, Frank
T1 - Das Management von Innovationen aus betriebswirtschaftlicher Sicht
JF - Humanität - Wandel - Utopie / Bernd Rebe (Hrsg.). Mit Beitr. von Ute Daniel
Y1 - 2000
N1 - Cloppenburger Wirtschaftsgespräche ; Bd. 9
SP - 33
EP - 64
PB - Olms
CY - Hildesheim
ER -
TY - JOUR
A1 - Thielemann, Frank
T1 - Druckindustrielle Innovation
JF - Der Siebdruck. 47 (1998), H. 4
Y1 - 1998
SN - 0178-2835
SP - 32
EP - ff
ER -
TY - JOUR
A1 - Thielemann, Frank
T1 - Mit vereinten Kräften
JF - Trockenbau, Akustik : Magazin für Planung und Ausführung. 15 (1998), H. 5
Y1 - 1998
SN - 0179-8006
SP - 60
EP - 68
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Staudt, Erich
A1 - Kriegesmann, Bernd
T1 - Neuformierung von Wertschöpfungsketten: Das Beispiel Druckindustrie . Staudt, Erich; Kriegesmann, Bernd; Thielemann, Frank
JF - Zeitschrift Führung und Organisation. 96 (1997), H. 2
Y1 - 1997
SN - 0044-3212
N1 - in der Bereichsbibliothek Eupener Str. unter der Signatur 43 Z 367-1997 vorhanden
SP - 75
EP - 80
ER -
TY - JOUR
A1 - Thielemann, Frank
T1 - Mit strategischen Allianzen ins nächste Jahrtausend
JF - Druckspiegel. 53 (1998), H. 5
Y1 - 1998
SN - 0012-6500
SP - 21
EP - 24
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Staudt, Erich
A1 - Kriegesmann, Bernd
T1 - Kooperationsverhalten in der Druckindustrie - zwischen Bestandssicherung und Offensive. Staudt, Erich; Kriegesmann, Bernd; Thielemann, Frank
JF - Die Betriebswirtschaft. 58 (1998), H. 6
Y1 - 1998
SN - 0342-7064
N1 - unter der Signatur 43 Z 411-1998 in der Bereichsbibliothek Eupener Str. vorhanden
SP - 803
EP - 815
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Lang, Franz Peter
T1 - Wissensmanagement und neue Informationstechnologie . Lang, Franz Peter; Thielemann, Frank
JF - Veränderungsmanagement in der Sozialwirtschaft / Bernd Maelicke (Hrsg.)
Y1 - 2000
SN - 3-7890-6738-5
N1 - Inhaltsverzeichnis
SP - 132
EP - 172
PB - Nomos-Verl.-Ges.
CY - Baden-Baden
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Chalupsky, J.
T1 - Der Markt verlangt nach Kooperationen
JF - Leipziger Wirtschaft. 5 (1994), H. 6
Y1 - 1994
SP - 14
EP - 18
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Lüdtke, C.
T1 - Balanced Scorecard - Von der Vision zur Strategie
JF - Wirtschafts-Nachrichten. 46 (2001), H. 9
Y1 - 2001
SN - 1436-5588
SP - 10
EP - f.
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Lüdtke, C.
T1 - Einfluß des KonTraG im Unternehmensbereich
JF - Wirtschafts-Nachrichten. 45 (2000), H. 8
Y1 - 2000
SN - 1436-5588
SP - 10
EP - f.
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Lüdtke, C.
T1 - Risikomanagement - Aufbau eines Frühwarnsystems
JF - Wirtschafts-Nachrichten. 45 (2000), H. 12
Y1 - 2000
SN - 1436-5588
SP - 14
EP - ff
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Lüdtke, C.
T1 - Wie sich Logistikunternehmen ihren Platz sichern können
JF - Deutsche Verkehrs-Zeitung (DVZ) (1999)
Y1 - 1999
SN - 0342-166X
SP - 42
EP - 42
ER -
TY - JOUR
A1 - Thielemann, Frank
A1 - Schaffner, M.
T1 - Vom Einzelkämpfertum zum kooperativen Kundenservice
JF - Polygraph. 49 (1996), H. 23-24
Y1 - 1996
SN - 0032-3842
SP - 40
EP - 42
ER -
TY - JOUR
A1 - Gebhardt, Andreas
A1 - Schmidt, Frank-Michael
A1 - Hötter, Jan-Steffen
A1 - Sokalla, Wolfgang
A1 - Sokalla, Patrick
T1 - Additive Manufacturing by selective laser melting the realizer desktop machine and its application for the dental industry
JF - Physics Procedia
Y1 - 2010
SN - 1875-3892
N1 - Laser Assisted Net Shape Engineering 6, Proceedings of the LANE 2010, Part 2
VL - 5
IS - 2
SP - 543
EP - 549
ER -
TY - JOUR
A1 - Berretz, Frank
A1 - Skorupa, Sasche
A1 - Sander, Volker
A1 - Belloum, Adam
A1 - Bubak, Marian
T1 - Actor-Driven Workflow Execution in Distributed Environments
JF - Euro-Par 2010 Parallel Processing Workshops : HeteroPAR, HPCC, HiBB, CoreGrid, UCHPC, HPCF, PROPER, CCPI, VHPC ; Ischia, Italy, August 31 - September 3, 2010 ; revised selected papers / Mario R. Guarracino ... (eds.)
Y1 - 2011
SN - 978-3-642-21877-4
N1 - Lecture Notes in Computer Science ; 6586
SP - 287
EP - 294
PB - Springer
CY - Berlin
ER -
TY - JOUR
A1 - Hartung, Frank
A1 - Husoy, J. H.
T1 - Wavelet and subband coding of images - A comparative study / Hartung, F. ; Husoy, J. H.
JF - Mathematical imaging: wavelet applications in signal and image processing : 15 - 16 July 1993, San Diego, California / sponsored and publ. by SPIE - the International Society for Optical Engineering. Andrew F. Laine, chair/ed
Y1 - 1993
SN - 081941283X
N1 - SPIE proceedings series ; 2034 ; Society of Photo-Optical Instrumentation Engineers ; Conference ; (1993.07.15-16 : ; San Diego, Calif.)
SP - 242
EP - 253
PB - SPIE
CY - Bellingham, Wash.
ER -
TY - JOUR
A1 - Weckesser, Matthias
A1 - Hufnagel, Andreas
A1 - Ziemons, Karl
A1 - Grießmeier, Martin
A1 - Sonnenberg, Frank
A1 - Hackländer, Thomas
A1 - Langen, Karl-J.
A1 - Holschbach, Markus
A1 - Elger, Christian E.
A1 - Müller-Gärtner, Hans-W.
