TY  - CHAP
A1  - Allal, D.
A1  - Bannister, R.
A1  - Buisman, K.
A1  - Capriglione, D.
A1  - Di Capua, G.
A1  - García-Patrón, M.
A1  - Gatzweiler, Thomas
A1  - Gellersen, F.
A1  - Harzheim, Thomas
A1  - Heuermann, Holger
A1  - Hoffmann, J.
A1  - Izbrodin, A.
A1  - Kuhlmann, K.
A1  - Lahbacha, K.
A1  - Maffucci, A.
A1  - Miele, G.
A1  - Mubarak, F.
A1  - Salter, M.
A1  - Pham, T.D.
A1  - Sayegh, A.
A1  - Singh, D.
A1  - Stein, F.
A1  - Zeier, M.
T1  - RF measurements for future communication applications: an overview
T2  - 2022 IEEE International Symposium on Measurements & Networking (M&N)
N2  - In this paper research activities developed within the FutureCom project are presented. The project, funded by the European Metrology Programme for Innovation and Research (EMPIR), aims at evaluating and characterizing: (i) active devices, (ii) signal- and power integrity of field programmable gate array (FPGA) circuits, (iii) operational performance of electronic circuits in real-world and harsh environments (e.g. below and above ambient temperatures and at different levels of humidity), (iv) passive inter-modulation (PIM) in communication systems considering different values of temperature and humidity corresponding to the typical operating conditions that we can experience in real-world scenarios. An overview of the FutureCom project is provided here, then the research activities are described.
KW  - FPGA
KW  - signal integrity
KW  - power integrity
KW  - passive inter-modulation
KW  - metrological characterization
Y1  - 2022
SN  - 978-1-6654-8362-9
SN  - 978-1-6654-8363-6
U6  - http://dx.doi.org/10.1109/MN55117.2022.9887740
SN  - 2639-5061
SN  - 2639-507X
N1  - 2022 IEEE International Symposium on Measurements & Networking (M&N), 18-20 July 2022, Padua, Italy.
SP  - 1
EP  - 6
PB  - IEEE
ER  - 
TY  - JOUR
A1  - Jordan, Sabine D.
A1  - Krüger, Markus
A1  - Willmes, Diana M.
A1  - Redemann, Nora
A1  - Wunderlich, F. Thomas
A1  - Brönneke, Hella S.
A1  - Merkwirth, Carsten
A1  - Kashkar, Hamid
A1  - Olkkonen, Vesa M.
A1  - Böttger, Thomas
A1  - Braun, Thomas
A1  - Seibler, Jost
A1  - Brüning, Jens C.
T1  - Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism
JF  - Nature Cell Biology
N2  - The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143–145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143–ORP8 pathway as a potential target for the treatment of obesity-associated diabetes.
Y1  - 2011
U6  - http://dx.doi.org/10.1038/ncb2211
SN  - 1465-7392
VL  - 13
IS  - 4
SP  - 434
EP  - 446
PB  - Nature
CY  - New York
ER  - 
TY  - JOUR
A1  - Esch, Thomas
A1  - Salber, W.
A1  - Kemper, Hans
A1  - Staay, F. van der
T1  - Der elektromechanische Ventiltrieb - Systembaustein für zukünftige Antriebskonzepte, Teil 2.
JF  - Motortechnische Zeitschrift (MTZ).
Y1  - 2001
U6  - http://dx.doi.org/10.1007/bf03227081
SN  - 0024-8525
VL  - 62
IS  - 1
SP  - 44
EP  - 55
PB  - Springer Nature
CY  - Basel
ER  - 
TY  - JOUR
A1  - Esch, Thomas
A1  - Salber, W.
A1  - Kemper, Hans
A1  - Staay, F. van der
T1  - Der elektromechanische Ventiltrieb - Systembaustein für zukünftige Antriebskonzepte, Teil 1.
JF  - Motortechnische Zeitschrift (MTZ).
Y1  - 2000
U6  - http://dx.doi.org/10.1007/bf03227081
SN  - 0024-8525
VL  - 61
IS  - 12
SP  - 826
EP  - 836
PB  - Springer Nature
CY  - Basel
ER  - 
TY  - JOUR
A1  - Esch, Thomas
A1  - Saupe, T.
A1  - Fahl, E.
A1  - Koch, F.
T1  - Verbrauchseinsparung durch bedarfsgerechten Antrieb der Nebenaggregate
JF  - Motortechnische Zeitschrift. 55 (1994), H. 7/8
Y1  - 1994
SN  - 0024-8525
SP  - 416
EP  - 431
ER  - 
TY  - JOUR
A1  - Mang, Thomas
A1  - Kolz, J.
A1  - Goga, N.
A1  - Casanova, F.
T1  - Spatial localization with single-sided NMR sensors / Kolz, J. ; Goga, N. ; Casanova, F. ; Mang, T. ; Blümich, B.
