TY  - JOUR
A1  - Valero, Daniel
A1  - Schalko, Isabella
A1  - Friedrich, Heide
A1  - Abad, Jorge D.
A1  - Bung, Daniel Bernhard
A1  - Donchyts, Gennadii
A1  - Felder, Stefan
A1  - Ferreira, Rui M. L.
A1  - Hohermuth, Benjamin
A1  - Kramer, Matthias
A1  - Li, Danxun
A1  - Mendes, Luis
A1  - Moreno-Rodenas, Antonio
A1  - Nones, Michael
A1  - Paron, Paolo
A1  - Ruiz-Villanueva, Virginia
A1  - Wang, Ruo-Qian
A1  - Franca, Mario J.
T1  - Pathways towards democratization of hydro-environment observations and data
JF  - Iahr White Paper Series
Y1  - 2021
IS  - 1
SP  - 1
EP  - 9
PB  - International Association for Hydro-Environment Engineering and Research (IAHR)
ER  - 
TY  - INPR
A1  - Ringers, Christa
A1  - Bialonski, Stephan
A1  - Solovev, Anton
A1  - Hansen, Jan N.
A1  - Ege, Mert
A1  - Friedrich, Benjamin M.
A1  - Jurisch-Yaksi, Nathalie
T1  - Preprint: Local synchronization of cilia and tissue-scale cilia alignment are sufficient for global metachronal waves
T2  - bioRxiv
N2  - Motile cilia are hair-like cell extensions present in multiple organs of the body. How cilia coordinate their regular beat in multiciliated epithelia to move fluids remains insufficiently understood, particularly due to lack of rigorous quantification. We combine here experiments, novel analysis tools, and theory to address this knowledge gap. We investigate collective dynamics of cilia in the zebrafish nose, due to its conserved properties with other ciliated tissues and its superior accessibility for non-invasive imaging. We revealed that cilia are synchronized only locally and that the size of local synchronization domains increases with the viscosity of the surrounding medium. Despite the fact that synchronization is local only, we observed global patterns of traveling metachronal waves across the multiciliated epithelium. Intriguingly, these global wave direction patterns are conserved across individual fish, but different for left and right nose, unveiling a chiral asymmetry of metachronal coordination. To understand the implications of synchronization for fluid pumping, we used a computational model of a regular array of cilia. We found that local metachronal synchronization prevents steric collisions and improves fluid pumping in dense cilia carpets, but hardly affects the direction of fluid flow. In conclusion, we show that local synchronization together with tissue-scale cilia alignment are sufficient to generate metachronal wave patterns in multiciliated epithelia, which enhance their physiological function of fluid pumping.
Y1  - 2021
U6  - https://doi.org/10.1101/2021.11.23.469646
N1  - Veröffentlicht in eLife 12:e77701 (https://doi.org/10.7554/eLife.77701).
ER  -