T1 - Effect of partial volume correction on muscarinic cholinergic receptor imaging with single-photon emission tomography in patients with temporal lobe epilepsy
JF - European Journal of Nuclear Medicine
N2 - Animal experiments and preliminary results in humans have indicated alterations of hippocampal muscarinic acetylcholine receptors (mAChR) in temporal lobe epilepsy. Patients with temporal lobe epilepsy often present with a reduction in hippocampal volume. The aim of this study was to investigate the influence of hippocampal atrophy on the quantification of mAChR with single photon emission tomography (SPET) in patients with temporal lobe epilepsy. Cerebral uptake of the muscarinic cholinergic antagonist [123I]4-iododexetimide (IDex) was investigated by SPET in patients suffering from temporal lobe epilepsy of unilateral (n=6) or predominantly unilateral (n=1) onset. Regions of interest were drawn on co-registered magnetic resonance images. Hippocampal volume was determined in these regions and was used to correct the SPET results for partial volume effects. A ratio of hippocampal IDex binding on the affected side to that on the unaffected side was used to detect changes in muscarinic cholinergic receptor density. Before partial volume correction a decrease in hippocampal IDex binding on the focus side was found in each patient. After partial volume no convincing differences remained. Our results indicate that the reduction in hippocampal IDex binding in patients with epilepsy is due to a decrease in hippocampal volume rather than to a decrease in receptor concentration.
Y1 - 1997
SN - 1619-7089
VL - 24
IS - 9
SP - 1156
EP - 1161
ER -
TY - JOUR
A1 - Weckesser, Martin
A1 - Grießmeier, Martin
A1 - Schmidt, Daniela
A1 - Sonnenberg, Frank
A1 - Ziemons, Karl
A1 - Kemna, Lars
A1 - Holschbach, Marcus
A1 - Langen, Karl-J.
A1 - Müller-Gärtner, Hans-W.
T1 - Iodine-123 α-methyl tyrosine single-photon emission tomography of cerebral gliomas: standardised evaluation of tumour uptake and extent
JF - European Journal of Nuclear Medicine
N2 - Single-photon emission tomography (SPET) with the amino acid analogue l-3-[123I]iodo-α-methyl tyrosine (IMT) is helpful in the diagnosis and monitoring of cerebral gliomas. Radiolabelled amino acids seem to reflect tumour infiltration more specifically than conventional methods like magnetic resonance imaging and computed tomography. Automatic tumour delineation based on maximal tumour uptake may cause an overestimation of mean tumour uptake and an underestimation of tumour extension in tumours with circumscribed peaks. The aim of this study was to develop a program for tumour delineation and calculation of mean tumour uptake which takes into account the mean background activity and is thus optimised to the problem of tumour definition in IMT SPET. Using the frequency distribution of pixel intensities of the tomograms a program was developed which automatically detects a reference brain region and draws an isocontour region around the tumour taking into account mean brain radioactivity. Tumour area and tumour/brain ratios were calculated. A three-compartment phantom was simulated to test the program. The program was applied to IMT SPET studies of 20 patients with cerebral gliomas and was compared to the results of manual analysis by three different investigators. Activity ratios and chamber extension of the phantom were correctly calculated by the automatic analysis. A method based on image maxima alone failed to determine chamber extension correctly. Manual region of interest analysis in patient studies resulted in a mean inter-observer standard deviation of 8.7%±6.1% (range 2.7%–25.0%). The mean value of the results of the manual analysis showed a significant correlation to the results of the automatic analysis (r = 0.91, P<0.0001 for the uptake ratio; r = 0.87, P<0.0001 for the tumour area). We conclude that the algorithm proposed simplifies the calculation of uptake ratios and may be used for observer-independent evaluation of IMT SPET studies. Three-dimensional tumour recognition and transfer to co-registered morphological images based on this program may be useful for the planning of surgical and radiation treatment.
Y1 - 1998
SN - 1619-7089
VL - 25
IS - 2
SP - 150
EP - 156
ER -
TY - JOUR
A1 - Meliß, Michael
A1 - Späte, Frank
T1 - The solar heating system with seasonal storage at the Solar-Campus Jülich
JF - Solar energy. Vol. 69 (2000), iss. 6
Y1 - 2000
SN - 0038-092X
SP - 525
EP - 533
ER -
TY - JOUR
A1 - Meliß, Michael
A1 - Späte, Frank
T1 - Erneuerbare Energien sollen in die Bresche springen. Geld, Kraft und politisches Wollen ist gefragt
JF - VDI-Nachrichten. Nr. 46 vom 17.11.1995
Y1 - 1995
SN - 0042-1758
SP - 33
ER -
TY - JOUR
A1 - Meliß, Michael
A1 - Späte, Frank
T1 - Sonne, Wind und Biomasse zur umweltfreundlichen Energieversorgung
JF - Wohnung + Gesundheit. Fachzeitschrift für ökologisches Bauen + Leben. 18 (1996), Nr. 79
Y1 - 1996
SN - 0176-0513
SP - 47
EP - 50
ER -
TY - JOUR
A1 - Mischke, Winfried
A1 - Neuß, Frank
A1 - Vollmert, Daniel
T1 - Beweislast für die Voraussetzungen der Geräte- und der Betreibervergütung nach § 54a UrhG / Rechtsanwälte Prof. Dr. Winfried Mischke, Dr. Frank Neuß und Dr. Daniel Vollmert, Aachen
JF - Zeitschrift für die Anwaltspraxis (2008)
Y1 - 2008
SN - 0936-7292
SP - 587
EP - 590
ER -
TY - JOUR
A1 - Mischke, Winfried
A1 - Neuß, Frank
A1 - Vollmert, Daniel
T1 - Ausgleich der vom Verbraucher gezogenen Nutzungen bei Rücktritt vom Kaufvertrag in der Lieferkette/ Prof. Dr. Winfried Mischke, Dr. Frank Neuß und Dr. Daniel Vollmert, alle Aachen
JF - Zeitschrift für das gesamte Schuldrecht. 6 (2007), H. 6
Y1 - 2007
SN - 1619-7011
SP - 217
EP - 218
ER -
TY - JOUR
A1 - Kern, Alexander
A1 - Dikta, Gerhard
A1 - Krichel, Frank
T1 - Zur Wahrscheinlichkeit für Schäden an elektrischen und elektronischen Einrichtungen durch indirekte Blitzeinschläge - Auswertung von Schadensstatistiken, analytischen und numerischen Berechnungen
JF - 7. VDE-ABB-Blitzschutztagung : Vorträge der VDE-ABB-Fachtagung vom 15. bis 16. November 2007 in Neu-Ulm / Veranst.: Ausschuss für Blitzschutz und Blitzforschung (ABB) im VDE, Verband der Elektrotechnik, Elektronik, Informationstechnik e.V. Wiss. Tagungsltg.: K. Stimper
Y1 - 2007
SN - 978-3-8007-3062-9
N1 - VDE-Fachbericht ; 64 ; Blitzschutztagung <7, 2007, Neu-Ulm>
SP - 1
EP - 9
PB - VDE-Verl.
