TY  - JOUR
A1  - Streese, Lukas
A1  - Kotliar, Konstantin
A1  - Deiseroth, Arne
A1  - Infanger, Denis
A1  - Gugleta, Konstantin
A1  - Schmaderer, Christoph
A1  - Hanssen, Henner
T1  - Retinal endothelial function in cardiovascular risk patients: A randomized controlled exercise trial
JF  - Scandinavian Journal of Medicine and Science in Sports
N2  - The aim of this study was to investigate, for the first time, the effects of high-intensity interval training (HIIT) on retinal microvascular endothelial function in cardiovascular (CV) risk patients. In the randomized controlled trial, middle-aged and previously sedentary patients with increased CV risk (aged 58 ± 6 years) with ≥ two CV risk factors were randomized into a 12-week HIIT (n = 33) or control group (CG, n = 36) with standard physical activity recommendations. A blinded examiner measured retinal endothelial function by flicker light-induced maximal arteriolar (ADmax) and venular (VDmax) dilatation as well as the area under the arteriolar (AFarea) and venular (VFarea) flicker curve using a retinal vessel analyzer. Standardized assessments of CV risk factors, cardiorespiratory fitness, and retinal endothelial function were performed before and after HIIT. HIIT reduced body mass index, fat mass, and low-density lipoprotein and increased muscle mass and peak oxygen uptake (VO2peak). Both ADmax (pre: 2.7 ± 2.1%, post: 3.0 ± 2.2%, P = .018) and AFarea (pre: 32.6 ± 28.4%*s, post: 37.7 ± 30.6%*s, P = .016) increased after HIIT compared with CG (ADmax, pre: 3.2 ± 1.8%, post: 2.9 ± 1.8%, P = .254; AFarea, pre: 41.6 ± 28.5%*s, post: 37.8 ± 27.0%*s, P = .186). Venular function remained unchanged after HIIT. There was a significant association between ∆-change VO2peak and ∆-changes ADmax and AFarea (P = .026, R² = 0.073; P = .019, R² = 0.081, respectively). 12-weeks of HIIT improved retinal endothelial function in middle-aged patients with increased CV risk independent of the reduction in classical CV risk factors. Exercise has the potential to reverse or at least postpone progression of small vessel disease in older adults with increased CV risk under standard medication. Dynamic retinal vessel analysis seems to be a sensitive tool to detect treatment effects of exercise interventions on retinal microvascular endothelial function in middle-aged individuals with increased CV risk.
Y1  - 2020
U6  - https://doi.org/10.1111/sms.13560
SN  - 1600-0838
VL  - 30
IS  - 2
SP  - 272
EP  - 280
PB  - Wiley
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Koshitz, I. N.
A1  - Svetlowa, O. V.
A1  - Zaseeva, M. V.
T1  - Physiological principles of hypotensive therapy of open-angle glaucoma during presbyopic period. Part II Promising algorithms of practical sparing applications / Koshitz, I. N. ; Svetlova, O. V. ; Zaseeva, M. V. ; Shuhaev, S. V. ; Makarov, F. N. ; Kotliar
JF  - Glaukoma (2006)
Y1  - 2006
N1  - Original in Russisch
SP  - 51
EP  - 70
PB  - -
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Koshitz, I. N.
A1  - Svetlowa, O. V.
A1  - Makarov, F. N.
T1  - Biomechanical analysis of traditional and contemporary conceptions on pathogenesis of the primary open angle glaucoma / Koshitz, I. N. ; Svetlova, O. V. ; Kotliar, K. E. ; Makarov, F. N. ;  Smolnikov, B. A.
JF  - Glaukoma (2005)
Y1  - 2005
N1  - Original in Russisch
SP  - 41
EP  - 63
PB  - -
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Svetlova, O. V.
A1  - Stegaev, V. A.
A1  - Parkhomov, S. D.
