TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Turek, M.
A1  - Heiden, W.
A1  - Riesen, A.
A1  - Chhabda, T. A.
A1  - Schubert, J.
A1  - Krüger, P.
A1  - Keusgen, M.
T1  - Artificial intelligence/fuzzy logic method for analysis of combined signals from heavy metal chemical sensors
JF  - Electrochimica Acta. 54 (2009), H. 25 Sp. Iss. SI
Y1  - 2009
SN  - 0013-4686
SP  - 6082
EP  - 6088
PB  - Elsevier
CY  - New York
ER  - 
TY  - JOUR
A1  - Jordan, Sabine D.
A1  - Krüger, Markus
A1  - Willmes, Diana M.
A1  - Redemann, Nora
A1  - Wunderlich, F. Thomas
A1  - Brönneke, Hella S.
A1  - Merkwirth, Carsten
A1  - Kashkar, Hamid
A1  - Olkkonen, Vesa M.
A1  - Böttger, Thomas
A1  - Braun, Thomas
A1  - Seibler, Jost
A1  - Brüning, Jens C.
T1  - Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism
JF  - Nature Cell Biology
N2  - The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143–145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143–ORP8 pathway as a potential target for the treatment of obesity-associated diabetes.
Y1  - 2011
U6  - https://doi.org/10.1038/ncb2211
SN  - 1465-7392
VL  - 13
IS  - 4
SP  - 434
EP  - 446
PB  - Nature
CY  - New York
ER  - 
TY  - JOUR
A1  - Chen, Chao
A1  - Jost, Peter
A1  - Volker, Hanno
A1  - Kaminski, Marvin
A1  - Wirtssohn, Matti R.
A1  - Engelmann, Ulrich M.
A1  - Krüger, K.
A1  - Schlich, Franziska F.
A1  - Schlockermann, Carl
A1  - Lobo, Ricardo P.S.M.
A1  - Wuttig, Matthias
T1  - Dielectric properties of amorphous phase-change materials
JF  - Physical Review B
Y1  - 2017
U6  - https://doi.org/10.1103/PhysRevB.95.094111
SN  - 2469-9950
VL  - 95
IS  - 9
SP  - Article number 094111
ER  - 
TY  - JOUR
A1  - Canzoneri, M.
A1  - Krüger, R.
A1  - Zang, Werner
A1  - Biselli, Manfred
T1  - Atmungsaktivität von Säugerzellen: Kontinuierliche Onlineermittlung im Schüttelkolben
JF  - BIOforum. 3 (2006)
Y1  - 2006
SN  - 0940-0079
SP  - 45
EP  - 47
ER  - 
TY  - JOUR
A1  - Förster, Arnold
A1  - Schäpers, T.
A1  - Krüger, M.
A1  - Appenzeller, J.
T1  - Effect of electron-electron interaction on hot ballistic electron beams / Th. Schäpers ; M. Krüger ; J. Appenzeller ; A. Förster ...
JF  - Applied physics letters. 66 (1995), H. 26
Y1  - 1995
SN  - 0003-6951
N1  - ISSN der E-Ausg.: 1077-3118
SP  - 3603
EP  - 3606
ER  - 
TY  - JOUR
A1  - Enning, Manfred
A1  - Pischinger, S.
A1  - Rake, H.
A1  - Krüger, M.
T1  - Mehrgrößenregelung beim direkt einspritzenden Pkw-Dieselmotor / Pischinger, S. ; Rake, H. ; Krüger, M. ; Enning, M. ; Fieweger, K. ; Kinoo, B. ; Schloßer, A.
JF  - Dieselmotorentechnik  2000 : aktueller Stand und Entwicklungstendenzen ; mit 17 Tabellen und 106 Literaturstellen / Michael Bargende. Ulf Essers (Hrsg.)
Y1  - 2000
SN  - 3-8169-1829-8
N1  - Kontakt & Studium ; 580
SP  - 198
EP  - 217
PB  - Expert-Verl.
CY  - Renningen-Malmsheim
ER  - 
TY  - JOUR
A1  - Enning, Manfred
A1  - Kinoo, B.
A1  - Krüger, M.
A1  - Schloßer, A.
T1  - Turbodiesel fährt umweltfreundlich ins nächste Jahrtausend. Neue Regelungs- und Steuerungsverfahren verbessern Fahrdynamik und Emissionsverhalten / Enning, M. ; Kinoo, B. ; Krüger, M. ; Schloßer, A.
JF  - RWTH-Themen. 1999 (1999), H. 2
Y1  - 1999
N1  - RWTH-Themen 2/1999: Automobiltechnik
SP  - 86
EP  - 91
ER  - 
TY  - JOUR
A1  - Schlieper, G.
A1  - Brandenburg, V.
A1  - Djuric, Z.
A1  - Damjanovic, T.
A1  - Markovic, N.
A1  - Schurgers, L.
A1  - Krüger, T.
A1  - Westenfeld, R.
A1  - Ackermann, D.
A1  - Haselhuhn, Angelika
A1  - Dimkovic, S.
A1  - Ketteler, M.
A1  - Floege, J.
A1  - Dimkovic, N.
T1  - Risk factors for cardiovascular calcifications in non-diabetic Caucasian haemodialysis patients
JF  - Kidney & blood pressure research
Y1  - 2009
SN  - 1423-0143 (E-Journal); 0378-5858 (Print); 1011-6524 (Print); 1420-4096 (Print)
VL  - Vol. 32
SP  - 161
EP  - 168
ER  -