CY - Berlin
ER -
TY - JOUR
A1 - Mischke, Winfried
A1 - Neuß, Frank
T1 - Führt die Übernahme der Domain eines anderen Unternehmers zur Haftung für dessen Schulden nach § 25 HGB?
JF - Zeitschrift für Vertragsgestaltung, Schuld- und Haftungsrecht : ZGS
Y1 - 2009
SN - 1619-7011
VL - 8
SP - 407
EP - 409
PB - ZAP, Verl. f. die Rechts- und Anwaltspraxis
CY - Recklinghausen
ER -
TY - JOUR
A1 - Bindal, Gaurav
A1 - Sharma, Sparsh
A1 - Janser, Frank
A1 - Neu, Eugen
T1 - Detailed analysis of variables affecting wing kinematics of bat flight
JF - SAE International Journal of Aerospace
Y1 - 2013
U6 - https://doi.org/10.4271/2013-01-9003
SN - 1946-3901
VL - 6
IS - 2
SP - 811
EP - 818
ER -
TY - JOUR
A1 - Delle, Lotta E.
A1 - Huck, Christina
A1 - Bäcker, Matthias
A1 - Müller, Frank
A1 - Grandthyll, Samuel
A1 - Jacobs, Karin
A1 - Lilischkis, Rainer
A1 - Vu, Xuan T.
A1 - Schöning, Michael Josef
A1 - Wagner, Patrick
A1 - Thoelen, Roland
A1 - Weil, Maryam
A1 - Ingebrandt, Sven
T1 - Impedimetric immunosensor for the detection of histamine based on reduced graphene oxide
JF - Physica status solidi (a)
Y1 - 2015
U6 - https://doi.org/10.1002/pssa.201431863
SN - 1862-6319
VL - 212
IS - 6
SP - 1327
EP - 1334
PB - Wiley
CY - Weinheim
ER -
TY - JOUR
A1 - Bouwman, Peter
A1 - Gulden, Hanneke van der
A1 - Heijden, Ingrid van der
A1 - Drost, Rinske
A1 - Klijn, Christiaan N.
A1 - Prasetyanti, Pramudita
A1 - Pieterse, Mark
A1 - Wientjens, Ellen
A1 - Seibler, Jost
A1 - Hogervorst, Frank B. L.
A1 - Jonkers, Jos
T1 - A High-Throughput Functional Complementation Assay for Classification of BRCA1 Missense Variants
JF - Cancer Discovery
Y1 - 2013
U6 - https://doi.org/10.1158/2159-8290.CD-13-0094
SN - 2159-8290
IS - 3
SP - 1142
EP - 1152
ER -
TY - JOUR
A1 - Hoeveler, Bastian
A1 - Janser, Frank
A1 - Bindewald, Thorsten
A1 - Gebhardt, Andreas
T1 - Entwurf, Fertigung und Untersuchung eines Windkanalmodells eines innovativen, senkrechtstartenden Kleinflugzeuges
JF - RTejournal - Forum für Rapid Technologie
Y1 - 2015
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0009-2-42921
SN - 1614-0923
IS - 12
SP - 1
EP - 5
PB - Fachhochschule Aachen
CY - Aachen
ER -
TY - JOUR
A1 - Bergmann, Ole
A1 - Möhren, Felix
A1 - Braun, Carsten
A1 - Janser, Frank
T1 - On the influence of elasticity on swept propeller noise
JF - AIAA SCITECH 2023 Forum
N2 - High aerodynamic efficiency requires propellers with high aspect ratios, while propeller sweep potentially reduces noise. Propeller sweep and high aspect ratios increase elasticity and coupling of structural mechanics and aerodynamics, affecting the propeller performance and noise. Therefore, this paper analyzes the influence of elasticity on forward-swept, backward-swept, and unswept propellers in hover conditions. A reduced-order blade element momentum approach is coupled with a one-dimensional Timoshenko beam theory and Farassat's formulation 1A. The results of the aeroelastic simulation are used as input for the aeroacoustic calculation. The analysis shows that elasticity influences noise radiation because thickness and loading noise respond differently to deformations. In the case of the backward-swept propeller, the location of the maximum sound pressure level shifts forward by 0.5 °, while in the case of the forward-swept propeller, it shifts backward by 0.5 °. Therefore, aeroacoustic optimization requires the consideration of propeller deformation.
Y1 - 2023
U6 - https://doi.org/10.2514/6.2023-0210
N1 - Session: Propeller, Open Rotor, and Rotorcraft Noise II
AIAA SCITECH 2023 Forum, 23-27 January 2023, National Harbor, MD & Online
PB - AIAA
CY - Reston, Va.
ER -
TY - JOUR
A1 - Möhren, Felix
A1 - Bergmann, Ole
A1 - Janser, Frank
A1 - Braun, Carsten
T1 - Assessment of structural mechanical effects related to torsional deformations of propellers
JF - CEAS Aeronautical Journal
N2 - Lifting propellers are of increasing interest for Advanced Air Mobility. All propellers and rotors are initially twisted beams, showing significant extension–twist coupling and centrifugal twisting. Torsional deformations severely impact aerodynamic performance. This paper presents a novel approach to assess different reasons for torsional deformations. A reduced-order model runs large parameter sweeps with algebraic formulations and numerical solution procedures. Generic beams represent three different propeller types for General Aviation, Commercial Aviation, and Advanced Air Mobility. Simulations include solid and hollow cross-sections made of aluminum, steel, and carbon fiber-reinforced polymer. The investigation shows that centrifugal twisting moments depend on both the elastic and initial twist. The determination of the centrifugal twisting moment solely based on the initial twist suffers from errors exceeding 5% in some cases. The nonlinear parts of the torsional rigidity do not significantly impact the overall torsional rigidity for the investigated propeller types. The extension–twist coupling related to the initial and elastic twist in combination with tension forces significantly impacts the net cross-sectional torsional loads. While the increase in torsional stiffness due to initial twist contributes to the overall stiffness for General and Commercial Aviation propellers, its contribution to the lift propeller’s stiffness is limited. The paper closes with the presentation of approximations for each effect identified as significant. Numerical evaluations are necessary to determine each effect for inhomogeneous cross-sections made of anisotropic material.
KW - Lifting propeller
KW - Extension–twist coupling
KW - Trapeze effect
KW - Centrifugal twisting moment
Y1 - 2024
U6 - https://doi.org/10.1007/s13272-024-00737-7
SN - 1869-5590 (eISSN)
SN - 1869-5582
N1 - Corresponding author: Felix Möhren
PB - Springer
CY - Wien
ER -
TY - JOUR
A1 - Neu, Eugen
A1 - Janser, Frank
A1 - Khatibi, Akbar A.
