TY - CHAP A1 - Pfetsch, Marc E. A1 - Abele, Eberhard A1 - Altherr, Lena A1 - Bölling, Christian A1 - Brötz, Nicolas A1 - Dietrich, Ingo A1 - Gally, Tristan A1 - Geßner, Felix A1 - Groche, Peter A1 - Hoppe, Florian A1 - Kirchner, Eckhard A1 - Kloberdanz, Hermann A1 - Knoll, Maximilian A1 - Kolvenbach, Philip A1 - Kuttich-Meinlschmidt, Anja A1 - Leise, Philipp A1 - Lorenz, Ulf A1 - Matei, Alexander A1 - Molitor, Dirk A. A1 - Niessen, Pia A1 - Pelz, Peter F. A1 - Rexer, Manuel A1 - Schmitt, Andreas A1 - Schmitt, Johann M. A1 - Schulte, Fiona A1 - Ulbrich, Stefan A1 - Weigold, Matthias T1 - Strategies for mastering uncertainty T2 - Mastering uncertainty in mechanical engineering N2 - This chapter describes three general strategies to master uncertainty in technical systems: robustness, flexibility and resilience. It builds on the previous chapters about methods to analyse and identify uncertainty and may rely on the availability of technologies for particular systems, such as active components. Robustness aims for the design of technical systems that are insensitive to anticipated uncertainties. Flexibility increases the ability of a system to work under different situations. Resilience extends this characteristic by requiring a given minimal functional performance, even after disturbances or failure of system components, and it may incorporate recovery. The three strategies are described and discussed in turn. Moreover, they are demonstrated on specific technical systems. Y1 - 2021 SN - 978-3-030-78353-2 U6 - https://doi.org/10.1007/978-3-030-78354-9_6 N1 - Part of the Springer Tracts in Mechanical Engineering book series (STME) SP - 365 EP - 456 PB - Springer CY - Cham ER - TY - JOUR A1 - Kämper, Klaus-Peter A1 - Picard, A. A1 - Schütze, A. T1 - Die Ausbildungsfoundry pro-mst und das virtuelle Technologielabor: Ein Konzept für eine exzellente praktische MST-Ausbildung in einem modernen Reinraum zu niedrigen Gesamtkosten. Picard, A.; Kämper, K.-P.; Schütze, A. JF - Mikrosystemtechnik-Kongress 2005 : 10. bis 12. Oktober 2005 in Freiburg ; gemeinsame Veranstaltung von: Bundesministerium für Bildung und Forschung (BMBF) ... / organisiert von: GMM VDE/VDI-Gesellschaft Mikroelektronik, Mikro- und Feinwerktechnik ... Chairman: Roland Zengerle Y1 - 2005 SN - 3-8007-2926-1 N1 - Mikrosystemtechnik-Kongress <2005, Freiburg, Breisgau> SP - 127 PB - VDE-Verl. CY - Berlin ER - TY - JOUR A1 - Kämper, Klaus-Peter A1 - Picard, A. A1 - Schütze, A. A1 - Wallach, D. T1 - Adopting the Foundry Concept of Semiconductor Fabrication on Educational Schemes and the Virtual Technology Lab (VTL). Picard, A.; Kämper, K.-P.; Schütze, A.; Wallach, D.; Walter, T. JF - Mst-News (2006) Y1 - 2006 SN - 0948-3128 SP - 15, 16 EP - u. 35 ER - TY - JOUR A1 - Kurz, R. A1 - Linder, Peter A1 - Trzewik, Jürgen A1 - Rüffer, M. A1 - Artmann, Gerhard A1 - Digel, Ilya A1 - Rothermel, A. A1 - Robitzki, A. A1 - Temiz Artmann, Aysegül T1 - Contractile tension and beating rates of self-exciting monolayers and 3D-tissue constructs of neonatal rat cardiomyocytes JF - Medical and Biological Engineering and Computing N2 - The CellDrum technology (The term 'CellDrum technology' includes a couple of slightly different technological setups for measuring lateral mechanical tension in various types of cell monolayers or 3D-tissue constructs) was designed to quantify the contraction rate and mechanical tension of self-exciting cardiac myocytes. Cells were grown either within flexible, circular collagen gels or as monolayer on top of respective 1-mum thin silicone membranes. Membrane and cells were bulged outwards by air pressure. This biaxial strain distribution is rather similar