TY  - JOUR
A1  - Biselli, Manfred
A1  - Rolef, G.
A1  - Dunker, R.
A1  - Wandrey, Christian
T1  - Optimization of antibody production in a fluidized bed bioreactor / Rolef, G. ; Biselli, M. ; Dunker, R. ; Wandrey, C.
JF  - Animal cell technology : products of today, prospects for tomorrow ; ESACT, European Society for Animal Cell Technology, the 12th meeting / Ed. R. E. Spier
Y1  - 1994
SN  - 0750618450
N1  - Meeting / European Society for Animal Cell Technology ; 12
SP  - 481
EP  - 484
PB  - Butterworth-Heinemann
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Thömmes, J.
A1  - Kula, M.-R.
A1  - Wandrey, Christian
T1  - Batch kinetic data of hybridoma growth and productivity as a basis for the simulation of antibody production in various culture systems /  Thömmes, J. ; Biselli, M. ; Kula, M.-R. ; Wandrey, C.
JF  - Animal cell technology : products of today, prospects for tomorrow ; ESACT, European Society for Animal Cell Technology, the 12th meeting / Ed. R. E. Spier
Y1  - 1994
SN  - 0750618450
N1  - Meeting / European Society for Animal Cell Technology ; 12
SP  - 513
EP  - 517
PB  - Butterworth-Heinemann
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Van der Pol, Jens J.
A1  - Machnik, Marc
A1  - Portela-Klein, Theresa
T1  - On-line immunoanalysis of monoclonal antibodies during a continuous culture of hybridoma cells / Jens J. van der Pol, Marc Machnik, Manfred Biselli, Theresa Portela-Klein, Cornelis D. de Gooijer, Johannes Tramper und Christian Wandrey
JF  - Cytotechnology. 24 (1997), H. 1
Y1  - 1997
SN  - 0920-9069
SP  - 19
EP  - 30
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Meissner, Petra
A1  - Schröder, Bernd
A1  - Herfurth, Cornelia
T1  - Development of a fixed bed bioreactor for the expansion of human hematopoietic progenitor cells / Meissner, Petra ; Schröder, Bernd ; Herfurth, Cornelia ; Biselli, Manfred
JF  - Cytotechnology. 30 (1999), H. 1
Y1  - 1999
SN  - 0920-9069
SP  - 227
EP  - 234
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Schmidt, S.
A1  - Büchs, J.
A1  - Born, C.
T1  - A new correlation for the wall-to-fluid mass transfer in liquid-sol fluidized beds / Schmidt, S. ; Büchs, J. ; Born, C. ; Biselli, M.
JF  - Chemical Engineering Science. 54 (1999), H. 6
Y1  - 1999
SN  - 0009-2509
SP  - 829
EP  - 839
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Hilbert, Ulrike
A1  - Jelinek, Nanni
A1  - Schmidt, Sebastian
T1  - Biotechnologische Aspekte der Kultivierung humaner T-Lymphozyten / Hilbert, Ulrike ; Jelinek, Nanni ; Schmidt, Sebastian ; Biselli, Manfred
JF  - Chemie Ingenieur Technik. 72 (2000), H. 7
Y1  - 2000
SN  - 1522-2640
SP  - 746
EP  - 750
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Wandrey, Christian
T1  - Reaction Mechanism of an Endoglucanase of Trichoderma Reesei QM 9414 using Cellodextrins as Substrate
JF  - Technology of biological processes, safety in biotechnology, applied genetic engineering : lectures held at the 5th DECHEMA Annual Meeting of Biotechnologists, May 12 - 13, 1987, [Frankfurt, Main] / [hrsg. von Dieter Behrens ...]
Y1  - 1988
N1  - Jahrestagung der Biotechnologen ; <5, 1987, Frankfurt, Main> ; DECHEMA Biotechnology Conferences series ; 1
SP  - 425
EP  - 429
PB  - VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Schmid, Georg
A1  - Wandrey, Christian
T1  - Preparation of cellodextrins and isolation of oligomeric side components and their characterization / Schmid, Georg ; Biselli, Manfred ; Wandrey, Christian
JF  - Analytical Biochemistry. 175 (1988)
Y1  - 1988
SN  - 0003-2697
SP  - 573
EP  - 583
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Thömmes, J.
A1  - Garske, U.
A1  - Wandrey, Christian
T1  - Integrated detoxification: Reduction of ammonium concentration by dialysis with cation exchange membranes / Thömmes, J. ; Garske, U. ; Biselli, M. ; Wandrey, C.
JF  - Animal cell technology : developments, processes, and products ; ESACT, European Society for Animal Cell Technology, the 11th meeting / Ed. R. E. Spier
Y1  - 1992
SN  - 0750604212
SP  - 171
EP  - 175
PB  - Butterworth-Heinemann
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Winckler, Silvia
A1  - Krueger, Rolf
A1  - Schnitzler, Thomas
A1  - Zang, Werner
A1  - Fischer, Rainer
A1  - Biselli, Manfred
T1  - A sensitive monitoring system for mammalian cell cultivation processes: a PAT approach
JF  - Bioprocess and biosystems engineering
N2  - Biopharmaceuticals such as antibodies are produced in cultivated mammalian cells, which must be monitored to comply with good manufacturing practice. We, therefore, developed a fully automated system comprising a specific exhaust gas analyzer, inline analytics and a corresponding algorithm to precisely determine the oxygen uptake rate, carbon dioxide evolution rate, carbon dioxide transfer rate, transfer quotient and respiratory quotient without interrupting the ongoing cultivation, in order to assess its reproducibility. The system was verified using chemical simulation experiments and was able to measure the respiratory activity of hybridoma cells and DG44 cells (derived from Chinese hamster ovary cells) with satisfactory results at a minimum viable cell density of ~2.0 × 10⁵ cells ml⁻¹. The system was suitable for both batch and fed-batch cultivations in bubble-aerated and membrane-aerated reactors, with and without the control of pH and dissolved oxygen.
Y1  - 2014
U6  - https://doi.org/10.1007/s00449-013-1062-8
SN  - 1615-7591 (Print) 1615-7605 (Online)
VL  - 37
IS  - 5
SP  - 901
EP  - 912
PB  - Springer
CY  - Berlin, Heidelberg
ER  -