A1 - Braun, Carsten
A1 - Orifici, Adrian C.
T1 - Operational Modal Analysis of a wing excited by transonic flow
JF - Aerospace Science and Technology
N2 - Operational Modal Analysis (OMA) is a promising candidate for flutter testing and Structural Health Monitoring (SHM) of aircraft wings that are passively excited by wind loads. However, no studies have been published where OMA is tested in transonic flows, which is the dominant condition for large civil aircraft and is characterized by complex and unique aerodynamic phenomena. We use data from the HIRENASD large-scale wind tunnel experiment to automatically extract modal parameters from an ambiently excited wing operated in the transonic regime using two OMA methods: Stochastic Subspace Identification (SSI) and Frequency Domain Decomposition (FDD). The system response is evaluated based on accelerometer measurements. The excitation is investigated from surface pressure measurements. The forcing function is shown to be non-white, non-stationary and contaminated by narrow-banded transonic disturbances. All these properties violate fundamental OMA assumptions about the forcing function. Despite this, all physical modes in the investigated frequency range were successfully identified, and in addition transonic pressure waves were identified as physical modes as well. The SSI method showed superior identification capabilities for the investigated case. The investigation shows that complex transonic flows can interfere with OMA. This can make existing approaches for modal tracking unsuitable for their application to aircraft wings operated in the transonic flight regime. Approaches to separate the true physical modes from the transonic disturbances are discussed.
Y1 - 2016
U6 - https://doi.org/10.1016/j.ast.2015.11.032
SN - 1270-9638
VL - 49
SP - 73
EP - 79
PB - Elsevier
CY - Amsterdam
ER -
TY - JOUR
A1 - Ferrein, Alexander
A1 - Dylla, Frank
A1 - Lakemeyer, Gerhard
T1 - Specifying Multirobot Coordination in ICPGolog - From Simulation towards Real Robots / Dylla, Frank ; Ferrein, Alexander ; Lakemeyer, Gerhard
Y1 - 2003
N1 - AOS-4 at IJCAI-03
SP - 1
EP - 10
ER -
TY - JOUR
A1 - Defosse, Jerome
A1 - Kleinschmidt, Joris
A1 - Schmutz, Axel
A1 - Loop, Torsten
A1 - Staat, Manfred
A1 - Gatzweiler, Karl-Heinz
A1 - Wappler, Frank
A1 - Schieren, Mark
T1 - Dental strain on maxillary incisors during tracheal intubation with double-lumen tubes and different laryngoscopy techniques - a blinded manikin study
JF - Journal of Cardiothoracic and Vascular Anesthesia
KW - anaesthetic complications
KW - dental trauma
KW - difficult airway
KW - double-lumen tube intubation
KW - videolaryngoscopy
Y1 - 2022
U6 - https://doi.org/10.1053/j.jvca.2022.02.017
SN - 1053-0770
VL - 36
IS - 8, Part B
SP - 3021
EP - 3027
PB - Elsevier
CY - New York, NY
ER -
TY - JOUR
A1 - Iken, Heiko
A1 - Bronder, Thomas
A1 - Goretzki, Alexander
A1 - Kriesel, Jana
A1 - Ahlborn, Kristina
A1 - Gerlach, Frank
A1 - Vonau, Winfried
A1 - Zander, Willi
A1 - Schubert, Jürgen
A1 - Schöning, Michael Josef
T1 - Development of a Combined pH- and Redox-Sensitive Bi-Electrode Glass Thin-Film Sensor
JF - physica status solidi a : applications and materials sciences
Y1 - 2019
U6 - https://doi.org/10.1002/pssa.201900114
SN - 1862-6319
VL - 216
IS - 12
SP - 1
EP - 8
PB - Wiley
CY - Weinheim
ER -
TY - JOUR
A1 - Schossig, Peter
A1 - Dötsch, Christian
A1 - Drück, Harald
A1 - Göttsche, Joachim
A1 - Huenges, Ernst
A1 - Kabus, Frank
A1 - Tamme, Rainer
T1 - Wärmespeicher für die Hausenergieversorgung
JF - Wärme und Kälte - Energie aus Sonne und Erde : Jahrestagung des Forschungsverbunds Sonnenenergie in Kooperation mit der Landesinitiative Zukunftsenergie NRW / Stadermann, Gerd, Hrsg.
Y1 - 2005
UR - http://publica.fraunhofer.de/documents/N-54108.html
SP - 120
EP - 125
PB - Forschungsverbund Sonnenenergie
CY - Berlin
ER -
TY - JOUR
A1 - Slabu, Ioana
A1 - Roeth, Anjali A.
A1 - Engelmann, Ulrich M.
A1 - Wiekhorst, Frank
A1 - Buhl, Eva M.
A1 - Neumann, Ulf P.
A1 - Schmitz-Rode, Thomas
T1 - Modeling of magnetoliposome uptake in human pancreatic tumor cells in vitro
JF - Nanotechnology
Y1 - 2019
U6 - https://doi.org/10.1088/1361-6528/ab033e
SN - 1361-6528
VL - 30
IS - 18
SP - 184004
ER -
TY - JOUR
A1 - Engelmann, Ulrich M.
A1 - Buhl, Eva Miriam
A1 - Draack, Sebastian
A1 - Viereck, Thilo
A1 - Frank,
A1 - Schmitz-Rode, Thomas
A1 - Slabu, Ioana
T1 - Magnetic relaxation of agglomerated and immobilized iron oxide nanoparticles for hyperthermia and imaging applications
JF - IEEE Magnetic Letters
N2 - Magnetic nanoparticles (MNPs) are used as therapeutic and diagnostic agents for local delivery of heat and image contrast enhancement in diseased tissue. Besides magnetization, the most important parameter that determines their performance for these applications is their magnetic relaxation, which can be affected when MNPs immobilize and agglomerate inside tissues. In this letter, we investigate different MNP agglomeration states for their magnetic relaxation properties under excitation in alternating fields and relate this to their heating efficiency and imaging properties. With focus on magnetic fluid hyperthermia, two different trends in MNP heating efficiency are measured: an increase by up to 23% for agglomerated MNP in suspension and a decrease by up to 28% for mixed states of agglomerated and immobilized MNP, which indicates that immobilization is the dominant effect. The same comparatively moderate effects are obtained for the signal amplitude in magnetic particle spectroscopy.