the beating, blood-filled heart. The setup allowed presetting the mechanical residual stress level externally by adjusting the centre deflection, thus, mimicking hypertension in vitro. Tension was measured as oscillating differential pressure change between chamber and environment. A 0.5-mm thick collagen-cardiac myocyte tissue construct induced after 2 days of culturing (initial cell density 2 x 10(4) cells/ml), a mechanical tension of 1.62 +/- 0.17 microN/mm(2). Mechanical load is an important growth regulator in the developing heart, and the orientation and alignment of cardiomyocytes is stress sensitive. Therefore, it was necessary to develop the CellDrum technology with its biaxial stress-strain distribution and defined mechanical boundary conditions. Cells were exposed to strain in two directions, radially and circumferentially, which is similar to biaxial loading in real heart tissues. Thus, from a biomechanical point of view, the system is preferable to previous setups based on uniaxial stretching. Y1 - 2010 U6 - https://doi.org/10.1007/s11517-009-0552-y SN - 1741-0444 VL - 48 IS - 1 SP - 59 EP - 65 PB - Springer Nature CY - Cham ER - TY - JOUR A1 - Krause, Gregor A1 - Forsyth, Paul A. A1 - Peter, Till T1 - Robuste Filter in der Energieversorgung / Paul A. Forsyth, Gregor Krause, Till Peter JF - ETZ. 114 (1993), H. 22 Y1 - 1993 N1 - Printausgabe: Aachen Eupener Str.: 23 Z 133; Jülich: 63 ZS 035 SP - 1382 EP - 1385 ER - TY - JOUR A1 - Kämper, Klaus-Peter A1 - Berg, U. A1 - Wolf, A. A1 - Lehr, H. T1 - Entwicklung von Linsenhaltern für ein SMIF-kompatibles Magazinsystem und deren Fertigung durch Mikrospritzguß. Berg, U.; Kämper, K.-P.; Wolf, A.; Lehr, H.; Ehrfeld, W. JF - Produktionstechnik für Mikrosysteme. IPA-Seminar, 5. und 6. November 1996, Stuttgart. Pro Mikro. Fraunhofer-Institut für Produktionstechnik und Automatisierung -IPA-, Stuttgart Y1 - 1996 ER - TY - JOUR A1 - Kämper, Klaus-Peter A1 - Schmitt, W. A1 - Wesner, D. A. A1 - Güntherodt, G. T1 - Thickness dependence of the spin- and angle-resolved photoemission of ultrathin, epitaxial Ni(111)/W(110) layers JF - Applied Physics A: Materials Science and Processing. 49 (1989), H. 6 Y1 - 1989 SN - 1432-0630 SP - 573 EP - 578 ER - TY - JOUR A1 - Sparla, Peter A1 - Benning, W. A1 - Sieprath, A. T1 - Berührungslose 3D-Vermessung von Sickerwasserschächten im Deponiebereich JF - Vermessungswesen und Raumordnung : VR. 57 (1995), H. 7-8 Y1 - 1995 SN - 0340-5141 SP - 397 EP - 407 ER - TY - JOUR A1 - Prume, Klaus A1 - Peter, F. A1 - Rüdiger, A. A1 - Dittmann, R. T1 - Analysis of shape effects on the piezoresponse in ferroelectric nanograins with and without adsorbates / Peter, F. ; Rüdiger, A. ; Dittmann, R. ; Waser, R. ; Szot, K. ; Reichenberg, B. ; Prume, K. ; JF - Applied Physics Letters . 87 (2005), H. 8 Y1 - 2005 SN - 0003-6951 SP - 082901 EP - 082901-3 ER - TY - JOUR A1 - Immel, Timo A. A1 - Groth, Ulrich A1 - Huhn, Thomas A1 - Öhlschläger, Peter T1 - Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice JF - PLoS ONE N2 - The anticancer activity of titanium complexes has been known since the groundbreaking studies of Köpf and Köpf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan complexes are much more stabile in aqueous media. In this study we describe the biological activity of two titanium salan complexes in a mouse model of cervical cancer. High efficiency of this promising complex family was demonstrated for the first time in vivo. From these data we conclude that titanium salan complexes display very strong antitumor properties exhibiting only minor side effects. Our results may influence the chemotherapy with metallo therapeutics in the future. Y1 - 2011 U6 - https://doi.org/10.1371/journal.pone.0017869 VL - 6 IS - 3 PB - Plos CY - San Francisco, California, US ER - TY - JOUR A1 - Fischer, W. A. A1 - Dören, Horst-Peter A1 - Janke, Dieter T1 - Aluminium nitride probes for application in iron melts JF - Archiv für das Eisenhüttenwesen. 