TY  - JOUR
A1  - Jansen, Sebastian
A1  - Behbahani, Mehdi
A1  - Laumen, Marco
A1  - Kaufmann, Tim
A1  - Hormes, Marcus
A1  - Schmitz-Rode, Thomas
A1  - Behr, Marek
A1  - Steinseifer, Ulrich
T1  - 3D Stereo-PIV Validation for CFD-Simulation of Steady Flow through the Human Aorta using Rapid-Prototyping techniques
Y1  - 2010
N1  - abstract ; IV International Symposium on Modelling of Physiological Flows, Sardinia, Italy, June 02-05, 2010 ; MPF2010
ER  - 
TY  - JOUR
A1  - Brockhaus, Moritz K.
A1  - Behbahani, Mehdi
A1  - Muris, Farina
A1  - Jansen, Sebastian V.
A1  - Schmitz- Rode, Thomas
A1  - Steinseifer, Ulrich
A1  - Clauser, Johanna C.
T1  - In vitro thrombogenicity testing of pulsatile mechanical circulatory support systems: Design and proof-of-concept
JF  - Artificial Organs
N2  - Thrombogenic complications are a main issue in mechanical circulatory support (MCS). There is no validated in vitro method available to quantitatively assess the thrombogenic performance of pulsatile MCS devices under realistic hemodynamic conditions. The aim of this study is to propose a method to evaluate the thrombogenic potential of new designs without the use of complex in-vivo trials. This study presents a novel in vitro method for reproducible thrombogenicity testing of pulsatile MCS systems using low molecular weight heparinized porcine blood. Blood parameters are continuously measured with full blood thromboelastometry (ROTEM; EXTEM, FIBTEM and a custom-made analysis HEPNATEM). Thrombus formation is optically observed after four hours of testing. The results of three experiments are presented each with two parallel loops. The area of thrombus formation inside the MCS device was reproducible. The implantation of a filter inside the loop catches embolizing thrombi without a measurable increase of platelet activation, allowing conclusions of the place of origin of thrombi inside the device. EXTEM and FIBTEM parameters such as clotting velocity (α) and maximum clot firmness (MCF) show a total decrease by around 6% with a characteristic kink after 180 minutes. HEPNATEM α and MCF rise within the first 180 minutes indicate a continuously increasing activation level of coagulation. After 180 minutes, the consumption of clotting factors prevails, resulting in a decrease of α and MCF. With the designed mock loop and the presented protocol we are able to identify thrombogenic hot spots inside a pulsatile pump and characterize their thrombogenic potential.
Y1  - 2021
U6  - https://doi.org/10.1111/aor.14046
SN  - 1525-1594
VL  - 45
IS  - 12
SP  - 1513
EP  - 1521
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Müller-Abdelrazeq, Sarah Luisa
A1  - Brauner, Philipp
A1  - Calero Valdez, André
A1  - Jansen, Ulrich
A1  - Platte, Laura
A1  - Schaar, Anne-Kathrin
A1  - Steuer-Dankert, Linda
A1  - Zachow, Sebastian
A1  - Schönefeld, Kathrin
A1  - Haberstroh, Max
A1  - Leicht-Scholten, Carmen
A1  - Ziefle, Martina
ED  - Pather, Shaun
T1  - Interdisciplinary cooperation management in research clusters: a review of twelve years.
T2  - Proceedings of the 15th International Conference on Intellectual Capital, Knowledge Management & Organisational Learning
N2  - As an interdisciplinary research network, the Cluster of Excellence “Integrative Production Technology for High-Wage Countries” (CoE) comprises of around 150 researchers. Their scientific background ranges from mechanical engineering and computer science to social sciences such as sociology and psychology. In addition to content- and methodbased challenges, the CoE’s employees are faced with heterogenic organizational cultures, different hierarchical levels, an imbalanced gender distribution, and a high employee fluctuation. The sub-project Scientific Cooperation Engineering 1 (CSP1) addresses the challenge of interdisciplinary cooperation and organizational learning and aims at fostering interdisciplinarity and its synergies as a source of innovation. Therefore, the project examines means of reaching an organizational development, ranging from temporal structures to a sustainable network in production technology. To achieve this aim, a broad range of means has been developed during the last twelve years: In addition to physical measures such as regular network events and trainings, virtual measures such as the Terminology App were focused. The app is an algorithmic analysis method for uncovering latent topic structures of publications of the CoE to highlight thematic intersections and synergy potentials. The detection and promotion of has been a vital and long known element in knowledge management. Furthermore, CSP1 focusses on project management and thus developed evaluation tools to measure and control the success of interdisciplinary cooperation. In addition to the cooperation fostering measures, CSP1 conducted studies about interdisciplinarity and diversity and their relationship with innovation. The scientific background of these means and the research results of CSP1 are outlined in this paper to offer approaches for successful interdisciplinary cooperation management.
Y1  - 2018
SN  - 978-1-912764-09-9
N1  - hosted by University of the Western Cape, South Africa 29-30 November 2018
SP  - 216
EP  - 224
PB  - ACPIL
ER  -