Y1 - 2018
U6 - https://doi.org/10.1109/LMAG.2018.2879034
SN - 1949-307X
VL - 9
IS - Article number 8519617
PB - IEEE
CY - New York, NY
ER -
TY - JOUR
A1 - Czarnecki, Christian
A1 - Bensberg, Frank
A1 - Auth, Gunnar
T1 - Die Rolle von Softwarerobotern für die zukünftige Arbeitswelt
JF - HMD Praxis der Wirtschaftsinformatik
N2 - Im Rahmen der Digitalisierung ist die zunehmende Automatisierung von bisher manuellen Prozessschritten ein Aspekt, der massive Auswirkungen auf die zukünftige Arbeitswelt haben wird. In diesem Kontext werden an den Einsatz von Softwarerobotern zur Prozessautomatisierung hohe Erwartungen geknüpft. Bei den Implementierungsansätzen wird die Diskussion aktuell insbesondere durch Robotic Process Automation (RPA) und Chatbots geprägt. Beide Ansätze verfolgen das gemeinsame Ziel einer 1:1-Automatisierung von menschlichen Handlungen und dadurch ein direktes Ersetzen von Mitarbeitern durch Maschinen. Bei RPA werden Prozesse durch Softwareroboter erlernt und automatisiert ausgeführt. Dabei emulieren RPA-Roboter die Eingaben auf der bestehenden Präsentationsschicht, so dass keine Änderungen an vorhandenen Anwendungssystemen notwendig sind. Am Markt werden bereits unterschiedliche RPA-Lösungen als Softwareprodukte angeboten. Durch Chatbots werden Ein- und Ausgaben von Anwendungssystemen über natürliche Sprache realisiert. Dadurch ist die Automatisierung von unternehmensexterner Kommunikation (z. B. mit Kunden) aber auch von unternehmensinternen Assistenztätigkeiten möglich. Der Beitrag diskutiert die Auswirkungen von Softwarerobotern auf die Arbeitswelt anhand von Anwendungsbeispielen und erläutert die unternehmensindividuelle Entscheidung über den Einsatz von Softwarerobotern anhand von Effektivitäts- und Effizienzzielen.
KW - Robotic Process Automation
KW - Chatbots
KW - Prozessautomatisierung
KW - Arbeit 4.0
KW - Digitalisierung
Y1 - 2019
U6 - https://doi.org/10.1365/s40702-019-00548-z
SN - 2198-2775
VL - 56
IS - 4
SP - 795
EP - 808
PB - Springer
CY - Cham
ER -
TY - JOUR
A1 - Bensberg, Frank
A1 - Auth, Gunnar
A1 - Czarnecki, Christian
T1 - Einsatz von Text Analytics zur Unterstützung literaturintensiver Forschungsprozesse: Konzeption, Realisierung und Lessons Learned
JF - Anwendungen und Konzepte der Wirtschaftsinformatik
N2 - Das anhaltende Wachstum wissenschaftlicher Veröffentlichungen wirft die Fragestellung auf, wie Literaturana-lysen im Rahmen von Forschungsprozessen digitalisiert und somit produktiver realisiert werden können. Insbesondere in informationstechnischen Fachgebieten ist die Forschungspraxis durch ein rasant wachsendes Publikationsaufkommen gekennzeichnet. Infolgedessen bietet sich der Einsatz von Methoden der Textanalyse (Text Analytics) an, die Textdaten automatisch vorbereiten und verarbeiten können. Erkenntnisse entstehen dabei aus Analysen von Wortarten und Subgruppen, Korrelations- sowie Zeitreihenanalysen. Dieser Beitrag stellt die Konzeption und Realisierung eines Prototypen vor, mit dem Anwender bibliographische Daten aus der etablierten Literaturdatenbank EBSCO Discovery Service mithilfe textanalytischer Methoden erschließen können. Der Prototyp basiert auf dem Analysesystem IBM Watson Explorer, das Hochschulen lizenzkostenfrei zur Verfügung steht. Potenzielle Adressaten des Prototypen sind Forschungseinrichtungen, Beratungsunternehmen sowie Entscheidungsträger in Politik und Unternehmenspraxis.
KW - Text Analytics
KW - Literaturanalyse
KW - Forschungsprozess
KW - EBSCO Discovery Service
KW - IBM Watson Explorer
Y1 - 2018
U6 - https://doi.org/10.26034/lu.akwi.2018.3221
SN - 2296-4592
VL - 2018
IS - 8
SP - 1
EP - 6
PB - AKWI
CY - Luzern
ER -
TY - JOUR
A1 - Bensberg, Frank
A1 - Auth, Gunnar
A1 - Czarnecki, Christian
ED - Haake, Jörg M.
T1 - Literaturanalyse mit Text Mining
JF - E-Learning and Education (eleed)
N2 - Die Durchführung einer systematischen Literaturrecherche ist eine zentrale Kompetenz wissenschaftlichen Arbeitens und bildet daher einen festen Ausbildungsbestandteil von Bachelor- und Masterstudiengängen. In entsprechenden Lehrveranstaltungen werden Studierende zwar mit den grundlegenden Hilfsmitteln zur Suche und Verwaltung von Literatur vertraut gemacht, allerdings werden die Potenziale textanalytischer Methoden und Anwendungssysteme (Text Mining, Text Analytics) dabei zumeist nicht abgedeckt. Folglich werden Datenkompetenzen, die zur systemgestützten Analyse und Erschließung von Literaturdaten erforderlich sind, nicht hinreichend ausgeprägt. Um diese Kompetenzlücke zu adressieren, ist an der Hochschule Osnabrück eine Lehrveranstaltung konzipiert und projektorientiert umgesetzt worden, die sich insbesondere an Studierende wirtschaftswissenschaftlicher Studiengänge richtet. Dieser Beitrag dokumentiert die fachliche sowie technische Ausgestaltung dieser Veranstaltung und zeigt Potenziale für die künftige Weiterentwicklung auf.
KW - E-Learning
KW - Text Mining
KW - Text Analytics
KW - Literaturrecherche
KW - Literaturanalyse
Y1 - 2020
SN - 1860-7470
N1 - Volltext, nur online
IS - 13
SP - 1
EP - 13
PB - FernUniversität in Hagen
CY - Hagen
ER -
TY - JOUR
A1 - Bartella, Alexander K.
A1 - Kamal, Mohammad
A1 - Scholl, Ingrid
A1 - Schiffer, Stefan
A1 - Steegmann, Julius
A1 - Ketelsen, Dominik
A1 - Hölzle, Frank W.
A1 - Lethaus, Bernd
T1 - Virtual reality in preoperative imaging in maxillofacial surgery: implementation of “the next level”?
JF - British Journal of Oral and Maxillofacial Surgery
Y1 - 2019
U6 - https://doi.org/10.1016/j.bjoms.2019.02.014
SN - 0266-4356
VL - 57
IS - 7
SP - 644
EP - 648
PB - Elsevier
CY - Amsterdam
ER -
TY - JOUR
A1 - Hoeveler, B.