52 (1981), H. 3 Y1 - 1981 SN - 0003-8962 SP - 91 EP - 98 ER - TY - JOUR A1 - Henken, F. E. A1 - Oosterhuis, K. A1 - Öhlschläger, Peter A1 - Bosch, L. A1 - Hooijberg, E. A1 - Haanen, J. B. A. G. A1 - Steenbergen, R. D. M. T1 - Preclinical safety evaluation of DNA vaccines encoding modified HPV16 E6 and E7 JF - Vaccine N2 - Persistent infection with high-risk human papillomaviruses (hrHPV) can result in the formation of anogenital cancers. As hrHPV proteins E6 and E7 are required for cancer initiation and maintenance, they are ideal targets for immunotherapeutic interventions. Previously, we have described the development of DNA vaccines for the induction of HPV16 E6 and E7 specific T cell immunity. These vaccines consist of ‘gene-shuffled’ (SH) versions of HPV16 E6 and E7 that were fused to Tetanus Toxin Fragment C domain 1 (TTFC) and were named TTFC-E6SH and TTFC-E7SH. Gene-shuffling was performed to avoid the risk of inducing malignant transformation at the vaccination site. Here, we describe the preclinical safety evaluation of these candidate vaccines by analysis of their transforming capacity in vitro using established murine fibroblasts (NIH 3T3 cells) and primary human foreskin keratinocytes (HFKs). We demonstrate that neither ectopic expression of TTFC-E6SH and TTFC-E7SH alone or in combination enabled NIH 3T3 cells to form colonies in soft agar. In contrast, expression of HPV16 E6WT and E7WT alone or in combination resulted in effective transformation. Similarly, retroviral transduction of HFKs from three independent donors with both TTFC-E6SH and TTFC-E7SH alone or in combination did not show any signs of immortalization. In contrast, the combined expression of E6WT and E7WT induced immortalization in HFKs from all donors. Based on these results we consider it justified to proceed to clinical evaluation of DNA vaccines encoding TTFC-E6SH and TTFC-E7SH in patients with HPV16 associated (pre)malignancies. Y1 - 2012 U6 - https://doi.org/10.1016/j.vaccine.2012.04.013 SN - 0264-410X VL - 30 IS - 28 SP - 4259 EP - 4266 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Kowalski, Julia A1 - Linder, Peter A1 - Zierke, S. A1 - Wulfen, B. van A1 - Clemens, J. A1 - Konstantinidis, K. A1 - Ameres, G. A1 - Hoffmann, R. A1 - Mikucki, J. A1 - Tulaczyk, S. A1 - Funke, O. A1 - Blandfort, D. A1 - Espe, Clemens A1 - Feldmann, Marco A1 - Francke, Gero A1 - Hiecker, S. A1 - Plescher, Engelbert A1 - Schöngarth, Sarah A1 - Dachwald, Bernd A1 - Digel, Ilya A1 - Artmann, Gerhard A1 - Eliseev, D. A1 - Heinen, D. A1 - Scholz, F. A1 - Wiebusch, C. A1 - Macht, S. A1 - Bestmann, U. A1 - Reineking, T. A1 - Zetzsche, C. A1 - Schill, K. A1 - Förstner, R. A1 - Niedermeier, H. A1 - Szumski, A. A1 - Eissfeller, B. A1 - Naumann, U. A1 - Helbing, K. T1 - Navigation technology for exploration of glacier ice with maneuverable melting probes JF - Cold Regions Science and Technology N2 - The Saturnian moon Enceladus with its extensive water bodies underneath a thick ice sheet cover is a potential candidate for extraterrestrial life. Direct exploration of such extraterrestrial aquatic ecosystems requires advanced access and sampling technologies with a high level of autonomy. A new technological approach has been developed as part of the collaborative research project Enceladus Explorer (EnEx). The concept is based upon a minimally invasive melting