TY  - CHAP
A1  - Schmiegel, A.
A1  - Koch, K.
A1  - Dittmer, M.
A1  - Braun, M.
A1  - Landau, M.
A1  - Dick, C.
A1  - Bragard, Michael
A1  - [u.a.], 
T1  - Das Sol-ion System : ein System zur Optimierung des Eigenverbrauchs von PV-Strom
T2  - Photovoltaische Solarenergie : 25. Symposium ; 03. - 05. März 2010, Kloster Banz, Bad Staffelstein. - (Wissen für Profis)
Y1  - 2010
SN  - 978-3-941785-23-6
SP  - 354
EP  - 359
PB  - OTTI, Ostbayerisches Technologie-Transfer-Inst.
CY  - Regensburg
ER  - 
TY  - JOUR
A1  - Jordan, Sabine D.
A1  - Krüger, Markus
A1  - Willmes, Diana M.
A1  - Redemann, Nora
A1  - Wunderlich, F. Thomas
A1  - Brönneke, Hella S.
A1  - Merkwirth, Carsten
A1  - Kashkar, Hamid
A1  - Olkkonen, Vesa M.
A1  - Böttger, Thomas
A1  - Braun, Thomas
A1  - Seibler, Jost
A1  - Brüning, Jens C.
T1  - Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism
JF  - Nature Cell Biology
N2  - The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143–145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143–ORP8 pathway as a potential target for the treatment of obesity-associated diabetes.
Y1  - 2011
U6  - https://doi.org/10.1038/ncb2211
SN  - 1465-7392
VL  - 13
IS  - 4
SP  - 434
EP  - 446
PB  - Nature
CY  - New York
ER  - 
TY  - CHAP
A1  - Braun, Carsten
A1  - Boucke, Alexander
A1  - Hanke, M.
A1  - Karavas, Alexandros
A1  - Ballmann, Josef
T1  - Prediction of the model deformation of a high speed transport aircraft type wing by direct aeroelastic simulation
T2  - High performance computing in science and engineering '03. Transactions of the High Performance Computing Center Stuttgart (HLRS) 2003 /  Eds.: Egon Krause ...
Y1  - 2003
SN  - 978-3-540-40850-5
SP  - 331
EP  - 342
PB  - Springer
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Britten, G.
A1  - Braun, Carsten
A1  - Hesse, M.
A1  - Ballmann, Josef
T1  - Computational aeroelasticity with reduced structural models
T2  - Flow modulation and fluid-structure interaction at airplane wings : research results of the Collaborative Research Center SFB 401 at RWTH Aachen, University of Technology, Aachen, Germany / Josef Ballmann (Ed.) Notes on numerical fluid mechanics and multidisciplinary design. Vol. 84
Y1  - 2003
SN  - 3-540-40209-8
SP  - 275
EP  - 299
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Götten, Falk
A1  - Finger, Felix
A1  - Havermann, Marc
A1  - Braun, Carsten
A1  - Marino, M.
A1  - Bil, C.
T1  - Full configuration drag estimation of short-to-medium range fixed-wing UAVs and its impact on initial sizing optimization
JF  - CEAS Aeronautical Journal
N2  - The paper presents the derivation of a new equivalent skin friction coefficient for estimating the parasitic drag of short-to-medium range fixed-wing unmanned aircraft. The new coefficient is derived from an aerodynamic analysis of ten different unmanned aircraft used for surveillance, reconnaissance, and search and rescue missions. The aircraft is simulated using a validated unsteady Reynolds-averaged Navier Stokes approach. The UAV’s parasitic drag is significantly influenced by the presence of miscellaneous components like fixed landing gears or electro-optical sensor turrets. These components are responsible for almost half of an unmanned aircraft’s total parasitic drag. The new equivalent skin friction coefficient accounts for these effects and is significantly higher compared to other aircraft categories. It is used to initially size an unmanned aircraft for a typical reconnaissance mission. The improved parasitic drag estimation yields a much heavier unmanned aircraft when compared to the sizing results using available drag data of manned aircraft.
KW  - Parasitic drag
KW  - UAV
KW  - CFD
KW  - Aircraft sizing
Y1  - 2021
U6  - https://doi.org/10.1007/s13272-021-00522-w
SN  - 1869-5590 (Online)
SN  - 1869-5582 (Print)
N1  - Corresponding author: Falk Götten
VL  - 12
SP  - 589
EP  - 603
PB  - Springer
CY  - Berlin
ER  -