A1 - Bauknecht, André
A1 - Wolf, C. Christian
A1 - Janser, Frank
T1 - Wind-Tunnel Study of a Wing-Embedded Lifting Fan Remaining Open in Cruise Flight
JF - Journal of Aircraft
N2 - It is investigated whether a nonrotating lifting fan remaining uncovered during cruise flight, as opposed to being covered by a shutter system, can be realized with limited additional drag and loss of lift during cruise flight. A wind-tunnel study of a wing-embedded lifting fan has been conducted at the Side Wind Test Facility Göttingen of DLR, German Aerospace Center in Göttingen using force, pressure, and stereoscopic particle image velocimetry techniques. The study showed that a step on the lower side of the wing in front of the lifting fan duct increases the lift-to-drag ratio of the whole model by up to 25% for all positive angles of attack. Different sizes and inclinations of the step had limited influence on the surface pressure distribution. The data indicate that these parameters can be optimized to maximize the lift-to-drag ratio. A doubling of the curvature radius of the lifting fan duct inlet lip on the upper side of the wing affected the lift-to-drag ratio by less than 1%. The lifting fan duct inlet curvature can therefore be optimized to maximize the vertical fan thrust of the rotating lifting fan during hovering without affecting the cruise flight performance with a nonrotating fan.
Y1 - 2020
U6 - https://doi.org/10.2514/1.C035422
SN - 1533-3868
VL - 57
IS - 4
PB - AIAA
CY - Reston, Va.
ER -
TY - JOUR
A1 - Neu, Eugen
A1 - Janser, Frank
A1 - Khatibi, Akbar A.
A1 - Orifici, Adrian C.
T1 - Fully Automated Operational Modal Analysis using multi-stage clustering
JF - Mechanical Systems and Signal Processing
Y1 - 2017
U6 - https://doi.org/10.1016/j.ymssp.2016.07.031
SN - 0888-3270
VL - Vol. 84, Part A
SP - 308
EP - 323
PB - Elsevier
CY - Amsterdam
ER -
TY - JOUR
A1 - Neu, Eugen
A1 - Janser, Frank
A1 - Khatibi, Akbar A.
A1 - Orifici, Adrian C.
T1 - Automated modal parameter-based anomaly detection under varying wind excitation
JF - Structural Health Monitoring
N2 - Wind-induced operational variability is one of the major challenges for structural health monitoring of slender engineering structures like aircraft wings or wind turbine blades. Damage sensitive features often show an even bigger sensitivity to operational variability. In this study a composite cantilever was subjected to multiple mass configurations, velocities and angles of attack in a controlled wind tunnel environment. A small-scale impact damage was introduced to the specimen and the structural response measurements were repeated. The proposed damage detection methodology is based on automated operational modal analysis. A novel baseline preparation procedure is described that reduces the amount of user interaction to the provision of a single consistency threshold. The procedure starts with an indeterminate number of operational modal analysis identifications from a large number of datasets and returns a complete baseline matrix of natural frequencies and damping ratios that is suitable for subsequent anomaly detection. Mahalanobis distance-based anomaly detection is then applied to successfully detect the damage under varying severities of operational variability and with various degrees of knowledge about the present operational conditions. The damage detection capabilities of the proposed methodology were found to be excellent under varying velocities and angles of attack. Damage detection was less successful under joint mass and wind variability but could be significantly improved through the provision of the currently encountered operational conditions.
Y1 - 2016
U6 - https://doi.org/10.1177/1475921716665803
SN - 1475-9217
VL - 15
IS - 6
SP - 1
EP - 20
PB - Sage
CY - London
ER -
TY - JOUR
A1 - Wert, Stefan
A1 - Iken, Heiko
A1 - Schöning, Michael Josef
A1 - Matysik, Frank-Michael
T1 - Development of a temperature‐pulse enhanced electrochemical glucose biosensor and characterization of its stability via scanning electrochemical microscopy
JF - Electroanalysis
N2 - Glucose oxidase (GOx) is an enzyme frequently used in glucose biosensors. As increased temperatures can enhance the performance of electrochemical sensors, we investigated the impact of temperature pulses on GOx that was drop-coated on flattened Pt microwires. The wires were heated by an alternating current. The sensitivity towards glucose and the temperature stability of GOx was investigated by amperometry. An up to 22-fold increase of sensitivity was observed. Spatially resolved enzyme activity changes were investigated via scanning electrochemical microscopy. The application of short (<100 ms) heat pulses was associated with less thermal inactivation of the immobilized GOx than long-term heating.
Y1 - 2021
U6 - https://doi.org/10.1002/elan.202100089
SN - 1521-4109
IS - Early View
PB - Wiley-VCH
CY - Weinheim
ER -
TY - JOUR
A1 - Bergmann, Ole
A1 - Götten, Falk
A1 - Braun, Carsten
A1 - Janser, Frank
T1 - Comparison and evaluation of blade element methods against RANS simulations and test data
JF - CEAS Aeronautical Journal
N2 - This paper compares several blade element theory (BET) method-based propeller simulation tools, including an evaluation against static propeller ground tests and high-fidelity Reynolds-Average Navier Stokes (RANS) simulations. Two proprietary propeller geometries for paraglider applications are analysed in static and flight conditions. The RANS simulations are validated with the static test data and used as a reference for comparing the BET in flight conditions. The comparison includes the analysis of varying 2D aerodynamic airfoil parameters and different induced velocity calculation methods. The evaluation of the BET propeller simulation tools shows the strength of the BET tools compared to RANS simulations. The RANS simulations underpredict static experimental data within 10% relative error, while appropriate BET tools overpredict the RANS results by 15–20% relative error. A variation in 2D aerodynamic data depicts the need for highly accurate 2D data for accurate BET results. The nonlinear BET coupled with XFOIL for the 2D aerodynamic data matches best with RANS in static operation and flight conditions. The novel BET tool PropCODE combines both approaches and offers further correction models for highly accurate static and flight condition results.
KW - BET
KW - CFD propeller simulation
KW - Propeller aerodynamics
KW - Actuator disk modelling
KW - Propeller performance
Y1 - 2022
U6 - https://doi.org/10.1007/s13272-022-00579-1
SN - 1869-5590 (Online)
SN - 1869-5582 (Print)
N1 - Corresponding author: Ole Bergmann
VL - 13
SP - 535
EP - 557
PB - Springer
CY - Wien
ER -
TY - JOUR
A1 - Raffeis, Iris
A1 - Adjei-Kyeremeh, Frank
A1 - Vroomen, Uwe
A1 - Westhoff, Elmar
A1 - Bremen, Sebastian
A1 - Hohoi, Alexandru
A1 - Bührig-Polaczek, Andreas
T1 - Qualification of a Ni-Cu alloy for the laser powder bed fusion process (LPBF): Its microstructure and mechanical properties
JF - Applied Sciences
N2 - As researchers continue to seek the expansion of the material base for additive manufacturing, there is a need to focus attention on the Ni–Cu group of alloys which conventionally has wide industrial applications. In this work, the G-NiCu30Nb casting alloy, a variant of the Monel family of alloys with Nb and high Si content is, for the first time, processed via the laser powder bed fusion process (LPBF). Being novel to the LPBF processes, optimum LPBF parameters were determined, and hardness and tensile tests were performed in as-built conditions and after heat treatment at 1000 °C. Microstructures of the as-cast and the as-built condition were compared. Highly dense samples (99.8% density) were achieved after varying hatch distance (80 µm and 140 µm) with scanning speed (550 mm/s–1500 mm/s). There was no significant difference in microhardness between varied hatch distance print sets. Microhardness of the as-built condition (247 HV0.2) exceeded the as-cast microhardness (179 HV0.2.). Tensile specimens built in vertical (V) and horizontal (H) orientations revealed degrees of anisotropy and were superior to conventionally reported figures. Post heat treatment increased ductility from 20% to 31% (V), as well as from 16% to 25% (H), while ultimate tensile strength (UTS) and yield strength (YS) were considerably reduced.