probe called the IceMole. The force-regulated, heater-controlled IceMole is able to travel along a curved trajectory as well as upwards. Hence, it allows maneuvers which may be necessary for obstacle avoidance or target selection. Maneuverability, however, necessitates a sophisticated on-board navigation system capable of autonomous operations. The development of such a navigational system has been the focal part of the EnEx project. The original IceMole has been further developed to include relative positioning based on in-ice attitude determination, acoustic positioning, ultrasonic obstacle and target detection integrated through a high-level sensor fusion. This paper describes the EnEx technology and discusses implications for an actual extraterrestrial mission concept. Y1 - 2016 U6 - https://doi.org/10.1016/j.coldregions.2015.11.006 SN - 0165-232X IS - 123 SP - 53 EP - 70 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Belavy, Daniel L. A1 - Albracht, Kirsten A1 - Bruggemann, Gert-Peter A1 - Vergroesen, Pieter-Paul A. A1 - Dieen, Jaap H. van T1 - Can exercise positively influence the intervertebral disc? JF - Sports Medicine N2 - To better understand what kinds of sports and exercise could be beneficial for the intervertebral disc (IVD), we performed a review to synthesise the literature on IVD adaptation with loading and exercise. The state of the literature did not permit a systematic review; therefore, we performed a narrative review. The majority of the available data come from cell or whole-disc loading models and animal exercise models. However, some studies have examined the impact of specific sports on IVD degeneration in humans and acute exercise on disc size. Based on the data available in the literature, loading types that are likely beneficial to the IVD are dynamic, axial, at slow to moderate movement speeds, and of a magnitude experienced in walking and jogging. Static loading, torsional loading, flexion with compression, rapid loading, high-impact loading and explosive tasks are likely detrimental for the IVD. Reduced physical activity and disuse appear to be detrimental for the IVD. We also consider the impact of genetics and the likelihood of a ‘critical period’ for the effect of exercise in IVD development. The current review summarises the literature to increase awareness amongst exercise, rehabilitation and ergonomic professionals regarding IVD health and provides recommendations on future directions in research. KW - Intradiscal Pressure KW - Annulus Fibrosus KW - Disc Degeneration KW - Nucleus Pulposus KW - Intervertebral Disc Y1 - 2016 U6 - https://doi.org/10.1007/s40279-015-0444-2 SN - 1179-2035 VL - 46 IS - 4 SP - 473 EP - 485 PB - Springer CY - Berlin ER - TY - JOUR A1 - Digel, Ilya A1 - Wehlitz, V. A1 - Kayser, Peter A1 - Figiel-Lange, A. A1 - Bassam, R. A1 - Rundstedt, F. von T1 - Suspension depletion approach for exemption of infected Solanum jasminoides cells from pospiviroids JF - Plant Pathology N2 - Despite numerous studies, viroid elimination from infected plants remains a very challenging task. This study introduces for the first time a novel ‘suspension depletion’ approach for exemption of Solanum jasminoides plants from viroids. The proposed method implies initial establishment of suspension cultures of the infected plant cells. The suspended cells were then physically treated (mild thermotherapy, 33 °C), which presumably delayed the replication of the viroid. The viroid concentration in the treated biomass was monitored weekly using pospiviroid-specific PCR. After 10–12 weeks of continuous treatment, a sufficient decrease in viroid concentration was observed such that