TY  - JOUR
A1  - Fuest, Matthias
A1  - Kotliar, Konstantin
A1  - Walter, Peter
A1  - Plange, Niklas
T1  - Monitoring intraocular pressure changes after intravitreal Ranibizumab injection using rebound tonometry
JF  - Ophthalmic and physiological optics
Y1  - 2014
U6  - https://doi.org/10.1111/opo.12134
SN  - 1475-1313 (E-Journal); 0275-5408 (Print)
N1  - Special Issue: The Ageing Visual System
VL  - 34
IS  - 4
SP  - 438
EP  - 444
PB  - Wiley-Blackwell
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Kuerten, David
A1  - Kotliar, Konstantin
A1  - Fuest, Matthias
A1  - Walter, Peter
A1  - Hollstein, Muriel
A1  - Plange, Niklas
ED  - Neri, Piergiorgio
T1  - Does hemispheric vascular regulation differ significantly in glaucoma patients with altitudinal visual field asymmetry? A single-center, prospective study
JF  - International Ophthalmology
N2  - Purpose Vascular risk factors and ocular perfusion are heatedly discussed in the pathogenesis of glaucoma. The retinal vessel analyzer (RVA, IMEDOS Systems, Germany) allows noninvasive measurement of retinal vessel regulation. Significant differences especially in the veins between healthy subjects and patients suffering from glaucoma were previously reported. In this pilot-study we investigated if localized vascular regulation is altered in glaucoma patients with altitudinal visual field defect asymmetry. Methods 15 eyes of 12 glaucoma patients with advanced altitudinal visual field defect asymmetry were included. The mean defect was calculated for each hemisphere separately (-20.99 ± 10.49 pro- found hemispheric visual field defect vs -7.36 ± 3.97 dB less profound hemisphere). After pupil dilation, RVA measurements of retinal arteries and veins were conducted using the standard protocol. The superior and inferior retinal vessel reactivity were measured consecutively in each eye. Results Significant differences were recorded in venous vessel constriction after flicker light stimulation and overall amplitude of the reaction (p \ 0.04 and p \ 0.02 respectively) in-between the hemispheres spheres. Vessel reaction was higher in the hemisphere corresponding to the more advanced visual field defect. Arterial diameters reacted similarly, failing to reach statistical significance. Conclusion Localized retinal vessel regulation is significantly altered in glaucoma patients with asymmetri altitudinal visual field defects. Veins supplying the hemisphere concordant to a less profound visual field defect show diminished diameter changes. Vascular dysregulation might be particularly important in early glaucoma stages prior to a significant visual field defect.
KW  - Glaucoma
KW  - Visual field asymmetry
KW  - Ocular blood flow
KW  - RVA
KW  - Vascular response
Y1  - 2021
SN  - 1573-2630
U6  - https://doi.org/10.1007/s10792-021-01876-0
VL  - 41
IS  - 41
SP  - 3109
EP  - 3119
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Albanna, Walid
A1  - Conzen, Catharina
A1  - Weiss, Miriam
A1  - Clusmann, Hans
A1  - Fuest, Matthias
A1  - Mueller, Marguerite
A1  - Brockmann, Marc Alexander
A1  - Vilser, Walthard
A1  - Schmidt-Trucksäss, Arno
A1  - Hoellig, Anke
A1  - Seiz, Marcel
A1  - Thomé, Claudius
A1  - Kotliar, Konstantin
A1  - Schubert, Gerrit Alexander
T1  - Retinal Vessel Analysis (RVA) in the context of subarachnoid hemorrhage: A proof of concept study
JF  - PLoS ONE
N2  - Background
Timely detection of impending delayed cerebral ischemia after subarachnoid hemorrhage (SAH) is essential to improve outcome, but poses a diagnostic challenge. Retinal vessels as an embryological part of the intracranial vasculature are easily accessible for analysis and may hold the key to a new and non-invasive monitoring technique. This investigation aims to determine the feasibility of standardized retinal vessel analysis (RVA) in the context of SAH.

Methods
In a prospective pilot study, we performed RVA in six patients awake and cooperative with SAH in the acute phase (day 2–14) and eight patients at the time of follow-up (mean 4.6±1.7months after SAH), and included 33 age-matched healthy controls. Data was acquired using a manoeuvrable Dynamic Vessel Analyzer (Imedos Systems UG, Jena) for examination of retinal vessel dimension and neurovascular coupling.

Results
Image quality was satisfactory in the majority of cases (93.3%). In the acute phase after SAH, retinal arteries were significantly dilated when compared to the control group (124.2±4.3MU vs 110.9±11.4MU, p<0.01), a difference that persisted to a lesser extent in the later stage of the disease (122.7±17.2MU, p<0.05). Testing for neurovascular coupling showed a trend towards impaired primary vasodilation and secondary vasoconstriction (p = 0.08, p = 0.09 resp.) initially and partial recovery at the time of follow-up, indicating a relative improvement in a time-dependent fashion.

Conclusion
RVA is technically feasible in patients with SAH and can detect fluctuations in vessel diameter and autoregulation even in less severely affected patients. Preliminary data suggests potential for RVA as a new and non-invasive tool for advanced SAH monitoring, but clinical relevance and prognostic value will have to be determined in a larger cohort.
Y1  - 2016
U6  - https://doi.org/10.1371/journal.pone.0158781
SN  - 1932-6203
VL  - 11
IS  - 7
PB  - PLOS
CY  - San Francisco
ER  -