Y1 - 2020
U6 - https://doi.org/10.3390/app10103401
SN - 2076-3417
N1 - Special Issue Materials Development by Additive Manufacturing Techniques
VL - 10
IS - Art. 3401
SP - 1
EP - 15
PB - MDPI
CY - Basel
ER -
TY - JOUR
A1 - Elsen, Ingo
A1 - Hartung, Frank
A1 - Horn, Uwe
A1 - Kampmann, Markus
A1 - Peters, Liliane
ED - Voas, Jeffrey
T1 - Streaming technology in 3G mobile communication systems
JF - Computer : innovative technology for computer professionals
N2 - Third-generation mobile communication systems will combine standardized streaming with a range of unique services to provide high-quality Internet content that meets the specific needs of the rapidly growing mobile market.
Y1 - 2001
SN - 0018-9162
SN - 1558-0814
VL - 34
IS - 9 Seiten
SP - 46
EP - 52
PB - IEEE
CY - New York
ER -
TY - JOUR
A1 - Möhren, Felix
A1 - Bergmann, Ole
A1 - Janser, Frank
A1 - Braun, Carsten
T1 - On the influence of elasticity on propeller performance: a parametric study
JF - CEAS Aeronautical Journal
N2 - The aerodynamic performance of propellers strongly depends on their geometry and, consequently, on aeroelastic deformations. Knowledge of the extent of the impact is crucial for overall aircraft performance. An integrated simulation environment for steady aeroelastic propeller simulations is presented. The simulation environment is applied to determine the impact of elastic deformations on the aerodynamic propeller performance. The aerodynamic module includes a blade element momentum approach to calculate aerodynamic loads. The structural module is based on finite beam elements, according to Timoshenko theory, including moderate deflections. Several fixed-pitch propellers with thin-walled cross sections made of both isotropic and non-isotropic materials are investigated. The essential parameters are varied: diameter, disc loading, sweep, material, rotational, and flight velocity. The relative change of thrust between rigid and elastic blades quantifies the impact of propeller elasticity. Swept propellers of large diameters or low disc loadings can decrease the thrust significantly. High flight velocities and low material stiffness amplify this tendency. Performance calculations without consideration of propeller elasticity can lead to decreased efficiency. To avoid cost- and time-intense redesigns, propeller elasticity should be considered for swept planforms and low disc loadings.
KW - Propeller
KW - Finite element method
KW - Blade element method
KW - Propeller elasticity
KW - Aeroelasticity
Y1 - 2023
U6 - https://doi.org/10.1007/s13272-023-00649-y
SN - 1869-5590 (Online)
SN - 1869-5582 (Print)
N1 - Corresponding author: Felix Möhren
VL - 14
SP - 311
EP - 323
PB - Springer Nature
CY - Berlin
ER -
TY - JOUR
A1 - Ferrein, Alexander
A1 - Dylla, Frank
A1 - Lakemeyer, Gerhard
A1 - Murray, Jan
T1 - Approaching a formal soccer theory from behaviour specifications in robotic soccer / Dylla, Frank ; Ferrein, Alexander ; Lakemeyer, Gerhard ; Murray, Jan ; Obst, Oliver ; Röfer, Thomas ; Schiffer, Stefan ; Stolzenburg, Frieder ; Visser, Ubbo ; Wagner, Tho
JF - Computers in sport / editors: P Dabnichki
Y1 - 2008
SN - 978-1-8456-4064-4
SP - 161
EP - 185
PB - WIT Press
CY - Southampton
ER -
TY - JOUR
A1 - Saretzki, Charlotte
A1 - Bergmann, Ole
A1 - Dahmann, Peter
A1 - Janser, Frank
A1 - Keimer, Jona
A1 - Machado, Patricia
A1 - Morrison, Audry
A1 - Page, Henry
A1 - Pluta, Emil
A1 - Stübing, Felix
A1 - Küpper, Thomas
T1 - Are small airplanes safe with regards to COVID-19 transmission?
JF - Journal of Travel Medicine
Y1 - 2021
U6 - https://doi.org/10.1093/jtm/taab105
SN - 1708-8305
VL - 28
IS - 7
PB - Oxford University Press
CY - Oxford
ER -
TY - JOUR
A1 - Weemstra, Monique
A1 - Eilmann, Britta
A1 - Sass-Klaassen, Ute G. W.
A1 - Sterck, Frank J.
T1 - Summer droughts limit tree growth across 10 temperate species on a productive forest site
JF - Forest Ecology and Management
Y1 - 2013
U6 - https://doi.org/doi:10.1016/j.foreco.2013.06.007
SN - 0378-1127 (Print)
SN - 1872-7042 (Online)
VL - 2013
IS - 306
SP - 142
EP - 149
PB - Elsevier
CY - Amsterdam
ER -
TY - JOUR
A1 - Dieringer, Matthias A.
A1 - Renz, Wolfgang
A1 - Lindel, Tomasz D.
A1 - Seifert, Frank
A1 - Frauenrath, Tobias
A1 - von Knobelsdorf-Brenkenhoff, Florian
A1 - Waiczies, Helmar
A1 - Hoffmann, Werner
A1 - Rieger, Jan
A1 - Pfeiffer, Harald
A1 - Ittermann, Bernd
A1 - Schulz-Menger, Jeanette
A1 - Niendorf, Thoralf
T1 - Design and application of a four-channel transmit/receive surface coil for functional cardiac imaging at 7T
JF - Journal of Magnetic Resonance Imaging
N2 - Purpose
To design and evaluate a four-channel cardiac transceiver coil array for functional cardiac imaging at 7T.
Materials and Methods
A four-element cardiac transceiver surface coil array was developed with two rectangular loops mounted on an anterior former and two rectangular loops on a posterior former. specific absorption rate (SAR) simulations were performed and a Burn:x-wiley:10531807:media:JMRI22451:tex2gif-stack-1 calibration method was applied prior to obtain 2D FLASH CINE (mSENSE, R = 2) images from nine healthy volunteers with a spatial resolution of up to 1 × 1 × 2.5 mm3.