the infection became undetectable by PCR. The treated single cells then gave rise to microcolonies on a solid culture medium and the obtained viroid-negative clones were further promoted to regenerate into viroid-free plants. Three years of accumulated experimental data suggests feasibility, broad applicability, and good efficacy of the proposed approach. Y1 - 2018 U6 - https://doi.org/10.1111/ppa.12750 SN - 1365-3059 VL - 67 IS - 2 SP - 358 EP - 365 PB - Wiley CY - Oxford ER - TY - CHAP A1 - Grundmann, Jan Thimo A1 - Bauer, Waldemar A1 - Boden, Ralf Christian A1 - Ceriotti, Matteo A1 - Cordero, Federico A1 - Dachwald, Bernd A1 - Dumont, Etienne A1 - Grimm, Christian D. A1 - Hercik, D. A1 - Herique, A. A1 - Ho, Tra-Mi A1 - Jahnke, Rico A1 - Kofman, Wlodek A1 - Lange, Caroline A1 - Lichtenheldt, Roy A1 - McInnes, Colin R. A1 - Mikschl, Tobias A1 - Montenegro, Sergio A1 - Moore, Iain A1 - Pelivan, Ivanka A1 - Peloni, Alessandro A1 - Plettenmeier, Dirk A1 - Quantius, Dominik A1 - Reershemius, Siebo A1 - Renger, Thomas A1 - Riemann, Johannes A1 - Rogez, Yves A1 - Ruffer, Michael A1 - Sasaki, Kaname A1 - Schmitz, Nicole A1 - Seboldt, Wolfgang A1 - Seefeldt, Patric A1 - Spietz, Peter A1 - Spröwitz, Tom A1 - Sznajder, Maciej A1 - Toth, Norbert A1 - Viavattene, Giulia A1 - Wejmo, Elisabet A1 - Wolff, Friederike A1 - Ziach, Christian T1 - Responsive exploration and asteroid characterization through integrated solar sail and lander development using small spacecraft technologies T2 - IAA Planetary Defense Conference N2 - In parallel to the evolution of the Planetary Defense Conference, the exploration of small solar system bodies has advanced from fast fly-bys on the sidelines of missions to the planets to the implementation of dedicated sample-return and in-situ analysis missions. Spacecraft of all sizes have landed, touch-and-go sampled, been gently beached, or impacted at hypervelocity on asteroid and comet surfaces. More have flown by close enough to image their surfaces in detail or sample their immediate environment, often as part of an extended or re-purposed mission. And finally, full-scale planetary defense experiment missions are in the making. Highly efficient low-thrust propulsion is increasingly applied beyond commercial use also in mainstream and flagship science missions, in combination with gravity assist propulsion. Another development in the same years is the growth of small spacecraft solutions, not in size but in numbers and individual capabilities. The on-going NASA OSIRIS-REx and JAXA HAYABUSA2 missions exemplify the trend as well as the upcoming NEA SCOUT mission or the landers MINERVA-II and MASCOT recently deployed on Ryugu. We outline likely as well as possible and efficient routes of continuation of all these developments towards a propellant-less and highly efficient class of spacecraft for small solar system body exploration: small spacecraft solar sails designed for carefree handling and equipped with carried landers and application modules, for all asteroid user communities –planetary science, planetary defence, and in-situ resource utilization. This projection builds on the experience gained in the development of deployable membrane structures leading up to the successful ground deployment test of a (20 m)² solar sail at DLR Cologne and in the 20 years since. It draws on the background of extensive trajectory optimization studies, the qualified technology of the DLR GOSSAMER-1 deployment demonstrator, and the MASCOT asteroid lander. These enable ‘now-term’ as well as near-term hardware solutions, and thus responsive fast-paced development. Mission types directly applicable to planetary defense