TY - CHAP A1 - Pfetsch, Marc E. A1 - Abele, Eberhard A1 - Altherr, Lena A1 - Bölling, Christian A1 - Brötz, Nicolas A1 - Dietrich, Ingo A1 - Gally, Tristan A1 - Geßner, Felix A1 - Groche, Peter A1 - Hoppe, Florian A1 - Kirchner, Eckhard A1 - Kloberdanz, Hermann A1 - Knoll, Maximilian A1 - Kolvenbach, Philip A1 - Kuttich-Meinlschmidt, Anja A1 - Leise, Philipp A1 - Lorenz, Ulf A1 - Matei, Alexander A1 - Molitor, Dirk A. A1 - Niessen, Pia A1 - Pelz, Peter F. A1 - Rexer, Manuel A1 - Schmitt, Andreas A1 - Schmitt, Johann M. A1 - Schulte, Fiona A1 - Ulbrich, Stefan A1 - Weigold, Matthias T1 - Strategies for mastering uncertainty T2 - Mastering uncertainty in mechanical engineering N2 - This chapter describes three general strategies to master uncertainty in technical systems: robustness, flexibility and resilience. It builds on the previous chapters about methods to analyse and identify uncertainty and may rely on the availability of technologies for particular systems, such as active components. Robustness aims for the design of technical systems that are insensitive to anticipated uncertainties. Flexibility increases the ability of a system to work under different situations. Resilience extends this characteristic by requiring a given minimal functional performance, even after disturbances or failure of system components, and it may incorporate recovery. The three strategies are described and discussed in turn. Moreover, they are demonstrated on specific technical systems. Y1 - 2021 SN - 978-3-030-78353-2 U6 - https://doi.org/10.1007/978-3-030-78354-9_6 N1 - Part of the Springer Tracts in Mechanical Engineering book series (STME) SP - 365 EP - 456 PB - Springer CY - Cham ER - TY - JOUR A1 - Kämper, Klaus-Peter A1 - Picard, A. A1 - Schütze, A. T1 - Die Ausbildungsfoundry pro-mst und das virtuelle Technologielabor: Ein Konzept für eine exzellente praktische MST-Ausbildung in einem modernen Reinraum zu niedrigen Gesamtkosten. Picard, A.; Kämper, K.-P.; Schütze, A. JF - Mikrosystemtechnik-Kongress 2005 : 10. bis 12. Oktober 2005 in Freiburg ; gemeinsame Veranstaltung von: Bundesministerium für Bildung und Forschung (BMBF) ... / organisiert von: GMM VDE/VDI-Gesellschaft Mikroelektronik, Mikro- und Feinwerktechnik ... Chairman: Roland Zengerle Y1 - 2005 SN - 3-8007-2926-1 N1 - Mikrosystemtechnik-Kongress <2005, Freiburg, Breisgau> SP - 127 PB - VDE-Verl. CY - Berlin ER - TY - JOUR A1 - Kämper, Klaus-Peter A1 - Picard, A. A1 - Schütze, A. A1 - Wallach, D. T1 - Adopting the Foundry Concept of Semiconductor Fabrication on Educational Schemes and the Virtual Technology Lab (VTL). Picard, A.; Kämper, K.-P.; Schütze, A.; Wallach, D.; Walter, T. JF - Mst-News (2006) Y1 - 2006 SN - 0948-3128 SP - 15, 16 EP - u. 35 ER - TY - JOUR A1 - Kurz, R. A1 - Linder, Peter A1 - Trzewik, Jürgen A1 - Rüffer, M. A1 - Artmann, Gerhard A1 - Digel, Ilya A1 - Rothermel, A. A1 - Robitzki, A. A1 - Temiz Artmann, Aysegül T1 - Contractile tension and beating rates of self-exciting monolayers and 3D-tissue constructs of neonatal rat cardiomyocytes JF - Medical and Biological Engineering and Computing N2 - The CellDrum technology (The term 'CellDrum technology' includes a couple of slightly different technological setups for measuring lateral mechanical tension in various types of cell monolayers or 3D-tissue constructs) was designed to quantify the contraction rate and mechanical tension of self-exciting cardiac myocytes. Cells were grown either within flexible, circular collagen gels or as monolayer on top of respective 1-mum thin silicone membranes. Membrane and cells were bulged outwards by air pressure. This biaxial strain distribution is rather similar the beating, blood-filled heart. The setup allowed presetting