Results
Tuning and matching was found to be better than 10 dB for all subjects. The decoupling (S21) was measured to be >18 dB between neighboring loops, >20 dB for opposite loops, and >30 dB for other loop combinations. SAR values were well within the limits provided by the IEC. Imaging provided clinically acceptable signal homogeneity with an excellent blood-myocardium contrast applying the Burn:x-wiley:10531807:media:JMRI22451:tex2gif-stack-2 calibration approach.
Conclusion
A four-channel cardiac transceiver coil array for 7T was built, allowing for cardiac imaging with clinically acceptable signal homogeneity and an excellent blood-myocardium contrast. Minor anatomic structures, such as pericardium, mitral, and tricuspid valves and their apparatus, as well as trabeculae, were accurately delineated.
Y1 - 2011
U6 - https://doi.org/10.1002/jmri.22451
SN - 1522-2586
VL - 33
IS - 3
SP - 736
EP - 741
PB - Wiley-Liss
CY - New York
ER -
TY - JOUR
A1 - Eilmann, Britta
A1 - Sterck, Frank J.
A1 - Wegner, L.
A1 - de Vries, Sven M. G.
A1 - von Arx, G.
A1 - Mohren, Godefridus M. J.
A1 - den Ouden, Jan
A1 - Sass-Klaassen, Ute G. W.
T1 - Wood structural differences between northern and southern beech provenances growing at a moderate site
JF - Tree Physiology
Y1 - 2014
U6 - https://doi.org/10.1093/treephys/tpu069
SN - 1758-4469 (Online)
SN - 0829-318X (Print)
VL - 34
IS - 8
SP - 882
EP - 893
PB - Oxford University Press
CY - Oxford
ER -
TY - JOUR
A1 - Ferrein, Alexander
A1 - Dylla, Frank
A1 - Lakemeyer, Gerhard
T1 - Acting and Deliberating using Golog in Robotic Soccer - A Hybrid Architecture / Dylla, Frank ; Ferrein, Alexander ; Lakemeyer, Gerhard
JF - Proc. 3rd International Cognitive Robotics Workshop (CogRob 2002)
Y1 - 2002
SP - 1
EP - 7
ER -
TY - JOUR
A1 - Ferrein, Alexander
A1 - Dylla, Frank
A1 - Lakemeyer, Gerhard
A1 - Murray, Jan
T1 - Towards a League-Independent Qualitative Soccer Theory for RoboCup / Dylla, Frank ; Ferrein, Alexander ; Lakemeyer, Gerhard ; Murray, Jan ; Obst, Oliver ; Röfer, Thomas ; Stolzenburg, Frieder ; Visser, Ubbo
JF - RoboCup 2004: Robot Soccer World Cup VIII / Daniele Nardi ... (ed.).
Y1 - 2005
SN - 978-3-540-25046-8
N1 - Lecture Notes in Computer Science ; 3276
SP - 611
EP - 618
PB - Springer
CY - Berlin
ER -
TY - JOUR
A1 - Schieren, Mark
A1 - Kleinschmidt, Joris
A1 - Schmutz, Axel
A1 - Loop, Torsten
A1 - Gatzweiler, Karl-Heinz
A1 - Staat, Manfred
A1 - Wappler, Frank
A1 - Defosse, Jerome
T1 - Comparison of forces acting on maxillary incisors during tracheal intubation with different laryngoscopy techniques: a blinded manikin study
JF - Anaesthesia
Y1 - 2019
SN - 1365-2044
U6 - https://doi.org/10.1111/anae.14815
N1 - Die Anhänge "Table S1 (Impact of sex and level of training on dental force. Results presented as median (IQR [range]) and n (%))" und
"Appendix S1 (Measurement technique.)" stehen unter "Supporting Information" zum Download bereit.
VL - 74
IS - 12
PB - Wiley-Blackwell
CY - Oxford
ER -
TY - JOUR
A1 - Luisier, Raphaëlle
A1 - Lempiäinen, Harri
A1 - Scherbichler, Nina
A1 - Braeuning, Albert
A1 - Geissler, Miriam
A1 - Dubost, Valerie
A1 - Müller, Arne
A1 - Scheer, Nico
A1 - Chibout, Salah-Dine
A1 - Hara, Hisanori
A1 - Picard, Frank
A1 - Theil, Diethilde
A1 - Couttet, Philippe
A1 - Vitobello, Antonio
A1 - Grenet, Olivier
A1 - Grasl-Kraupp, Bettina
A1 - Ellinger-Ziegelbauer, Heidrung
A1 - Thomson, John P.
A1 - Meehan, Richard R.
A1 - Elcombe, Clifford R.
A1 - Henderson, Colin J.
A1 - Wolf, C. Roland
A1 - Schwarz, Michael
A1 - Moulin, Pierre
A1 - Terranova, Remi
A1 - Moggs, Jonathan G.
T1 - Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors
JF - Toxicological Sciences
N2 - The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcinogenesis. Here, we have used a humanized CAR/PXR mouse model to examine potential species differences in receptor-dependent mechanisms underlying liver tissue molecular responses to PB. Early and late transcriptomic responses to sustained PB exposure were investigated in liver tissue from double knock-out CAR and PXR (CARᴷᴼ-PXRᴷᴼ), double humanized CAR and PXR (CARʰ-PXRʰ), and wild-type C57BL/6 mice. Wild-type and CARʰ-PXRʰ mouse livers exhibited temporally and quantitatively similar transcriptional responses during 91 days of PB exposure including the sustained induction of the xenobiotic response gene Cyp2b10, the Wnt signaling inhibitor Wisp1, and noncoding RNA biomarkers from the Dlk1-Dio3 locus. Transient induction of DNA replication (Hells, Mcm6, and Esco2) and mitotic genes (Ccnb2, Cdc20, and Cdk1) and the proliferation-related nuclear antigen Mki67 were observed with peak expression occurring between 1 and 7 days PB exposure. All these transcriptional responses were absent in CARᴷᴼ-PXRᴷᴼ mouse livers and largely reversible in wild-type and CARʰ-PXRʰ mouse livers following 91 days of PB exposure and a subsequent 4-week recovery period. Furthermore, PB-mediated upregulation of the noncoding RNA Meg3, which has recently been associated with cellular pluripotency, exhibited a similar dose response and perivenous hepatocyte-specific localization in both wild-type and CARʰ-PXRʰ mice. Thus, mouse livers coexpressing human CAR and PXR support both the xenobiotic metabolizing and the proliferative transcriptional responses following exposure to PB.
Y1 - 2014
U6 - https://doi.org/https://doi.org/10.1093/toxsci/kfu038
SN - 1094-2025
VL - 139
IS - 2
SP - 501
EP - 511
PB - Oxford University Press
CY - Oxford
ER -