TY  - JOUR
A1  - Koch, Claudia
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Wege, Christian
T1  - Penicillin Detection by Tobacco Mosaic Virus-Assisted Colorimetric Biosensors
JF  - Nanotheranostics
N2  - The presentation of enzymes on viral scaffolds has beneficial effects such as an increased enzyme loading and a prolonged reusability in comparison to conventional immobilization platforms. Here, we used modified tobacco mosaic virus (TMV) nanorods as enzyme carriers in penicillin G detection for the first time. Penicillinase enzymes were conjugated with streptavidin and coupled to TMV rods by use of a bifunctional biotin-linker. Penicillinase-decorated TMV particles were characterized extensively in halochromic dye-based biosensing. Acidometric analyte detection was performed with bromcresol purple as pH indicator and spectrophotometry. The TMV-assisted sensors exhibited increased enzyme loading and strongly improved reusability, and higher analysis rates compared to layouts without viral adapters. They extended the half-life of the sensors from 4 - 6 days to 5 weeks and thus allowed an at least 8-fold longer use of the sensors. Using a commercial budget-priced penicillinase preparation, a detection limit of 100 µM penicillin was obtained. Initial experiments also indicate that the system may be transferred to label-free detection layouts.
Y1  - 2018
U6  - http://dx.doi.org/10.7150/ntno.22114
SN  - 2206-7418
VL  - 2
IS  - 2
SP  - 184
EP  - 196
PB  - Ivyspring
CY  - Sydney
ER  - 
TY  - CHAP
A1  - Finkenberger, Isabel Maria
A1  - Baumeister, Eva-Maria
A1  - Koch, Christian
T1  - Komplement und Verstärker : Wandel durch neue Allianzen
T1  - Amplifier and complement : creating change through new alliances
T2  - Komplement und Verstärker : zum Verhältnis von Stadtplanung, künstlerischen Praktiken und Kulturinstitutionen
Y1  - 2019
SN  - 978-3-86859-578-9
SP  - 10
EP  - 39
PB  - JOVIS Verlag
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Finkenberger, Isabel Maria
A1  - Baumeister, Eva-Maria
A1  - Koch, Christian
T1  - Komplement und Verstärker : der Diskurs geht weiter
T1  - Amplifier and complement : the discourse continues
T2  - Komplement und Verstärker : zum Verhältnis von Stadtplanung, künstlerischen Praktiken und Kulturinstitutionen
Y1  - 2019
SN  - 978-3-86859-578-9
SP  - 40
EP  - 49
PB  - JOVIS Verlag
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Finkenberger, Isabel Maria
A1  - Herbert, Saskia
A1  - Malorny, Thomas
A1  - Koch, Christian
T1  - Perforierte Wirklichkeit und mögliche Zukünfte : ein Gespräch
T1  - Perforated reality and possible futures : a conversation
T2  - Komplement und Verstärker : zum Verhältnis von Stadtplanung, künstlerischen Praktiken und Kulturinstitutionen
Y1  - 2019
SN  - 978-3-86859-578-9
SP  - 108
EP  - 129
PB  - JOVIS Verlag
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Finkenberger, Isabel Maria
A1  - Baumeister, Eva-Maria
A1  - Koch, Christian
T1  - Themen
T1  - Topics
T2  - Komplement und Verstärker: zum Verhältnis von Stadtplanung, künstlerischen Praktiken und Kulturinstitutionen
Y1  - 2019
SN  - 978-3-86859-578-9
SP  - 50
EP  - 57
PB  - JOVIS Verlag
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Grundmann, Jan Thimo
A1  - Lange, Caroline
A1  - Dachwald, Bernd
A1  - Grimm, Christian
A1  - Koch, Aaron
A1  - Ulamec, Stephan
T1  - Small Spacecraft in Planetary Defence Related Applications–Capabilities, Constraints, Challenges
T2  - IEEE Aerospace Conference
N2  - In this paper we present an overview of the characteristics and peculiarities of small spacecraft missions related to planetary defence applications. We provide a brief overview of small spacecraft missions to small solar system bodies. On this background we present recent missions and selected projects and related studies at the German Aerospace Center, DLR, that contribute to planetary defence related activities. These range from Earth orbit technology demonstrators to active science missions in interplanetary space. We provide a summary of experience from recently flown missions with DLR participation as well as a number of studies. These include PHILAE, the lander recently arrived on comet 67P/Churyumov-Gerasimenko aboard ESA’s ROSETTA comet rendezvous mission, and the Mobile Asteroid Surface Scout, MASCOT, now underway to near-Earth asteroid (162173) 1999 JU3 aboard the Japanese sample-return probe HAYABUSA-2. We introduce the differences between the conventional methods employed in the design, integration and testing of large spacecraft and the new approaches developed by small spacecraft projects. We expect that the practical experience that can be gained from projects on extremely
compressed timelines or with high-intensity operation phases on a newly explored small solar system body can contribute significantly to the study, preparation and realization of future planetary defence related missions. One is AIDA (Asteroid Impact & Deflection Assessment), a joint effort of ESA,JHU/APL, NASA, OCA and DLR, combining JHU/APL’s DART (Double Asteroid Redirection Test) and ESA’s AIM (Asteroid Impact Monitor) spacecraft in a mission towards
near-Eath binary asteroid (65803) Didymos.
KW  - small spacecraft
KW  - planetary defence
KW  - asteroid lander
KW  - solar sail
KW  - flotilla missions
Y1  - 2015
N1  - 2015 IEEE Aerospace Conference, 7.-13. Mar. 2015, Big Sky, Montana, USA.
SP  - 1
EP  - 18
ER  -