the mechanical residual stress level externally by adjusting the centre deflection, thus, mimicking hypertension in vitro. Tension was measured as oscillating differential pressure change between chamber and environment. A 0.5-mm thick collagen-cardiac myocyte tissue construct induced after 2 days of culturing (initial cell density 2 x 10(4) cells/ml), a mechanical tension of 1.62 +/- 0.17 microN/mm(2). Mechanical load is an important growth regulator in the developing heart, and the orientation and alignment of cardiomyocytes is stress sensitive. Therefore, it was necessary to develop the CellDrum technology with its biaxial stress-strain distribution and defined mechanical boundary conditions. Cells were exposed to strain in two directions, radially and circumferentially, which is similar to biaxial loading in real heart tissues. Thus, from a biomechanical point of view, the system is preferable to previous setups based on uniaxial stretching. Y1 - 2010 U6 - https://doi.org/10.1007/s11517-009-0552-y SN - 1741-0444 VL - 48 IS - 1 SP - 59 EP - 65 PB - Springer Nature CY - Cham ER - TY - JOUR A1 - Krause, Gregor A1 - Forsyth, Paul A. A1 - Peter, Till T1 - Robuste Filter in der Energieversorgung / Paul A. Forsyth, Gregor Krause, Till Peter JF - ETZ. 114 (1993), H. 22 Y1 - 1993 N1 - Printausgabe: Aachen Eupener Str.: 23 Z 133; Jülich: 63 ZS 035 SP - 1382 EP - 1385 ER - TY - JOUR A1 - Kämper, Klaus-Peter A1 - Berg, U. A1 - Wolf, A. A1 - Lehr, H. T1 - Entwicklung von Linsenhaltern für ein SMIF-kompatibles Magazinsystem und deren Fertigung durch Mikrospritzguß. Berg, U.; Kämper, K.-P.; Wolf, A.; Lehr, H.; Ehrfeld, W. JF - Produktionstechnik für Mikrosysteme. IPA-Seminar, 5. und 6. November 1996, Stuttgart. Pro Mikro. Fraunhofer-Institut für Produktionstechnik und Automatisierung -IPA-, Stuttgart Y1 - 1996 ER - TY - JOUR A1 - Kämper, Klaus-Peter A1 - Schmitt, W. A1 - Wesner, D. A. A1 - Güntherodt, G. T1 - Thickness dependence of the spin- and angle-resolved photoemission of ultrathin, epitaxial Ni(111)/W(110) layers JF - Applied Physics A: Materials Science and Processing. 49 (1989), H. 6 Y1 - 1989 SN - 1432-0630 SP - 573 EP - 578 ER - TY - JOUR A1 - Sparla, Peter A1 - Benning, W. A1 - Sieprath, A. T1 - Berührungslose 3D-Vermessung von Sickerwasserschächten im Deponiebereich JF - Vermessungswesen und Raumordnung : VR. 57 (1995), H. 7-8 Y1 - 1995 SN - 0340-5141 SP - 397 EP - 407 ER - TY - JOUR A1 - Prume, Klaus A1 - Peter, F. A1 - Rüdiger, A. A1 - Dittmann, R. T1 - Analysis of shape effects on the piezoresponse in ferroelectric nanograins with and without adsorbates / Peter, F. ; Rüdiger, A. ; Dittmann, R. ; Waser, R. ; Szot, K. ; Reichenberg, B. ; Prume, K. ; JF - Applied Physics Letters . 87 (2005), H. 8 Y1 - 2005 SN - 0003-6951 SP - 082901 EP - 082901-3 ER - TY - JOUR A1 - Immel, Timo A. A1 - Groth, Ulrich A1 - Huhn, Thomas A1 - Öhlschläger, Peter T1 - Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice JF - PLoS ONE N2 - The anticancer activity of titanium complexes has been known since the groundbreaking studies of Köpf and Köpf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan complexes are much more stabile in aqueous media. In this study we describe the biological activity of two titanium salan complexes in a mouse model of cervical cancer. High efficiency of this promising complex family was demonstrated for the first time in vivo. From these data we conclude that titanium salan complexes display very strong antitumor properties exhibiting only minor side effects. Our results may influence the chemotherapy with metallo therapeutics in the future. Y1 - 2011 U6 - https://doi.org/10.1371/journal.pone.0017869 VL - 6 IS - 3 PB - Plos CY - San Francisco, California, US ER -