T1  - Biomechanical substantiation of relatively low efficiency of recurrent laser trabeculoplasty / Svetlova, O. V. ; Stagaev, V. A. ; Parkhomov, S. D. ; Kotliar, K. E. ; Makarov, F. N. ;  Smolnikov, B. A. ; Koshitz, I. N.
JF  - Glaukoma (2004)
Y1  - 2004
N1  - Original in Russisch
SP  - 29
EP  - 39
PB  - -
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Svetlova, O. V.
A1  - Sourjikov, A. V.
A1  - Zaseeva, M. V.
T1  - Biomechanical peculiarities of aqueous humor production system and outflow regulation system / Svetlova, O. V. ; Sourjikov, A. V. ; Kotliar, K. E. ; Zaseeva, M. V. ; Shukhaev, S. V. ; Koshitz, I. N.
JF  - Glaukoma (2004)
Y1  - 2004
N1  - Original in Russisch
SP  - 66
EP  - 76
PB  - -
ER  - 
TY  - THES
A1  - Kotliar, Konstantin
T1  - Functional in-vivo assessment and biofluidmechanical analysis of age-related and pathological microstructural changes in retinal vessels [Elektronische Ressource]
Y1  - 2008
N1  - München, Techn. Univ., Diss., 2008
PB  - -
ER  - 
TY  - THES
A1  - Kotliar, Konstantin
T1  - Razrabotka i analiz matematicheskih modelei nezavisimogo i svyazannogo funkcionirovaniya drenazhnoi i akkomodacionnoi regulyatornyh sistem chelovecheskogo glaza
T2  - Mathematische Modelle der interaktiven und unabhängigen Funktion von Drainage- und Akkommodations-Regelungssystemen des menschlichen Auges
Y1  - 1998
N1  - St.-Petersburg, Russland, Univ., Diss., 1998 
[Lehrstuhl für Theoretische Mechanik der
Staatlichen Polytechnischen Universität St.-Petersburg] 
Originaltitel: Razrabotka i analiz
matematicheskih modelei nezavisimogo i svyazannogo funkcionirovaniya
drenazhnoi i akkomodacionnoi regulyatornyh sistem chelovecheskogo
glaza. 328 S.
PB  - -
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Hanssen, Henner
A1  - Eberhardt, Karla
A1  - Vilser, Walthard
A1  - Schmaderer, Christoph
A1  - Halle, Martin
A1  - Heemann, Uwe
A1  - Baumann, M.
T1  - Retinal pulse wave velocity in young male normotensive and mildly hypertensive subjects
JF  - Microcirculation
Y1  - 2013
SN  - 1549-8719
N1  - Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)
PB  - Wiley
CY  - Malden
ER  - 
TY  - JOUR
A1  - Murgan, Ilina
A1  - Beyer, Sonja
A1  - Kotliar, Konstantin
A1  - Weber, Lutz
A1  - Bechtold-Dalla Pozza, Susanne
A1  - Dalla Pozza, Robert
A1  - Wegner, Aharon
A1  - Sitnikova, Diana
A1  - Stock, Konrad
A1  - Heemann, Uwe
A1  - Schmaderer, Christoph
A1  - Baumann, M.
T1  - Arterial and Retinal Vascular Changes in Hypertensive and Prehypertensive Adolescents
JF  - American Journal of Hypertension
Y1  - 2013
SN  - 1941-7225
VL  - 26
IS  - 3
SP  - 400
EP  - 408
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Feucht, Nikolaus
A1  - Schönbach, Etienne Michael
A1  - Lanzl, Ines
A1  - Kotliar, Konstantin
A1  - Lohmann, Chris Patrick
A1  - Maier, Mathias
T1  - Changes in the foveal microstructure after intravitreal bevacizumab application in patients with retinal vascular disease
JF  - Clinical Ophthalmology
Y1  - 2013
SN  - 1177-5483
VL  - 7
SP  - 173
EP  - 178
PB  - Dove Medical Press
CY  - Auckland, New Zealand
ER  -