include: single and Multiple NEA Rendezvous ((M)NR) for mitigation precursor, target monitoring and deflection follow-up tasks; sail-propelled head-on retrograde kinetic impactors (RKI) for mitigation; and deployable membrane based methods to modify the asteroid’s properties or interact with it. The DLR-ESTEC GOSSAMER Roadmap initiated studies of missions uniquely feasible with solar sails such as Displaced L1 (DL1) space weather advance warning and monitoring and Solar Polar Orbiter (SPO) delivery which demonstrate the capability of near-term solar sails to achieve NEA rendezvous in any kind of orbit, from Earth-coorbital to extremely inclined and even retrograde orbits. For those mission types using separable payloads, such as SPO, (M)NR and RKI, design concepts can be derived from the separable Boom Sail Deployment Units characteristic of DLR GOSSAMER solar sail technology, nanolanders like MASCOT, or microlanders like the JAXA-DLR Jupiter Trojan Asteroid Lander for the OKEANOS mission which can shuttle from the sail to the asteroids visited and enable multiple NEA sample-return missions. These are an ideal match for solar sails in micro-spacecraft format whose launch configurations are compatible with ESPA and ASAP secondary payload platforms. Y1 - 2019 N1 - Conference: IAA Planetary Defense ConferenceAt: Washington DC, USA 29.04-03.05.2019 ER - TY - CHAP A1 - Grundmann, Jan Thimo A1 - Bauer, Waldemar A1 - Boden, Ralf Christian A1 - Ceriotti, Matteo A1 - Cordero, Federico A1 - Dachwald, Bernd A1 - Dumont, Etienne A1 - Grimm, Christian D. A1 - Hercik, D. A1 - Herique, A. A1 - Ho, Tra-Mi A1 - Jahnke, Rico A1 - Kofman, Wlodek A1 - Lange, Caroline A1 - Lichtenheldt, Roy A1 - McInnes, Colin R. A1 - Mikschl, Tobias A1 - Mikulz, Eugen A1 - Montenegro, Sergio A1 - Moore, Iain A1 - Pelivan, Ivanka A1 - Peloni, Alessandro A1 - Plettemeier, Dirk A1 - Quantius, Dominik A1 - Reershemius, Siebo A1 - Renger, Thomas A1 - Riemann, Johannes A1 - Rogez, Yves A1 - Ruffer, Michael A1 - Sasaki, Kaname A1 - Schmitz, Nicole A1 - Seboldt, Wolfgang A1 - Seefeldt, Patric A1 - Spietz, Peter A1 - Spröwitz, Tom A1 - Sznajder, Maciej A1 - Toth, Norbert A1 - Viavattene, Giulia A1 - Wejmo, Elisabet A1 - Wolff, Friederike A1 - Ziach, Christian T1 - Responsive integrated small spacecraft solar sail and payload design concepts and missions T2 - Conference: 5th International Symposium on Solar Sailing (ISSS 2019) N2 - Asteroid mining has the potential to greatly reduce the cost of in-space manufacturing, production of propellant for space transportation and consumables for crewed spacecraft, compared to launching the required resources from Earth’s deep gravity well. This paper discusses the top-level mission architecture and trajectory design for these resource-return missions, comparing high-thrust trajectories with continuous low-thrust solar-sail trajectories. This work focuses on maximizing the economic Net Present Value, which takes the time-cost of finance into account and therefore balances the returned resource mass and mission duration. The different propulsion methods will then be compared in terms of maximum economic return, sets of attainable target asteroids, and mission flexibility. This paper provides one more step towards making commercial asteroid mining an economically viable reality by integrating trajectory design, propulsion technology and economic modelling. Y1 - 2019 N1 - Conference: 5th International Symposium on Solar Sailing (ISSS 2019)At: Aachen, Germany ER - TY - CHAP A1 - Butenweg, Christoph A1 - Marinković, Marko A1 - Pavese, Alberto A1 - Lanese, Igor A1 - Hoffmeister, Benno A1 - Pinkawa, Marius A1 - Vulcu, Mihai-Cristian