TY  - JOUR
A1  - Schieren, Mark
A1  - Kleinschmidt, Joris
A1  - Schmutz, Axel
A1  - Loop, Torsten
A1  - Gatzweiler, Karl-Heinz
A1  - Staat, Manfred
A1  - Wappler, Frank
A1  - Defosse, Jerome
T1  - Comparison of forces acting on maxillary incisors during tracheal intubation with different laryngoscopy techniques: a blinded manikin study
JF  - Anaesthesia
Y1  - 2019
SN  - 1365-2044
U6  - https://doi.org/10.1111/anae.14815
N1  - Die Anhänge "Table S1 (Impact of sex and level of training on dental force. Results presented as median (IQR [range]) and n (%))" und 
"Appendix S1 (Measurement technique.)" stehen unter "Supporting Information" zum Download bereit.
VL  - 74
IS  - 12
PB  - Wiley-Blackwell
CY  - Oxford
ER  - 
TY  - GEN
A1  - Dieringer, Matthias A.
A1  - Renz, Wolfgang
A1  - Lindel, Tomasz
A1  - Seifert, Frank
A1  - Frauenrath, Tobias
A1  - Waiczies, Helmar
A1  - von Knobelsdorff-Brenkhoff, Florian
A1  - Santoro, Davide
A1  - Hoffmann, Werner
A1  - Ittermann, Bernd
A1  - Schulz-Menger, Jeanette
A1  - Niendorf, Thoralf
T1  - 4CH TX/RX Surface Coil for 7T: Design, Optimization and Application for Cardiac Function Imaging
T2  - 2010 ISMRM-ESMRMB joint annual meeting
N2  - Practical impediments of ultra high field cardiovascular MR (CVMR) can be catalogued in exacerbated magnetic field and radio frequency (RF) inhomogeneities, susceptibility and off-resonance effects, conductive and dielectric effects in tissue, and RF power deposition constraints, which all bear the potential to spoil the benefit of CVMR at 7T. Therefore, a four element cardiac transceive surface coil array was developed. Cardiac imaging provided clinically acceptable signal homogeneity with an excellent blood myocardium contrast. Subtle anatomic structures, such as pericardium, mitral and tricuspid valves and their apparatus, papillary muscles, and trabecles were accurately delineated.
Y1  - 2010
SN  - 1545-4428
N1  - ISMRM-ESMRMB joint annual meeting, 1 - 7 May 2010, Stockholm, Sweden
ER  - 
TY  - JOUR
A1  - Luisier, Raphaëlle
A1  - Lempiäinen, Harri
A1  - Scherbichler, Nina
A1  - Braeuning, Albert
A1  - Geissler, Miriam
A1  - Dubost, Valerie
A1  - Müller, Arne
A1  - Scheer, Nico
A1  - Chibout, Salah-Dine
A1  - Hara, Hisanori
A1  - Picard, Frank
A1  - Theil, Diethilde
A1  - Couttet, Philippe
A1  - Vitobello, Antonio
A1  - Grenet, Olivier
A1  - Grasl-Kraupp, Bettina
A1  - Ellinger-Ziegelbauer, Heidrung
A1  - Thomson, John P.
A1  - Meehan, Richard R.
A1  - Elcombe, Clifford R.
A1  - Henderson, Colin J.
A1  - Wolf, C. Roland
A1  - Schwarz, Michael
A1  - Moulin, Pierre
A1  - Terranova, Remi
A1  - Moggs, Jonathan G.
T1  - Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors
JF  - Toxicological Sciences
N2  - The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcinogenesis. Here, we have used a humanized CAR/PXR mouse model to examine potential species differences in receptor-dependent mechanisms underlying liver tissue molecular responses to PB. Early and late transcriptomic responses to sustained PB exposure were investigated in liver tissue from double knock-out CAR and PXR (CARᴷᴼ-PXRᴷᴼ), double humanized CAR and PXR (CARʰ-PXRʰ), and wild-type C57BL/6 mice. Wild-type and CARʰ-PXRʰ mouse livers exhibited temporally and quantitatively similar transcriptional responses during 91 days of PB exposure including the sustained induction of the xenobiotic response gene Cyp2b10, the Wnt signaling inhibitor Wisp1, and noncoding RNA biomarkers from the Dlk1-Dio3 locus. Transient induction of DNA replication (Hells, Mcm6, and Esco2) and mitotic genes (Ccnb2, Cdc20, and Cdk1) and the proliferation-related nuclear antigen Mki67 were observed with peak expression occurring between 1 and 7 days PB exposure. All these transcriptional responses were absent in CARᴷᴼ-PXRᴷᴼ mouse livers and largely reversible in wild-type and CARʰ-PXRʰ mouse livers following 91 days of PB exposure and a subsequent 4-week recovery period. Furthermore, PB-mediated upregulation of the noncoding RNA Meg3, which has recently been associated with cellular pluripotency, exhibited a similar dose response and perivenous hepatocyte-specific localization in both wild-type and CARʰ-PXRʰ mice. Thus, mouse livers coexpressing human CAR and PXR support both the xenobiotic metabolizing and the proliferative transcriptional responses following exposure to PB.
Y1  - 2014
U6  - https://doi.org/https://doi.org/10.1093/toxsci/kfu038
SN  - 1094-2025
VL  - 139
IS  - 2
SP  - 501
EP  - 511
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - BOOK
A1  - Jochim, Haldor E.
A1  - Lademann, Frank
T1  - Planung von Bahnanlagen: Grundlagen - Planung - Berechnung
Y1  - 2018
SN  - 978-3-446-44220-7
U6  - https://doi.org/10.3139/9783446448940
PB  - Fachbuchverlag Leipzig im Carl Hanser Verlag
CY  - München
ET  - 2., aktualisierte und erweiterte Auflage
ER  -