JF  - Applied Magnetic Resonance. 32 (2007), H. 1-2
Y1  - 2007
SN  - 0937-9347
SP  - 171
EP  - 184
ER  - 
TY  - CHAP
A1  - Takenaga, Shoko
A1  - Herrera, Cony F.
A1  - Werner, Frederik
A1  - Biselli, Manfred
A1  - Schnitzler, Thomas
A1  - Schöning, Michael Josef
A1  - Öhlschläger, Peter
A1  - Wagner, Torsten
T1  - Detection of the metabolic activity of cells by differential measurements based on a single light-addressable potentiometric sensor chip
T2  - 11. Dresdner Sensor-Symposium : 9.-11.12.2013
Y1  - 2013
SN  - 978-3-9813484-5-3
SP  - 63
EP  - 67
ER  - 
TY  - CHAP
A1  - Thomas, F.
A1  - Wollert, Jörg
T1  - Internet und OO-Systeme in der Logistik
T2  - Risikofaktor Software : Tagung Mannheim, 21. und 22.November 2000. (VDI-Berichte ; 1577)
Y1  - 2000
SN  - 3180915773
SP  - 149
EP  - 164
PB  - VDI-Verl.
CY  - Hüthig
ER  - 
TY  - JOUR
A1  - Koch, Linda
A1  - Wunderlich, F. Thomas
A1  - Seibler, Jost
A1  - Könner, A. Christine
A1  - Hampel, Brigitte
A1  - Irlenbusch, Sigrid
A1  - Brabant, Georg
A1  - Kahn, C. Ronald
A1  - Schwenk, Frieder
A1  - Brüning, Jens C.
T1  - Central insulin action regulates peripheral glucose and fat metabolism in mice
JF  - The Journal of Clinical Investigation (JCI)
Y1  - 2008
U6  - http://dx.doi.org/10.1172/JCI31073
SN  - 1558-8238
VL  - 118
IS  - 6
SP  - 2132
EP  - 2147
ER  - 
TY  - JOUR
A1  - Inagaki, Akiko
A1  - Sleddens-Linkels, Esther
A1  - Wassenaar, Evelyne
A1  - Ooms, Marja
A1  - Cappellen, Wiggert A. van
A1  - Hoeijmakers, Jan H. J.
A1  - Seibler, Jost
A1  - Vogt, Thomas F.
A1  - Shin, Myung K.
A1  - Grootegoed, J. Anton
A1  - Baarends, Willy M.
T1  - Meiotic functions of RAD18
JF  - Journal of Cell Science
Y1  - 2011
U6  - http://dx.doi.org/10.1242/jcs.081968
SN  - 1477-9137
VL  - 124
IS  - 16
SP  - 2837
EP  - 2850
PB  - Company of Biologists Limited
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Handtke, Stefan
A1  - Schroeter, Rebecca
A1  - Jürgen, Britta
A1  - Methling, Karen
A1  - Schlüter, Rabea
A1  - Albrecht, Dirk
A1  - Hijum, Sacha A. F. T. van
A1  - Bongaerts, Johannes
A1  - Maurer, Karl-Heinz
A1  - Lalk, Michael
A1  - Schweder, Thomas
A1  - Hecker, Michael
A1  - Voigt, Birgit
T1  - Bacillus pumilus reveals a remarkably high resistance to hydrogen peroxide provoked oxidative stress
JF  - PLOS one
N2  - Bacillus pumilus is characterized by a higher oxidative stress resistance than other comparable industrially relevant Bacilli such as B. subtilis or B. licheniformis. In this study the response of B. pumilus to oxidative stress was investigated during a treatment with high concentrations of hydrogen peroxide at the proteome, transcriptome and metabolome level. Genes/proteins belonging to regulons, which are known to have important functions in the oxidative stress response of other organisms, were found to be upregulated, such as the Fur, Spx, SOS or CtsR regulon. Strikingly, parts of the fundamental PerR regulon responding to peroxide stress in B. subtilis are not encoded in the B. pumilus genome. Thus, B. pumilus misses the catalase KatA, the DNA-protection protein MrgA or the alkyl hydroperoxide reductase AhpCF. Data of this study suggests that the catalase KatX2 takes over the function of the missing KatA in the oxidative stress response of B. pumilus. The genome-wide expression analysis revealed an induction of bacillithiol (Cys-GlcN-malate, BSH) relevant genes. An analysis of the intracellular metabolites detected high intracellular levels of this protective metabolite, which indicates the importance of bacillithiol in the peroxide stress resistance of B. pumilus.
Y1  - 2014
U6  - http://dx.doi.org/10.1371/journal.pone.0085625
SN  - 1932-6203
VL  - 9
IS  - 1
PB  - PLOS
CY  - San Francisco
ER  -