A1 - Bursi, Oreste A1 - Nardin, Chiara A1 - Paolacci, Fabrizio A1 - Quinci, Gianluca A1 - Fragiadakis, Michalis A1 - Weber, Felix A1 - Huber, Peter A1 - Renault, Philippe A1 - Gündel, Max A1 - Dyke, Shirley A1 - Ciucci, M. A1 - Marino, A. T1 - Seismic performance of multi-component systems in special risk industrial facilities T2 - Proceedings of the seventeenth world conference on earthquake engineering N2 - Past earthquakes demonstrated the high vulnerability of industrial facilities equipped with complex process technologies leading to serious damage of the process equipment and multiple and simultaneous release of hazardous substances in industrial facilities. Nevertheless, the design of industrial plants is inadequately described in recent codes and guidelines, as they do not consider the dynamic interaction between the structure and the installations and thus the effect of seismic response of the installations on the response of the structure and vice versa. The current code-based approach for the seismic design of industrial facilities is considered not enough for ensure proper safety conditions against exceptional event entailing loss of content and related consequences. Accordingly, SPIF project (Seismic Performance of Multi- Component Systems in Special Risk Industrial Facilities) was proposed within the framework of the European H2020 - SERA funding scheme (Seismology and Earthquake Engineering Research Infrastructure Alliance for Europe). The objective of the SPIF project is the investigation of the seismic behavior of a representative industrial structure equipped with complex process technology by means of shaking table tests. The test structure is a three-story moment resisting steel frame with vertical and horizontal vessels and cabinets, arranged on the three levels and connected by pipes. The dynamic behavior of the test structure and installations is investigated with and without base isolation. Furthermore, both firmly anchored and isolated components are taken into account to compare their dynamic behavior and interactions with each other. Artificial and synthetic ground motions are applied to study the seismic response at different PGA levels. After each test, dynamic identification measurements are carried out to characterize the system condition. The contribution presents the numerical simulations to calibrate the tests on the prototype, the experimental setup of the investigated structure and installations, selected measurement data and finally describes preliminary experimental results. KW - industrial facilities KW - piping KW - installations KW - seismic loading KW - earthquakes Y1 - 2021 N1 - 17. World Conference on Earthquake Engineering, 17WCEE, Sendai, Japan, 2021-09-27 - 2021-10-02 ER - TY - JOUR A1 - Gräßl, Andreas A1 - Renz, Wolfgang A1 - Hezel, Fabian A1 - Dieringer, Matthias A. A1 - Winter, Lukas A1 - Özerdem, Celal A1 - Rieger, Jan A1 - Kellmann, Peter A1 - Santoro, Davide A1 - Lindel, Tomasz D. A1 - Frauenrath, Tobias A1 - Pfeiffer, Harald A1 - Niendorf, Thoralf T1 - Modular 32-channel transceiver coil array for cardiac MRI at 7.0T JF - Magnetic Resonance in Medicine N2 - Purpose To design and evaluate a modular transceiver coil array with 32 independent channels for cardiac MRI at 7.0T. Methods The modular coil array comprises eight independent building blocks, each containing four transceiver loop elements. Numerical simulations were used for B1+ field homogenization and radiofrequency (RF) safety validation. RF characteristics were examined in a phantom study. The array's suitability for accelerated high spatial resolution two-dimensional (2D) FLASH CINE imaging of