TY  - JOUR
A1  - Jordan, Sabine D.
A1  - Krüger, Markus
A1  - Willmes, Diana M.
A1  - Redemann, Nora
A1  - Wunderlich, F. Thomas
A1  - Brönneke, Hella S.
A1  - Merkwirth, Carsten
A1  - Kashkar, Hamid
A1  - Olkkonen, Vesa M.
A1  - Böttger, Thomas
A1  - Braun, Thomas
A1  - Seibler, Jost
A1  - Brüning, Jens C.
T1  - Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism
JF  - Nature Cell Biology
N2  - The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143–145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143–ORP8 pathway as a potential target for the treatment of obesity-associated diabetes.
Y1  - 2011
U6  - https://doi.org/10.1038/ncb2211
SN  - 1465-7392
VL  - 13
IS  - 4
SP  - 434
EP  - 446
PB  - Nature
CY  - New York
ER  - 
TY  - CHAP
A1  - Finger, Felix
A1  - Khalsa, R.
A1  - Kreyer, Jörg
A1  - Mayntz, Joscha
A1  - Braun, Carsten
A1  - Dahmann, Peter
A1  - Esch, Thomas
A1  - Kemper, Hans
A1  - Schmitz, O.
A1  - Bragard, Michael
T1  - An approach to propulsion system modelling for the conceptual design of hybrid-electric general aviation aircraft
T2  - Deutscher Luft- und Raumfahrtkongress 2019, 30.9.-2.10.2019, Darmstadt
N2  - In this paper, an approach to propulsion system modelling for hybrid-electric general aviation aircraft is presented. Because the focus is on general aviation aircraft, only combinations of electric motors and reciprocating combustion engines are explored. Gas turbine hybrids will not be considered. The level of the component's models is appropriate for the conceptual design stage. They are simple and adaptable, so that a wide range of designs with morphologically different propulsive system architectures can be quickly compared. Modelling strategies for both mass and efficiency of each part of the propulsion system (engine, motor, battery and propeller) will be presented.
Y1  - 2019
ER  - 
TY  - RPRT
A1  - Thoma, Andreas
A1  - Laarmann, Lukas
A1  - Merkens, Torsten
A1  - Franzke, Till
A1  - Möhren, Felix
A1  - Buttermann, Lilly
A1  - van der Weem, Dirk
A1  - Fischer, Maximilian
A1  - Misch, Philipp
A1  - Böhme, Mirijam
A1  - Röth, Thilo
A1  - Hebel, Christoph
A1  - Ritz, Thomas
A1  - Franke, Marina
A1  - Braun, Carsten
T1  - Entwicklung eines intermodalen Mobilitätskonzeptes für die Pilotregion NRW/Rhein-Maas Euregio und Schaffung voller Kundenakzeptanz durch Transfer von Standards aus dem PKW-Bereich auf ein Flugtaxi : Schlussbericht : Projektakronym: SkyCab (Kategorie B) : Laufzeit in Monaten: 6 : Hauptthema: Kategorie B: Innovative Ideen mit Bezug zu UAS/Flugtaxis
Y1  - 2020
N1  - Förderkennzeichen BMVI 45UAS1027A-F
PB  - FH Aachen
CY  - Aachen
ER  -