the heart was examined in a volunteer study. Results Transmission field adjustments and RF characteristics were found to be suitable for the volunteer study. The signal-to-noise intrinsic to 7.0T together with the coil performance afforded a spatial resolution of 1.1 × 1.1 × 2.5 mm3 for 2D CINE FLASH MRI, which is by a factor of 6 superior to standardized CINE protocols used in clinical practice at 1.5T. The 32-channel transceiver array supports one-dimensional acceleration factors of up to R = 4 without impairing image quality significantly. Conclusion The modular 32-channel transceiver cardiac array supports accelerated and high spatial resolution cardiac MRI. The array is compatible with multichannel transmission and provides a technological basis for future clinical assessment of parallel transmission techniques at 7.0T. Y1 - 2013 U6 - https://doi.org/10.1002/mrm.24903 SN - 1522-2594 VL - 72 IS - 1 SP - 276 EP - 290 PB - Wiley-Liss CY - New York ER - TY - GEN A1 - Eccleston, Paul A1 - Drummond, Rachel A1 - Middleton, Kevin A1 - Bishop, Georgia A1 - Caldwell, Andrew A1 - Desjonqueres, Lucile A1 - Tosh, Ian A1 - Cann, Nick A1 - Crook, Martin A1 - Hills, Matthew A1 - Pearson, Chris A1 - Simpson, Caroline A1 - Stamper, Richard A1 - Tinetti, Giovanna A1 - Pascale, Enzo A1 - Swain, Mark A1 - Holmes, Warren A. A1 - Wong, Andre A1 - Puig, Ludovic A1 - Pilbratt, Göran A1 - Linder, Martin A1 - Boudin, Nathalie A1 - Ertel, Hanno A1 - Gambicorti, Lisa A1 - Halain, Jean-Philippe A1 - Pace, Emanuele A1 - Vilardell, Francesc A1 - Gómez, José M. A1 - Colomé, Josep A1 - Amiaux, Jérôme A1 - Cara, Christophe A1 - Berthe, Michel A1 - Moreau, Vincent A1 - Morgante, Gianluca A1 - Malaguti, Giuseppe A1 - Alonso, Gustavo A1 - Álvarez, Javier P. A1 - Ollivier, Marc A1 - Philippon, Anne A1 - Hellin, Marie-Laure A1 - Roose, Steve A1 - Frericks, Martin A1 - Krijger, Matthijs A1 - Rataj, Miroslaw A1 - Wawer, Piotr A1 - Skup, Konrad A1 - Sobiecki, Mateusz A1 - Christian Jessen, Niels A1 - Møller Pedersen, Søren A1 - Hargrave, Peter A1 - Griffin, Matt A1 - Ottensamer, Roland A1 - Hunt, Thomas A1 - Rust, Duncan A1 - Saleh, Aymen A1 - Winter, Berend A1 - Focardi, Mauro A1 - Da Deppo, Vania A1 - Zuppella, Paola A1 - Czupalla, Markus ED - Lystrup, Makenzie ED - Perrin, Marshall D. ED - Batalha, Natalie ED - Siegler, Nicholas ED - Tong, Edward C. T1 - The ARIEL payload: A technical overview T2 - Space Telescopes and Instrumentation 2020: Optical, Infrared, and Millimeter Wave N2 - The Atmospheric Remote-Sensing Infrared Exoplanet Large-survey, ARIEL, has been selected to be the next (M4) medium class space mission in the ESA Cosmic Vision programme. From launch in 2028, and during the following 4 years of operation, ARIEL will perform precise spectroscopy of the atmospheres of ~1000 known transiting exoplanets using its metre-class telescope. A three-band photometer and three spectrometers cover the 0.5 µm to 7.8 µm region of the electromagnetic spectrum. This paper gives an overview of the mission payload, including the telescope assembly, the FGS (Fine Guidance System) - which provides both pointing information to the spacecraft and scientific photometry and low-resolution spectrometer data, the ARIEL InfraRed Spectrometer (AIRS), and other payload infrastructure such as the warm electronics, structures and cryogenic cooling systems. KW - Exoplanet KW - Spectroscopy KW - Transit KW - Atmospheres KW - Payload Y1 - 2020 U6 - https://doi.org/10.1117/12.2561478 N1 - Space Telescopes and Instrumentation 2020: Optical, Infrared, and Millimeter Wave, 14–22 December 2020, Online Only, United States VL - 11443 SP - 114430Z PB - SPIE CY - Washington ER -